| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Davis, D I Strachan, E Kas. Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle. Science (New York, N.Y.). vol 209. issue 4455. 1980-09-26. PMID:7394520. |
serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. |
1980-09-26 |
2023-08-12 |
rat |
| R S Ehsanulla. Uptake of 5-hydroxytryptamine and dopamine into platelets from depressed patients and normal subjects--influence of clomipramine, desmethylclomipramine and maprotiline. Postgraduate medical journal. vol 56 Suppl 1. 1980-09-23. PMID:7393826. |
platelet uptake of 5-ht and da in both types of depression is lower than in healthy, which supports the hypothesis that central monamine function is reduced or impaired in depressives. |
1980-09-23 |
2023-08-12 |
human |
| M Miśkiewicz, A Rokosz-Pelc, J Vetulan. The effect of quipazine and LSD on monoamines in the rat striatum. Polish journal of pharmacology and pharmacy. vol 31. issue 5. 1980-08-25. PMID:94944. |
lsd at the peak of its action depressed the level of 5-hiaa, and in the next period produced a significant depression of striatal levels of na, 5ht and 5-hiaa. |
1980-08-25 |
2023-08-11 |
rat |
| H M van Praa. [Central serotonin metabolism in depression]. Nederlands tijdschrift voor geneeskunde. vol 124. issue 24. 1980-08-25. PMID:6966766. |
[central serotonin metabolism in depression]. |
1980-08-25 |
2023-08-12 |
Not clear |
| J M Woo. Effect of depletion of brain 5-hydroxytryptamine by 5,7-dihydroxytryptamine on ethanol tolerance and dependence in the rat. Psychopharmacology. vol 67. issue 1. 1980-06-16. PMID:6768080. |
depletion of brain 5-ht by 5,7-dht appears to result in a non-specific central nervous system depression that potentiates the depressant actions of ethanol and pentobarbitone and antagonises the hyperexcitability of ethanol withdrawal. |
1980-06-16 |
2023-08-12 |
rat |
| B T Griersmith, A W Dugga. Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methysergide. Brain research. vol 187. issue 1. 1980-05-30. PMID:6244070. |
prolonged depression of spinal transmission of nociceptive information by 5-ht administered in the substantia gelatinosa: antagonism by methysergide. |
1980-05-30 |
2023-08-12 |
Not clear |
| C Sangdee, D N Fran. Lithium enhancement of central 5-HT transmission induced by 5-HT precursors. Biological psychiatry. vol 15. issue 1. 1980-05-14. PMID:6244011. |
acute lithium administration (2 meq/kg) produced insignificant depression of the reflex pathway but markedly depressed transmission through the intraspinal pathway, an effect that was prevented by depletion or blockage of 5-ht. |
1980-05-14 |
2023-08-12 |
Not clear |
| J R Fozard, A T Mobarok Ali, G Newgros. Blockade of serotonin receptors on autonomic neurones by (-)-cocaine and some related compounds. European journal of pharmacology. vol 59. issue 3-4. 1980-04-26. PMID:527645. |
low concentrations of (--)-cocaine or its stereoisomer, (4)-pseudococaine, produced shifts to the right of the 5-ht dose-response curves on heart and ileum with no depression of the maximum responses to electrical stimulation or dimethylphenylpiperazinium remained unaffected. |
1980-04-26 |
2023-08-11 |
rabbit |
| J Vetulani, B Byrska, K Reichenber. Head twitches produced by serotonergic drugs and opiates after lesion of the mesostriatal serotonergic system of the rat. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:316525. |
there was a good correlation between the extent of lesion, measured by the depression of the level of prosencephalic serotonin, and the depression of head twitch frequency produced by 5-hydroxytryptophan and quipazine, while the correlation was not significant for the action of lsd. |
1980-03-17 |
2023-08-11 |
rat |
| J Tuomisto, E Tukiainen, U G Ahlfor. Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. Psychopharmacology. vol 65. issue 2. 1980-02-15. PMID:117482. |
decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. |
1980-02-15 |
2023-08-11 |
human |
| J Tuomisto, E Tukiainen, U G Ahlfor. Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. Psychopharmacology. vol 65. issue 2. 1980-02-15. PMID:117482. |
5-hydroxytryptamine (5-ht) uptake was studied by using blood platelets from 13 patients with endogenous depression (hamilton rating scale 33 +/- 7) and 13 healthy volunteers. |
1980-02-15 |
2023-08-11 |
human |
| S O Ogren, K Fuxe, L F Agnati, J A Gustafsson, G Jonsson, A C Hol. Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs. Journal of neural transmission. vol 46. issue 2. 1980-02-15. PMID:574536. |
thus, a new indoleamine hypothesis of depression is presented: the therapeutic action of antidepressant drugs may in part be due to a reduced functional acitivity of some central 5-ht systems. |
1980-02-15 |
2023-08-11 |
mouse |
| G F Oxenkru. The content and uptake of 5-HT by blood platelets in depressive patients. Journal of neural transmission. vol 45. issue 4. 1979-12-20. PMID:490151. |
these data suggest that the acceleration of 5-ht reuptake in neurones may be one of the reasons of insufficiency of 5-ht-ergic processes in depression of 5-ht type (asberg, 1976). |
1979-12-20 |
2023-08-11 |
Not clear |
| R L Carasso, S Yehuda, M Streifle. Clomipramine and amitriptyline in the treatment of severe pain. The International journal of neuroscience. vol 9. issue 3. 1979-12-18. PMID:489262. |
the results support the hypothesis that in certain pain situations, clomipramine exerts a beneficial effect, not only because of its effect on the depression and anxiety level of the patient, but also via its effects on the 5-ht brain system. |
1979-12-18 |
2023-08-11 |
Not clear |
| D N Franz, B D Hare, R J Neumay. Depression of sympathetic preganglionic neurons by clonidine: evidence for stimulation of 5-HT receptors. Clinical and experimental hypertension. vol 1. issue 1. 1979-12-18. PMID:755644. |
depression of sympathetic preganglionic neurons by clonidine: evidence for stimulation of 5-ht receptors. |
1979-12-18 |
2023-08-11 |
Not clear |
| F R Bell, D E Webbe. Gastric emptying and secretion in the calf on duodenal infusion of tryptophan, tryptamine and 5-hydroxytryptamine. The Journal of physiology. vol 291. 1979-11-29. PMID:480233. |
tryptamine and 5-hydroxytryptamine (5-ht) incorporated in low concentration into isotonic nahco(3) also produced depression of gastric emptying, acid and pepsinogen levels comparable to the response initiated by acid infusate. |
1979-11-29 |
2023-08-11 |
Not clear |
| O Benker. [Biochemical research in depression (author's transl)]. Klinische Wochenschrift. vol 57. issue 13. 1979-11-29. PMID:480857. |
the noradrenalin and serotonin-hypothesis was propounded postulating a disturbance in noradrenalin, or serotonin regulation, respectively at the receptor in depression. |
1979-11-29 |
2023-08-11 |
Not clear |
| J A Armijo, A Mediavilla, J Flóre. Inhibition of the activity of the respiratory and vasomotor centers by centrally administered 5-hydroxytryptamine in cats. Revista espanola de fisiologia. vol 35. issue 2. 1979-11-21. PMID:582627. |
50 mu g of 5-ht injected into the fourth ventricle induced a depression of respiration similar to that observed in the lateral ventricle studies, with the exception that the early stimulation was abolished. |
1979-11-21 |
2023-08-11 |
Not clear |
| C Sangdee, D N Fran. Enhancement of central norepinephrine and 5-hydroxytryptamine transmission by tricyclic antidepressants. A comparison. Psychopharmacology. vol 62. issue 1. 1979-07-28. PMID:220658. |
effects on 5-ht transmission were assessed on 5-ht-mediated depression of spinal sympathetic reflexes produced by 30 mg/kg of 5-htp. |
1979-07-28 |
2023-08-11 |
Not clear |
| C Sangdee, D N Fran. Enhancement of central norepinephrine and 5-hydroxytryptamine transmission by tricyclic antidepressants. A comparison. Psychopharmacology. vol 62. issue 1. 1979-07-28. PMID:220658. |
each of the four drugs also enhanced the 5-htp-induced depression of spinal sympathetic reflexes, but their relative potencies on 5-ht transmission were just the opposite to those found on ne transmission. |
1979-07-28 |
2023-08-11 |
Not clear |