| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Curzo. Study of disturbed tryptophan metabolism in depressive illness. Annales de biologie clinique. vol 37. issue 1. 1979-07-16. PMID:443610. |
the evidence for disturbances of tryptophan and 5-hydroxytryptamine in depression and for various mechanisms by which such disturbances could occur is discussed. |
1979-07-16 |
2023-08-11 |
human |
| P E Garfinkel, J J Warsh, H C Stance. Depression: new evidence in support of biological differentiation. The American journal of psychiatry. vol 136. issue 4B. 1979-05-23. PMID:426139. |
the authors state that their research design reveals changes in serotonin and nonrepinephrine metabolism in unipolar depressed subjects that distinguish this group from normal and bipolar depressed subjects, suggesting a reduced cns uptake of tryptophan in unipolar depression. |
1979-05-23 |
2023-08-11 |
human |
| T A Reader, A Ferron, L Descarries, H H Jaspe. Modulatory role for biogenic amines in the cerebral cortex. Microiontophoretic studies. Brain research. vol 160. issue 2. 1979-04-28. PMID:761065. |
most units inhibited by da, na and 5-ht also showed marked depression of their excitatory response to ach when pretreated with these biogenic amines. |
1979-04-28 |
2023-08-11 |
rat |
| A Aberg, G Holmber. Preliminary clinical test of zimelidine (H 102/09), a new 5-HT uptake inhibitor. Acta psychiatrica Scandinavica. vol 59. issue 1. 1979-04-25. PMID:369299. |
zimelidine, a bicyclic compound, which in animal experiments causes specific inhibition of the uptake of 5-ht, was tried on 15 patients with depression of endogenous type. |
1979-04-25 |
2023-08-11 |
rat |
| S C Brooks, J J Linn, N Disne. Serotonin, folic acid, and uric acid metabolism in the diagnosis of neuropsychiatric disorders. Biological psychiatry. vol 13. issue 6. 1979-04-25. PMID:737255. |
conversely, deficient serotonin, induced by a psychological loss or transport deficit, could be compensated by raising the folate ratio, which would normalize the beta-carboline index and prevent further depression. |
1979-04-25 |
2023-08-11 |
Not clear |
| A Akintonwa, J V Auditor. Reversal of adenine-induced depression of mouse locomotor activity by amphetamine. Archives internationales de pharmacodynamie et de therapie. vol 235. issue 2. 1979-03-24. PMID:736702. |
mice treated with adenine showed marked depletion of brain norepinephrine, dopamine and serotonin, irrespective of whether or not they had been treated with d- or l-amphetamine, and whether or not these agents were capable of reversing adenine-induced depression of locomotor activity. |
1979-03-24 |
2023-08-11 |
mouse |
| K Krnjević, Y Lamour, J F MacDonald, A Nistr. Intracellular actions of monoamine transmitters. Canadian journal of physiology and pharmacology. vol 56. issue 5. 1979-01-26. PMID:30529. |
intracellular injections of 5-hydroxytryptamine have some depolarizing action and increased input resistance, but they produced no comparable depression of the action potential and tended to enhance the after-potentials and increase excitability. |
1979-01-26 |
2023-08-11 |
Not clear |
| D Moussaou. [Biochemistry of depression. Literature analysis]. L'Encephale. vol 4. issue 3. 1979-01-26. PMID:30616. |
beyond all existing contradictory results, a review of the main works in this field enables us to point out some leading ideas:--depression would be due to and/or accompanied by a monoaminergic deficiency: some authors emphasize the serotonin one, others the noradrenaline one.--the regulation of mood most probably finds its origin in the monoaminergic balance, rather than in the gross rates of any particular monoamine.--disturbances are to be found on all metabolic levels: monoaminergic, hydroelectrolytic, hormonal, glucidic, lipidic, lipidic... close intrication exists between those different metabolisms.--the interaction between the different aminergic systems and the metabolic ways, as well as the dispersion of the acknowledged results, impose more and more the necessity of a biochemical typology of depression, which would lead to a predictive approach to the evolution and treatment of depressive illness. |
1979-01-26 |
2023-08-11 |
Not clear |
| L M Jordan, D R Kenshalo, F R Martin, L H Haber, W D Willi. Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine. Pain. vol 5. issue 2. 1978-11-29. PMID:99715. |
depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine. |
1978-11-29 |
2023-08-11 |
monkey |
| E R Bloc. Recovery from hyperoxic depression of pulmonary 5-hydroxytryptamine clearance: effect of inspired O2 tension. Lung. vol 155. issue 2. 1978-09-25. PMID:672255. |
recovery from hyperoxic depression of pulmonary 5-hydroxytryptamine clearance: effect of inspired o2 tension. |
1978-09-25 |
2023-08-11 |
Not clear |
| A Wirz-Justice, W Pühringe. Seasonal incidence of an altered diurnal rhythm of platelet serotonin in unipolar depression. Journal of neural transmission. vol 42. issue 1. 1978-06-28. PMID:565390. |
seasonal incidence of an altered diurnal rhythm of platelet serotonin in unipolar depression. |
1978-06-28 |
2023-08-11 |
Not clear |
| A Wirz-Justice, W Pühringe. Increased platelet serotonin in bipolar depression and hypomania. Journal of neural transmission. vol 42. issue 1. 1978-06-28. PMID:565391. |
increased platelet serotonin in bipolar depression and hypomania. |
1978-06-28 |
2023-08-11 |
Not clear |
| A Wirz-Justice, W Pühringe. Increased platelet serotonin in bipolar depression and hypomania. Journal of neural transmission. vol 42. issue 1. 1978-06-28. PMID:565391. |
a longitudinal study of a bipolar ii patient throughout three hospitalizations for depression followed by the switch into hypomania, indicated that 5-ht was state independent, remaining constantly high in all clinical conditions and upon remission, reduced only during and after treatment with clomipramine, a 5-ht uptakt dysfunction of indoleamines underlying bipolar illness. |
1978-06-28 |
2023-08-11 |
Not clear |
| C M Bank. 5-Hydroxytryptamine content of the whole blood in psychiatric illness and alcoholism. Acta psychiatrica Scandinavica. vol 57. issue 3. 1978-06-12. PMID:645413. |
neuroleptic drugs in mania did not alter the blood 5ht levels, but in depression tricyclic antidepressants caused an elevation after 3 weeks of treatment. |
1978-06-12 |
2023-08-11 |
Not clear |
| K Mitsunob. [Depression and serotonin metabolism]. Nihon rinsho. Japanese journal of clinical medicine. vol 36. issue 1. 1978-05-24. PMID:416250. |
[depression and serotonin metabolism]. |
1978-05-24 |
2023-08-11 |
Not clear |
| A R Green, D G Grahame-Smit. Processes regulating the functional activity of brain 5-hydroxytryptamine: results of animal experimentation and their relevance to the understanding and treatment of depression. Pharmakopsychiatrie, Neuro-Psychopharmakologie. vol 11. issue 1. 1978-05-08. PMID:565059. |
processes regulating the functional activity of brain 5-hydroxytryptamine: results of animal experimentation and their relevance to the understanding and treatment of depression. |
1978-05-08 |
2023-08-11 |
rat |
| A R Green, D G Grahame-Smit. Processes regulating the functional activity of brain 5-hydroxytryptamine: results of animal experimentation and their relevance to the understanding and treatment of depression. Pharmakopsychiatrie, Neuro-Psychopharmakologie. vol 11. issue 1. 1978-05-08. PMID:565059. |
investigation has been made into the processes regulating the function activity of rat brain 5-hydroxytryptamine (5-ht) and the way that drugs used to treat depression act on these processes. |
1978-05-08 |
2023-08-11 |
rat |
| D A Cook, K M Macleo. Responses of rabbit portal vein to histamine. British journal of pharmacology. vol 62. issue 2. 1978-04-17. PMID:23880. |
4 desensitization to high doses of 5-hydroxytryptamine caused a concomitant depression in the response to histamine but not to noradrenaline or acetylcholine. |
1978-04-17 |
2023-08-11 |
rabbit |
| M Smialowsk. Nomifensine and central monoamine neurons: histofluorescence studies. Polish journal of pharmacology and pharmacy. vol 29. issue 5. 1978-02-18. PMID:145591. |
the effect of nomifensine (nf) on the content of serotonin (5-ht) and catecholamines (ca) in discrete regions of rat brain was studied with the histofluorescence technique of falck, nf, 20 and 40 mg/kg ip, produced, after 30 min, a depression of 5-ht content in the neurocytes of dorsal and median raphe nuclei (ndr and nmr). |
1978-02-18 |
2023-08-11 |
rat |
| P L Nola. The effects of serotonin precursors on the pressor response to intravenous clonidine in conscious rats. Clinical and experimental pharmacology & physiology. vol 4. issue 6. 1978-02-18. PMID:303969. |
the depression by l-tryptophan of the clonidine-induced pressor response could be prevented by pretreatment with either the l-aromatic amino acid decarboxylase inhibitor rö44602 or the serotonin antagonist methysergide. |
1978-02-18 |
2023-08-11 |
rat |