| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung-Hoon Kwon, Jin Young Kim, Se-Young Kim, Hye Kyeong Min, Hyoung-Joo Lee, In Jung Ji, Taewook Kang, Gun Wook Park, Hyun Joo An, Bonghee Lee, Rivka Ravid, Isidro Ferrer, Chun Kee Chung, Young-Ki Paik, William S Hancock, Young Mok Park, Jong Shin Yo. Chromosome 11-centric human proteome analysis of human brain hippocampus tissue. Journal of proteome research. vol 12. issue 1. 2013-06-07. PMID:23286719. |
as a model study, human hippocampal tissues from patients suffering from alzheimer's disease and epilepsy were prepared to evaluate the gene-centric statistics related to the gene expression and disorders of chromosome 11. |
2013-06-07 |
2023-08-12 |
human |
| Kyung-Hoon Kwon, Jin Young Kim, Se-Young Kim, Hye Kyeong Min, Hyoung-Joo Lee, In Jung Ji, Taewook Kang, Gun Wook Park, Hyun Joo An, Bonghee Lee, Rivka Ravid, Isidro Ferrer, Chun Kee Chung, Young-Ki Paik, William S Hancock, Young Mok Park, Jong Shin Yo. Chromosome 11-centric human proteome analysis of human brain hippocampus tissue. Journal of proteome research. vol 12. issue 1. 2013-06-07. PMID:23286719. |
analysis of the proteome data set from the hippocampus provides a significant network associated with genes and proteins and leads to new insights into the biological and genetic mechanisms of chromosome 11-specific diseases such as alzheimer's disease. |
2013-06-07 |
2023-08-12 |
human |
| Georges Mairet-Coello, Julien Courchet, Simon Pieraut, Virginie Courchet, Anton Maximov, Franck Polleu. The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation. Neuron. vol 78. issue 1. 2013-06-07. PMID:23583109. |
amyloid-β 1-42 (aβ42) oligomers are synaptotoxic for excitatory cortical and hippocampal neurons and might play a role in early stages of alzheimer's disease (ad) progression. |
2013-06-07 |
2023-08-12 |
mouse |
| Malgorzata Duszczyk, Magdalena Kuszczyk, Maitea Guridi, Jerzy W Lazarewicz, Martin J Sadowsk. In vivo hippocampal microdialysis reveals impairment of NMDA receptor-cGMP signaling in APP(SW) and APP(SW)/PS1(L166P) Alzheimer's transgenic mice. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22841892. |
in vivo hippocampal microdialysis reveals impairment of nmda receptor-cgmp signaling in app(sw) and app(sw)/ps1(l166p) alzheimer's transgenic mice. |
2013-06-05 |
2023-08-12 |
mouse |
| Romain Goutagny, Slavica Kranti. Hippocampal oscillatory activity in Alzheimer's disease: toward the identification of early biomarkers? Aging and disease. vol 4. issue 3. 2013-06-05. PMID:23730529. |
hippocampal oscillatory activity in alzheimer's disease: toward the identification of early biomarkers? |
2013-06-05 |
2023-08-12 |
Not clear |
| M R Carratù, C Marasco, A Signorile, C Scuderi, L Steard. Are retinoids a promise for Alzheimer's disease management? Current medicinal chemistry. vol 19. issue 36. 2013-06-03. PMID:23092137. |
the ability of retinoids to exert antioxidant effects, inhibit amyloid-β (aβ) deposits and likely aβ-induced mitochondrial dysfunction, tau hyperphosphorylation, aβ-induced il6 production and neuroinflammation, increase survival in hippocampal neurons, and reverse cognitive deficits in animal models of alzheimer's disease (ad) is discussed. |
2013-06-03 |
2023-08-12 |
Not clear |
| Harim Cho, Yuyoung Joo, Seonghan Kim, Ran-Sook Woo, Sang Hyung Lee, Hye-Sun Ki. Plasminogen activator inhibitor-1 promotes synaptogenesis and protects against aβ(1-42)-induced neurotoxicity in primary cultured hippocampal neurons. The International journal of neuroscience. vol 123. issue 1. 2013-05-30. PMID:22937735. |
taken together, our results suggest that pai-1 has therapeutic potential in alzheimer's disease by promoting synaptogenesis and by demonstrating neuroprotective effects against aβ(1-42)-oligomer-induced neurotoxicity in rat primary cultured hippocampal neurons. |
2013-05-30 |
2023-08-12 |
rat |
| Angela K Troyer, Kelly J Murphy, Nicole D Anderson, Fergus I M Craik, Morris Moscovitch, Andrea Maione, Fuqiang Ga. Associative recognition in mild cognitive impairment: relationship to hippocampal volume and apolipoprotein E. Neuropsychologia. vol 50. issue 14. 2013-05-30. PMID:23103838. |
associative recognition in mild cognitive impairment: relationship to hippocampal volume and apolipoprotein e. associative memory involves remembering relations between items of information and is critically dependent on the hippocampus, a brain structure that shows early changes in amnestic mild cognitive impairment (amci) and alzheimer's disease. |
2013-05-30 |
2023-08-12 |
Not clear |
| Angela K Troyer, Kelly J Murphy, Nicole D Anderson, Fergus I M Craik, Morris Moscovitch, Andrea Maione, Fuqiang Ga. Associative recognition in mild cognitive impairment: relationship to hippocampal volume and apolipoprotein E. Neuropsychologia. vol 50. issue 14. 2013-05-30. PMID:23103838. |
our findings replicate and extend previous studies by showing an associative recognition impairment in amci that is not accounted for by an item recognition deficit, is related to structural integrity of the hippocampus, and increases with genetic risk for alzheimer's disease. |
2013-05-30 |
2023-08-12 |
Not clear |
| Ling Zhang, Shuli Sheng, Chuan Qi. The role of HDAC6 in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:22936009. |
the expression of histone deacetylase 6 (hdac6)--a versatile enzyme with a known role in epigenetics--increases significantly in the hippocampus and other relevant brain regions in both patients with alzheimer's disease (ad) and animal models of ad. |
2013-05-28 |
2023-08-12 |
Not clear |
| Hye Won Eom, Sun Young Park, Young Hun Kim, Su Jin Seong, Mei Ling Jin, Eun Yeon Ryu, Min Ju Kim, Sang Joon Le. Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. International journal of molecular medicine. vol 30. issue 6. 2013-05-28. PMID:22992724. |
recent evidence indicates that microglial activation and hippocampal damage may play important roles in neurodegenerative diseases, including alzheimer's disease. |
2013-05-28 |
2023-08-12 |
Not clear |
| Erzsebet M Szatmari, Ana F Oliveira, Elizabeth J Sumner, Ryohei Yasud. Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 12. 2013-05-28. PMID:23516302. |
therefore, the centa1-ras-elk-1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to aβ in hippocampal neurons, providing new pharmacological targets for alzheimer's disease. |
2013-05-28 |
2023-08-12 |
mouse |
| Vasco Meneghini, Valeria Bortolotto, Maria Teresa Francese, Anna Dellarole, Lorenzo Carraro, Slavica Terzieva, Mariagrazia Grill. High-mobility group box-1 protein and β-amyloid oligomers promote neuronal differentiation of adult hippocampal neural progenitors via receptor for advanced glycation end products/nuclear factor-κB axis: relevance for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 14. 2013-05-28. PMID:23554486. |
high-mobility group box-1 protein and β-amyloid oligomers promote neuronal differentiation of adult hippocampal neural progenitors via receptor for advanced glycation end products/nuclear factor-κb axis: relevance for alzheimer's disease. |
2013-05-28 |
2023-08-12 |
mouse |
| Vasco Meneghini, Valeria Bortolotto, Maria Teresa Francese, Anna Dellarole, Lorenzo Carraro, Slavica Terzieva, Mariagrazia Grill. High-mobility group box-1 protein and β-amyloid oligomers promote neuronal differentiation of adult hippocampal neural progenitors via receptor for advanced glycation end products/nuclear factor-κB axis: relevance for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 14. 2013-05-28. PMID:23554486. |
dysregulated hippocampal neurogenesis has been associated with neurodegenerative disorders, including alzheimer's disease (ad), in which it may potentially represent an auto-reparatory mechanism that could counteract neuronal loss and cognitive impairment. |
2013-05-28 |
2023-08-12 |
mouse |
| Emma J Burton, Elizabeta B Mukaetova-Ladinska, Robert H Perry, Evelyn Jaros, Robert Barber, John T O'Brie. Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21353336. |
lewy body, but not alzheimer's disease (ad) pathology was associated with reduced amygdala volume in pathologically-verified lbd cases but neither lewy body nor alzheimer's disease pathology was associated with volume loss in the hippocampus or entorhinal cortex, suggesting other neuropathological factors account for atrophy in these structures in lbd. |
2013-05-27 |
2023-08-12 |
human |
| Leonardo C de Souza, Marie Chupin, Foudil Lamari, Claude Jardel, Delphine Leclercq, Olivier Colliot, Stéphane Lehéricy, Bruno Dubois, Marie Sarazi. CSF tau markers are correlated with hippocampal volume in Alzheimer's disease. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21489655. |
csf tau markers are correlated with hippocampal volume in alzheimer's disease. |
2013-05-27 |
2023-08-12 |
Not clear |
| Leonardo C de Souza, Marie Chupin, Foudil Lamari, Claude Jardel, Delphine Leclercq, Olivier Colliot, Stéphane Lehéricy, Bruno Dubois, Marie Sarazi. CSF tau markers are correlated with hippocampal volume in Alzheimer's disease. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21489655. |
hippocampal atrophy as assessed by magnetic resonance imaging (mri) and abnormal cerebrospinal fluid (csf) biomarkers are supportive features for the diagnosis of alzheimer's disease (ad) and are assumed to be indirect pathological markers of the disease. |
2013-05-27 |
2023-08-12 |
Not clear |
| Heather Kenna, Fumiko Hoeft, Ryan Kelley, Tonita Wroolie, Bevin DeMuth, Allan Reiss, Natalie Rasgo. Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22770543. |
brain imaging studies in alzheimer's disease research have demonstrated structural and functional perturbations in the hippocampus and default mode network (dmn). |
2013-05-24 |
2023-08-12 |
human |
| R Killick, T R Hughes, B P Morgan, S Loveston. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neuroscience letters. vol 533. 2013-05-23. PMID:23153828. |
to begin to explore its role in alzheimer's disease we examined hippocampal lysates from crry(-/-) mice and age matched controls by immunoblotting. |
2013-05-23 |
2023-08-12 |
mouse |
| Miranka Wirth, Cindee M Madison, Gil D Rabinovici, Hwamee Oh, Susan M Landau, William J Jagus. Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 13. 2013-05-23. PMID:23536070. |
β-amyloid (aβ) plaque deposition and neurodegeneration within temporoparietal and hippocampal regions may indicate increased risk of alzheimer's disease (ad). |
2013-05-23 |
2023-08-12 |
human |