| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
microglia in cerebellar plaques in alzheimer's disease. |
1991-01-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
cerebellar amyloid deposits in alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-hla-dr, ln-1, leu-m5 and leukocyte common antigen. |
1991-01-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
these results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in alzheimer's disease. |
1991-01-17 |
2023-08-11 |
human |
| B W Brooksbank, J McGover. Gangliosides in the brain in adult Down's syndrome and Alzheimer's disease. Molecular and chemical neuropathology. vol 11. issue 3. 1990-12-07. PMID:2534985. |
quantitative analysis of total gangliosides and of ganglioside composition by hptlc has been carried out on the gray matter of frontal cerebral cortex of six brains from down's syndrome (ds) adults, six age-matched controls, six alzheimer's disease (ad) adults, and six controls matched for age with the ad brains, as well as on three ds and six control cerebellum specimens. |
1990-12-07 |
2023-08-11 |
Not clear |
| B W Brooksbank, M Martine. Lipid abnormalities in the brain in adult Down's syndrome and Alzheimer's disease. Molecular and chemical neuropathology. vol 11. issue 3. 1990-12-07. PMID:2534986. |
quantitative analysis by hptlc of the major lipid classes and dolichol, and of fatty acyl groups of separated phosphoglycerides by capillary glc, has been carried out on the gray matter of frontal cerebral cortex of brains from six down's syndrome (ds) and six alzheimer's disease (ad) adults, and six each of two corresponding sets of age-matched controls; specimens of ds and control cerebellum and corpus callosum were also analyzed. |
1990-12-07 |
2023-08-11 |
Not clear |
| T Suenaga, A Hirano, J F Llena, H Ksiezak-Reding, S H Yen, D W Dickso. Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. Annals of neurology. vol 28. issue 2. 1990-11-16. PMID:2171419. |
similar to cerebellar senile plaques in alzheimer's disease, many kuru plaques contained ubiquitin-positive, tau-negative small granular elements, presumably representing dystrophic neurites. |
1990-11-16 |
2023-08-11 |
Not clear |
| T Suenaga, A Hirano, J F Llena, H Ksiezak-Reding, S H Yen, D W Dickso. Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. Annals of neurology. vol 28. issue 2. 1990-11-16. PMID:2171419. |
our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in creutzfeldt-jakob and alzheimer's diseases despite differences of amyloid proteins in the plaques. |
1990-11-16 |
2023-08-11 |
Not clear |
| D M Mann, D Jones, D Prinja, M S Purkis. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease. Acta neuropathologica. vol 80. issue 3. 1990-10-16. PMID:1698007. |
the extent of amyloid deposition within the cerebellum and the cerebral cortex was assessed and compared, using anti-amyloid protein (a4) immunostaining and a novel methenamine silver method, in 20 patients aged between 60 and 77 years with alzheimer's disease (ad), 29 patients aged between 13 and 71 years with down's syndrome (ds), 26 demented patients with disorders other than ad and ds and in 20 non-demented elderly individuals of age range 60-102 years. |
1990-10-16 |
2023-08-11 |
Not clear |
| A J Barton, P J Harrison, A Najlerahim, J Heffernan, B McDonald, J R Robinson, D C Davies, W J Harrison, P Mitra, J A Hard. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American journal of pathology. vol 137. issue 3. 1990-10-12. PMID:2119143. |
we detected tau mrna using in situ hybridization histochemistry in the hippocampus, visual cortex, and cerebellum, and compared its level in alzheimer's disease with controls. |
1990-10-12 |
2023-08-11 |
Not clear |
| A J Barton, P J Harrison, A Najlerahim, J Heffernan, B McDonald, J R Robinson, D C Davies, W J Harrison, P Mitra, J A Hard. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American journal of pathology. vol 137. issue 3. 1990-10-12. PMID:2119143. |
in contrast, no change was found in the visual cortex or cerebellum in alzheimer's disease. |
1990-10-12 |
2023-08-11 |
Not clear |
| K V Subbarao, J S Richardson, L C An. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. Journal of neurochemistry. vol 55. issue 1. 1990-07-20. PMID:2355227. |
the formation of thiobarbituric acid-reactive products was measured as an index of peroxidation by oxygen free radicals in homogenates of frontal cortex and cerebellum from brains taken at autopsy and verified histologically as being alzheimer's (n = 6) or normal (n = 6). |
1990-07-20 |
2023-08-11 |
Not clear |
| K V Subbarao, J S Richardson, L C An. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. Journal of neurochemistry. vol 55. issue 1. 1990-07-20. PMID:2355227. |
peroxidation in cerebellum and levels of total glutathione, rna, and dna in cortex and cerebellum do not differ significantly between alzheimer's brain and controls. |
1990-07-20 |
2023-08-11 |
Not clear |
| A M Iacopino, S Christako. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 11. 1990-07-12. PMID:2140897. |
comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mrna in the substantia nigra (parkinson disease), in the corpus striatum (huntington disease), in the nucleus basalis (alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (parkinson, huntington, and alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus. |
1990-07-12 |
2023-08-11 |
human |
| D W Dickson, A Wertkin, L A Mattiace, E Fier, Y Kress, P Davies, S H Ye. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta neuropathologica. vol 79. issue 5. 1990-05-24. PMID:2158201. |
ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of alzheimer's disease. |
1990-05-24 |
2023-08-11 |
human |
| D W Dickson, A Wertkin, L A Mattiace, E Fier, Y Kress, P Davies, S H Ye. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta neuropathologica. vol 79. issue 5. 1990-05-24. PMID:2158201. |
senile plaques are present in the cerebellum of most alzheimer patients. |
1990-05-24 |
2023-08-11 |
human |
| D W Dickson, A Wertkin, L A Mattiace, E Fier, Y Kress, P Davies, S H Ye. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta neuropathologica. vol 79. issue 5. 1990-05-24. PMID:2158201. |
these results suggest that the same mechanisms involved in the generation of dystrophic neurites in pathological aging are involved in generating dystrophic neurites in the cerebellum in alzheimer's disease. |
1990-05-24 |
2023-08-11 |
human |
| S A Johnson, J Rogers, C E Finc. APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum. Neurobiology of aging. vol 10. issue 6. 1990-04-24. PMID:2483450. |
app-695 transcript prevalence is selectively reduced during alzheimer's disease in cortex and hippocampus but not in cerebellum. |
1990-04-24 |
2023-08-11 |
Not clear |
| J M Brucher, C Gillain, H Baro. [Cerebellar amyloid plaques in Alzheimer's disease]. Acta neurologica Belgica. vol 89. issue 3-4. 1990-04-24. PMID:2516979. |
[cerebellar amyloid plaques in alzheimer's disease]. |
1990-04-24 |
2023-08-11 |
Not clear |
| J M Brucher, C Gillain, H Baro. [Cerebellar amyloid plaques in Alzheimer's disease]. Acta neurologica Belgica. vol 89. issue 3-4. 1990-04-24. PMID:2516979. |
in a consecutive series of 30 brains of demented patients (presenile, senile and familial types) with the histological hallmarks of alzheimer's disease, cerebellar amyloid plaques and cerebellar amyloid angiopathy were observed in 80% of the cases. |
1990-04-24 |
2023-08-11 |
Not clear |
| J M Brucher, C Gillain, H Baro. [Cerebellar amyloid plaques in Alzheimer's disease]. Acta neurologica Belgica. vol 89. issue 3-4. 1990-04-24. PMID:2516979. |
the absence of neuritic changes around the numerous cerebellar amyloid plaques frequently observed in cases of alzheimer's disease is an interesting feature and will perhaps explain the mechanism of cytoskeleton changes occurring in the neurons of the cerebral cortex. |
1990-04-24 |
2023-08-11 |
Not clear |