| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhan. HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. PloS one. vol 10. issue 11. 2016-06-29. PMID:26565401. |
in this study, we focused on the high-mobility group box 1 (hmgb1) protein, which is important in oxidative stress signaling as well as in autophagy and apoptosis, to explore whether the mechanisms of autophagy and apoptosis in neurodegenerative diseases are associated with metabolic impairment. |
2016-06-29 |
2023-08-13 |
rat |
| Jie Wu, Ming Cheng, Qiufang Liu, Jinghua Yang, Shengwen Wu, Xiaobo Lu, Cuihong Jin, Honglin Ma, Yuan Ca. Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25911493. |
in contrast, induction of detoxifying and antioxidant genes through activation of nf-e2-related factor 2 (nrf2) has been implicated in preventing oxidative stress and apoptosis in neurodegenerative diseases. |
2016-06-24 |
2023-08-13 |
rat |
| Yosra Hamdi, Hadhemi Kaddour, David Vaudry, Jérôme Leprince, Amira Zarrouk, Mohamed Hammami, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouk. Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes. Peptides. vol 71. 2016-06-17. PMID:26143507. |
oxidative stress, associated with a variety of disorders including neurodegenerative diseases, is a major cause of cellular dysfunction and biomolecule damages which play a crucial role in neuronal apoptosis. |
2016-06-17 |
2023-08-13 |
rat |
| Jie Wei, Hua Jiang, Hongrui Gao, Guangjie Wan. Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush. Journal of molecular neuroscience : MN. vol 57. issue 2. 2016-06-17. PMID:26160696. |
raf-1 kinase inhibitory protein (rkip), a member of the phosphatidylethanolamine-binding protein (pebp) family, plays an important role in neuronal apoptosis and cognitive deficits associated with neurodegenerative diseases. |
2016-06-17 |
2023-08-13 |
mouse |
| Xiao-long Sun, Li Duan, Xi-ying Jiao, Liang-wei Che. [The "Yin/Yang" Functional Features of Neurotrophic Factors]. Sheng li ke xue jin zhan [Progress in physiology]. vol 46. issue 3. 2016-06-10. PMID:26521480. |
growing evidences have revealed that pro-forms of various neurotrophic factors, which are generated in process of protein synthesis and might exert opposite roles involving in inducement of neuronal apoptosis and implication in pathogenesis of neurodegenerative diseases. |
2016-06-10 |
2023-08-13 |
Not clear |
| Gabriela D Colpo, Bruna M Ascoli, Bianca Wollenhaupt-Aguiar, Bianca Pfaffenseller, Emily G Silva, Elizabeth O Cirne-Lima, João Quevedo, Flávio Kapczinski, Adriane R Ros. Mesenchymal stem cells for the treatment of neurodegenerative and psychiatric disorders. Anais da Academia Brasileira de Ciencias. vol 87. issue 2 Suppl. 2016-05-23. PMID:26247151. |
therapies with mscs have shown promising results neurodegenerative diseases, in addition to regulating inflammation, they can promote other beneficial effects, such as neuronal growth, decrease free radicals, and reduce apoptosis. |
2016-05-23 |
2023-08-13 |
Not clear |
| Wioletta Rozpędek, Łukasz Markiewicz, J Alan Diehl, Dariusz Pytel, Ireneusz Majstere. [The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 39. issue 234. 2016-04-15. PMID:26802695. |
recent research allows for a conclusion that the deregulation of upr is the main causative factor for functional cell loss and moreover, cell death by apoptosis, which is strictly linked to the pathology of human diseases to include: cancer, diabetes mellitus type 2 and neurodegenerative diseases such as alzheimer's, parkinson's and prion diseases. |
2016-04-15 |
2023-08-13 |
human |
| Neda Masoudian, Gholam Hossein Riazi, Ali Afrasiabi, Seyed Mohamad Sadegh Modaresi, Ali Dadras, Shahrbanoo Rafiei, Meysam Yazdankhah, Atiye Lyaghi, Mostafa Jarah, Shahin Ahmadian, Hossein Seidkhan. Variations of glutamate concentration within synaptic cleft in the presence of electromagnetic fields: an artificial neural networks study. Neurochemical research. vol 40. issue 4. 2016-04-05. PMID:25577979. |
excessive elevated concentrations of glu in synaptic cleft results in neural cell apoptosis which is called excitotoxicity causing neurodegenerative diseases. |
2016-04-05 |
2023-08-13 |
Not clear |
| Sergiy A Starosyla, Galyna P Volynets, Sergiy S Lukashov, Oksana B Gorbatiuk, Andriy G Golub, Volodymyr G Bdzhola, Sergiy M Yarmolu. Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorganic & medicinal chemistry. vol 23. issue 10. 2016-01-26. PMID:25882527. |
apoptosis signal-regulating kinase 1 (ask1) plays important roles in the pathogenesis of type 1 and type 2 diabetes, autoimmune disorders, cancer and neurodegenerative diseases suggesting that small compounds inhibiting ask1 could be used for the treatment of these pathologies. |
2016-01-26 |
2023-08-13 |
Not clear |
| Ramon Yarza, Silvia Vela, Maite Solas, Maria J Ramire. c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease. Frontiers in pharmacology. vol 6. 2016-01-21. PMID:26793112. |
in addition, activation of jnk has been identified as a key element responsible for the regulation of apoptosis signals and therefore, it is critical for pathological cell death associated with neurodegenerative diseases and, among them, with alzheimer's disease (ad). |
2016-01-21 |
2023-08-13 |
Not clear |
| Blanca Arango-Gonzalez, Dragana Trifunović, Ayse Sahaboglu, Katharina Kranz, Stylianos Michalakis, Pietro Farinelli, Susanne Koch, Fred Koch, Sandra Cottet, Ulrike Janssen-Bienhold, Karin Dedek, Martin Biel, Eberhart Zrenner, Thomas Euler, Per Ekström, Marius Ueffing, François Paquet-Duran. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PloS one. vol 9. issue 11. 2016-01-15. PMID:25392995. |
cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration. |
2016-01-15 |
2023-08-13 |
human |
| Dongfeng Wei, Tong Chen, Mingfei Yan, Wanghong Zhao, Fei Li, Weidong Cheng, Lixia Yua. Synthesis, characterization, antioxidant activity and neuroprotective effects of selenium polysaccharide from Radix hedysari. Carbohydrate polymers. vol 125. 2016-01-01. PMID:25857971. |
furthermore, both rhp and se-rhp3 had neuroprotective effects against aβ25-35-induced oxidative stress and apoptosis in sh-sy5y human neuroblastoma cells, which might be a potential therapeutic agent for preventing or treating neurodegenerative diseases. |
2016-01-01 |
2023-08-13 |
human |
| Wenbin Zeng, Xiaobo Wang, Pengfei Xu, Gang Liu, Henry S Eden, Xiaoyuan Che. Molecular imaging of apoptosis: from micro to macro. Theranostics. vol 5. issue 6. 2015-12-17. PMID:25825597. |
apoptosis, or programmed cell death, is involved in numerous human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer, and is often confused with other types of cell death. |
2015-12-17 |
2023-08-13 |
human |
| Xiaoxi Han, Shengkun Sun, Ming Zhao, Xiang Cheng, Guozhu Chen, Song Lin, Yifu Guan, Xiaodan Y. Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis. PloS one. vol 9. issue 11. 2015-12-14. PMID:25383959. |
celastrol, a tripterine derived from the traditional chinese medicine plant tripterygium wilfordii hook f. ("thunder of god vine"), has been reported to have multiple effects, such as anti-inflammation, suppression of tumor angiogenesis, inhibition of tumor growth, induction of apoptosis and protection of cells against human neurodegenerative diseases. |
2015-12-14 |
2023-08-13 |
human |
| En-Ping Jiang, He Li, Chun-Rong Yu, Chun-Yan Yu, Shu Jing, Hong-Xia Sun, Chun-Mei Wang, Xin-Tian Fan, Jian-Guang Chen, Sen Wan. Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases. Neuroreport. vol 26. issue 6. 2015-12-14. PMID:25756908. |
results indicate that sch b can protect pc12 cells from apoptosis by activating the phosphatidylinositol-3 kinase/akt signaling pathway and may emerge as a potential drug for neurodegenerative diseases. |
2015-12-14 |
2023-08-13 |
Not clear |
| Hai-Jie Yang, Mian Wang, Lei Wang, Bin-Feng Cheng, Xiao-Yu Lin, Zhi-Wei Fen. NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis. PloS one. vol 10. issue 2. 2015-11-16. PMID:25695505. |
found in neurons and neuroblastoma cells, fas-induced apoptosis and accompanied activation of nf-κb signaling were thought to be associated with neurodegenerative diseases. |
2015-11-16 |
2023-08-13 |
Not clear |
| Alex Stoyanov, Roger Pamphlet. Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study. PloS one. vol 9. issue 7. 2015-11-13. PMID:25058637. |
this suggests that some pathogenetic mechanisms, such as apoptosis, are less relevant in smnd than in other neurodegenerative diseases where negative associations with cancer have been found. |
2015-11-13 |
2023-08-13 |
Not clear |
| Asokan Prema, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozh. Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice. Neuroscience letters. vol 599. 2015-10-16. PMID:25980996. |
as to conclude, lycopene reverses neurochemical deficts, oxidative stress, apoptosis and physiological abnormalities in pd mice and offer promise strategy in the treatment of this neurodegenerative disease. |
2015-10-16 |
2023-08-13 |
mouse |
| Peter G E Kenned. Viruses, apoptosis, and neuroinflammation--a double-edged sword. Journal of neurovirology. vol 21. issue 1. 2015-09-30. PMID:25604493. |
apoptosis has been reported in several neurodegenerative diseases and also psychiatric disorders but the true clinical significance of such observations is not certain, and, though interesting, it is very difficult to ascribe causation in these conditions. |
2015-09-30 |
2023-08-13 |
human |
| Lingxin Zhu, Jingwen Yang, Jie Zhang, Bin Pen. The presence of autophagy in human periapical lesions. Journal of endodontics. vol 39. issue 11. 2015-09-29. PMID:24139258. |
autophagy, a lysosome- or endosome-mediated self-degradation process, participates in diverse neurodegenerative diseases, cancer, and inflammatory diseases associated with apoptosis. |
2015-09-29 |
2023-08-12 |
human |