| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muneaki Takahashi, Haruka Miyata, Fuyuki Kametani, Takashi Nonaka, Haruhiko Akiyama, Shin-ichi Hisanaga, Masato Hasegaw. Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau. Acta neuropathologica. vol 129. issue 6. 2016-02-10. PMID:25869641. |
alzheimer's disease (ad) is characterized by extracellular amyloid β (aβ) deposition and intracellular tau aggregation. |
2016-02-10 |
2023-08-13 |
Not clear |
| C Ising, M Stanley, D M Holtzma. Current thinking on the mechanistic basis of Alzheimer's and implications for drug development. Clinical pharmacology and therapeutics. vol 98. issue 5. 2016-02-10. PMID:26250900. |
alzheimer disease (ad) is the most common cause of dementia and is characterized by the aggregation and accumulation of two proteins in the brain, amyloid-β (aβ) and tau. |
2016-02-10 |
2023-08-13 |
Not clear |
| Juan Deng, Ahsan Habib, Demian F Obregon, Steven W Barger, Brian Giunta, Yan-Jiang Wang, Huayan Hou, Darrell Sawmiller, Jun Ta. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway. Journal of neurochemistry. vol 135. issue 3. 2016-02-10. PMID:26342176. |
because inhibition of bace1 decreases glycogen synthase kinase 3 beta (gsk3β)-mediated alzheimer's disease (ad)-like tau phosphorylation in ad patient-derived neurons, we determined whether sappα also reduces gsk3β-mediated tau phosphorylation. |
2016-02-10 |
2023-08-13 |
mouse |
| Mariangela Iovino, Sylvia Agathou, Ana González-Rueda, Martin Del Castillo Velasco-Herrera, Barbara Borroni, Antonella Alberici, Timothy Lynch, Sean O'Dowd, Imbisaat Geti, Daniel Gaffney, Ludovic Vallier, Ole Paulsen, Ragnhildur Thóra Káradóttir, Maria Grazia Spillantin. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26220942. |
tauopathies, such as alzheimer's disease, some cases of frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy, are characterized by aggregates of the microtubule-associated protein tau, which are linked to neuronal death and disease development and can be caused by mutations in the mapt gene. |
2016-02-09 |
2023-08-13 |
human |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience. vol 18. issue 11. 2016-02-09. PMID:26436904. |
accumulation of pathological tau protein is a major hallmark of alzheimer's disease. |
2016-02-09 |
2023-08-13 |
mouse |
| b' David A Loeffler, Lynnae M Smith, Andrea C Klaver, Sanela Marti\\xc4\\x8. Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report. Experimental gerontology. vol 67. 2016-02-08. PMID:25914109.' |
phosphorylation of multiple amino acids on tau protein ("hyperphosphorylation") is required for the development of tau pathology in alzheimer's disease. |
2016-02-08 |
2023-08-13 |
mouse |
| Cecilie Morland, Knut Husø Lauritzen, Maja Puchades, Signe Holm-Hansen, Krister Andersson, Albert Gjedde, Håvard Attramadal, Jon Storm-Mathisen, Linda Hildegard Bergerse. The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain. Journal of neuroscience research. vol 93. issue 7. 2016-02-05. PMID:25881750. |
for instance, in the prefrontal cortex, excessively high camp levels are implicated in impaired cognition in old age, fatigue, stress, and schizophrenia and in the deposition of phosphorylated tau protein in alzheimer's disease. |
2016-02-05 |
2023-08-13 |
Not clear |
| Kurt R Stover, Mackenzie A Campbell, Christine M Van Winssen, Richard E Brow. Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease. Behavioural brain research. vol 289. 2016-02-05. PMID:25896362. |
the 3xtg-ad mouse model of alzheimer's disease (ad) has three transgenes (appswe, ps1m146v, and tau p301l) which cause the development of amyloid beta plaques, neurofibrillary tangles, and cognitive deficits with age. |
2016-02-05 |
2023-08-13 |
mouse |
| Steven Moore, Lewis D B Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J Livese. APP metabolism regulates tau proteostasis in human cerebral cortex neurons. Cell reports. vol 11. issue 5. 2016-02-05. PMID:25921538. |
accumulation of aβ peptide fragments of the app protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of alzheimer's disease (ad). |
2016-02-05 |
2023-08-13 |
human |
| Sergio Camero, María J Benítez, Raquel Cuadros, Félix Hernández, Jesús Avila, Juan S Jiméne. Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNA. PloS one. vol 9. issue 8. 2016-02-04. PMID:25126942. |
thermodynamics of the interaction between alzheimer's disease related tau protein and dna. |
2016-02-04 |
2023-08-13 |
Not clear |
| Sergio Camero, María J Benítez, Raquel Cuadros, Félix Hernández, Jesús Avila, Juan S Jiméne. Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNA. PloS one. vol 9. issue 8. 2016-02-04. PMID:25126942. |
tau hyperphosphorylation can be considered as one of the hallmarks of alzheimer's disease and other tauophaties. |
2016-02-04 |
2023-08-13 |
Not clear |
| Sergio Camero, María J Benítez, Raquel Cuadros, Félix Hernández, Jesús Avila, Juan S Jiméne. Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNA. PloS one. vol 9. issue 8. 2016-02-04. PMID:25126942. |
our results suggest that hydrophobicity may control tau location and dna interaction and that impairment of this tau-dna interaction, due to tau hyperphosphorylation, could contribute to alzheimer's pathogenesis. |
2016-02-04 |
2023-08-13 |
Not clear |
| Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijania. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933020. |
in alzheimer's disease (ad), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. |
2016-02-04 |
2023-08-13 |
mouse |
| Shaolong Zhu, Agnesa Shala, Alexandr Bezginov, Adnan Sljoka, Gerald Audette, Derek J Wilso. Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble. PloS one. vol 10. issue 3. 2016-02-02. PMID:25767879. |
in alzheimer's and other tauopathies, tau forms intracellular insoluble amyloid aggregates known as neurofibrillary tangles, a process that appears in many cases to be preceded by hyperphosphorylation of tau monomers. |
2016-02-02 |
2023-08-13 |
Not clear |
| Jonathan J Sabbagh, Chad A Dicke. The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost. Frontiers in neuroscience. vol 10. 2016-02-02. PMID:26834532. |
accumulation of the microtubule associated protein tau occurs in several neurodegenerative diseases including alzheimer's disease (ad). |
2016-02-02 |
2023-08-13 |
Not clear |
| Haochen Liu, Chunxiang Wei, Hua He, Xiaoquan Li. Evaluating Alzheimer's Disease Progression by Modeling Crosstalk Network Disruption. Frontiers in neuroscience. vol 9. 2016-02-02. PMID:26834548. |
aβ, tau, and p-tau have been widely accepted as reliable markers for alzheimer's disease (ad). |
2016-02-02 |
2023-08-13 |
Not clear |
| Robert Underly, Mee-Sook Song, Gary L Dunbar, Charles L Weave. Expression of Alzheimer-Type Neurofibrillary Epitopes in Primary Rat Cortical Neurons Following Infection with Enterococcus faecalis. Frontiers in aging neuroscience. vol 7. 2016-02-02. PMID:26834627. |
the neurofibrillary tau pathology and amyloid deposits seen in alzheimer's disease (ad) also have been seen in bacteria-infected brains. |
2016-02-02 |
2023-08-13 |
rat |
| Robert Underly, Mee-Sook Song, Gary L Dunbar, Charles L Weave. Expression of Alzheimer-Type Neurofibrillary Epitopes in Primary Rat Cortical Neurons Following Infection with Enterococcus faecalis. Frontiers in aging neuroscience. vol 7. 2016-02-02. PMID:26834627. |
highlightsenterococcus faecalis used in the generation of ad neurofibrillary epitopes in rat.infection increases alz-50, phospho-serine 202 tau, and map2 expression.infection by enterococcus may play a role in early alzheimer neurofibrillary changes. |
2016-02-02 |
2023-08-13 |
rat |
| Jay Amin, Claire Paquet, Alex Baker, Ayodeji A Asuni, Seth Love, Clive Holmes, Jacques Hugon, James A R Nicoll, Delphine Boch. Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β. Neuropathology and applied neurobiology. vol 41. issue 4. 2016-02-01. PMID:25486988. |
active amyloid-β (aβ) immunotherapy in alzheimer's disease (ad) induces removal of aβ and phosphorylated tau (ptau). |
2016-02-01 |
2023-08-13 |
Not clear |
| Hiroyuki Watanabe, Masahiro Ono, Hideo Saj. Novel PET/SPECT probes for imaging of tau in Alzheimer's disease. TheScientificWorldJournal. vol 2015. 2016-02-01. PMID:25879047. |
novel pet/spect probes for imaging of tau in alzheimer's disease. |
2016-02-01 |
2023-08-13 |
Not clear |