| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sounak Bagchi, Ehsan Nozohouri, Yeseul Ahn, Dhavalkumar Patel, Ulrich Bickel, Vardan T Karamya. Systemic and Brain Pharmacokinetics of Milnacipran in Mice: Comparison of Intraperitoneal and Intravenous Administration. Pharmaceutics. vol 16. issue 1. 2024-01-23. PMID:38258064. |
milnacipran is a dual serotonin and norepinephrine reuptake inhibitor, clinically used for the treatment of major depression or fibromyalgia. |
2024-01-23 |
2024-01-25 |
mouse |
| Mariko Nakamura, Akira Yoshimi, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Tomoya Miyauchi, Kunihiro Iwamoto, Mikiko Ito, Aiji Sato-Boku, Akihiro Mouri, Toshitaka Nabeshima, Norio Ozaki, Yukihiro Nod. Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein. Pain. 2024-01-16. PMID:38227563. |
as the result, decrease of plasma serotonin concentrations may be related to the efficacy of dlx in relieving pain and depression in cop patients. |
2024-01-16 |
2024-01-19 |
Not clear |
| Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Mary Morrison, Armine Darbinyan, Huaqing Zhao, Laura Goetzl, Michael Edgar Selze. Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH. Cells. vol 13. issue 1. 2024-01-11. PMID:38201206. |
many women who use alcohol (ethanol, etoh) during pregnancy suffer from depression and take selective serotonin reuptake inhibitors (ssris), which might influence these monoaminergic pathways in the fetus. |
2024-01-11 |
2024-01-13 |
Not clear |
| Volkan Uzungil, Sandra Luza, Carlos M Opazo, Isaline Mees, Shanshan Li, Ching-Seng Ang, Nicholas A Williamson, Ashley I Bush, Anthony J Hannan, Thibault Renoi. Phosphoproteomics implicates glutamatergic and dopaminergic signalling in the antidepressant-like properties of the iron chelator deferiprone. Neuropharmacology. 2024-01-06. PMID:38184274. |
polymorphisms of the serotonin transporter (5-htt) gene have been linked to depression (when combined with stressful life events) and to altered response to selective serotonergic reuptake inhibitors. |
2024-01-06 |
2024-01-09 |
mouse |
| Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimot. Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys. PLoS biology. vol 22. issue 1. 2024-01-01. PMID:38163325. |
serotonin (5-ht) deficiency is a core biological pathology underlying depression and other psychiatric disorders whose key symptoms include decreased motivation. |
2024-01-01 |
2024-01-05 |
monkey |
| Evgenii Gusev, Alexey Sarapultse. Interplay of G-Proteins and Serotonin in the Neuroimmunoinflammatory Model of Chronic Stress and Depression: A Narrative Review. Current pharmaceutical design. 2023-12-28. PMID:38151838. |
interplay of g-proteins and serotonin in the neuroimmunoinflammatory model of chronic stress and depression: a narrative review. |
2023-12-28 |
2023-12-30 |
Not clear |
| Ivana Jelić, Goran Mihajlović, Miloš Ratinac, Katarina Mihajlović, Sara Mijailović, Ivan Čekereva. Psychophysical and Social Functioning of Patients with Chronic Obstructive Lung Disease and Depression. European journal of investigation in health, psychology and education. vol 13. issue 12. 2023-12-22. PMID:38131895. |
this study aims to examine the relationship between the psychophysical and social functioning of copd patients who have been diagnosed with depression and the therapeutic benefits of selective serotonin reuptake inhibitors (ssris). |
2023-12-22 |
2023-12-24 |
human |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
here, we investigated the effects of six lactobacillus reuteri strains on bdnf, serotonin, and il-6 expression in neuronal or macrophage cells and pdi fecal microbiota-cultured microbiota (pcm)-induced depression in mice. |
2023-12-21 |
2023-12-23 |
mouse |
| Victor H Molina-Lopez, Jose Escabi-Mendoz. The Critical Role of Lambda-Shaped QRS-ST-T Wave Fusion ST-Elevation in Diagnosing and Managing Takotsubo Cardiomyopathy: A Case Report and Review of Literature. Cureus. vol 15. issue 11. 2023-12-20. PMID:38116354. |
this case report discusses a complex clinical scenario involving an adult female with severe depression who attempted suicide through drug overdose, subsequently developing serotonin syndrome. |
2023-12-20 |
2023-12-23 |
Not clear |
| Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng X. Corrigendum: Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview. Frontiers in pharmacology. vol 14. 2023-12-13. PMID:38026939. |
corrigendum: could peripheral 5-ht level be used as a biomarker for depression diagnosis and treatment? |
2023-12-13 |
2023-12-17 |
Not clear |
| Lorissa Lamoureux, Joel Beverley, Heinz Steiner, Michela Marinell. Methylphenidate with or without fluoxetine triggers reinstatement of cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-12-12. PMID:38086900. |
combined exposure to mp and selective serotonin reuptake inhibitors such as fluoxetine (flx) can also occur, such as in the treatment of adhd with depression comorbidity or when patients taking flx use mp for non-medical purposes. |
2023-12-12 |
2023-12-17 |
rat |
| Hannah P Fricke, Chandler J Krajco, Molly J Perry, Lauren J Brettingen, Lella A Wake, Julia F Charles, Laura L Hernande. Fluoxetine treatment during the postpartal period may have short-term impacts on murine maternal skeletal physiology. Frontiers in pharmacology. vol 14. 2023-12-11. PMID:38074149. |
postpartum depression affects many individuals after parturition, and selective serotonin reuptake inhibitors (ssris) are often used as the first-line treatment; however, both ssris and lactation are independently associated with bone loss due to the role of serotonin in bone remodeling. |
2023-12-11 |
2023-12-17 |
mouse |
| Tianqu Xie, Xiaoxiao Fan, Hanghang Pang, Tianzi Zang, Ni Wu, Juan Liu, Ziying Li, Sha Li, Quanfei Zhu, Julia Elise Slack, Jinbing Bai, Yu Xu, Yanqun Li. Association between gut microbiota and its functional metabolites with prenatal depression in women. Neurobiology of stress. vol 28. 2023-12-11. PMID:38075020. |
the purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (scfas), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-ht) on prenatal depression in association with the gut microbiota and its metabolites (i.e. |
2023-12-11 |
2023-12-17 |
Not clear |
| Thierry Coppola, Guillaume Daziano, Ilona Legroux, Sophie Béraud-Dufour, Nicolas Blondeau, Patricia Lebru. Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types. Cells. vol 12. issue 23. 2023-12-09. PMID:38067196. |
to this end, we firstly remind readers of the close link existing between depression and diabetes and secondly address the potential benefit of the pleiotropic actions of two major active molecules used to treat central and peripheral disorders, first a serotonin reuptake inhibitor (prozac |
2023-12-09 |
2023-12-17 |
Not clear |
| Juana Monroy, Omar D Cortés, Roberto Domínguez, María Eugenia Mendoza-Garrido, Eloir Gallegos, Mario Cárdenas, Andrés Aragón, María E Ayal. The differential sensitivity of the hypothalamic-hypophysial-ovarian axis to 5-hydroxytryptophan alters the secretion of estradiol. Experimental physiology. 2023-12-08. PMID:38064347. |
the precursor of 5-ht, 5-hydroxytryptophan (5-htp), has been used to treat depression. |
2023-12-08 |
2023-12-17 |
rat |
| Albino J Oliveira-Maia, Benoit Rive, Joachim Morrens, Yordan Godinov, Jedelyn Cabrieto, Nolen Perualila, Siobhán Mulhern-Haughe. Indirect adjusted comparison of 6-month clinical outcomes between esketamine nasal spray and other real-world polypharmacy treatment strategies for treatment resistant depression: results from the ICEBERG study. Frontiers in psychiatry. vol 14. 2023-12-01. PMID:38025416. |
the efficacy of esketamine nasal spray (ns) as a rapid-acting agent for treatment resistant depression (trd) was demonstrated in comparisons with placebo, when both were given in addition to a newly initiated selective serotonin reuptake inhibitor (ssri)/serotonin norepinephrine reuptake inhibitor (snri). |
2023-12-01 |
2023-12-07 |
Not clear |
| Jia-Wei Zeng, Juan-Li Zhao, Zhen-Jie Han, Yan-Jun Duan, Li Li. Narrative Review: Pathogenesis of the Inflammatory Response and Intestinal Flora in Depression. Neuropsychiatric disease and treatment. vol 19. 2023-12-01. PMID:38029049. |
the pathogenesis of depression is complex, and the current therapeutic drugs such as tricyclic antidepressants (tcas), monoamine oxidase inhibitors, and secondary serotonin reuptake inhibitors have certain shortcomings. |
2023-12-01 |
2023-12-10 |
Not clear |
| Albino J Oliveira-Maia, Benoit Rive, Joachim Morrens, Yordan Godinov, Jedelyn Cabrieto, Nolen Perualila, Siobhán Mulhern-Haughe. Indirect adjusted comparison of 6-month clinical outcomes between esketamine nasal spray and other real-world polypharmacy treatment strategies for treatment resistant depression: results from the ICEBERG study. Frontiers in psychiatry. vol 14. 2023-12-01. PMID:38025416. |
the efficacy of esketamine nasal spray (ns) as a rapid-acting agent for treatment resistant depression (trd) was demonstrated in comparisons with placebo, when both were given in addition to a newly initiated selective serotonin reuptake inhibitor (ssri)/serotonin norepinephrine reuptake inhibitor (snri). |
2023-11-29 |
2023-12-07 |
Not clear |
| Yu Fang, Yanqing Li, Xin Liao, Jie Deng, Qiannan Wang, Jingtao Liang, Bohua Ya. Journal of medicinal food. 2023-11-27. PMID:38010856. |
increasing evidence suggested that the gut microbiota and the 5-hydroxytryptamine (5-ht) pathway both contribute significantly to depression. |
2023-11-27 |
2023-11-29 |
Not clear |
| Wei Li, Zuqi Shen, Xuan Yin, Weiqi Chang, Xiaorong Chen, Jin Yu, Shifen X. Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors. Translational psychiatry. vol 13. issue 1. 2023-11-24. PMID:37993435. |
the dorsal raphe nucleus (drn), the main brain region producing 5-ht, is crucially involved in the pathophysiology of depression. |
2023-11-24 |
2023-11-28 |
Not clear |