| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Domenico Plantone, Matteo Pardini, Sara Locci, Flavio Nobili, Nicola De Stefan. B Lymphocytes in Alzheimer's Disease-A Comprehensive Review. Journal of Alzheimer's disease : JAD. 2022-06-27. PMID:35754274. |
alzheimer's disease (ad) represents the most common type of neurodegenerative dementia and is characterized by extracellular amyloid-β (aβ) deposition, pathologic intracellular tau protein tangles, and neuronal loss. |
2022-06-27 |
2023-08-14 |
Not clear |
| Sonia Podvin, Zhenze Jiang, Ben Boyarko, Leigh-Ana Rossitto, Anthony O'Donoghue, Robert A Rissman, Vivian Hoo. Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS chemical neuroscience. 2022-06-27. PMID:35758417. |
dysregulation of neuropeptide and tau peptide signatures in human alzheimer's disease brain. |
2022-06-27 |
2023-08-14 |
human |
| Saikat Pal, Rituparna Roy, Sandip Pau. Deciphering the Role of ATP on PHF6 Aggregation. The journal of physical chemistry. B. 2022-06-27. PMID:35759245. |
the aggregation of tau protein, which are involved in alzheimer's disease, are associated with the self-assembly of the hexapeptide sequence, paired helical filament 6 (phf6) from repeat 3 of tau. |
2022-06-27 |
2023-08-14 |
Not clear |
| Saikat Pal, Rituparna Roy, Sandip Pau. Deciphering the Role of ATP on PHF6 Aggregation. The journal of physical chemistry. B. 2022-06-27. PMID:35759245. |
in order to treat alzheimer's disease and other such tauopathies, one of the therapeutic strategies is to inhibit aggregation of tau and its nucleating segments. |
2022-06-27 |
2023-08-14 |
Not clear |
| Saikat Pal, Rituparna Roy, Sandip Pau. Deciphering the Role of ATP on PHF6 Aggregation. The journal of physical chemistry. B. 2022-06-27. PMID:35759245. |
ultimately, this work establishes the inhibitory activity of atp against tau aggregation; hence, the therapeutic effect of atp should be explored further in regard to the effective treatment of alzheimer's disease. |
2022-06-27 |
2023-08-14 |
Not clear |
| Phuong H Nguyen, Philippe Derreumau. Molecular Dynamics Simulations of the Tau Amyloid Fibril Core Dimer at the Surface of a Lipid Bilayer Model: I. In Alzheimer's Disease. The journal of physical chemistry. B. 2022-06-27. PMID:35759677. |
a tau r3-r4 domain spanning residues 306-378 was shown to form an amyloid fibril core of a full-length tau in the brain of patients with alzheimer's disease. |
2022-06-27 |
2023-08-14 |
Not clear |
| Himanshu Rai, Sarika Gupta, Saroj Kumar, Jian Yang, Sushil K Singh, Chongzhao Ran, Gyan Mod. Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease. Journal of medicinal chemistry. 2022-06-27. PMID:35759679. |
near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and tau aggregates in alzheimer's disease. |
2022-06-27 |
2023-08-14 |
Not clear |
| Himanshu Rai, Sarika Gupta, Saroj Kumar, Jian Yang, Sushil K Singh, Chongzhao Ran, Gyan Mod. Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease. Journal of medicinal chemistry. 2022-06-27. PMID:35759679. |
a person suspected of having alzheimer's disease (ad) is clinically diagnosed for the presence of principal biomarkers, especially misfolded amyloid-beta (aβ) and tau proteins in the brain regions. |
2022-06-27 |
2023-08-14 |
Not clear |
| Antonia Moll, Lisa Marie Ramirez, Momchil Ninov, Juliane Schwarz, Henning Urlaub, Markus Zweckstette. Hsp multichaperone complex buffers pathologically modified Tau. Nature communications. vol 13. issue 1. 2022-06-27. PMID:35760815. |
alzheimer's disease is a neurodegenerative disorder in which misfolding and aggregation of pathologically modified tau is critical for neuronal dysfunction and degeneration. |
2022-06-27 |
2023-08-14 |
human |
| M B Huynh, N Rebergue, H Merrick, W Gomez-Henao, E Jospin, D S F Biard, D Papy-Garci. HS3ST2 expression induces the cell autonomous aggregation of tau. Scientific reports. vol 12. issue 1. 2022-06-27. PMID:35760982. |
heparan sulfates have long been known to intracellularly accumulate in alzheimer's disease neurons, where they colocalize with neurofibrillary tangles made of abnormally phosphorylated and aggregated tau protein. |
2022-06-27 |
2023-08-14 |
human |
| M B Huynh, N Rebergue, H Merrick, W Gomez-Henao, E Jospin, D S F Biard, D Papy-Garci. HS3ST2 expression induces the cell autonomous aggregation of tau. Scientific reports. vol 12. issue 1. 2022-06-27. PMID:35760982. |
previously, we showed that the neural heparan sulfate 3-o-sulfotransferase hs3st2 is critical for the abnormal phosphorylation of tau in alzheimer's disease-related tauopathy. |
2022-06-27 |
2023-08-14 |
human |
| Jing Kang, Zongsheng Tian, Jun Wei, Zhuangzhuang Mu, Jianmin Liang, Mingxian L. Association between obstructive sleep apnea and Alzheimer's disease-related blood and cerebrospinal fluid biomarkers: A meta-analysis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 102. 2022-06-26. PMID:35753156. |
recent studies indicate that alzheimer's disease- (ad) related biomarkers, including amyloid β (aβ40 and aβ42) and tau proteins (p-tau and t-tau), in blood and cerebrospinal fluid (csf) are associated with obstructive sleep apnea (osa). |
2022-06-26 |
2023-08-14 |
Not clear |
| Cécilia Tremblay, Geidy E Serrano, Anthony J Intorcia, Monica R Mariner, Lucia I Sue, Richard A Arce, Alireza Atri, Charles H Adler, Christine M Belden, Holly A Shill, Erika Driver-Dunckley, Shyamal H Mehta, Thomas G Beac. Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment. Journal of neuropathology and experimental neurology. 2022-06-25. PMID:35751438. |
the alzheimer disease (ad) neuropathological hallmarks amyloid β (aβ) and tau neurofibrillary (nf) pathology have been reported in the olfactory bulb (ob) in aging and in different neurodegenerative diseases, which coincides with frequently reported olfactory dysfunction in these conditions. |
2022-06-25 |
2023-08-14 |
Not clear |
| Yetirajam Rajesh, Thirumala-Devi Kannegant. Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease. Cells. vol 11. issue 12. 2022-06-24. PMID:35741014. |
alzheimer's disease (ad) is a neurodegenerative disorder molecularly characterized by the formation of amyloid β (aβ) plaques and type 2 microtubule-associated protein (tau) abnormalities. |
2022-06-24 |
2023-08-14 |
Not clear |
| Qianyun Chen, Jill Abrigo, Wanting Liu, Elyia Yixun Han, David Ka Wai Yeung, Lin Shi, Lisa Wing Chi Au, Min Deng, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Vincent Chung Tong Mok, Winnie Chiu Wing Ch. Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer's Disease. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741606. |
alzheimer's disease (ad) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid and tau are required for a diagnosis of ad. |
2022-06-24 |
2023-08-14 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamarí. Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742871. |
altered protein phosphorylation is a major pathologic modification in tauopathies and alzheimer's disease (ad) linked to abnormal tau fibrillar deposits in neurofibrillary tangles (nfts) and pre-tangles and β-amyloid deposits in ad. |
2022-06-24 |
2023-08-14 |
mouse |
| Haijun Yang, Fantian Zeng, Yunchun Luo, Chao Zheng, Chongzhao Ran, Jian Yan. Curcumin Scaffold as a Multifunctional Tool for Alzheimer's Disease Research. Molecules (Basel, Switzerland). vol 27. issue 12. 2022-06-24. PMID:35745002. |
alzheimer's disease (ad) is one of the most common neurodegenerative disorders, which is caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β (aβ) plaques and neurofibrillary tangles of tau proteins. |
2022-06-24 |
2023-08-14 |
Not clear |
| Clíona Farrell, Paige Mumford, Frances K Wisema. Rodent Modeling of Alzheimer's Disease in Down Syndrome: Frontiers in neuroscience. vol 16. 2022-06-24. PMID:35747206. |
in developed countries, the vast majority of these individuals will develop alzheimer's disease neuropathology characterized by the accumulation of amyloid-β (aβ) plaques and tau neurofibrillary tangles within the brain, which leads to the early onset of dementia (ad-ds) and reduced life-expectancy. |
2022-06-24 |
2023-08-14 |
Not clear |
| Becky C Carlyle, Robert R Kitchen, Zoe Mattingly, Amanda M Celia, Bianca A Trombetta, Sudeshna Das, Bradley T Hyman, Pia Kivisäkk, Steven E Arnol. Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease. Frontiers in neurology. vol 13. 2022-06-23. PMID:35734478. |
the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers; amyloid-β (aß), total tau (t-tau), and phosphorylated tau (p-tau181), are strong indicators of the presence of ad pathology, but do not correlate well with disease progression, and can be difficult to implement in longitudinal studies where repeat biofluid sampling is required. |
2022-06-23 |
2023-08-14 |
Not clear |
| Laura M Wright, Matteo De Marco, Annalena Venner. Verbal fluency discrepancies as a marker of the prehippocampal stages of Alzheimer's disease. Neuropsychology. 2022-06-23. PMID:35737533. |
prior to evidence of episodic memory decline, a lengthy preclinical phase of alzheimer's disease (ad) exists characterized by the build-up of tau pathology within extrahippocampal structures. |
2022-06-23 |
2023-08-14 |
Not clear |