| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R N Mustafin, E K Khusnutdinov. Involvement of transposable elements in Alzheimer's disease pathogenesis. Vavilovskii zhurnal genetiki i selektsii. vol 28. issue 2. 2024-04-29. PMID:38680184. |
study of mirna involvement in alzheimer's disease pathogenesis is relevant, since the associations of protein-coding genes (apoe4, abca7, bin1, clu, cr1, picalm, trem2) with the disease revealed as a result of gwas make it difficult to explain its complex pathogenesis. |
2024-04-29 |
2024-05-01 |
human |
| Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d'Ydewalle, Renzo Mancus. Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-04-24. PMID:38654375. |
the discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2), as the strongest risk factors for alzheimer's disease (ad) highlights the importance of microglial biology in the brain. |
2024-04-24 |
2024-04-26 |
human |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
microglia play a pivotal role in the pathology of alzheimer's disease (ad), with the triggering receptor expressed on myeloid cells 2 (trem2) central to their neuroprotective functions. |
2024-04-13 |
2024-04-16 |
mouse |
| Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fu. Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation. American journal of Alzheimer's disease and other dementias. vol 39. 2024-04-09. PMID:38592304. |
triggering receptor expressed on myeloid cells 2 (trem2) is upregulated in activated microglia and may be related to cognitive decline in patients with alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Ryan Arsenault, Steven Marshall, Patrick Salois, Qiao Li, Wandong Zhan. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway. Biology. vol 13. issue 2. 2024-02-23. PMID:38392305. |
mutations in trem2 are linked to several neurodegenerative diseases including alzheimer's disease (ad). |
2024-02-23 |
2024-02-25 |
Not clear |
| Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Aastha Dheer, Jadyn F Perry, Manling Xie, Aivi T Nguyen, Gregory A Worrell, Long-Jun W. Impaired microglial phagocytosis promotes seizure development. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260601. |
trem2 plays an important role in neurodegenerative diseases, such as alzheimer's disease and amyotrophic lateral sclerosis. |
2024-01-23 |
2024-01-25 |
mouse |
| Emilia Zgorzynsk. TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges. Molecular and cellular neurosciences. 2024-01-20. PMID:38244651. |
trem2 in alzheimer's disease: structure, function, therapeutic prospects, and activation challenges. |
2024-01-20 |
2024-01-23 |
Not clear |
| Emilia Zgorzynsk. TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges. Molecular and cellular neurosciences. 2024-01-20. PMID:38244651. |
this review provides a comprehensive overview of trem2 structure and functions, highlighting the role of its variants in the development and progression of alzheimer's disease (ad), a devastating neurodegenerative disease that affects millions of people worldwide. |
2024-01-20 |
2024-01-23 |
Not clear |
| Kostantin Kiianitsa, Maria E Lukes, Brian J Hayes, Julianna Brutman, Paul N Valdmanis, Thomas D Bird, Wendy H Raskind, Olena Korvatsk. TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing. Brain : a journal of neurology. 2024-01-16. PMID:38226698. |
trem2 variants that cause early dementia and increase alzheimer's disease risk affect gene splicing. |
2024-01-16 |
2024-01-18 |
Not clear |
| Xiao-Fen Chen, Guojun B. TREMendous microglial effects on neurons. Immunity. vol 57. issue 1. 2024-01-10. PMID:38198847. |
trem2 is exclusively expressed by microglia in the brain and is strongly associated with alzheimer's disease risk. |
2024-01-10 |
2024-01-13 |
Not clear |
| Guangtong Liu, Linlin Zhang, Yongzhao Fan, Wenliang J. The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target. Journal of integrative neuroscience. vol 22. issue 6. 2024-01-04. PMID:38176932. |
the pathogenesis in alzheimer's disease: trem2 as a potential target. |
2024-01-04 |
2024-01-07 |
Not clear |
| Lihua Wang, Niko-Petteri Nykänen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Mercè Boada, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Agustín Ruiz, Raquel Puerta, Adelina Orellana, Jarod Rutledge, Hamilton Oh, Michael D Greicius, Yann Le Guen, Richard J Perrin, Tony Wyss-Coray, Angela Jefferson, Timothy J Hohman, Neill Graff-Radford, Hiroshi Mori, Alison Goate, Johannes Levin, Yun Ju Sung, Carlos Cruchag. Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-01-03. PMID:38172904. |
proteo-genomics of soluble trem2 in cerebrospinal fluid provides novel insights and identifies novel modulators for alzheimer's disease. |
2024-01-03 |
2024-01-06 |
Not clear |
| Lihua Wang, Niko-Petteri Nykänen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Mercè Boada, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Agustín Ruiz, Raquel Puerta, Adelina Orellana, Jarod Rutledge, Hamilton Oh, Michael D Greicius, Yann Le Guen, Richard J Perrin, Tony Wyss-Coray, Angela Jefferson, Timothy J Hohman, Neill Graff-Radford, Hiroshi Mori, Alison Goate, Johannes Levin, Yun Ju Sung, Carlos Cruchag. Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-01-03. PMID:38172904. |
triggering receptor expressed on myeloid cells 2 (trem2) plays a critical role in microglial activation, survival, and apoptosis, as well as in alzheimer's disease (ad) pathogenesis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteol. Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. Immunity. 2023-12-30. PMID:38159572. |
triggering receptor expressed on myeloid cells 2 (trem2) is a myeloid cell-specific gene expressed in brain microglia, with variants that are associated with neurodegenerative diseases, including alzheimer's disease. |
2023-12-30 |
2024-01-05 |
Not clear |
| Kevin Johnston, Bereket B Berackey, Kristine Minh Tran, Alon Gelber, Zhaoxia Yu, Grant MacGregor, Eran A Mukamel, Zhiqun Tan, Kim Green, Xiangmin X. Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Research square. 2023-12-25. PMID:38106071. |
single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the the r47h missense mutation of the trem2 gene is a strong risk factor for development of alzheimer's disease. |
2023-12-25 |
2023-12-27 |
Not clear |
| Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Le. Correction to: Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Molecular neurobiology. 2023-12-22. PMID:38129702. |
correction to: cyanidin-3-o-glucoside regulates the m1/m2 polarization of microglia via pparγ and aβ42 phagocytosis through trem2 in an alzheimer's disease model. |
2023-12-22 |
2023-12-24 |
Not clear |
| Meng Wang, Tao Wei, Chaoji Yu, Ruiyang Li, Yunsi Yin, Hanchen Yang, Run Di, Xinyi Xia, Qi Qin, Yi Tan. Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer's Disease. Molecular neurobiology. 2023-12-08. PMID:38066402. |
integrative metabolomics and whole transcriptome sequencing reveal role for trem2 in metabolism homeostasis in alzheimer's disease. |
2023-12-08 |
2023-12-17 |
mouse |
| Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
the role of trem2 in alzheimer's disease: from the perspective of tau. |
2023-12-01 |
2023-12-07 |
Not clear |
| Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
triggering receptor expressed on myeloid cells 2 (trem2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for alzheimer's disease (ad). |
2023-12-01 |
2023-12-07 |
Not clear |
| Sam Gandy, Michelle E Ehrlic. Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer's amyloidopathy. Journal of neuroinflammation. vol 20. issue 1. 2023-12-01. PMID:38037091. |
correction: mir155, trem2, inpp5d: disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of alzheimer's amyloidopathy. |
2023-12-01 |
2023-12-10 |
mouse |