| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Male. Central action of narcotic analgesics. VI. Further studies on the participation of serotonin in the action of analgesics. Polish journal of pharmacology and pharmacy. vol 32. issue 5. 1981-10-14. PMID:6115369. |
depression of the cerebral level of 5-ht usually antagonized the behavioral effects of analgesics, but the effect varied with the agent depressing the 5-ht level. |
1981-10-14 |
2023-08-12 |
rat |
| B Morgan, M Winic. A possible control of food intake during pregnancy in the rat. The British journal of nutrition. vol 46. issue 1. 1981-10-14. PMID:7260030. |
the increase food intake of the dams during gestation and lactation increased to the same extent as elevation in hypothalamic norepinephrine content and depression in serotonin content. |
1981-10-14 |
2023-08-12 |
rat |
| R Philo, R J Reite. The involvement of brain amines in pinealectomy-induced convulsions in the gerbil: I. Serotonin. Behavioural brain research. vol 3. issue 1. 1981-09-15. PMID:6972773. |
serotonin is apparently of little importance in the px-induced convulsion since the artificial elevation by administration of tryptophan and 5-hydroxytryptophan, or depression by treatment with p-chloramphetamine, of telencephalic 5-ht had little effect on the convulsions. |
1981-09-15 |
2023-08-12 |
Not clear |
| S Greenberg, C McGowan, T M Glen. Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock. The American journal of physiology. vol 241. issue 1. 1981-08-27. PMID:7246787. |
the depression in the sensitivity to 5-ht and maximal tension development to 5-ht and ne was selective, since the responses to potassium ion were not depressed. |
1981-08-27 |
2023-08-12 |
Not clear |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
4 5-ht or noradrenaline injected intravenously into 5 day-old chicks caused a dose-dependent behavioural depression resembling sleep. |
1981-08-20 |
2023-08-12 |
mouse |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
tryptamine at low doses had no overt effects but enhanced depression induced by 5-ht. |
1981-08-20 |
2023-08-12 |
mouse |
| R S Jone. In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British journal of pharmacology. vol 73. issue 2. 1981-08-20. PMID:6972243. |
at behaviourally excitatory doses tryptamine reduced the duration of the 5-ht depression. |
1981-08-20 |
2023-08-12 |
mouse |
| M K DeMyer, P A Shea, H C Hendrie, N N Yoshimur. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of general psychiatry. vol 38. issue 6. 1981-08-10. PMID:7247626. |
decreases in brain serotonin levels have been implicated in the pathogenesis of human depression. |
1981-08-10 |
2023-08-12 |
human |
| M K DeMyer, P A Shea, H C Hendrie, N N Yoshimur. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of general psychiatry. vol 38. issue 6. 1981-08-10. PMID:7247626. |
this finding tends to support the idea that changes in brain serotonin level reflect changes in depression severity. |
1981-08-10 |
2023-08-12 |
human |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
since ethanol may interact with central serotonergic (5ht) neurons, and since 5ht systems have been found to play a role in modulating lh release, we examined the possible role of central serotonergic neurons in the ethanol-induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
acute pcpa (400 mg/kg, 20 hr before 2.0 g/kg ethanol) was effective in preventing the ethanol-induced depression of lh, suggesting that ethanol activates 5ht systems to lower lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
x 3 days before ethanol) produced similar reductions in hypothalamic 5ht but did not block the ethanol effect, and because electrolytic lesions of the median raphe nucleus were also ineffective in preventing the post-ethanol depression of lh, we conclude that activation of serotonergic systems does not play a major role in the ethanol induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| N Matusse. [Development of biological psychiatric depression research (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 123. issue 19. 1981-07-20. PMID:6262640. |
the concern with the neurochemical actions of these substances led to putting forth the noradrenaline and serotonin hypothesis of depression in the mid-60s. |
1981-07-20 |
2023-08-12 |
Not clear |
| N Matusse. [Development of biological psychiatric depression research (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 123. issue 19. 1981-07-20. PMID:6262640. |
according to this, there is supposed to be a deficiency of noradrenaline and/or serotonin at the nerve endings in depression. |
1981-07-20 |
2023-08-12 |
Not clear |
| A A Borbély, H U Neuhaus, I Toble. Effect of p-chlorophenylalanine and tryptophan on sleep, EEG and motor activity in the rat. Behavioural brain research. vol 2. issue 1. 1981-07-20. PMID:6452888. |
the experiments show that the depression of sws and rems, and the hyperactivity 1-2 days after pcpa administration, are a consequence of the reduced 5-ht level, whereas the involvement of serotonergic mechanisms in the initial sedative phase and in the recovery phase is less clear. |
1981-07-20 |
2023-08-12 |
rat |
| H M van Praa. Management of depression with serotonin precursors. Biological psychiatry. vol 16. issue 3. 1981-07-09. PMID:6164407. |
management of depression with serotonin precursors. |
1981-07-09 |
2023-08-12 |
Not clear |
| L Träskman-Bendz, M Asberg, L Bertilsso. Serotonin and noradrenaline uptake inhibitors in the treatment of depression--relationship to 5-HIAA in spinal fluid. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6164251. |
serotonin and noradrenaline uptake inhibitors in the treatment of depression--relationship to 5-hiaa in spinal fluid. |
1981-06-13 |
2023-08-12 |
Not clear |
| J Wålinder, A Carlsson, R Persso. 5-HT reuptake inhibitors plus tryptophan in endogenous depression. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6452791. |
5-ht reuptake inhibitors plus tryptophan in endogenous depression. |
1981-06-13 |
2023-08-12 |
Not clear |
| A Aber. Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6452794. |
a double-blind comparison of zimelidine, a potent and fairly selective 5-hydroxytryptamine (5-ht) uptake inhibitor, and desipramine, a noradrenaline (na) uptake inhibitor, was carried out in hospitalized patients with endogenous depression. |
1981-06-13 |
2023-08-12 |
rat |
| S Agurel. Biogenic amines and depression (introduction to symposium). Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6939311. |
it has generally been assumed that these "tricyclics" alleviate depression by influencing the neurotransmitters (na, 5-ht) at crucial receptor sites in the brain. |
1981-06-13 |
2023-08-12 |
Not clear |