| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arzoo Pannu, Ramesh K Goya. Serotonin and Depression: Scrutiny of New Targets for Future Anti-Depressant Drug Development. Current drug targets. 2023-05-12. PMID:37170981. |
serotonin and depression: scrutiny of new targets for future anti-depressant drug development. |
2023-05-12 |
2023-08-14 |
Not clear |
| Arzoo Pannu, Ramesh K Goya. Serotonin and Depression: Scrutiny of New Targets for Future Anti-Depressant Drug Development. Current drug targets. 2023-05-12. PMID:37170981. |
the "serotonin hypothesis of depression" is approximately fifty years old, and in spite of vast literature, the exact role of serotonin in depression pathophysiology is still unclear, as whether a lower serotonin level causes depression or depression causes a reduction in serotonin level has become a tough challenge for researchers to understand the actual involvement of serotonin in depression. |
2023-05-12 |
2023-08-14 |
Not clear |
| Arzoo Pannu, Ramesh K Goya. Serotonin and Depression: Scrutiny of New Targets for Future Anti-Depressant Drug Development. Current drug targets. 2023-05-12. PMID:37170981. |
several pre-clinical and clinical studies have illustrated the multi-faceted signalling action of serotonin in depression and vouch for the significant or unavoidable role of serotonin in depression. |
2023-05-12 |
2023-08-14 |
Not clear |
| Arzoo Pannu, Ramesh K Goya. Serotonin and Depression: Scrutiny of New Targets for Future Anti-Depressant Drug Development. Current drug targets. 2023-05-12. PMID:37170981. |
in this review, the journey of the serotonin hypothesis of depression from the 1950s to the present time has been analysed to understand the serotonin hypothesis of depression and investigate the new molecular targets for the development of new future anti- depressants. |
2023-05-12 |
2023-08-14 |
Not clear |
| Arzoo Pannu, Ramesh K Goya. Serotonin and Depression: Scrutiny of New Targets for Future Anti-Depressant Drug Development. Current drug targets. 2023-05-12. PMID:37170981. |
the old and new theories of possible cellular mechanisms found to be involved in the pathophysiology of major depression or stress, such as polymorphism of serotonin transporters, enzyme modulating serotonergic activity, reduction in the level of serotonin and involvement of different sub-types of receptors, have been discussed in the respective review. |
2023-05-12 |
2023-08-14 |
Not clear |
| Hua Min, Farrokh Alemi, Janusz Wojtusia. Selecting Antidepressants Based on Medical History and Stress Mechanism. Cureus. vol 15. issue 4. 2023-05-11. PMID:37168173. |
conclusions many studies have raised doubt about the serotonin hypothesis as the central mechanism for depression treatment. |
2023-05-11 |
2023-08-14 |
Not clear |
| Hua Min, Farrokh Alemi, Janusz Wojtusia. Selecting Antidepressants Based on Medical History and Stress Mechanism. Cureus. vol 15. issue 4. 2023-05-11. PMID:37168173. |
the identification of a wide range of predictors for prescribing antidepressants highlights the complexity of depression treatment and the need for individualized approaches that consider patients' comorbidities and previous treatments. the significant impact of comorbidities on the response to treatment makes it improbable that the mechanism of action of antidepressants is solely based on the serotonin hypothesis. |
2023-05-11 |
2023-08-14 |
Not clear |
| Shun Hao, Wantong Shi, Weiqi Liu, Qi-Yu Chen, Min Zhu. Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety. Frontiers in synaptic neuroscience. vol 15. 2023-05-05. PMID:37143481. |
serotonin (5-ht) in the central nervous system (cns) has been recognized as an important neurotransmitter and neuromodulator which regulates various physiological functions, such as pain sensation, cognition, and emotions-especially anxiety and depression. |
2023-05-05 |
2023-08-14 |
Not clear |
| Patrizia Ambrogini, Davide Lattanzi, Marica Pagliarini, Michael Di Palma, Stefano Sartini, Riccardo Cuppini, Kjell Fuxe, Dasiel Oscar Borroto-Escuel. 5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108630. |
5ht1ar-fgfr1 heteroreceptor complexes differently modulate girk currents in the dorsal hippocampus and the dorsal raphe serotonin nucleus of control rats and of a genetic rat model of depression. |
2023-04-28 |
2023-08-14 |
rat |
| Hannah P Fricke, Laura L Hernande. The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad. Journal of mammary gland biology and neoplasia. vol 28. issue 1. 2023-04-22. PMID:37086330. |
it is estimated that postpartum depression affects 10-15% of the population, and selective serotonin reuptake inhibitors (ssri) are often used as the first-line treatment. |
2023-04-22 |
2023-08-14 |
human |
| Chungsoo Kim, Dong Yun Lee, Jimyung Park, Su-Jin Yang, Eng Hooi Tan, Daniel-Prieto Alhambra, Yo Han Lee, Sangha Lee, Seong-Ju Kim, Jeewon Lee, Rae Woong Park, Yunmi Shi. Safety Outcomes of Selective Serotonin Reuptake Inhibitors in Adolescent Attention-Deficit/Hyperactivity Disorder with Comorbid Depression: The ASSURE Study - CORRIGENDUM. Psychological medicine. 2023-04-20. PMID:37078398. |
safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: the assure study - corrigendum. |
2023-04-20 |
2023-08-14 |
Not clear |
| Han Zhao, Yue Yin, Tong Lin, Wushuang Wang, Lan Gon. Administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors. Experimental eye research. 2023-04-20. PMID:37080380. |
administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors. |
2023-04-20 |
2023-08-14 |
human |
| Talia R Lester, Jessica E Herrmann, Yair Bannett, Rebecca M Gardner, Heidi M Feldman, Lynne C Huffma. Anxiety and Depression Treatment in Primary Care Pediatrics. Pediatrics. 2023-04-17. PMID:37066669. |
the objective of this study was to describe pcp care practices around prescription of selective serotonin reuptake inhibitors (ssri) for patients with anxiety and/or depression by using medical record review. |
2023-04-17 |
2023-08-14 |
Not clear |
| Konstantinos N Fountoulakis, Magdalini Ioannou, Mauricio Tohen, Bartholomeus C M Haarman, Carlos A Zarat. Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 72. 2023-04-15. PMID:37060629. |
the original model suggests that a constellation of effects on different receptors is necessary and that serotonin reuptake inhibition does not appear to play a significant role in acute bipolar depression. |
2023-04-15 |
2023-08-14 |
Not clear |
| María Montserrat Somoza-Moncada, Francisco Javier Turrubiates-Hernández, José Francisco Muñoz-Valle, Jesús Alberto Gutiérrez-Brito, Saúl Alberto Díaz-Pérez, Adriana Aguayo-Arelis, Jorge Hernández-Bell. Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049606. |
among the beneficial mechanisms of vitamin d, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. |
2023-04-13 |
2023-08-14 |
Not clear |
| Qiaoyi Cui, Wei We. Comparison of the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression. JPMA. The Journal of the Pakistan Medical Association. vol 73. issue 4. 2023-04-13. PMID:37052005. |
post treatment assessment revealed that after treatment, national institutes of health stroke scale scores, hamilton depression rating scale scores, serum 5-hydroxytryptamine and brain-derived neurotrophic factor levels of group b were lower than those of group a (all p<0.001). |
2023-04-13 |
2023-08-14 |
Not clear |
| Roland Grad, Mark H Ebel. Top 20 Research Studies of 2022 for Primary Care Physicians. American family physician. vol 107. issue 4. 2023-04-13. PMID:37054418. |
combination therapy using a selective serotonin reuptake inhibitor, serotonin-norepinephrine reuptake inhibitor, or tricyclic antidepressant with mirtazapine or trazodone is more effective than monotherapy for first-line treatment of acute severe depression and when monotherapy fails. |
2023-04-13 |
2023-08-14 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a Common Thread Linking Different Classes of Antidepressants. Research square. 2023-04-10. PMID:37034599. |
our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis and the monoamine hypothesis). |
2023-04-10 |
2023-08-14 |
mouse |
| Harika Topal Önal, Derya Yetkin, Furkan Aya. Escitalopram's inflammatory effect on the mammalian macrophages and its intracellular mechanism of action. Progress in neuro-psychopharmacology & biological psychiatry. 2023-04-09. PMID:37031947. |
the majority of patients with depression are treated with antidepressant drugs that are in the serotonin reuptake inhibitor (ssri) group. |
2023-04-09 |
2023-08-14 |
Not clear |
| Yusuf Oloruntoyin Ayipo, Iqrar Ahmad, Chien Fung Chong, Nurul Amira Zainurin, Sani Yahaya Najib, Harun Patel, Mohd Nizam Mord. Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology. Journal of biomolecular structure & dynamics. 2023-04-06. PMID:37021485. |
the human serotonin transporters (hserts) are neurotransmitter sodium symporters of the aminergic g protein-coupled receptors, regulating the synaptic serotonin and neuropharmacological processes related to neuropsychiatric disorders, notably, depression. |
2023-04-06 |
2023-08-14 |
human |