| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yara Mashal, Hosam Abdelhady, Arun K Iye. Comparison of Tau and Amyloid-β Targeted Immunotherapy Nanoparticles for Alzheimer's Disease. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883556. |
comparison of tau and amyloid-β targeted immunotherapy nanoparticles for alzheimer's disease. |
2022-07-27 |
2023-08-14 |
Not clear |
| b' Ena \\xc5\\xa0pani\\xc4\\x87, Lea Langer Horvat, Katarina Ili\\xc4\\x87, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. NLRP1 Inflammasome Activation in the Hippocampal Formation in Alzheimer\'s Disease: Correlation with Neuropathological Changes and Unbiasedly Estimated Neuronal Loss. Cells. vol 11. issue 14. 2022-07-27. PMID:35883667.' |
neuroinflammation is one of the core pathological features of alzheimer's disease (ad) as both amyloid β (aβ) and tau monomers and oligomers can trigger the long-term pro-inflammatory phenotype of microglial cells with consequent overactivation of the inflammasomes. |
2022-07-27 |
2023-08-14 |
human |
| Michael Wolgin, Magdalena Zobernig, Valentyn Dvornyk, Ralf J Braun, Andrej M Kielbass. Systematic Review on Saliva Biomarkers in Patients Diagnosed with Morbus Alzheimer and Morbus Parkinson. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35885007. |
extracellular plaques composed of the hydrophobic peptide amyloid-β and intraneuronal accumulation of the hyperphosphorylated protein tau (p-tau) are pathological hallmarks found in the brains of most people affected by alzheimer's disease (ad). |
2022-07-27 |
2023-08-14 |
Not clear |
| Yunxing Ma, Julia Brettschneider, Joanna F Collingwoo. A Systematic Review and Meta-Analysis of Cerebrospinal Fluid Amyloid and Tau Levels Identifies Mild Cognitive Impairment Patients Progressing to Alzheimer's Disease. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35885018. |
a systematic review and meta-analysis of cerebrospinal fluid amyloid and tau levels identifies mild cognitive impairment patients progressing to alzheimer's disease. |
2022-07-27 |
2023-08-14 |
human |
| Yunxing Ma, Julia Brettschneider, Joanna F Collingwoo. A Systematic Review and Meta-Analysis of Cerebrospinal Fluid Amyloid and Tau Levels Identifies Mild Cognitive Impairment Patients Progressing to Alzheimer's Disease. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35885018. |
reported levels of amyloid-beta and tau in human cerebrospinal fluid (csf) were evaluated to discover if these biochemical markers can predict the transition from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2022-07-27 |
2023-08-14 |
human |
| Long Wang, Xindong Shui, Yingxue Mei, Yongfang Xia, Guihua Lan, Li Hu, Mi Zhang, Chen-Ling Gan, Ruomeng Li, Yuan Tian, Quling Wang, Xi Gu, Dongmei Chen, Tao Zhang, Tae Ho Le. miR-143-3p Inhibits Aberrant Tau Phosphorylation and Amyloidogenic Processing of APP by Directly Targeting DAPK1 in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887339. |
mir-143-3p inhibits aberrant tau phosphorylation and amyloidogenic processing of app by directly targeting dapk1 in alzheimer's disease. |
2022-07-27 |
2023-08-14 |
human |
| Long Wang, Xindong Shui, Yingxue Mei, Yongfang Xia, Guihua Lan, Li Hu, Mi Zhang, Chen-Ling Gan, Ruomeng Li, Yuan Tian, Quling Wang, Xi Gu, Dongmei Chen, Tao Zhang, Tae Ho Le. miR-143-3p Inhibits Aberrant Tau Phosphorylation and Amyloidogenic Processing of APP by Directly Targeting DAPK1 in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887339. |
the neuropathology of alzheimer's disease (ad) is characterized by intracellular aggregation of hyperphosphorylated tau and extracellular accumulation of beta-amyloid (aβ). |
2022-07-27 |
2023-08-14 |
human |
| Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines. vol 10. issue 8. 2022-07-27. PMID:35892700. |
aβ and tau regulate microglia metabolism via exosomes in alzheimer's disease. |
2022-07-27 |
2023-08-14 |
Not clear |
| Antonio Boza-Serrano, Agathe Vrillon, Karolina Minta, Agnes Paulus, Lluís Camprubí-Ferrer, Megg Garcia, Ulf Andreasson, Anna Antonell, Malin Wennström, Gunnar Gouras, Julien Dumurgier, Emmanuel Cognat, Laura Molina-Porcel, Mircea Balasa, Javier Vitorica, Raquel Sánchez-Valle, Claire Paquet, Jose Luis Venero, Kaj Blennow, Tomas Deierbor. Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer's disease. Acta neuropathologica. 2022-07-27. PMID:35895141. |
galectin-3 is elevated in csf and is associated with aβ deposits and tau aggregates in brain tissue in alzheimer's disease. |
2022-07-27 |
2023-08-14 |
mouse |
| Victor Montal, Ibai Diez, Chan-Mi Kim, William Orwig, Elisenda Bueichekú, Raquel Gutiérrez-Zúñiga, Alexandre Bejanin, Jordi Pegueroles, Oriol Dols-Icardo, Patrizia Vannini, Georges El-Fakhri, Keith A Johnson, Reisa A Sperling, Juan Fortea, Jorge Sepulcr. Network Tau spreading is vulnerable to the expression gradients of Science translational medicine. vol 14. issue 655. 2022-07-27. PMID:35895837. |
network tau spreading is vulnerable to the expression gradients of a key hallmark of alzheimer's disease (ad) pathology is the intracellular accumulation of tau protein in the form of neurofibrillary tangles across large-scale networks of the human brain cortex. |
2022-07-27 |
2023-08-14 |
human |
| Longfei Li, Yanli Jiang, Gang Wu, Yacoubou Abdoul Razak Mahaman, Dan Ke, Qun Wang, Bin Zhang, Jian-Zhi Wang, Hong-Lian Li, Rong Liu, Xiaochuan Wan. Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration. Molecular neurobiology. 2022-07-27. PMID:35896773. |
abnormal posttranslational modifications of tau play important roles in mediating neurodegeneration in tauopathies including alzheimer's disease. |
2022-07-27 |
2023-08-14 |
mouse |
| Anastassia M Mena, Antonio P Strafell. Imaging pathological tau in atypical parkinsonisms: A review. Clinical parkinsonism & related disorders. vol 7. 2022-07-26. PMID:35880206. |
recent advances in positron emission tomography (pet) radiotracer development have allowed for targeting pathological tau in alzheimer's disease (ad). |
2022-07-26 |
2023-08-14 |
Not clear |
| Naresh Damuka, Miranda E Orr, Avinash H Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L Macauley, Christopher T Whitlow, Akiva Mintz, Suzanne Craft, Kiran Kumar Solingapuram Sa. Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI research. vol 12. issue 1. 2022-07-26. PMID:35881263. |
mt instability may contribute to alzheimer's disease (ad) pathogenesis as evidenced by persistent negative regulation (phosphorylation) of the neuronal microtubule-associated protein tau. |
2022-07-26 |
2023-08-14 |
mouse |
| Marcos Otero-Garcia, Sameehan U Mahajani, Debia Wakhloo, Weijing Tang, Yue-Qiang Xue, Samuel Morabito, Jie Pan, Jane Oberhauser, Angela E Madira, Tamara Shakouri, Yongning Deng, Thomas Allison, Zihuai He, William E Lowry, Riki Kawaguchi, Vivek Swarup, Inma Cobo. Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease. Neuron. 2022-07-26. PMID:35882228. |
tau aggregation in neurofibrillary tangles (nfts) is closely associated with neurodegeneration and cognitive decline in alzheimer's disease (ad). |
2022-07-26 |
2023-08-14 |
human |
| Selena P Maxwell, Meghan K Cash, Sultan Darves. Neuropathology and cholinesterase expression in the brains of octogenarians and older. Chemico-biological interactions. 2022-07-25. PMID:35872043. |
tissues from age- and sex-matched cnoo and alzheimer's disease (ad) rpfc and hippocampal formation were stained for β-amyloid (aβ), tau, α-synuclein, phosphorylated tar dna-binding protein 43 (ptdp-43), acetylcholinesterase (ache), and butyrylcholinesterase (bche). |
2022-07-25 |
2023-08-14 |
Not clear |
| Ahmed Othman, Ahmed M Sayed, Yhiya Amen, Kuniyoshi Shimiz. Possible neuroprotective effects of amide alkaloids from RSC advances. vol 12. issue 29. 2022-07-25. PMID:35873339. |
possible neuroprotective effects of amide alkaloids from in alzheimer's disease (ad), the accumulation of amyloid-β plaques, overactivity of mao-b, and phosphorylated tau protein in the central nervous system result in neuroinflammation and cognitive impairments. |
2022-07-25 |
2023-08-14 |
Not clear |
| Xiaomin Yin, Yuanyuan Li, Xing Fan, Fang Huang, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Qun Gu, Liye Xia, Junze Bao, Xiaochuan Wang, Fei Liu, Wei Qia. SIRT1 deficiency increases O-GlcNAcylation of tau, mediating synaptic tauopathy. Molecular psychiatry. 2022-07-25. PMID:35879403. |
hyperphosphorylation of the microtubule associated protein tau is associated with several neurodegenerative diseases including alzheimer's disease (ad), collectively referred to as tauopathies. |
2022-07-25 |
2023-08-14 |
mouse |
| Mackenzie Heal, G Peggy McFall, David Vergote, Jack H Jhamandas, David Westaway, Roger A Dixo. Bridging Integrator 1 (BIN1, rs6733839) and Sex Are Moderators of Vascular Health Predictions of Memory Aging Trajectories. Journal of Alzheimer's disease : JAD. 2022-07-24. PMID:35871342. |
a promising risk loci for sporadic alzheimer's disease (ad), bridging integrator 1 (bin1), is thought to operate through the tau pathology pathway. |
2022-07-24 |
2023-08-14 |
Not clear |
| Yangyang Zhang, Yin Yang, Zhengtao Hu, Manyi Zhu, Shuangying Qin, Pengpeng Yu, Bo Li, Jitian Xu, Tomas Ondrejcak, Igor Klyubin, Michael J Rowan, Neng-Wei H. Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats. Journal of Alzheimer's disease : JAD. 2022-07-24. PMID:35871344. |
cognitive decline in alzheimer's disease (ad) correlates with the extent of tau pathology, in particular tau hyperphosphorylation, which is strongly age-associated. |
2022-07-24 |
2023-08-14 |
rat |
| Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica. 2022-07-23. PMID:35871112. |
regional distribution and maturation of tau pathology among phenotypic variants of alzheimer's disease. |
2022-07-23 |
2023-08-14 |
Not clear |