| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sae H Min, Jung S Cho, Jae H Oh, Sun B Shim, Dae Y Hwang, Su H Lee, Seung W Jee, Hwa J Lim, Min Y Kim, Yhun Y Sheen, Seok H Lee, Yong K Ki. Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation. Neurochemical research. vol 30. issue 8. 2006-01-24. PMID:16258844. |
thus, these observations suggest that pin1 might have an inhibitive role in phosphorylating tau and gsk3beta for protecting against alzheimer's disease. |
2006-01-24 |
2023-08-12 |
mouse |
| Isidro Ferrer, Marta Barrachina, Berta Puig, M Martínez de Lagrán, Eulalia Martí, Jesús Avila, Mara Diersse. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiology of disease. vol 20. issue 2. 2006-01-23. PMID:16242644. |
dyrk1 phosphorylates the human microtubule-associated protein tau at thr212 in vitro, a residue that is phosphorylated in fetal tau and hyper-phosphorylated in alzheimer disease (ad) and tauopathies, including pick disease (pid). |
2006-01-23 |
2023-08-12 |
mouse |
| Kate M Webber, Arun K Raina, Michael W Marlatt, Xiongwei Zhu, María I Prat, Laura Morelli, Gemma Casadesus, George Perry, Mark A Smit. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of ageing and development. vol 126. issue 10. 2006-01-20. PMID:15936057. |
several hypotheses have been proposed attempting to explain the pathogenesis of alzheimer disease including, among others, theories involving amyloid deposition, tau phosphorylation, oxidative stress, metal ion dysregulation and inflammation. |
2006-01-20 |
2023-08-12 |
Not clear |
| Kate M Webber, Arun K Raina, Michael W Marlatt, Xiongwei Zhu, María I Prat, Laura Morelli, Gemma Casadesus, George Perry, Mark A Smit. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of ageing and development. vol 126. issue 10. 2006-01-20. PMID:15936057. |
neuronal changes supporting alterations in cell cycle control in the etiology of alzheimer disease include the ectopic expression of markers of the cell cycle, organelle kinesis and cytoskeletal alterations including tau phosphorylation. |
2006-01-20 |
2023-08-12 |
Not clear |
| Kate M Webber, Arun K Raina, Michael W Marlatt, Xiongwei Zhu, María I Prat, Laura Morelli, Gemma Casadesus, George Perry, Mark A Smit. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of ageing and development. vol 126. issue 10. 2006-01-20. PMID:15936057. |
such mitotic alterations are not only one of the earliest neuronal abnormalities in the disease, but as discussed herein, are also intimately linked to all of the other pathological hallmarks of alzheimer disease including tau protein, amyloid beta protein precursor and oxidative stress, and even risk factors such as mutations in the presenilin genes. |
2006-01-20 |
2023-08-12 |
Not clear |
| Jeff Kuret, Erin E Congdon, Guibin Li, Haishan Yin, Xian Yu, Qi Zhon. Evaluating triggers and enhancers of tau fibrillization. Microscopy research and technique. vol 67. issue 3-4. 2006-01-20. PMID:16103995. |
alzheimer's disease is characterized in part by the aggregation of tau protein into filamentous inclusions. |
2006-01-20 |
2023-08-12 |
Not clear |
| Luca Dinoto, Michael A Deture, Daniel L Puric. Structural insights into Alzheimer filament assembly pathways based on site-directed mutagenesis and S-glutathionylation of three-repeat neuronal Tau protein. Microscopy research and technique. vol 67. issue 3-4. 2006-01-20. PMID:16104002. |
structural insights into alzheimer filament assembly pathways based on site-directed mutagenesis and s-glutathionylation of three-repeat neuronal tau protein. |
2006-01-20 |
2023-08-12 |
Not clear |
| Luca Dinoto, Michael A Deture, Daniel L Puric. Structural insights into Alzheimer filament assembly pathways based on site-directed mutagenesis and S-glutathionylation of three-repeat neuronal Tau protein. Microscopy research and technique. vol 67. issue 3-4. 2006-01-20. PMID:16104002. |
although tau and map2 readily assemble into straight filaments (sfs), tau's unique ability to form paired-helical filaments (phfs) may offer clues as to why tau's microtubule-binding region (mtbr) is the exclusive building block of the neurofibrillary tangles that accumulate during alzheimer's disease. |
2006-01-20 |
2023-08-12 |
Not clear |
| Katharina Buerger, Stefan J Teipel, Raymond Zinkowski, Trey Sunderland, Niels Andreasen, Kaj Blennow, Michael Ewers, John DeBernardis, Yong Shen, Daniel Kerkman, Yansheng Du, Harald Hampe. Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment. Neuroscience letters. vol 391. issue 1-2. 2006-01-20. PMID:16165272. |
we investigated the correlation between the apolipoprotein e varepsilon4 allele (apoe epsilon4) carrier status, a major risk factor of alzheimer's disease (ad), and levels of tau protein phosphorylated at threonine 231 (p-tau(231p)) in cerebrospinal fluid (csf) in predementia and clinical stages of ad and healthy controls (hc). |
2006-01-20 |
2023-08-12 |
human |
| Marcus Pickhardt, Martin von Bergen, Zuzana Gazova, Antje Hascher, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Screening for inhibitors of tau polymerization. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974921. |
the histopathological diagnosis of alzheimer's disease relies on two kinds of proteinaceous aggregates: the extracellular plaques built from filaments of the abeta-peptide and the intracellular tangles consisting of tau polymerized into paired helical filaments (phfs). |
2006-01-18 |
2023-08-12 |
Not clear |
| Marcus Pickhardt, Martin von Bergen, Zuzana Gazova, Antje Hascher, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Screening for inhibitors of tau polymerization. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974921. |
thus the prevention of tau aggregation seems to be a valuable target for therapy of alzheimer's disease. |
2006-01-18 |
2023-08-12 |
Not clear |
| M L Michaelis, K I Seyb, S Ansa. Cytoskeletal integrity as a drug target. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974922. |
clearly the discovery that neurofibrillary tangles (nfts) in alzheimer's disease (ad) brain are made up of the microtubule (mt)-associated protein tau and evidence that the toxic amyloid peptides in ad can lead to tau hyper-phosphorylation and cytoskeletal dystrophy support the assertion that disruption of the mt network is an early signaling event in neurodegenerative cascades. |
2006-01-18 |
2023-08-12 |
Not clear |
| Yuko Saito, Yasufumi Motoyoshi, Takeshi Kashima, Naotaka Izumiyama-Shimomura, Tatsushi Toda, Imaharu Nakano, Masato Hasegawa, Shigeo Murayam. Unique tauopathy in Fukuyama-type congenital muscular dystrophy. Journal of neuropathology and experimental neurology. vol 64. issue 12. 2006-01-18. PMID:16319722. |
in addition, 3 to 4 tau bands of 60 to 68 kd, similar to tau in alzheimer disease, were also detected in the latter. |
2006-01-18 |
2023-08-12 |
Not clear |
| S Loveston. It takes tau to tangle--the molecular biology of Alzheimer's disease. Transactions of the Medical Society of London. vol 118. 2006-01-10. PMID:16116806. |
it takes tau to tangle--the molecular biology of alzheimer's disease. |
2006-01-10 |
2023-08-12 |
Not clear |
| Ricardo Nitrin. The cure of one of the most frequent types of dementia: a historical parallel. Alzheimer disease and associated disorders. vol 19. issue 3. 2006-01-10. PMID:16118533. |
the hypothesis of the syphilitic origin of general paralysis of the insane instigated heated debates during the 19th century, even surpassing those between proponents of the amyloid cascade versus the tau protein hypotheses for alzheimer disease. |
2006-01-10 |
2023-08-12 |
Not clear |
| Evan Elliott, Roee Atlas, Aya Lange, Irith Ginzbur. Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism. The European journal of neuroscience. vol 22. issue 5. 2006-01-10. PMID:16176349. |
hyperphosphorylation and intracellular fibrillar formation of tau protein is a pathology found in alzheimer's disease (ad) brains, and in a variety of neurodegenerative disorders referred to as 'taupathies'. |
2006-01-10 |
2023-08-12 |
mouse |
| Christian Humpel, Josef Marksteine. Cerebrovascular damage as a cause for Alzheimer's disease. Current neurovascular research. vol 2. issue 4. 2006-01-05. PMID:16181125. |
the neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for alzheimer's disease. |
2006-01-05 |
2023-08-12 |
Not clear |
| Dorthe Matenia, Bettina Griesshaber, Xiao-yu Li, Anja Thiessen, Cindy Johne, Jian Jiao, Eckhard Mandelkow, Eva-Maria Mandelko. PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Molecular biology of the cell. vol 16. issue 9. 2006-01-03. PMID:16014608. |
because the target sites of mark on tau occur at an early stage of alzheimer neurodegeneration, we searched for interaction partners of mark. |
2006-01-03 |
2023-08-12 |
Not clear |
| José Luna-Muñoz, Francisco García-Sierra, Viviana Falcón, Ivón Menéndez, Laura Chávez-Macías, Raúl Men. Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 8. issue 1. 2005-12-23. PMID:16155347. |
regional conformational change involving phosphorylation of tau protein at the thr231, precedes the structural change detected by alz-50 antibody in alzheimer's disease. |
2005-12-23 |
2023-08-12 |
Not clear |
| Casey N Cook, Matthew J Hejna, Debra J Magnuson, John M Le. Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 8. issue 1. 2005-12-23. PMID:16155351. |
protein phosphatase 2b (calcineurin) activity has been shown to be decreased in alzheimer's disease and is a possible mechanism(s) for the hyperphosphorylation of tau and subsequent neurofibrillary tangle formation. |
2005-12-23 |
2023-08-12 |
Not clear |