| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomohiro Miyasaka, Atsushi Watanabe, Yuko Saito, Shigeo Murayama, David M A Mann, Mineo Yamazaki, Rivka Ravid, Maho Morishima-Kawashima, Kazuo Nagashima, Yasuo Ihar. Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. Journal of neuropathology and experimental neurology. vol 64. issue 8. 2005-10-19. PMID:16106214. |
neurofibrillary tangles (nfts) and neuropil threads (nts), the major hallmark of alzheimer disease (ad), are composed of the microtubule-associated protein tau that has undergone posttranslational modifications, including deamidation and isomerization on asparaginyl or aspartyl residues. |
2005-10-19 |
2023-08-12 |
human |
| Manuel Lavados, Gustavo Farías, Francisco Rothhammer, Marta Guillon, Maria C Mujica, Cristóbal Maccioni, Ricardo B Maccion. ApoE alleles and tau markers in patients with different levels of cognitive impairment. Archives of medical research. vol 36. issue 5. 2005-10-13. PMID:16099324. |
the presence of brain hyperphosphorylated tau constitutes a hallmark of neurodegenerative disorders of the alzheimer's type. |
2005-10-13 |
2023-08-12 |
Not clear |
| Leif Dehmelt, Shelley Halpai. The MAP2/Tau family of microtubule-associated proteins. Genome biology. vol 6. issue 1. 2005-10-11. PMID:15642108. |
tau is also implicated in alzheimer's disease and other dementias. |
2005-10-11 |
2023-08-12 |
Not clear |
| I Ferrer, T Gomez-Isla, B Puig, M Freixes, E Ribé, E Dalfó, J Avil. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Current Alzheimer research. vol 2. issue 1. 2005-10-06. PMID:15977985. |
current advances on different kinases involved in tau phosphorylation, and implications in alzheimer's disease and tauopathies. |
2005-10-06 |
2023-08-12 |
mouse |
| I Ferrer, T Gomez-Isla, B Puig, M Freixes, E Ribé, E Dalfó, J Avil. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Current Alzheimer research. vol 2. issue 1. 2005-10-06. PMID:15977985. |
hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main pathologic hallmarks in alzheimer's disease (ad) and other tauopathies, including pick's disease (pid), progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease and familial frontotemporal dementia and parkinsonism linked to chromosome 17 due to mutations in the tau gene (ftdp-17-tau). |
2005-10-06 |
2023-08-12 |
mouse |
| Peter Klivenyi, Gabrielle Gardian, Noel Y Calingasan, Lichuan Yang, Reid von Borstel, Joel Saydoff, Susan E Browne, M Flint Bea. Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular medicine. vol 6. issue 2-3. 2005-10-05. PMID:15970626. |
tau has previously been shown to be neuroprotective in animal models of huntington's and alzheimer's diseases. |
2005-10-05 |
2023-08-12 |
Not clear |
| Frank Gillardon, Peter Steinlein, Erich Bürger, Tobias Hildebrandt, Christopher Gerne. Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. Proteomics. vol 5. issue 5. 2005-09-30. PMID:15712243. |
in alzheimer's disease and amyotrophic lateral sclerosis deregulation of cyclin-dependent kinase 5 (cdk5) causes hyperphosphorylation of tau and neurofilament proteins, respectively, leading to neuronal cell death. |
2005-09-30 |
2023-08-12 |
Not clear |
| Xu Li, Irina Alafuzoff, Hilkka Soininen, Bengt Winblad, Jin-Jing Pe. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. The FEBS journal. vol 272. issue 16. 2005-09-30. PMID:16098202. |
levels of mtor and its downstream targets 4e-bp1, eef2, and eef2 kinase in relationships with tau in alzheimer's disease brain. |
2005-09-30 |
2023-08-12 |
Not clear |
| Erin H Norris, Benoit I Giasso. Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxidants & redox signaling. vol 7. issue 5-6. 2005-09-27. PMID:15890012. |
it was reported recently that alpha-synuclein can induce the formation of filamentous tau inclusions, which are characteristic of disorders like alzheimer's disease and lewy body variant of alzheimer's disease, suggesting that a similar mechanism may exist between alpha-synuclein fibrillogenesis and tau polymerization. |
2005-09-27 |
2023-08-12 |
Not clear |
| Hyoung-Gon Lee, George Perry, Paula I Moreira, Matthew R Garrett, Quan Liu, Xiongwei Zhu, Atsushi Takeda, Akihiko Nunomura, Mark A Smit. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in molecular medicine. vol 11. issue 4. 2005-09-26. PMID:15823754. |
tau phosphorylation in alzheimer's disease: pathogen or protector? |
2005-09-26 |
2023-08-12 |
Not clear |
| Hyoung-Gon Lee, George Perry, Paula I Moreira, Matthew R Garrett, Quan Liu, Xiongwei Zhu, Atsushi Takeda, Akihiko Nunomura, Mark A Smit. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in molecular medicine. vol 11. issue 4. 2005-09-26. PMID:15823754. |
as such, in alzheimer's disease, phosphorylated tau protein, the major component of neurofibrillary tangles, is considered a central mediator of disease pathogenesis. |
2005-09-26 |
2023-08-12 |
Not clear |
| Frank M LaFerla, Salvatore Odd. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends in molecular medicine. vol 11. issue 4. 2005-09-26. PMID:15823755. |
alzheimer's disease: abeta, tau and synaptic dysfunction. |
2005-09-26 |
2023-08-12 |
mouse |
| Rong Liu, Jin-Jing Pei, Xiao-Chuan Wang, Xin-Wen Zhou, Qing Tian, Bengt Winblad, Jian-Zhi Wan. Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:15992372. |
abnormal phosphorylation of microtubule-associated protein tau plays a critical role in alzheimer's disease (ad), together with a distinct decrease of energy metabolism in the affected brain regions. |
2005-09-22 |
2023-08-12 |
rat |
| Hideyuki Yamamoto, Yukari Hiragami, Miyuki Murayama, Koko Ishizuka, Masahiro Kawahara, Akihiko Takashim. Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:16000144. |
interestingly, tau in neuronal soma in alzheimer's disease (ad) brain was strongly immunostained by the antibody. |
2005-09-22 |
2023-08-12 |
human |
| Naruhiko Sahara, Miyuki Murayama, Tatsuya Mizoroki, Makoto Urushitani, Yuzuru Imai, Ryosuke Takahashi, Shigeo Murata, Keiji Tanaka, Akihiko Takashim. In vivo evidence of CHIP up-regulation attenuating tau aggregation. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:16111477. |
ubiquitinated tau is one component in neurofibrillary tangles (nfts), which are a major histopathological feature of alzheimer's disease (ad). |
2005-09-22 |
2023-08-12 |
mouse |
| Toshiki Uchihara, Charles Duyckaerts, Danielle Seilhean, Ayako Nakamura, Françoise Lazarini, Jean-Jacques Hau. Exclusive induction of tau2 epitope in microglia/macrophages in inflammatory lesions-tautwopathy distinct from degenerative tauopathies. Acta neuropathologica. vol 109. issue 2. 2005-09-21. PMID:15549333. |
tau2 antibody recognizes a phosphorylation-independent epitope that is pathologically modified as tau protein is phosphorylated to form neurofibrillary tangles of alzheimer's disease (ad). |
2005-09-21 |
2023-08-12 |
human |
| J W Connell, T Rodriguez-Martin, G M Gibb, N M Kahn, A J Grierson, D P Hanger, T Revesz, P L Lantos, B H Anderton, J-M Gall. Quantitative analysis of tau isoform transcripts in sporadic tauopathies. Brain research. Molecular brain research. vol 137. issue 1-2. 2005-09-19. PMID:15950767. |
a number of neurodegenerative diseases, including alzheimer's disease (ad), are characterized by intraneuronal accumulation of the tau protein. |
2005-09-19 |
2023-08-12 |
Not clear |
| Robyn A Halverson, Jada Lewis, Shanti Frausto, Mike Hutton, Nancy A Mum. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689560. |
several lines of evidence suggest that transglutaminase may cross-link tau into stable, insoluble aggregates, leading to the formation of nfts in alzheimer's disease and progressive supranuclear palsy. |
2005-09-13 |
2023-08-12 |
mouse |
| Robyn A Halverson, Jada Lewis, Shanti Frausto, Mike Hutton, Nancy A Mum. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689560. |
cross-linked, phosphorylated tau from p301l tau transgenic mice runs as high-molecular mass aggregates on western blots, similar to cross-linked tau from paired helical filaments of alzheimer's disease. |
2005-09-13 |
2023-08-12 |
mouse |
| Clive Ballard, Christopher Morris, Rajesh Kalaria, Ian McKeith, Robert Perry, Elaine Perr. The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15802910. |
we examined the relationship between the k variant of buche and the severity of deposits of amyloid (abeta(1-42)) and phosphorylated tau in the temporal cortex (ba36) of 30 prospectively studied autopsy-diagnosed dementia (alzheimer's disease and dementia with lewy bodies) patients. |
2005-09-01 |
2023-08-12 |
Not clear |