| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Takashim. Tau aggregation is a therapeutic target for Alzheimer's disease. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678070. |
tau aggregation is a therapeutic target for alzheimer's disease. |
2011-11-23 |
2023-08-12 |
mouse |
| B Kovacech, M Nova. Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678071. |
tau truncation is a productive posttranslational modification of neurofibrillary degeneration in alzheimer's disease. |
2011-11-23 |
2023-08-12 |
human |
| B Kovacech, M Nova. Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678071. |
deposits of the misfolded neuronal protein tau are major hallmarks of neurodegeneration in alzheimer's disease (ad) and other tauopathies. |
2011-11-23 |
2023-08-12 |
human |
| B Kovacech, M Nova. Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678071. |
therefore, proteolytical abnormalities in the stressed neurons and production of aberrant tau cleavage products deserve closer attention and should be considered as early therapeutic targets for alzheimer's disease. |
2011-11-23 |
2023-08-12 |
human |
| M Deture, C Hicks, L Petrucell. Targeting heat shock proteins in tauopathies. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678072. |
tau proteins form the major structural component of the neurofibrillary protein aggregates that correlate with cognitive decline in alzheimer's disease, and appropriately this abnormal tau is targeted for corrective action by the heat shock proteins that recognize sequence motifs that are normally masked though microtubule binding. |
2011-11-23 |
2023-08-12 |
Not clear |
| S Souter, G Le. Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678073. |
tubulin-independent tau in alzheimer's disease and cancer: implications for disease pathogenesis and treatment. |
2011-11-23 |
2023-08-12 |
Not clear |
| S Souter, G Le. Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678073. |
the tau interactions with fyn and with pin1 have attracted the most attention and both interactions have been thought to have a role in alzheimer's disease. |
2011-11-23 |
2023-08-12 |
Not clear |
| S Souter, G Le. Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678073. |
in fact, structural similarities exist between alzheimer's disease tau and prostate cancer cell tau, raising the possibility that new tau functions uncovered in prostate cancer cells will have relevance to alzheimer's disease. |
2011-11-23 |
2023-08-12 |
Not clear |
| K Iqbal, F Liu, C-X Gong, I Grundke-Iqba. Tau in Alzheimer disease and related tauopathies. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678074. |
tau in alzheimer disease and related tauopathies. |
2011-11-23 |
2023-08-12 |
human |
| K Iqbal, F Liu, C-X Gong, I Grundke-Iqba. Tau in Alzheimer disease and related tauopathies. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20678074. |
in alzheimer disease (ad) brain tau is ~three to four-fold more hyperphosphorylated than the normal adult brain tau and in this hyperphosphorylated state it is polymerized into paired helical filaments ([phf) admixed with straight filaments (sf) forming neurofibrillary tangles. |
2011-11-23 |
2023-08-12 |
human |
| Alejandra Del Carmen Alons. Tau, neurodegeneration and Alzheimer's disease. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:21214513. |
tau, neurodegeneration and alzheimer's disease. |
2011-11-23 |
2023-08-12 |
Not clear |
| Jonathan H Williams, Gordon K Wilcock, Jeffrey Seeburger, Aimee Dallob, Omar Laterza, William Potter, A David Smit. Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. Alzheimer's research & therapy. vol 3. issue 1. 2011-11-23. PMID:21329517. |
levels of cerebrospinal fluid (csf) β-amyloid (aβ) and tau proteins change in alzheimer's disease (ad). |
2011-11-23 |
2023-08-12 |
Not clear |
| David E Kang, Seung Eon Roh, Jung A Woo, Tian Liu, Jung Hyun Bu, A-Rong Jung, Yeory Li. The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders. Experimental neurobiology. vol 20. issue 2. 2011-11-23. PMID:22110363. |
the major defining pathological hallmarks of alzheimer's disease (ad) are the accumulations of aβ in senile plaques and hyperphosphorylated tau in neurofibrillary tangles and neuropil threads. |
2011-11-23 |
2023-08-12 |
Not clear |
| Ludovic Martin, Guylene Page, Faraj Terr. Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β. Neurochemistry international. vol 59. issue 2. 2011-11-22. PMID:21672577. |
overactivation of gsk3β (glycogen synthase kinase-3β) and downregulation of pp2a (protein phosphatase-2a) have been proposed to be involved in the abnormal tau phosphorylation and aggregation in alzheimer's disease (ad). |
2011-11-22 |
2023-08-12 |
Not clear |
| Xiyun Chai, Su Wu, Tracey K Murray, Robert Kinley, Claire V Cella, Helen Sims, Nicola Buckner, Jenna Hanmer, Peter Davies, Michael J O'Neill, Michael L Hutton, Martin Citro. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. The Journal of biological chemistry. vol 286. issue 39. 2011-11-22. PMID:21841002. |
the microtubule-associated protein tau plays a critical role in the pathogenesis of alzheimer disease and several related disorders (tauopathies). |
2011-11-22 |
2023-08-12 |
mouse |
| Xiyun Chai, Su Wu, Tracey K Murray, Robert Kinley, Claire V Cella, Helen Sims, Nicola Buckner, Jenna Hanmer, Peter Davies, Michael J O'Neill, Michael L Hutton, Martin Citro. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. The Journal of biological chemistry. vol 286. issue 39. 2011-11-22. PMID:21841002. |
tau immunotherapy should therefore be considered as a therapeutic approach for the treatment of alzheimer disease and other tauopathies. |
2011-11-22 |
2023-08-12 |
mouse |
| Laziza Amniai, Guy Lippens, Isabelle Landrie. Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach. Biochemical and biophysical research communications. vol 412. issue 4. 2011-11-22. PMID:21871442. |
we present here the characterization of the epitope recognized by the at180 monoclonal antibody currently used to define an alzheimer's disease (ad)-related pathological form of the phosphorylated tau protein. |
2011-11-22 |
2023-08-12 |
Not clear |
| Anja Kunze, Robert Meissner, Serena Brando, Philippe Renau. Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies. Biotechnology and bioengineering. vol 108. issue 9. 2011-11-15. PMID:21391208. |
oa is a phosphatase inhibitor that induces hyperphosphorylation of tau proteins, a major hallmark in alzheimer disease. |
2011-11-15 |
2023-08-12 |
Not clear |
| Lilla Reiniger, Ana Lukic, Jacqueline Linehan, Peter Rudge, John Collinge, Simon Mead, Sebastian Brandne. Tau, prions and Aβ: the triad of neurodegeneration. Acta neuropathologica. vol 121. issue 1. 2011-11-14. PMID:20473510. |
it also discusses similarities between prion disease and alzheimer's disease: mechanisms of amyloid formation, neurotoxicity, pathways involved in triggering tau phosphorylation, links to cell cycle pathways and neuronal apoptosis. |
2011-11-14 |
2023-08-12 |
Not clear |
| Claire J Garwood, Jonathan D Cooper, Diane P Hanger, Wendy Nobl. Anti-inflammatory impact of minocycline in a mouse model of tauopathy. Frontiers in psychiatry. vol 1. 2011-11-10. PMID:21423446. |
alzheimer's disease (ad) is characterized by the extracellular deposition of β-amyloid in senile plaques, the intraneuronal accumulation of hyperphosphorylated tau aggregates as neurofibrillary tangles, and progressive neuronal loss leading to the onset of dementia. |
2011-11-10 |
2023-08-12 |
mouse |