| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shukai Lyu, Zhuoqing Lan, Caixia L. The triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway in diseases. Chinese medical journal. 2023-05-02. PMID:37130227. |
recently, trem2 has received extensive attention from researchers, and its activity has been found in alzheimer's disease, neuroinflammation, and traumatic brain injury. |
2023-05-02 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
genetic variation in the trem2 gene has been implicated in risk for alzheimer's disease and frontotemporal dementia, while homozygous trem2 mutations cause a rare leukodystrophy, nasu-hakola disease (nhd). |
2023-04-28 |
2023-08-14 |
human |
| John Bosco Ruganzu, Xiaoqian Peng, Yingying He, Xiangyuan Wu, Quzhao Zheng, Bo Ding, Chengheng Lin, Hongsong Guo, Zikang Yang, Xiao Zhang, Weina Yan. Corrigendum to "Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease", [Mol. Immunol. 142 (2022) 22-36]. Molecular immunology. 2023-04-24. PMID:37095032. |
corrigendum to "downregulation of trem2 expression exacerbates neuroinflammatory responses through tlr4-mediated mapk signaling pathway in a transgenic mouse model of alzheimer's disease", [mol. |
2023-04-24 |
2023-08-14 |
mouse |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
regulation of trem2 expression by transcription factor yy1 and its protective effect against alzheimer's disease. |
2023-04-12 |
2023-08-14 |
mouse |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
trem2 encoding the transmembrane receptor protein trem2 is a risk gene of alzheimer's disease (ad), and the impairment of trem2 functions in microglia due to mutations in trem2 may significantly increase the risk of ad by promoting ad pathologies. |
2023-04-12 |
2023-08-14 |
mouse |
| Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomit. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. vol 26. issue 4. 2023-04-10. PMID:37035000. |
the genetic associations of trem2 loss-of-function variants with alzheimer disease (ad) indicate the protective roles of microglia in ad pathogenesis. |
2023-04-10 |
2023-08-14 |
mouse |
| Ravi S Pandey, Kevin P Kotredes, Michael Sasner, Gareth R Howell, Gregory W Carte. Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease. BMC genomics. vol 24. issue 1. 2023-04-04. PMID:37016304. |
differential splicing of neuronal genes in a trem2*r47h mouse model mimics alterations associated with alzheimer's disease. |
2023-04-04 |
2023-08-14 |
mouse |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression associations with alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Lihua Gu, Hao Shu, Yanjuan Wan. Soluble TREM2 in body fluid in Alzheimer's disease and Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-13. PMID:36913148. |
soluble trem2 in body fluid in alzheimer's disease and parkinson's disease. |
2023-03-13 |
2023-08-14 |
Not clear |
| Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Y. Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid-soluble TREM2. CNS neuroscience & therapeutics. 2023-02-23. PMID:36815315. |
association of rs2062323 in the trem1 gene with alzheimer's disease and cerebrospinal fluid-soluble trem2. |
2023-02-23 |
2023-08-14 |
Not clear |
| Yahui Wang, Ying Chu, Fenghua Cao, Zhihong Chen, Huaxi Xu, Shengjun Wang, Jie M. The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor. Central-European journal of immunology. vol 47. issue 4. 2023-02-23. PMID:36817396. |
to date, trem2 has been confirmed as a key factor in many pathologies, such as alzheimer's disease, obesity-related metabolic syndrome, fatty liver and atherosclerosis. |
2023-02-23 |
2023-08-14 |
Not clear |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Kristine M Tran, Shimako Kawauchi, Enikö A Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S Sakr, Angela Gomez-Arboledas, Miguel A Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J Tenner, Frank M LaFerla, Marcelo A Wood, Ali Mortazavi, Grant R MacGregor, Kim N Gree. A Trem2 Molecular neurodegeneration. vol 18. issue 1. 2023-02-21. PMID:36803190. |
a trem2 the trem2 r47h variant is one of the strongest genetic risk factors for late-onset alzheimer's disease (ad). |
2023-02-21 |
2023-08-14 |
Not clear |
| Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jiménez, Maria A Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L Hsieh, Luis M Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J Nilsson, Guy C Brown, Antonia Gutierrez, Javier Vitorica, Jose Luis Venero, Tomas Deierbor. Correction to: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta neuropathologica. 2023-02-15. PMID:36790609. |
correction to: galectin-3, a novel endogenous trem2 ligand, detrimentally regulates inflammatory response in alzheimer's disease. |
2023-02-15 |
2023-08-14 |
Not clear |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
heterozygous loss-of-function mutations in trem2, including mutations enhancing shedding form the cell surface, have been associated with myelin/neuronal loss and neuroinflammation in neurodegenerative diseases, such as alzheimer`s disease and frontotemporal dementia. |
2023-02-09 |
2023-08-14 |
mouse |
| Douglas P Wightman, Jeanne E Savage, Christiaan A de Leeuw, Iris E Jansen, Danielle Posthum. Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36750708. |
all three of the replicated genes have been previously associated with clinically diagnosed alzheimer's disease (sorl1, trem2, and tomm40/apoe). |
2023-02-07 |
2023-08-14 |
Not clear |
| Chao Wu, Ya-Hui Ma, Hao Hu, Bing Zhao, Lan Ta. Soluble TREM2, Alzheimer's Disease Pathology, and Risk for Progression of Cerebral Small Vessel Disease: A Longitudinal Study. Journal of Alzheimer's disease : JAD. 2023-02-06. PMID:36744335. |
soluble trem2, alzheimer's disease pathology, and risk for progression of cerebral small vessel disease: a longitudinal study. |
2023-02-06 |
2023-08-14 |
human |
| Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J Madden, Cristine M Charlesworth, Yuka A Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C Ikezu, Kurti Aishe, Yiyang Zhu, Axel Meneses, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Lucy K Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun B. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Molecular neurodegeneration. vol 18. issue 1. 2023-02-01. PMID:36721205. |
the rare p.h157y variant of trem2 (triggering receptor expressed on myeloid cells 2) was found to increase alzheimer's disease (ad) risk. |
2023-02-01 |
2023-08-14 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
untangling the role of trem2 in conjugation with microglia in neuronal dysfunction: a hypothesis on a novel pathway in the pathophysiology of alzheimer's disease. |
2023-01-23 |
2023-08-14 |
Not clear |