| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelsey E McLimans, Bridget E Clark, Alexandra Plagman, Colleen Pappas, Brandon Klinedinst, Vellareddy Anatharam, Anumantha Kanthasamy, Auriel A Willett. Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease? Antioxidants & redox signaling. vol 31. issue 8. 2020-07-23. PMID:31088292. |
is cerebrospinal fluid superoxide dismutase 1 a biomarker of tau but not amyloid-induced neurodegeneration in alzheimer's disease? |
2020-07-23 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Özgür A Onur, Juraj Kukolja, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Elke Kalbe, Alexander Drzezga, Thilo van Eimere. Level of education mitigates the impact of tau pathology on neuronal function. European journal of nuclear medicine and molecular imaging. vol 46. issue 9. 2020-07-23. PMID:31183635. |
using pet imaging in a group of patients with alzheimer's disease (ad), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function. |
2020-07-23 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Haiyan Liu, William Lu, Paul T Kotzbauer, Randall J Bateman, Brendan P Luce. Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid. Annals of neurology. vol 87. issue 5. 2020-07-23. PMID:32057125. |
tau hyperphosphorylation is an early step in tau-mediated neurodegeneration and is associated with intracellular aggregation of tau as neurofibrillary tangles, neuronal and synaptic loss, and eventual cognitive dysfunction in alzheimer disease. |
2020-07-23 |
2023-08-13 |
human |
| Maximilian Strunz, Juliet T Jarrell, David S Cohen, Eric R Rosin, Charles R Vanderburg, Xudong Huan. Modulation of SPARC/Hevin Proteins in Alzheimer's Disease Brain Injury. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-22. PMID:30883351. |
alzheimer's disease (ad) is an age-related progressive form of dementia that features neuronal loss, intracellular tau, and extracellular amyloid-β (aβ) protein deposition. |
2020-07-22 |
2023-08-13 |
Not clear |
| Cassandra L Pattinson, Jessica M Gill, Sara M Lippa, Tracey A Brickell, Louis M French, Rael T Lang. Concurrent Mild Traumatic Brain Injury and Posttraumatic Stress Disorder Is Associated With Elevated Tau Concentrations in Peripheral Blood Plasma. Journal of traumatic stress. vol 32. issue 4. 2020-07-22. PMID:31291489. |
tau and amyloid-beta-42 (aβ42) are proteins that have been linked to cognitive impairment, neurological hallmarks of alzheimer's disease, and may also relate to recovery from mtbi. |
2020-07-22 |
2023-08-13 |
human |
| Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P Manfredsson, Xifei Yang, Hongbo R Luo, L Cameron Liles, David Weinshenker, Keqiang Y. Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. The Journal of clinical investigation. vol 130. issue 1. 2020-07-21. PMID:31793911. |
aberrant tau inclusions in the locus coeruleus (lc) are the earliest detectable alzheimer's disease-like (ad-like) neuropathology in the human brain. |
2020-07-21 |
2023-08-13 |
human |
| Christian Benedict, Kaj Blennow, Henrik Zetterberg, Jonathan Cedernae. Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men. Neurology. vol 94. issue 11. 2020-07-21. PMID:31915189. |
disrupted sleep increases csf levels of tau and β-amyloid (aβ) and is associated with an increased risk of alzheimer disease (ad). |
2020-07-21 |
2023-08-13 |
Not clear |
| Thomas K Karikari, Tharick A Pascoal, Nicholas J Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blenno. Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. The Lancet. Neurology. vol 19. issue 5. 2020-07-21. PMID:32333900. |
blood phosphorylated tau 181 as a biomarker for alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. |
2020-07-21 |
2023-08-13 |
Not clear |
| Thomas K Karikari, Tharick A Pascoal, Nicholas J Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blenno. Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. The Lancet. Neurology. vol 19. issue 5. 2020-07-21. PMID:32333900. |
csf and pet biomarkers of amyloid β and tau accurately detect alzheimer's disease pathology, but the invasiveness, high cost, and poor availability of these detection methods restrict their widespread use as clinical diagnostic tools. |
2020-07-21 |
2023-08-13 |
Not clear |
| Thomas K Karikari, Tharick A Pascoal, Nicholas J Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blenno. Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. The Lancet. Neurology. vol 19. issue 5. 2020-07-21. PMID:32333900. |
csf tau phosphorylated at threonine 181 (p-tau181) is a highly specific biomarker for alzheimer's disease pathology. |
2020-07-21 |
2023-08-13 |
Not clear |
| Soha Ahmadi, Shaolong Zhu, Renu Sharma, Derek J Wilson, Heinz-Bernhard Kraat. Interaction of metal ions with tau protein. The case for a metal-mediated tau aggregation. Journal of inorganic biochemistry. vol 194. 2020-07-20. PMID:30826589. |
tau protein aggregation and its hyperphosphorylation play an important role in the pathogenesis of alzheimer's disease. |
2020-07-20 |
2023-08-13 |
Not clear |
| Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jiménez, Maria A Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L Hsieh, Luis M Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J Nilsson, Guy C Brown, Antonia Gutierrez, Javier Vitorica, Jose Luis Venero, Tomas Deierbor. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta neuropathologica. vol 138. issue 2. 2020-07-20. PMID:31006066. |
alzheimer's disease (ad) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. |
2020-07-20 |
2023-08-13 |
mouse |
| Paul Matthew Seidler, David R Boyer, Kevin A Murray, Tianxiao P Yang, Megan Bentzel, Michael R Sawaya, Gregory Rosenberg, Duilio Cascio, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, David S Eisenber. Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. The Journal of biological chemistry. vol 294. issue 44. 2020-07-20. PMID:31537646. |
in alzheimer's disease (ad) and tauopathies, tau aggregation accompanies progressive neurodegeneration. |
2020-07-20 |
2023-08-13 |
Not clear |
| Tanusree Sen, Pampa Saha, Tong Jiang, Nilkantha Se. Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 8. 2020-07-17. PMID:32051249. |
in alzheimer's disease (ad), human tau is phosphorylated at s199 (htau-s199-p) by the protein kinase glycogen synthase kinase 3β (gsk3β). |
2020-07-17 |
2023-08-13 |
human |
| Abhinaba Ghosh, Sarah E Torraville, Bandhan Mukherjee, Susan G Walling, Gerard M Martin, Carolyn W Harley, Qi Yua. An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. Alzheimer's research & therapy. vol 11. issue 1. 2020-07-16. PMID:31266535. |
the earliest brain pathology related to alzheimer's disease (ad) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (lc) neurons. |
2020-07-16 |
2023-08-13 |
human |
| Abhinaba Ghosh, Sarah E Torraville, Bandhan Mukherjee, Susan G Walling, Gerard M Martin, Carolyn W Harley, Qi Yua. An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. Alzheimer's research & therapy. vol 11. issue 1. 2020-07-16. PMID:31266535. |
we use a rat model expressing pseudohyperphosphorylated human tau in lc to investigate the hypothesis that lc pretangles generate preclinical alzheimer pathology. |
2020-07-16 |
2023-08-13 |
human |
| Matthias Brendel, Maximilian Deussing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern-Sternberg, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Igor Yakushev, Paul Cumming, Guido Boening, Sibylle Ziegler, Jochen Herms, Armin Giese, Axel Rominge. Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau. Alzheimer's research & therapy. vol 11. issue 1. 2020-07-16. PMID:31370885. |
late-stage anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human alzheimer's disease tau. |
2020-07-16 |
2023-08-13 |
mouse |
| Ge Gao, Jing He, Yi Luo, Yan Sun, Yanping Zhou, Junxia Zhang, Ying Xing, Jiapei Da. Axonopathy Likely Initiates Neuropathological Processes Via a Mechanism of Axonal Leakage in Alzheimer's Mouse Models. Current molecular medicine. vol 19. issue 3. 2020-07-15. PMID:30961496. |
the formation of hyperphosphorylated tau and the production of β-amyloid are thought to be critical steps contributing to the pathological mechanisms in alzheimer's disease (ad). |
2020-07-15 |
2023-08-13 |
mouse |
| Leslie A Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T Calahatian, Devon S Placides, Mallory D Watler, Jerry B Hunt, April L Darling, Jeremy D Baker, Laura J Blair, Mackenzie D Martin, Sarah N Fontaine, Chad A Dickey, April L Lussier, Edwin J Weeber, Maj-Linda B Selenica, Kevin R Nash, Marcia N Gordon, Dave Morgan, Daniel C Le. Spermidine/spermine-N Alzheimer's research & therapy. vol 11. issue 1. 2020-07-15. PMID:31253191. |
spermidine/spermine-n tau stabilizes microtubules; however, in alzheimer's disease (ad) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. |
2020-07-15 |
2023-08-13 |
Not clear |
| Ramsey Najm, Antara Rao, Yadong Huan. Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease. Cell stem cell. vol 26. issue 3. 2020-07-15. PMID:32142656. |
too much tau in interneurons impairs adult hippocampal neurogenesis in alzheimer's disease. |
2020-07-15 |
2023-08-13 |
mouse |