| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megan A Iida, Kurt Farrell, Jamie M Walker, Timothy E Richardson, Gabriel A Marx, Clare H Bryce, Dushyant Purohit, Gai Ayalon, Thomas G Beach, Eileen H Bigio, Etty P Cortes, Marla Gearing, Vahram Haroutunian, Corey T McMillan, Edward B Lee, Dennis W Dickson, Ann C McKee, Thor D Stein, John Q Trojanowski, Randall L Woltjer, Gabor G Kovacs, Julia K Kofler, Jeffrey Kaye, Charles L White, John F Crar. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta neuropathologica communications. vol 9. issue 1. 2021-12-11. PMID:34353357. |
while part shares some features with alzheimer disease (ad), such as progressive accumulation of neurofibrillary tangle pathology in the medial temporal lobe and other brain regions, it does not progress extensively to neocortical regions. |
2021-12-11 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
in alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with brodmann area 35, and the entorhinal cortex. |
2021-12-09 |
2023-08-13 |
human |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
the mechanisms underlying accumulation of alzheimer's disease (ad)-related tau pathology outside of the medial temporal lobe (mtl) in older adults are unknown but crucial to understanding cognitive decline. |
2021-11-23 |
2023-08-13 |
human |
| Jenna N Adams, Anne Maass, David Berron, Theresa M Harrison, Suzanne L Baker, Wesley P Thomas, Morgan Stanfill, William J Jagus. Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 17. 2021-11-19. PMID:33731446. |
tau deposition begins in the medial temporal lobe (mtl) in aging and alzheimer's disease (ad), and mtl neural dysfunction is commonly observed in these groups. |
2021-11-19 |
2023-08-13 |
human |
| Ho Young Park, Chae Ri Park, Chong Hyun Suh, Woo Hyun Shim, Sang Joon Ki. Diagnostic performance of the medial temporal lobe atrophy scale in patients with Alzheimer's disease: a systematic review and meta-analysis. European radiology. vol 31. issue 12. 2021-11-16. PMID:34510246. |
diagnostic performance of the medial temporal lobe atrophy scale in patients with alzheimer's disease: a systematic review and meta-analysis. |
2021-11-16 |
2023-08-13 |
Not clear |
| Ho Young Park, Chae Ri Park, Chong Hyun Suh, Woo Hyun Shim, Sang Joon Ki. Diagnostic performance of the medial temporal lobe atrophy scale in patients with Alzheimer's disease: a systematic review and meta-analysis. European radiology. vol 31. issue 12. 2021-11-16. PMID:34510246. |
to evaluate the diagnostic performance and reliability of the medial temporal lobe atrophy (mta) scale in patients with alzheimer's disease. |
2021-11-16 |
2023-08-13 |
Not clear |
| Laura E Korthauer, Jenna K Blujus, Elizabeth Awe, Marijam Frahmand, Robert Prost, Ira Driscol. Brain-behavior investigation of potential cognitive markers of Alzheimer's disease in middle age: a multi-modal imaging study. Brain imaging and behavior. 2021-11-09. PMID:34751892. |
this study suggests that virtual morris water task performance is associated with medial temporal lobe integrity in middle age, a critical window for detection and prevention of alzheimer's disease, and may be useful as an early cognitive marker of alzheimer's disease risk. |
2021-11-09 |
2023-08-13 |
human |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
tau neurofibrillary tangle (nft) pathology in the medial temporal lobe (mtl) is closely linked to neurodegeneration, and is the early pathological change associated with alzheimer's disease (ad). |
2021-11-05 |
2023-08-13 |
human |
| Léa Chauveau, Elizabeth Kuhn, Cassandre Palix, Francesca Felisatti, Valentin Ourry, Vincent de La Sayette, Gaël Chételat, Robin de Flore. Medial Temporal Lobe Subregional Atrophy in Aging and Alzheimer's Disease: A Longitudinal Study. Frontiers in aging neuroscience. vol 13. 2021-11-02. PMID:34720998. |
medial temporal lobe subregional atrophy in aging and alzheimer's disease: a longitudinal study. |
2021-11-02 |
2023-08-13 |
Not clear |
| Léa Chauveau, Elizabeth Kuhn, Cassandre Palix, Francesca Felisatti, Valentin Ourry, Vincent de La Sayette, Gaël Chételat, Robin de Flore. Medial Temporal Lobe Subregional Atrophy in Aging and Alzheimer's Disease: A Longitudinal Study. Frontiers in aging neuroscience. vol 13. 2021-11-02. PMID:34720998. |
medial temporal lobe (mtl) atrophy is a key feature of alzheimer's disease (ad), however, it also occurs in typical aging. |
2021-11-02 |
2023-08-13 |
Not clear |
| David Berron, Danielle van Westen, Rik Ossenkoppele, Olof Strandberg, Oskar Hansso. Corrigendum to: Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 9. 2021-10-31. PMID:34259865. |
corrigendum to: medial temporal lobe connectivity and its associations with cognition in early alzheimer's disease. |
2021-10-31 |
2023-08-13 |
Not clear |
| Altin Kocinaj, Tabassum Chaudhury, Mohammed S Uddin, Rashad R Junaid, David B Ramsden, Geshanthi Hondhamuni, Fábio Klamt, Linda Parsons, Richard B Parson. High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer's Disease. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33387303. |
in this study, we have compared the expression of nnmt in post-mortem medial temporal lobe, hippocampus and cerebellum of 10 alzheimer's disease (ad) and 9 non-disease control subjects using a combination of quantitative western blotting, immunohistochemistry and dual-label confocal microscopy coupled with quantitative analysis of colocalisation. |
2021-10-27 |
2023-08-13 |
human |
| Omid Kohannim, Derrek P Hibar, Neda Jahanshad, Jason L Stein, Xue Hua, Arthur W Toga, Clifford R Jack, Michael W Weiner, Paul M Thompso. PREDICTING TEMPORAL LOBE VOLUME ON MRI FROM GENOTYPES USING L(1)-L(2) REGULARIZED REGRESSION. Proceedings. IEEE International Symposium on Biomedical Imaging. 2021-10-21. PMID:22903144. |
we applied a multivariate approach, based on l(1)-l(2)-regularized regression (elastic net) to predict a magnetic resonance imaging (mri) tensor-based morphometry-derived measure of temporal lobe volume from a genome-wide scan in 740 alzheimer's disease neuroimaging initiative (adni) subjects. |
2021-10-21 |
2023-08-12 |
human |
| Spyridon Tsiouris, Charalampos Bougias, Spyridon Konitsiotis, Athanasios Papadopoulos, Andreas Fotopoulo. Early-Onset Frontotemporal Dementia-Related Semantic Variant of Primary Progressive Aphasia: Multimodal Evaluation With Brain Perfusion SPECT, SPECT/MRI Coregistration, and MRI Volumetry. Clinical nuclear medicine. 2021-10-15. PMID:34653052. |
this revealed bilateral hypoperfusion of the anterior temporal lobe (sustained by software-fused spect/mri), pointing toward ftd rather than alzheimer disease. |
2021-10-15 |
2023-08-13 |
Not clear |
| Michael Ewers, Ying Luan, Lukas Frontzkowski, Julia Neitzel, Anna Rubinski, Martin Dichgans, Jason Hassenstab, Brian A Gordon, Jasmeer P Chhatwal, Johannes Levin, Peter Schofield, Tammie L S Benzinger, John C Morris, Alison Goate, Celeste M Karch, Anne M Fagan, Eric McDade, Ricardo Allegri, Sarah Berman, Helena Chui, Carlos Cruchaga, Marty Farlow, Neill Graff-Radford, Mathias Jucker, Jae-Hong Lee, Ralph N Martins, Hiroshi Mori, Richard Perrin, Chengjie Xiong, Martin Rossor, Nick C Fox, Antoinette O'Connor, Stephen Salloway, Adrian Danek, Katharina Buerger, Randall J Bateman, Christian Habeck, Yaakov Stern, Nicolai Franzmeie. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 7. 2021-09-24. PMID:33725114. |
in the sporadic alzheimer's sample, disease stage was assessed by temporal lobe tau-pet (i.e. |
2021-09-24 |
2023-08-13 |
human |
| Michael Ewers, Ying Luan, Lukas Frontzkowski, Julia Neitzel, Anna Rubinski, Martin Dichgans, Jason Hassenstab, Brian A Gordon, Jasmeer P Chhatwal, Johannes Levin, Peter Schofield, Tammie L S Benzinger, John C Morris, Alison Goate, Celeste M Karch, Anne M Fagan, Eric McDade, Ricardo Allegri, Sarah Berman, Helena Chui, Carlos Cruchaga, Marty Farlow, Neill Graff-Radford, Mathias Jucker, Jae-Hong Lee, Ralph N Martins, Hiroshi Mori, Richard Perrin, Chengjie Xiong, Martin Rossor, Nick C Fox, Antoinette O'Connor, Stephen Salloway, Adrian Danek, Katharina Buerger, Randall J Bateman, Christian Habeck, Yaakov Stern, Nicolai Franzmeie. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 7. 2021-09-24. PMID:33725114. |
similarly, for patients with sporadic alzheimer's disease, higher functional mri-assessed system segregation was associated with less decrement in global cognition (p = 0.001) and episodic memory (p = 0.004) per unit increase of temporal lobe tau-pet. |
2021-09-24 |
2023-08-13 |
human |
| Amy N Murray, Hannah L Chandler, Thomas M Lancaste. Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease. Neurobiology of aging. vol 98. 2021-09-20. PMID:33227567. |
preclinical models of alzheimer's disease (ad) suggest that volumetric reductions in medial temporal lobe (mtl) structures manifest before clinical onset. |
2021-09-20 |
2023-08-13 |
human |
| Eiman Al-Janahi, Georgios Ponirakis, Hanadi Al Hamad, Surjith Vattoth, Ahmed Elsotouhy, Ioannis N Petropoulos, Adnan Khan, Hoda Gad, Mani Chandran, Anoop Sankaranarayanan, Marwan Ramadan, Marwa Elorrabi, Masharig Gadelseed, Rhia Tosino, Priya V Gawhale, Anjum Arasn, Maryam Alobaidi, Shafi Khan, Pravija Manikoth, Yasmin Hamdi, Susan Osman, Navas Nadukkandiyil, Essa AlSulaiti, Noushad Thodi, Hamad Almuhannadi, Ziyad R Mahfoud, Ahmed Own, Ashfaq Shuaib, Rayaz A Mali. Corneal Nerve and Brain Imaging in Mild Cognitive Impairment and Dementia. Journal of Alzheimer's disease : JAD. vol 77. issue 4. 2021-09-10. PMID:32925064. |
visual rating of medial temporal lobe atrophy (mta) is an accepted structural neuroimaging marker of alzheimer's disease. |
2021-09-10 |
2023-08-13 |
Not clear |
| Can Sheng, Yu Sun, Min Wang, Xiaoni Wang, Yi Liu, Dongqing Pang, Jiaqi Liu, Xiaoxia Bi, Wenying Du, Mingyan Zhao, Yuxia Li, Xiaobo Li, Jiehui Jiang, Ying Ha. Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-09-08. PMID:32716355. |
visual rating scales for medial temporal lobe atrophy (mta) and posterior atrophy (pa) have been reported to be useful for alzheimer's disease diagnosis in routine clinical practice. |
2021-09-08 |
2023-08-13 |
Not clear |
| Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Jeiran Choupan, Ryan P Cabeen, Kirsten M Lynch, Malcolm S Crawford, Haoyu Lan, Wendy J Mack, Helena C Chui, John M Ringman, Arthur W Tog. Volumetric distribution of perivascular space in relation to mild cognitive impairment. Neurobiology of aging. vol 99. 2021-09-01. PMID:33422892. |
surprisingly, we noted lower pvs presence in the anterosuperior medial temporal lobe (asmtl) (1.29 times lower pvs volume fraction in cognitively impaired individuals, p < 0.0001), which was associated with entorhinal neurofibrillary tau tangle deposition (beta (standard error) = -0.98 (0.4); p = 0.014), one of the hallmarks of early alzheimer's disease pathology. |
2021-09-01 |
2023-08-13 |
human |