| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tony D Zhou, Zongpai Zhang, Arvind Balachandrasekaran, Cyrus A Raji, James T Becker, Lewis H Kuller, Yulin Ge, Oscar L Lopez, Weiying Dai, H Michael Gac. Prospective Longitudinal Perfusion in Probable Alzheimer's Disease Correlated with Atrophy in Temporal Lobe. Aging and disease. 2023-05-17. PMID:37196135. |
reduced cerebral blood flow (cbf) in the temporoparietal region and gray matter volumes (gmvs) in the temporal lobe were previously reported in patients with mild cognitive impairment (mci) and alzheimer's disease (ad). |
2023-05-17 |
2023-08-14 |
human |
| Zoe Papadatos, Natalie A Phillip. Olfactory function reflects episodic memory performance and atrophy in the medial temporal lobe in individuals at risk for Alzheimer's disease. Neurobiology of aging. vol 128. 2023-05-05. PMID:37146503. |
olfactory function reflects episodic memory performance and atrophy in the medial temporal lobe in individuals at risk for alzheimer's disease. |
2023-05-05 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
these results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of alzheimer's disease. |
2023-04-21 |
2023-08-14 |
Not clear |
| Robin de Flores, Solène Demeilliez-Servouin, Elizabeth Kuhn, Léa Chauveau, Brigitte Landeau, Nicolas Delcroix, Julie Gonneaud, Denis Vivien, Gaël Chétela. Respective influence of beta-amyloid and APOE ε4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults. Neurobiology of disease. 2023-04-15. PMID:37061167. |
medial temporal lobe (mtl) subregions are differentially affected in alzheimer's disease (ad), with a specific involvement of the entorhinal cortex (erc), perirhinal cortex and hippocampal cornu ammonis (ca)1. |
2023-04-15 |
2023-08-14 |
human |
| Jenna N Adams, Freddie Márquez, Myra S Larson, John T Janecek, Blake A Miranda, Jessica A Noche, Lisa Taylor, Martina K Hollearn, Liv McMillan, David B Keator, Elizabeth Head, Robert A Rissman, Michael A Yass. Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimer's & dementia (Amsterdam, Netherlands). vol 15. issue 2. 2023-04-10. PMID:37035460. |
we tested whether alzheimer's disease (ad) pathology predicts memory deficits in non-demented older adults through its effects on medial temporal lobe (mtl) subregional volume. |
2023-04-10 |
2023-08-14 |
Not clear |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
neurofibrillary tangles (nfts) contain abnormally phosphorylated tau proteins, which spread within components of the medial temporal lobe (mtl) memory circuit in alzheimer's disease (ad). |
2023-03-29 |
2023-08-14 |
human |
| Kaitlin M Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno P Witter, Can Ceritoglu, Marilyn S Albert, Susumu Mori, Juan Troncoso, Daniel J Tward, Michael I Mille. Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer's disease. NeuroImage. Clinical. vol 38. 2023-03-19. PMID:36934675. |
previous research has emphasized the unique impact of alzheimer's disease (ad) pathology on the medial temporal lobe (mtl), a reflection that tau pathology is particularly striking in the entorhinal and transentorhinal cortex (erc, tec) early in the course of disease. |
2023-03-19 |
2023-08-14 |
Not clear |
| Xiaoming Zheng, Justin Cawood, Chris Hayre, Shaoyu Wan. Computer assisted diagnosis of Alzheimer's disease using statistical likelihood-ratio test. PloS one. vol 18. issue 2. 2023-02-17. PMID:36800393. |
the probability density functions of the likelihood ratio were constructed by using medial temporal lobe (mtl) volumes of patients with alzheimer's disease (ad) and normal controls (nc). |
2023-02-17 |
2023-08-14 |
Not clear |
| Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Gu. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-02-08. PMID:36750884. |
to better assist with the design of future clinical trials for alzheimer's disease (ad) and aid in our understanding of the disease's symptomatology, it is essential to clarify what roles β-amyloid (aβ) plaques and tau tangles play in longitudinal tau accumulation inside and outside the medial temporal lobe (mtl) as well as how age, sex, apolipoprotein e (apoe) ε4 (apoe-ε4), and klotho-vs heterozygosity (kl-vs |
2023-02-08 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
aging and alzheimer's disease have dissociable effects on medial temporal lobe connectivity. |
2023-01-30 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
previous studies revealed that the anterior medial temporal lobe is more vulnerable to pathological and neurodegenerative processes in alzheimer's disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
to address this knowledge gap, we examined functional connectivity alterations in the medial temporal lobe and its immediate functional neighborhood - the anterior-temporal and posterior-medial brain networks - in normal agers, individuals with preclinical alzheimer's disease, and patients with mild cognitive impairment or mild dementia due to alzheimer's disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
according to our results, the preclinical phase of alzheimer's disease is characterized by increased functional connectivity between the perirhinal cortex and other regions of the medial temporal lobe, as well as between the anterior medial temporal lobe and its one-hop neighbors in the anterior-temporal system. |
2023-01-30 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
instead, patients with symptomatic alzheimer's disease displayed reduced hippocampal connectivity within the medial temporal lobe as well as hypoconnectivity within the posterior-medial system. |
2023-01-30 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
together, the current results highlight evolving medial temporal lobe dysfunction in alzheimer's disease and indicate different neurobiological mechanisms of the medial temporal lobe network disruption in aging vs. alzheimer's disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Batool Rizvi, Mithra Sathishkumar, Soyun Kim, Freddie Márquez, Steven J Granger, Myra S Larson, Blake A Miranda, Martina K Hollearn, Liv McMillan, Bin Nan, Nicholas J Tustison, Patrick J Lao, Adam M Brickman, Dana Greenia, Maria M Corrada, Claudia H Kawas, Michael A Yass. Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults. NeuroImage. Clinical. vol 37. 2022-12-31. PMID:36586358. |
similarly, medial temporal lobe atrophy is well-documented in aging and alzheimer's disease and is associated with memory decline. |
2022-12-31 |
2023-08-14 |
human |
| Dengrong Jiang, Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat, Emma Lucke, Abhay Moghekar, Jay J Pillai, Hanzhang L. MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe. NeuroImage. 2022-12-24. PMID:36565971. |
the medial temporal lobe (mtl) is a key area implicated in many brain diseases, such as alzheimer's disease. |
2022-12-24 |
2023-08-14 |
Not clear |
| Efthymia Maria Kapasouri, Diomidis C Ioannidis, Donnie Cameron, Vassilios S Vassiliou, Michael Hornberge. The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis. Diagnostics (Basel, Switzerland). vol 12. issue 12. 2022-12-23. PMID:36552974. |
the utility of arterial spin labeling mri in medial temporal lobe as a vascular biomarker in alzheimer's disease spectrum: a systematic review and meta-analysis. |
2022-12-23 |
2023-08-14 |
human |
| Efthymia Maria Kapasouri, Diomidis C Ioannidis, Donnie Cameron, Vassilios S Vassiliou, Michael Hornberge. The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis. Diagnostics (Basel, Switzerland). vol 12. issue 12. 2022-12-23. PMID:36552974. |
we sought to systematically review and meta-analy the role of cerebral blood flow (cbf) in the medial temporal lobe (mtl) using arterial spin labeling magnetic resonance imaging (asl-mri) and compare this in patients with alzheimer's disease (ad), individuals with mild cognitive impairment (mci), and cognitively normal adults (cn). |
2022-12-23 |
2023-08-14 |
human |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (mtl) and extracellular amyloid aggregates in the default network (dn). |
2022-12-13 |
2023-08-14 |
human |