| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
the role of trem2 in alzheimer's disease: from the perspective of tau. |
2023-11-29 |
2023-12-07 |
Not clear |
| Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
triggering receptor expressed on myeloid cells 2 (trem2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for alzheimer's disease (ad). |
2023-11-29 |
2023-12-07 |
Not clear |
| Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Ki. Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014048. |
triggering receptor expressed on myeloid cells 2 (trem2) plays a central role in microglial biology and the pathogenesis of alzheimer's disease (ad). |
2023-11-28 |
2023-11-29 |
human |
| Oliver Cousins, Julia J Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O'Neill, David Collier, Ramla Awais, Kerstin Sander, Erik Årstad, Oliver Howes, Federico Turkheimer, Angela Hodge. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge. Journal of neuroinflammation. vol 20. issue 1. 2023-11-22. PMID:37990275. |
the rs75932628 (p.r47h) trem2 variant is a well-established risk factor for alzheimer's disease. |
2023-11-22 |
2023-11-29 |
Not clear |
| Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. |
mutations in trem2 are strongly linked with a higher risk of developing neurodegenerative diseases, including alzheimer's disease. |
2023-11-09 |
2023-11-20 |
human |
| Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. |
although previous studies reported increased csf soluble trem2 (strem2) in different clinical stages of alzheimer's disease, the exact association between alzheimer's disease hallmarks such as amyloid-beta and tau pathology remains unclear. |
2023-11-09 |
2023-11-20 |
human |
| Preety Sthutika Swain, Sunita Panda, Sanghamitra Pati, Budheswar Dehur. Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease. Journal of molecular modeling. vol 29. issue 11. 2023-11-04. PMID:37924367. |
computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of trem2 associated with alzheimer's and nasu-hakola disease. |
2023-11-04 |
2023-11-08 |
Not clear |
| Preety Sthutika Swain, Sunita Panda, Sanghamitra Pati, Budheswar Dehur. Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease. Journal of molecular modeling. vol 29. issue 11. 2023-11-04. PMID:37924367. |
nasu-hakola disease (nhd), a rare autosomal recessive disorder, has been associated with mutations in trem2, which is also responsible for raising the risk of alzheimer's disease (ad). |
2023-11-04 |
2023-11-08 |
Not clear |
| Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhan. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-10-21. PMID:37865646. |
soluble trem2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in alzheimer's disease. |
2023-10-21 |
2023-11-08 |
mouse |
| Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhan. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-10-21. PMID:37865646. |
the proteolytic shedding of trem2 results in the release of soluble trem2 (strem2), which is increased in the cerebrospinal fluid of patients with alzheimer's disease (ad). |
2023-10-21 |
2023-11-08 |
mouse |
| Kai Schlepckow, Estrella Morenas-Rodríguez, Soyon Hong, Christian Haas. Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease. The Lancet. Neurology. vol 22. issue 11. 2023-10-20. PMID:37863592. |
stimulation of trem2 with agonistic antibodies-an emerging therapeutic option for alzheimer's disease. |
2023-10-20 |
2023-11-08 |
Not clear |
| Kai Schlepckow, Estrella Morenas-Rodríguez, Soyon Hong, Christian Haas. Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease. The Lancet. Neurology. vol 22. issue 11. 2023-10-20. PMID:37863592. |
one of the major risk genes for alzheimer's disease is trem2. |
2023-10-20 |
2023-11-08 |
Not clear |
| Kai Schlepckow, Estrella Morenas-Rodríguez, Soyon Hong, Christian Haas. Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease. The Lancet. Neurology. vol 22. issue 11. 2023-10-20. PMID:37863592. |
data from animal models, and biomarker studies in patients, further support a rationale for boosting trem2 functions during the preclinical stage of alzheimer's disease. |
2023-10-20 |
2023-11-08 |
Not clear |
| Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Rege. Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer's patients. Immunity & ageing : I & A. vol 20. issue 1. 2023-10-14. PMID:37833781. |
effects of autologous serum on trem2 and apoe in a personalized monocyte-derived macrophage assay of late-onset alzheimer's patients. |
2023-10-14 |
2023-10-15 |
Not clear |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 10. 2023-10-06. PMID:37802040. |
a cell therapy approach to restore microglial trem2 function in a mouse model of alzheimer's disease. |
2023-10-06 |
2023-10-15 |
mouse |
| Sam Gandy, Michelle E Ehrlic. miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer's amyloidopathy. Journal of neuroinflammation. vol 20. issue 1. 2023-09-25. PMID:37749581. |
mir155, trem2, inpp5d: disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of alzheimer's amyloidopathy. |
2023-09-25 |
2023-10-07 |
mouse |
| Xuezhen Chen, Yue Zhao, Yimin Huang, Kaichuan Zhu, Fan Zeng, Junyi Zhao, Huaqiu Zhang, Xinzhou Zhu, Helmut Kettenmann, Xianyuan Xian. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. Glia. 2023-08-29. PMID:37641212. |
triggering receptor expressed on myeloid cell 2 (trem2), a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis of alzheimer's disease and other neurodegenerative disorders. |
2023-08-29 |
2023-09-07 |
Not clear |
| Hao Liu, Lu Zhang, Zhen Liu, Jinyuan Lin, Xiaojing He, Siyi Wu, Yi Qin, Chen Zhao, Youyuan Guo, Fei Li. Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization. iScience. vol 26. issue 9. 2023-08-28. PMID:37636061. |
studies have reported gal3 as a ligand for triggering receptor expressed on myeloid cell 2 (trem2) in macrophages in alzheimer's disease. |
2023-08-28 |
2023-09-07 |
mouse |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Melanie Das, Wenjie Mao, Yuliya Voskobiynyk, Deanna Necula, Irene Lew, Cathrine Petersen, Allie Zahn, Gui-Qiu Yu, Xinxing Yu, Nicholas Smith, Faten Sayed, Li Gan, Jeanne T Paz, Lennart Muck. Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models. Neurobiology of disease. 2023-08-17. PMID:37591465. |
alzheimer risk-increasing trem2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models. |
2023-08-17 |
2023-09-07 |
mouse |