| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie Das, Wenjie Mao, Yuliya Voskobiynyk, Deanna Necula, Irene Lew, Cathrine Petersen, Allie Zahn, Gui-Qiu Yu, Xinxing Yu, Nicholas Smith, Faten Sayed, Li Gan, Jeanne T Paz, Lennart Muck. Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models. Neurobiology of disease. 2023-08-17. PMID:37591465. |
the r47h variant of triggering receptor expressed on myeloid cells 2 (trem2) increases the risk of alzheimer's disease (ad). |
2023-08-17 |
2023-09-07 |
mouse |
| C Y Daniel Lee, Amberlene J De La Rocha, Kellie Inouye, Peter Langfelder, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Zoe Pamonag, Raymond G Vaca, Jeffrey Richman, Riki Kawaguchi, Fuying Gao, Huaxi Xu, X William Yan. BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577582. |
genetic study of late-onset alzheimer's disease (ad) reveals that a rare arginine-to-histamine mutation at amino acid residue 47 (r47h) in triggering receptor expressed on myeloid cells 2 (trem2) results in increased disease risk. |
2023-08-14 |
2023-08-16 |
mouse |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
elevated levels of trem2 in cerebrospinal fluid have been associated with increased amyloid plaque burden, neurodegeneration, and cognitive decline in individuals with alzheimer's disease. |
2023-08-12 |
2023-08-16 |
Not clear |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
in this review, we focus on the role of cells (microglia, astrocytes, and oligodendrocytes) and molecules (trem2, tau, and β-amyloid) of the innate immune system in the pathogenesis of alzheimer's disease and their possible exploitation as disease biomarkers and targets of therapeutical approaches. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
a cell therapy approach to restore microglial trem2 function in a mouse model of alzheimer's disease. |
2023-08-04 |
2023-08-14 |
mouse |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
trem2: potential therapeutic targeting of microglia for alzheimer's disease. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
although the relationship between trem2 and alzheimer's disease has been extensively studied, its specific mechanism of action is not fully understood. |
2023-07-30 |
2023-08-14 |
Not clear |
| b' Ena \\xc5\\xa0pani\\xc4\\x87 Popova\\xc4\\x8dki, Mirjana Babi\\xc4\\x87 Leko, Lea Langer Horvat, Klara Brgi\\xc4\\x87, \\xc5\\xbdeljka Vogrinc, Marina Boban, Nata\\xc5\\xa1a Klepac, Fran Borove\\xc4\\x8dki, Goran \\xc5\\xa0imi\\xc4\\x8. Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer\'s Disease. Neurology international. vol 15. issue 3. 2023-07-25. PMID:37489359.' |
soluble trem2 concentrations in the cerebrospinal fluid correlate with the severity of neurofibrillary degeneration, cognitive impairment, and inflammasome activation in alzheimer's disease. |
2023-07-25 |
2023-08-14 |
Not clear |
| Marina Passero, Tianhua Zhai, Zuyi Huan. Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer's Disease. International journal of environmental research and public health. vol 20. issue 13. 2023-07-14. PMID:37444065. |
in this work, protein-protein interaction analysis was conducted based upon the genes from a clinical database to identify the top protein targets with most data-indicated involvement in alzheimer's disease, which include abca1, cyp46a1, bace1, trem2, gsk3b, and srebp2. |
2023-07-14 |
2023-08-14 |
mouse |
| Jacob Georg. TREM2 as an evolving therapeutic target in Alzheimer's disease. Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449620. |
trem2 as an evolving therapeutic target in alzheimer's disease. |
2023-07-14 |
2023-08-14 |
Not clear |
| Li Zhong, Xuan Sheng, Wanbing Wang, Yanzhong Li, Rengong Zhuo, Kai Wang, Lianshuai Zhang, Dan-Dan Hu, Yujuan Hong, Linting Chen, Hengjun Rao, Tingting Li, Muyang Chen, Zhihao Lin, Yun-Wu Zhang, Xin Wang, Xiao-Xin Yan, Xiaochun Chen, Guojun Bu, Xiao-Fen Che. TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration. Immunity. 2023-07-13. PMID:37442133. |
triggering receptor expressed on myeloid cells 2 (trem2) is strongly linked to alzheimer's disease (ad) risk, but its functions are not fully understood. |
2023-07-13 |
2023-08-14 |
mouse |
| Siyu Yang, Dong Chen, Lei Xie, Xiaoxiao Zou, Yanyuan Xiao, Lin Rao, Tianxiong Yao, Qing Zhang, Liping Cai, Fei Huang, Bin Yang, Lusheng Huan. Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus. Science China. Life sciences. 2023-07-10. PMID:37428306. |
we examined 27 alzheimer's disease-related genes in our data and found that 15 showed cell type-specific activity (trem2, rin3 and clu), and 15 genes displayed age-associated dynamic activity (bin1, rabep1 and apoe). |
2023-07-10 |
2023-08-14 |
human |
| Tao Yin, Luciano D'Adami. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398330. |
bri2-mediated regulation of trem2 processing in microglia and its potential implications for alzheimer's disease and related dementias. |
2023-07-03 |
2023-08-14 |
Not clear |
| Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L Oblak, Cristian A Lasagna-Reeve. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells. vol 12. issue 12. 2023-06-28. PMID:37371067. |
the role of trem2 in alzheimer's disease (ad) is not fully understood. |
2023-06-28 |
2023-08-14 |
mouse |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
whereas trem2 deletion has been studied extensively in experimental beta-amyloid and tau-based models of alzheimer's disease, its engagement, and subsequent agonism have not been tested in the context of tau pathology. |
2023-06-11 |
2023-08-14 |
mouse |
| Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kin. Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. Communications biology. vol 6. issue 1. 2023-06-08. PMID:37291187. |
elevated trem2 levels in these cells are associated with age-related pathological conditions, including alzheimer's disease. |
2023-06-08 |
2023-08-14 |
human |
| Francesca La Rosa, Simone Agostini, Federica Piancone, Ivana Marventano, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini, Marina Saresella, Mario Cleric. TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37239970. |
trem2 expression and amyloid-beta phagocytosis in alzheimer's disease. |
2023-05-27 |
2023-08-14 |
Not clear |
| Francesca La Rosa, Simone Agostini, Federica Piancone, Ivana Marventano, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini, Marina Saresella, Mario Cleric. TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37239970. |
herein, we focus on a receptor known as triggering-receptor-expressed-on-myeloid-cells2 (trem2), which promotes the optimal immune cells function required to attenuate ad-progression and is, therefore, a potential target as peripheral diagnostic and prognostic-biomarker for alzheimer's disease. |
2023-05-27 |
2023-08-14 |
Not clear |
| Nicoleta-Carmen Cosma, Neriman Eren, Berk Üsekes, Susanna Gerike, Isabella Heuser, Oliver Peters, Julian Hellmann-Rege. Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer's Patient-Derived Assay. Cellular and molecular neurobiology. 2023-05-17. PMID:37198381. |
acute and chronic macrophage differentiation modulates trem2 in a personalized alzheimer's patient-derived assay. |
2023-05-17 |
2023-08-14 |
human |
| Nicoleta-Carmen Cosma, Neriman Eren, Berk Üsekes, Susanna Gerike, Isabella Heuser, Oliver Peters, Julian Hellmann-Rege. Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer's Patient-Derived Assay. Cellular and molecular neurobiology. 2023-05-17. PMID:37198381. |
triggering receptor expressed on myeloid cells 2 (trem2) has been postulated as a putative therapeutic target in alzheimer's disease (ad). |
2023-05-17 |
2023-08-14 |
human |