| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiayue-Clara Jiang, Chenwen Hu, Andrew M McIntosh, Sonia Sha. Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis. Translational psychiatry. vol 13. issue 1. 2023-04-04. PMID:37015906. |
however, genetically proxied hmgcr inhibition was strongly associated with alterations in platelets (a prominent serotonin reservoir) and monocyte percentage, which have previously been implicated in depression. |
2023-04-04 |
2023-08-14 |
human |
| Xuelian Cui, Yongjuan Xu, Haiyan Zhu, Li Wang, Jun Zho. Long noncoding RNA NONHSAG045500 regulates serotonin transporter to ameliorate depressive-like behavior via the cAMP-PKA-CREB signaling pathway in a model of perinatal depression. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 36. issue 1. 2023-03-30. PMID:36997170. |
long noncoding rna nonhsag045500 regulates serotonin transporter to ameliorate depressive-like behavior via the camp-pka-creb signaling pathway in a model of perinatal depression. |
2023-03-30 |
2023-08-14 |
Not clear |
| Jan Lazur, Kamil Hnatyk, Katarzyna Kała, Katarzyna Sułkowska-Ziaja, Bożena Muszyńsk. Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978872. |
currently, psychopharmacotherapy is based mainly on the monoamine theory, which states that depression is caused by an insufficient level of monoamines such as serotonin, norepinephrine, and/or dopamine. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ayala Gover, Kareen Endrawes, Michal Molad, Karen Lavie-Nevo, Arieh Riski. The Effect of SSRI Exposure in Pregnancy on Early Respiratory and Metabolic Adaptation in Infants Born Preterm. Children (Basel, Switzerland). vol 10. issue 3. 2023-03-29. PMID:36980066. |
selective serotonin reuptake inhibitors (ssris) are increasingly used for maternal depression during pregnancy; however, their use has been linked to adverse effects in newborns. |
2023-03-29 |
2023-08-14 |
Not clear |
| Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Małgorzata Inglot, Małgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydeck. HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). Cells. vol 12. issue 6. 2023-03-29. PMID:36980311. |
seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during peg-ifn-α2a treatment, the aim of the current study is to examine (a) the associations between polymorphisms within the htr1a, tph2, and 5-htt genes and the severity of depression symptoms and (b) the relationships among rs6295, rs4570625, and 5-httlpr rs25531polymorphisms and indoleamine 2,3-dioxygenase (ido) activity, as well as kynurenine (kyn), tryptophan (trp), kynurenic acid (ka), and anthranilic acid (aa) concentrations. |
2023-03-29 |
2023-08-14 |
Not clear |
| Soner Gök, Berfin Can Gök, Erkan Alataş, Hande Senol, Osman Zülkif Topa. Effects of Selective Serotonin Reuptake Inhibitor Treatment on Ovarian Reserves in Patients with Depression. Medicina (Kaunas, Lithuania). vol 59. issue 3. 2023-03-29. PMID:36984518. |
effects of selective serotonin reuptake inhibitor treatment on ovarian reserves in patients with depression. |
2023-03-29 |
2023-08-14 |
Not clear |
| Punya Sachdeva, Seongmin Ji, Shampa Ghosh, Soumya Ghosh, Manchala Raghunath, Hyunjin Kim, Rakesh Bhaskar, Jitendra Kumar Sinha, Sung Soo Ha. Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression. Pharmaceutics. vol 15. issue 3. 2023-03-29. PMID:36986674. |
antidepressants manage clinical depression and function by modulating the serotonin, norepinephrine, and dopamine neurotransmitter levels in the brain. |
2023-03-29 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
manipulation of intake of serotonin precursor tryptophan has been exploited to rapidly induce and alleviate depression symptoms. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
our aim was to investigate the effect of habitual tryptophan intake on mood symptoms and to determine the effect of risk variants on depression in those with high and low tryptophan intake in the whole genome and specifically in serotonin and kynurenine pathways. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
npbwr1 among serotonin genes and poli in kynurenine pathway genes were significantly associated with depression in the low but not in the high tlr group. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
our findings demonstrate a markedly distinct genetic risk profile for depression in groups with low and high dietary tlr, with association with serotonin and kynurenine pathway variants only in case of habitual food intake leading to low tlr. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
our results confirm the relevance of the serotonin hypothesis in understanding the neurobiological background of depression and highlight the importance of understanding its differential role in the context of environmental variables such as complexity of diet in influencing mental health, pointing towards emerging possibilities of personalised prevention and intervention in mood disorders in those who are genetically vulnerable. |
2023-03-27 |
2023-08-14 |
Not clear |
| Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng X. Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview. Frontiers in pharmacology. vol 14. 2023-03-24. PMID:36959863. |
could peripheral 5-ht level be used as a biomarker for depression diagnosis and treatment? |
2023-03-24 |
2023-08-14 |
human |
| Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng X. Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview. Frontiers in pharmacology. vol 14. 2023-03-24. PMID:36959863. |
the serotonin hypothesis of depression is still influential, but the relationship between peripheral 5-ht levels and depression is still unknown. |
2023-03-24 |
2023-08-14 |
human |
| Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng X. Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview. Frontiers in pharmacology. vol 14. 2023-03-24. PMID:36959863. |
this review aimed to verify whether peripheral 5-ht levels could be used as a biomarker for depression diagnosis and treatment. |
2023-03-24 |
2023-08-14 |
human |
| Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng X. Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview. Frontiers in pharmacology. vol 14. 2023-03-24. PMID:36959863. |
33 studies were included: seven clinical trials about periphery 5-ht levels in depressive patients compared to normal subjects, 15 clinical trials about changes of peripheral 5-ht levels in patients with depression after drug treatment and 11 animal experiments about peripheral 5-ht levels in animal models of depression. |
2023-03-24 |
2023-08-14 |
human |
| Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng X. Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview. Frontiers in pharmacology. vol 14. 2023-03-24. PMID:36959863. |
peripheral 5-ht level could not be used as a biomarker both for depression diagnosis and for antidepressant efficacy evaluation. |
2023-03-24 |
2023-08-14 |
human |
| Richard Baskerville, Thomas McGrath, Lindy Castel. The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders. Frontiers in sports and active living. vol 5. 2023-03-23. PMID:36949894. |
there is therefore increasing interest in glutamatergic systems which offers new paradigms of understanding mechanisms connecting physical activity, stress, inflammation and depression, not explained by the serotonin theories of depression. |
2023-03-23 |
2023-08-14 |
Not clear |
| Chris F Johnson, Margaret Maxwell, Brian Williams, Nadine Dougall, Stephen MacGillivra. Dose-response effects of selective serotonin reuptake inhibitor monotherapy for the treatment of depression: systematic review of reviews and meta-narrative synthesis. BMJ medicine. vol 1. issue 1. 2023-03-20. PMID:36936596. |
dose-response effects of selective serotonin reuptake inhibitor monotherapy for the treatment of depression: systematic review of reviews and meta-narrative synthesis. |
2023-03-20 |
2023-08-14 |
Not clear |
| Chris F Johnson, Margaret Maxwell, Brian Williams, Nadine Dougall, Stephen MacGillivra. Dose-response effects of selective serotonin reuptake inhibitor monotherapy for the treatment of depression: systematic review of reviews and meta-narrative synthesis. BMJ medicine. vol 1. issue 1. 2023-03-20. PMID:36936596. |
to assess and clarify the relations between selective serotonin reuptake inhibitor (ssri) dose efficacy, acceptability (early treatment discontinuation (dropouts)), and tolerability (reported adverse drug effects), and critically evaluate methods previously used to examine ssri dose-response effects for the treatment of depression in adults. |
2023-03-20 |
2023-08-14 |
Not clear |