| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony M Downs, Xueliang Fan, Christine Donsante, H A Jinnah, Ellen J Hes. Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia. Neurobiology of disease. vol 125. 2019-12-16. PMID:30707939. |
trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of dyt1 dystonia. |
2019-12-16 |
2023-08-13 |
mouse |
| Anthony M Downs, Xueliang Fan, Christine Donsante, H A Jinnah, Ellen J Hes. Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia. Neurobiology of disease. vol 125. 2019-12-16. PMID:30707939. |
because dty1 dystonia is associated with both abnormal cholinergic neurotransmission and abnormal dopamine regulation, we tested the hypothesis that trihexyphenidyl normalizes striatal dopamine release in a mouse model of dyt1 dystonia using ex vivo fast scan cyclic voltammetry and in vivo microdialysis. |
2019-12-16 |
2023-08-13 |
mouse |
| Bomi Sul, Joon Sung Kim, Bo Young Hong, Seong Hoon Li. The effect of dopamine for focal hand dystonia after stroke. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 40. issue 6. 2019-12-11. PMID:30635800. |
the effect of dopamine for focal hand dystonia after stroke. |
2019-12-11 |
2023-08-13 |
Not clear |
| Peter D Szigetvari, Gopinath Muruganandam, Juha P Kallio, Erik I Hallin, Agnete Fossbakk, Remy Loris, Inari Kursula, Lisbeth B Møller, Per M Knappskog, Petri Kursula, Jan Haavi. The quaternary structure of human tyrosine hydroxylase: effects of dystonia-associated missense variants on oligomeric state and enzyme activity. Journal of neurochemistry. vol 148. issue 2. 2019-10-28. PMID:30411798. |
missense variants of human th are associated with a recessive neurometabolic disease with low levels of brain dopamine and noradrenaline, resulting in a variable clinical picture, from progressive brain encephalopathy to adolescent onset dopa-responsive dystonia (drd). |
2019-10-28 |
2023-08-13 |
human |
| Xueliang Fan, Yuping Donsante, H A Jinnah, Ellen J Hes. Dopamine Receptor Agonist Treatment of Idiopathic Dystonia: A Reappraisal in Humans and Mice. The Journal of pharmacology and experimental therapeutics. vol 365. issue 1. 2019-05-28. PMID:29348266. |
although dystonia is often associated with abnormal dopamine neurotransmission, dopaminergic drugs are not currently used to treat dystonia because there is a general view that dopaminergic drugs are ineffective. |
2019-05-28 |
2023-08-13 |
mouse |
| Xueliang Fan, Yuping Donsante, H A Jinnah, Ellen J Hes. Dopamine Receptor Agonist Treatment of Idiopathic Dystonia: A Reappraisal in Humans and Mice. The Journal of pharmacology and experimental therapeutics. vol 365. issue 1. 2019-05-28. PMID:29348266. |
these results support a reconsideration of dopamine receptors as targets for the treatment of dystonia, particularly because recent genetic and diagnostic advances may facilitate the identification of the subtypes of dystonia patients who respond and those who do not. |
2019-05-28 |
2023-08-13 |
mouse |
| Kristina Simonyan, Hyun Cho, Azadeh Hamzehei Sichani, Estee Rubien-Thomas, Mark Hallet. The direct basal ganglia pathway is hyperfunctional in focal dystonia. Brain : a journal of neurology. vol 140. issue 12. 2019-05-23. PMID:29087445. |
we found that availability of dopamine d1 receptors was significantly increased in bilateral putamen by 19.6–22.5% in writer’s cramp and in right putamen and caudate nucleus by 24.6–26.8% in laryngeal dystonia (all p ≤ 0.009). |
2019-05-23 |
2023-08-13 |
Not clear |
| Kristina Simonyan, Hyun Cho, Azadeh Hamzehei Sichani, Estee Rubien-Thomas, Mark Hallet. The direct basal ganglia pathway is hyperfunctional in focal dystonia. Brain : a journal of neurology. vol 140. issue 12. 2019-05-23. PMID:29087445. |
our findings paralleled abnormally decreased dopaminergic function via the indirect basal ganglia pathway and decreased symptom-induced phasic striatal dopamine release in writer’s cramp and laryngeal dystonia. |
2019-05-23 |
2023-08-13 |
Not clear |
| Kristina Simonyan, Hyun Cho, Azadeh Hamzehei Sichani, Estee Rubien-Thomas, Mark Hallet. The direct basal ganglia pathway is hyperfunctional in focal dystonia. Brain : a journal of neurology. vol 140. issue 12. 2019-05-23. PMID:29087445. |
in conclusion, a comprehensive pathophysiological mechanism of abnormal basal ganglia function in focal dystonia is built upon upregulated dopamine d1 receptors that abnormally increase excitation of the direct pathway, downregulated dopamine d2 receptors that abnormally decrease inhibition within the indirect pathway, and weakened nigro-striatal phasic dopamine release during symptomatic task performance. |
2019-05-23 |
2023-08-13 |
Not clear |
| Woong-Woo Lee, Beomseok Jeon, Ryul Ki. Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike. Journal of Korean medical science. vol 33. issue 28. 2019-03-15. PMID:29983692. |
however, there have been many reports of dystonia responsive to dopaminergic drugs that do not fit into drd or drd-plus (genetic defects in the dopamine synthetic pathway without nigral cell loss). |
2019-03-15 |
2023-08-13 |
Not clear |
| Woong-Woo Lee, Beomseok Jeon, Ryul Ki. Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike. Journal of Korean medical science. vol 33. issue 28. 2019-03-15. PMID:29983692. |
examples of dystonia that is responsive to dopaminergic drugs include the following: transportopathies (dopamine transporter deficiency; vesicular monoamine transporter 2 deficiency); |
2019-03-15 |
2023-08-13 |
Not clear |
| Samuel J Rose, Porter Harrast, Christine Donsante, Xueliang Fan, Valerie Joers, Malú G Tansey, H A Jinnah, Ellen J Hes. Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice. Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 12. 2018-07-19. PMID:28949038. |
parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice. |
2018-07-19 |
2023-08-13 |
mouse |
| H M Mazhar Asjad, Ameya Kasture, Ali El-Kasaby, Michael Sackel, Thomas Hummel, Michael Freissmuth, Sonja Suci. Pharmacochaperoning in a The Journal of biological chemistry. vol 292. issue 47. 2018-01-23. PMID:28972153. |
pharmacochaperoning in a point mutations in the gene encoding the human dopamine transporter (hdat, slc6a3) cause a syndrome of infantile/juvenile dystonia and parkinsonism. |
2018-01-23 |
2023-08-13 |
human |
| b' M Svetel, A Tomi\\xc4\\x87, M Mijajlovi\\xc4\\x87, V Dobri\\xc4\\x8di\\xc4\\x87, I Novakovi\\xc4\\x87, T Pekmezovi\\xc4\\x87, L Brajkovi\\xc4\\x87, V S Kosti\\xc4\\x8. Transcranial sonography in dopa-responsive dystonia. European journal of neurology. vol 24. issue 1. 2017-12-22. PMID:27731537.' |
mutations in the gch1 gene, encoding gtp cyclohydrolase 1, the enzyme critically important for dopamine production in nigrostriatal neurons, are the most common cause of dopa-responsive dystonia (drd), characterized predominantly by limb dystonia, although parkinsonian features may also be present. |
2017-12-22 |
2023-08-13 |
Not clear |
| Jennifer R Friedma. What Is Not in the Name? Dopa-Responsive Dystonia May Respond to More Than L-Dopa. Pediatric neurology. vol 59. 2017-12-15. PMID:27080360. |
however, literal application of this label or consideration of dopa-responsive dystonia as a diagnostic end without molecular and/or biochemical definition may contribute to misdiagnosis and incomplete treatment in dopa-responsive conditions that impair synthesis of monoamine neurotransmitters besides dopamine. |
2017-12-15 |
2023-08-13 |
Not clear |
| Mariangela Scarduzio, Chelsea N Zimmerman, Karen L Jaunarajs, Qin Wang, David G Standaert, Lori L McMaho. Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Experimental neurology. vol 295. 2017-08-14. PMID:28587876. |
strength of cholinergic tone dictates the polarity of dopamine d2 receptor modulation of striatal cholinergic interneuron excitability in dyt1 dystonia. |
2017-08-14 |
2023-08-13 |
mouse |
| Mariangela Scarduzio, Chelsea N Zimmerman, Karen L Jaunarajs, Qin Wang, David G Standaert, Lori L McMaho. Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Experimental neurology. vol 295. 2017-08-14. PMID:28587876. |
in dyt1, an early-onset genetic form of dystonia caused by a mutation in the protein torsina (tora), the suspected heightened cholinergic tone is commonly attributed to faulty dopamine d2 receptor (d2r) signaling where d2r agonists cause excitation of striatal cholinergic interneurons (chis), rather than the normal inhibition of firing observed in wild-type animals, an effect known as "paradoxical excitation". |
2017-08-14 |
2023-08-13 |
mouse |
| Roderick P P W M Maas, Tessa Wassenberg, Jean-Pierre Lin, Bart P C van de Warrenburg, Michèl A A P Willemse. l-Dopa in dystonia: A modern perspective. Neurology. vol 88. issue 19. 2017-06-02. PMID:28389587. |
rather, in high-resource countries, we suggest to use l-dopa after biochemical corroboration of a defect in dopamine biosynthesis, in genetically confirmed drd, or if nigrostriatal degeneration has been demonstrated by nuclear imaging in adult patients presenting with lower limb dystonia. |
2017-06-02 |
2023-08-13 |
Not clear |
| Yuji Shiga, Yuhei Kanaya, Ryuhei Kono, Shinichi Takeshima, Yutaka Shimoe, Masaru Kuriyam. Dementia with Lewy bodies presenting marked tongue protrusion and bite due to lingual dystonia: A case report. Rinsho shinkeigaku = Clinical neurology. vol 56. issue 6. 2017-03-23. PMID:27212676. |
it is believed that these treatments stimulated and sensitized dopamine d1 receptors, thereby inducing lingual dystonia. |
2017-03-23 |
2023-08-13 |
Not clear |
| Dhanya Vijayakumar, Joseph Jankovi. Drug-Induced Dyskinesia, Part 1: Treatment of Levodopa-Induced Dyskinesia. Drugs. vol 76. issue 7. 2017-03-08. PMID:27091215. |
peak-dose dyskinesia is treated mainly by reducing individual doses of levodopa and adding amantadine and dopamine agonists, whereas off-period dystonia often responds to baclofen and botulinum toxin injections. |
2017-03-08 |
2023-08-13 |
Not clear |