| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10173. |
the depressant effects of certain antipsychotic drugs and piperoxane on 5ht neurons appears to be mediated by a cnetral adrenergic system since (1) the depression could be reversed by the catecholamine releasing agents 1- and d-amphetamine; (2) the depression could be abolished by destruction of adrenergic pathways in the cns by chemical, mechanical, or electrothermic lesions. |
1977-01-03 |
2023-08-11 |
Not clear |
| R Takahashi, K H Tachiki, K Nishiwaki, E Nakamura, T Tateish. Biochemical basis of an animal model of depressive illness--a preliminary report--. Folia psychiatrica et neurologica japonica. vol 30. issue 2. 1976-12-03. PMID:9342. |
biochemical analyses of brain samples of an animal model of depression indicate the state of motionlessness observed in response to a conditioned stimulus was due to an excess in functional activity of serotonin. |
1976-12-03 |
2023-08-11 |
human |
| H M van Praag, J Kor. Central monoamine deficiency in depressions: causative of secondary phenomenon? Pharmakopsychiatrie, Neuro-Psychopharmakologie. vol 8. issue 5. 1976-12-01. PMID:1085937. |
there are indications for a functional deficiency of 5-ht and da in certain kinds of depression. |
1976-12-01 |
2023-08-11 |
Not clear |
| L Kirstein, M B Bowers, G Heninge. CSF amine metabolites, clinical symptoms, and body movement in psychiatric patients. Biological psychiatry. vol 11. issue 4. 1976-11-21. PMID:963133. |
the effects of serotonin turnover and arousal in schizophrenia and the association between csf metabolite gradients, stress, motor movement, and biogenic amine levels in depression are discussed. |
1976-11-21 |
2023-08-11 |
Not clear |
| J E Smith, J N Hingtgen, W J McBride, M H Apriso. Neurochemical correlates of behavior. Content of tryptophan, 5-hydroxytryptophan, serotonin, 5-hydroxyindoleacetic acid, tyrosine, dopamine and norepinephrine in a nerve ending fraction isolated from three brain areas of the pigeon during the period of behavioral depression following an injection of tryptophan. Journal of neurochemistry. vol 27. issue 3. 1976-11-21. PMID:1085813. |
content of tryptophan, 5-hydroxytryptophan, serotonin, 5-hydroxyindoleacetic acid, tyrosine, dopamine and norepinephrine in a nerve ending fraction isolated from three brain areas of the pigeon during the period of behavioral depression following an injection of tryptophan. |
1976-11-21 |
2023-08-11 |
pigeon |
| C O Hallstrom, W L Rees, C M Pare, A Trenchard, P Turne. Platelet uptake of 5-hydroxytryptamine and dopamine in depression. Postgraduate medical journal. vol 52. issue 3 suppl. 1976-11-01. PMID:959089. |
platelet uptake of 5-hydroxytryptamine and dopamine in depression. |
1976-11-01 |
2023-08-11 |
Not clear |
| D F Kripk. Letter: Serotonin depression. Science (New York, N.Y.). vol 194. issue 4261. 1976-11-01. PMID:959853. |
letter: serotonin depression. |
1976-11-01 |
2023-08-11 |
Not clear |
| B Sanders, A C Collins, V H Wesle. Reduction of alcohol selection by pargyline in mice. Psychopharmacologia. vol 46. issue 2. 1976-10-02. PMID:133369. |
like other agents which increase 5-ht, parygyline produced a depression in ethanol intake which lasted beyond the time of drug administration. |
1976-10-02 |
2023-08-11 |
mouse |
| M Smialowsk. Histofluorescence studies on the effect of 1,3-dimethyl-5-adamantanamine (D-145) on serotonin neurons in midbrain raphe nuclei. Polish journal of pharmacology and pharmacy. vol 28. issue 3. 1976-10-02. PMID:951305. |
spiroperidol, 2 mg/kg ip, given 5 min before d-145, prevented the depression of serotonin fluorescence in the dorsal raphe nucleus (ndr), but not in the other groups of serotonin midbrain neurons. |
1976-10-02 |
2023-08-11 |
rat |
| P M Lundy, C W Gowdey, E H Colhou. The actions of ketamine on vascular smooth muscle. Archives internationales de pharmacodynamie et de therapie. vol 220. issue 2. 1976-10-02. PMID:952582. |
ketamine caused a slight depression of the isolated aorta but potentiated responses to adrenaline but not to noradrenaline or 5-hydroxytryptamine. |
1976-10-02 |
2023-08-11 |
rat |
| I Paasch. [Biochemistry of depression]. Psychiatrie, Neurologie, und medizinische Psychologie. vol 28. issue 2. 1976-09-25. PMID:181773. |
in patients with endogenous depression a functional deficiency of noradrenalin and serotonin is presupposed. |
1976-09-25 |
2023-08-11 |
Not clear |
| N K Popova, V D Bertogaev. [Participation of the serotonin-reactive brain structure in certain forms of behavior in golden hamsters]. Farmakologiia i toksikologiia. vol 38. issue 2. 1976-09-01. PMID:1084283. |
a similar depression of the serotonin level in the brain stem was also noted in an aggressive behavior and stress conditions arising when adult male-hamsters are grouped together. |
1976-09-01 |
2023-08-11 |
Not clear |
| N S Saponov, V E Ryzhenko. [Activity of the hypophyseal-adrenal system under the influence of substances of mediator type action]. Problemy endokrinologii. vol 21. issue 4. 1976-08-03. PMID:131938. |
at the same time it was shown that depression of catecholamine and serotonin synthesis in the brain after the administration of alpha-methylparatyrosine or parachlorphenylalanine, respectively, and also an exhaustion of the tissue stores of the monoamines in administration of reserpine failed to influence significantly the reaction of the hypophysio-adrenal system to the immobilization of the animals. |
1976-08-03 |
2023-08-11 |
rat |
| J E Smith, J N Hingtgen, J D Lane, M H Apriso. Neurochemical correlates of behaviour--content of tryptophan, 5-hydroxytryptophan, serotonin, 5-hydroxyindoleacetic acid, tyrosine, dopamine and norepinephrine in four brain parts of the pigeon during behavioural depression following an injection of tryptophan. Journal of neurochemistry. vol 26. issue 3. 1976-07-06. PMID:4584. |
neurochemical correlates of behaviour--content of tryptophan, 5-hydroxytryptophan, serotonin, 5-hydroxyindoleacetic acid, tyrosine, dopamine and norepinephrine in four brain parts of the pigeon during behavioural depression following an injection of tryptophan. |
1976-07-06 |
2023-08-11 |
pigeon |
| B E Leonar. Acute and chronic effects of 4-chloroamphetamine on monoamine metabolism in the rat brain. Psychopharmacologia. vol 46. issue 1. 1976-05-25. PMID:1257360. |
such findings are difficult to reconcile with the widely accepted theory that antidepressant drugs counteract the symptoms of depression by increasing the concentration of noradrenaline and/or serotonin at receptor sites within the brain. |
1976-05-25 |
2023-08-11 |
rat |
| M Asberg, P Thorén, L Träskman, L Bertilsson, V Ringberge. "Serotonin depression"--a biochemical subgroup within the affective disorders? Science (New York, N.Y.). vol 191. issue 4226. 1976-03-30. PMID:1246632. |
"serotonin depression"--a biochemical subgroup within the affective disorders? |
1976-03-30 |
2023-08-11 |
Not clear |
| P M Headley, D Lodg. The effects of beta-carbolines on responses to acetylcholine, noradrenaline, 5-hydroxytryptamine and amino acids in the rat spinal cord. Brain research. vol 101. issue 3. 1976-03-15. PMID:1244986. |
responses to noradrenaline (na) and 5-hydroxytryptamine (5-ht) have not previously been described at this site and were of two types; either monophasic depression or biphasic depression-excitation. |
1976-03-15 |
2023-08-11 |
rat |
| N K Popova, S G Kolaeva, I I Dianov. [State of the epiphysis during winter hibernation]. Biulleten' eksperimental'noi biologii i meditsiny. vol 79. issue 4. 1976-02-19. PMID:1191758. |
hybernation was accompanied by reduced concentration of serotonin in the pineal gland, by the disappearance of differences between the cortical and the medullary zones and by a number of morphological signs of functional depression. |
1976-02-19 |
2023-08-11 |
rat |
| K Nish. The action of 5-hydroxytryptamine on chemoreceptor discharges of the cat's carotid body. British journal of pharmacology. vol 55. issue 1. 1976-01-14. PMID:1182345. |
2 intra-carotid injections of 5-ht (2-20 mug) induced a sharp and brief increase in chemoreceptor discharges, followed by depression or block which lasted for several seconds. |
1976-01-14 |
2023-08-11 |
cat |
| J Hano, J Bugajski, L Danek, C Wantuc. The influence of serotonin on insulin-stimulated gastric secretion, blood glucose and serum electrolyte levels in the unanesthetized rat. Archives internationales de pharmacodynamie et de therapie. vol 216. issue 1. 1975-12-05. PMID:1164102. |
the prevention by 5-ht of insulin hypoglycemia and hypokalemia may be of significant importance in the mechanism of the depression of insulin-stimulated gastric secretion. |
1975-12-05 |
2023-08-11 |
rat |