| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony M Downs, Yuping Donsante, H A Jinnah, Ellen J Hes. Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia. Neurobiology of disease. 2022-03-22. PMID:35314320. |
blockade of m4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of tor1a dystonia. |
2022-03-22 |
2023-08-13 |
mouse |
| Anthony M Downs, Yuping Donsante, H A Jinnah, Ellen J Hes. Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia. Neurobiology of disease. 2022-03-22. PMID:35314320. |
we previously found that thp normalizes the deficit in striatal dopamine (da) release in a mouse model of tor1a dystonia (tor1a |
2022-03-22 |
2023-08-13 |
mouse |
| Anne Weissbach, Annika Steinmeier, Martje Pauly, Duha M Al-Shorafat, Gerard Saranza, Anthony Lang, Norbert Brüggemann, Vera Tadic, Christine Klein, Alexander Münchau, Tobias Bäumer, Matt J N Brow. Longitudinal evaluations of somatosensory-motor inhibition in Dopa-responsive dystonia. Parkinsonism & related disorders. vol 95. 2022-01-09. PMID:34999542. |
gch1 mutations have been linked to decreased striatal dopamine and development of dopa-responsive dystonia (drd) and parkinsonism. |
2022-01-09 |
2023-08-13 |
Not clear |
| Anna Kuukasjärvi, Juan C Landoni, Jyrki Kaukonen, Mika Juhakoski, Mari Auranen, Tommi Torkkeli, Vidya Velagapudi, Anu Suomalaine. IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder. European journal of human genetics : EJHG. vol 29. issue 12. 2021-12-01. PMID:34305140. |
impdh2 is the first and rate-limiting enzyme in the de novo biosynthesis of guanine nucleotides, a dopamine synthetic pathway previously linked to childhood or adolescence-onset dystonia disorders. |
2021-12-01 |
2023-08-13 |
Not clear |
| Anna Kuukasjärvi, Juan C Landoni, Jyrki Kaukonen, Mika Juhakoski, Mari Auranen, Tommi Torkkeli, Vidya Velagapudi, Anu Suomalaine. IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder. European journal of human genetics : EJHG. vol 29. issue 12. 2021-12-01. PMID:34305140. |
the evidence underlines the important link between guanine metabolism, dopamine biosynthesis and dystonia. |
2021-12-01 |
2023-08-13 |
Not clear |
| Gyrid Nygaard, Peter D Szigetvari, Ann Kari Grindheim, Peter Ruoff, Aurora Martinez, Jan Haavik, Rune Kleppe, Marte I Flyda. Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency. Journal of personalized medicine. vol 11. issue 11. 2021-11-30. PMID:34834538. |
dopa-responsive dystonia (drd) is a rare movement disorder associated with defective dopamine synthesis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Anton Jm Loonen, Svetlana A Ivanov. Neurobiological mechanisms associated with antipsychotic drug-induced dystonia. Journal of psychopharmacology (Oxford, England). vol 35. issue 1. 2021-11-22. PMID:32900259. |
the incidence of drug-induced dystonia is associated with the affinity to inhibitory dopamine d2 receptors. |
2021-11-22 |
2023-08-13 |
Not clear |
| Fumiaki Yokoi, Huan-Xin Chen, Janneth Oleas, Mai Tu Dang, Hong Xing, Kelly M Dexter, Yuqing L. Characterization of the direct pathway in Dyt1 ΔGAG heterozygous knock-in mice and dopamine receptor 1-expressing-cell-specific Dyt1 conditional knockout mice. Behavioural brain research. vol 411. 2021-10-18. PMID:34038798. |
dyt1 dystonia patients show trends of decreased striatal ligand-binding activities to dopamine receptors 1 (d1r) and 2 (d2r). |
2021-10-18 |
2023-08-13 |
mouse |
| Michelle Ann C Sy, Hubert H Fernande. Dystonia and leveraging oral pharmacotherapy. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 4. 2021-10-15. PMID:33877451. |
treatment of dystonia primarily involves agents that target dopamine and acetylcholine receptors. |
2021-10-15 |
2023-08-13 |
Not clear |
| Anthony M Downs, Xueliang Fan, Radhika F Kadakia, Yuping Donsante, H A Jinnah, Ellen J Hes. Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of TOR1A dystonia. Neurobiology of disease. vol 155. 2021-10-02. PMID:33894367. |
cell-intrinsic effects of torsina(Δe) disrupt dopamine release in a mouse model of tor1a dystonia. |
2021-10-02 |
2023-08-13 |
mouse |
| Virgilio Gerald H Evidente, Danica H Evidente, Susan C Ortega, Todd D Levine, Roy Freeman, ChristopherH Gibbon. X-Linked Dystonia-Parkinsonism ("Lubag") May Present with Peripheral Synucleinopathy. Movement disorders : official journal of the Movement Disorder Society. 2021-09-28. PMID:34582053. |
x-linked dystonia parkinsonism (xdp) or "lubag" is a genetic dystonia syndrome observed among filipinos that can present with levodopa-responsive parkinsonism and abnormal dopamine transporter (dat) imaging. |
2021-09-28 |
2023-08-13 |
Not clear |
| Maria A Briscione, Ashok R Dinasarapu, Pritha Bagchi, Yuping Donsante, Kaitlyn M Roman, Anthony M Downs, Xueliang Fan, Jessica Hoehner, H A Jinnah, Ellen J Hes. Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders. Molecular genetics and metabolism. vol 133. issue 4. 2021-09-16. PMID:34092491. |
the inherited metabolic disorder dopa-responsive dystonia is considered a prototype for understanding basal ganglia dysfunction in dystonia because it is caused by mutations in genes necessary for the synthesis of the neurotransmitter dopamine, which mediates the activity of the basal ganglia. |
2021-09-16 |
2023-08-13 |
mouse |
| Shreyas Bhat, Daryl A Guthrie, Ameya Kasture, Ali El-Kasaby, Jianjing Cao, Alessandro Bonifazi, Therese Ku, JoLynn B Giancola, Thomas Hummel, Michael Freissmuth, Amy Hauck Newma. Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters. ACS pharmacology & translational science. vol 4. issue 2. 2021-08-29. PMID:33860180. |
ibogaine and its active metabolite noribogaine correct folding defects in the dopamine transporter (dat), but they rescue only a very limited number of folding-deficient dat mutant proteins, which give rise to infantile parkinsonism and dystonia. |
2021-08-29 |
2023-08-13 |
Not clear |
| Maeve Bradley, Shane Lyons, Sarah Coleman, Roisin Vance, Fiona Molloy, Peter Widdess-Wals. A Case of GCH-1 Mutation Dopa-Responsive Dystonia Requiring High Doses of Levodopa for Treatment. Tremor and other hyperkinetic movements (New York, N.Y.). vol 11. 2021-08-02. PMID:34221698. |
mutations in the gch-1 gene are associated with autosomal dominant dopamine responsive dystonia (dyt 5). |
2021-08-02 |
2023-08-13 |
Not clear |
| Marilena Mangiardi, Guido Alfan. A clinical improvement of a idiopathic cervical dystonia in a patient treated with transdermal Rotigotine: a case-report. Acta bio-medica : Atenei Parmensis. vol 91. issue 3. 2021-06-25. PMID:32921774. |
these results support the assumption that dopamine receptors could be considered as targets for treating dystonia. |
2021-06-25 |
2023-08-13 |
mouse |
| Marilena Mangiardi, Guido Alfan. A clinical improvement of a idiopathic cervical dystonia in a patient treated with transdermal Rotigotine: a case-report. Acta bio-medica : Atenei Parmensis. vol 91. issue 3. 2021-06-25. PMID:32921774. |
furthermore, a dopamine agonist-response dystonia in patients with an autosomal recessive l-amino acid decarboxylase deficiency, has been described in the scientific literature. |
2021-06-25 |
2023-08-13 |
mouse |
| Marilena Mangiardi, Guido Alfan. A clinical improvement of a idiopathic cervical dystonia in a patient treated with transdermal Rotigotine: a case-report. Acta bio-medica : Atenei Parmensis. vol 91. issue 3. 2021-06-25. PMID:32921774. |
we report a case of focal cervical dystonia successful treated with a dopamine agonist (d3>d2>d1) rotigotine, a transdermal drug that induces a continuous dopaminergic stimulation. |
2021-06-25 |
2023-08-13 |
mouse |
| Yuning Liu, Hong Xing, Fumiaki Yokoi, David E Vaillancourt, Yuqing L. Investigating the role of striatal dopamine receptor 2 in motor coordination and balance: Insights into the pathogenesis of DYT1 dystonia. Behavioural brain research. vol 403. 2021-06-18. PMID:33476687. |
dyt1 dystonia patients show reduced striatal dopamine d2 receptor (d2r) binding activity. |
2021-06-18 |
2023-08-13 |
mouse |
| Jessica Qiu, Kishore Raj Kumar, Eloise Watson, Kate Ahmad, Carolyn M Sue, Michael W Haye. Dystonia Responsive to Dopamine: POLG Mutations Should Be Considered If Sensory Neuropathy Is Present. Journal of movement disorders. vol 14. issue 2. 2021-06-11. PMID:34062649. |
dystonia responsive to dopamine: polg mutations should be considered if sensory neuropathy is present. |
2021-06-11 |
2023-08-13 |
Not clear |
| Parvane Rashidpour, Zahra Poursharif, Mina Ayatollahi, Elham Farzanneja. Bupropion-induced acute dystonia in a patient with bulimia nervosa: A case report. Journal of family medicine and primary care. vol 10. issue 2. 2021-05-28. PMID:34041117. |
a physician who administers dopamine blocking agents must be aware of the prevalence of and the risk factors for acute dystonia and also the way of prevention and treatment. |
2021-05-28 |
2023-08-13 |
Not clear |