| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ran Lin, Alessia Angelin, Federico Da Settimo, Claudia Martini, Sabrina Taliani, Shigong Zhu, Douglas C Wallac. Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. Aging cell. vol 13. issue 3. 2015-03-30. PMID:24977274. |
therefore, dtspo is an essential mediator of apoptosis in drosophila and plays a central role in controlling longevity and neurodegenerative disease, making it a promising drug target. |
2015-03-30 |
2023-08-13 |
drosophila_melanogaster |
| Md Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuch. Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling. PloS one. vol 8. issue 12. 2015-03-02. PMID:24376709. |
neuronal cells are susceptible to many stresses, which will cause the apoptosis and neurodegenerative diseases. |
2015-03-02 |
2023-08-12 |
mouse |
| Jana Hroudová, Namrata Singh, Zdeněk Fiša. Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease. BioMed research international. vol 2014. 2015-01-21. PMID:24900954. |
in the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ros production, impaired mitochondrial dynamics, and apoptosis. |
2015-01-21 |
2023-08-13 |
Not clear |
| Zhi Chen, Qingge Fu, Baoliang Shen, Xuan Huang, Kun Wang, Ping He, Fengning Li, Fan Zhang, Hongxing She. Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24715058. |
p62 is a multidomain adapter protein, which is involved in apoptosis and cell survival as well as autophagy, and is a common component of protein aggregations in neurodegenerative diseases. |
2015-01-05 |
2023-08-13 |
rat |
| A-Rang Im, Sung-Wook Chae, Gui Jun Zhang, Mi-Young Le. Neuroprotective effects of Psoralea corylifolia Linn seed extracts on mitochondrial dysfunction induced by 3-nitropropionic acid. BMC complementary and alternative medicine. vol 14. 2014-12-22. PMID:25277760. |
mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as huntington's disease (hd). |
2014-12-22 |
2023-08-13 |
Not clear |
| Jun Ma, Rong Wu, Qiang Zhang, Jun-bing Wu, Jizhong Lou, Zheng Zheng, Jian-qing Ding, Zengqiang Yua. DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. The Biochemical journal. vol 462. issue 3. 2014-10-28. PMID:24947010. |
taken together, the dj-1-rack1 complex protects neurons from oxidative stress-induced apoptosis, with the implication that dj-1 and rack1 might be novel targets in the treatment of neurodegenerative diseases. |
2014-10-28 |
2023-08-13 |
Not clear |
| Xiao-Long Sun, Bei-Yu Chen, Li Duan, Yi Xia, Zhuo-Jing Luo, Jing-Jie Wang, Zhi-Ren Rao, Liang-Wei Che. The proform of glia cell line-derived neurotrophic factor: a potentially biologically active protein. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23934644. |
growing evidences have revealed that the proforms of several neurotrophins including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt3), by binding to p75 neurotrophin receptor and sortilin, could induce neuronal apoptosis and are implicated in the pathogenesis of various neurodegenerative diseases. |
2014-10-27 |
2023-08-12 |
Not clear |
| J C Koch, L Tönges, E Barski, U Michel, M Bähr, P Lingo. ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS. Cell death & disease. vol 5. 2014-10-21. PMID:24832597. |
taken together, our data characterize rock2 as a specific therapeutic target in neurodegenerative diseases and demonstrate new downstream effects of rock2 including axonal degeneration, apoptosis and autophagy. |
2014-10-21 |
2023-08-13 |
rat |
| Xiqing Chai, Weina Kong, Lingyun Liu, Wenguo Yu, Zhenqing Zhang, Yimin Su. A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural regeneration research. vol 9. issue 11. 2014-09-10. PMID:25206774. |
our in vitro and in vivo findings demonstrate that hif-1 has potential for attenuating hippocampal neuronal apoptosis induced by amyloid-beta protein, and provides experimental support for treatment of neurodegenerative diseases using gene therapy. |
2014-09-10 |
2023-08-13 |
human |
| Agnieszka Wąsik, Małgorzata Kajta, Tomasz Lenda, Lucyna Antkiewicz-Michalu. Concentration-dependent opposite effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline on markers of apoptosis: in vitro and ex vivo studies. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24190811. |
summarizing the studies, we suggest that 1bntiq is a rather weak endogenous neurotoxin; however, it should be taken into account that in higher μmoles concentrations, it can initiate apoptosis in the central nervous system and may be involved in the etiopathology of neurodegenerative diseases. |
2014-08-28 |
2023-08-12 |
rat |
| Tomohiro Omura, Masayuki Kaneko, Yasunobu Okuma, Kazuo Matsubara, Yasuyuki Nomur. Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23710284. |
endoplasmic reticulum stress and parkinson's disease: the role of hrd1 in averting apoptosis in neurodegenerative disease. |
2014-08-13 |
2023-08-12 |
human |
| Costanza Savino, PierGiuseppe Pelicci, Marco Giorgi. The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23766859. |
mitochondrial-mediated oxidative stress and apoptosis play a crucial role in neurodegenerative disease and aging. |
2014-08-13 |
2023-08-12 |
mouse |
| Ana Joyce Munoz, Kwanjeera Wanichthanarak, Eugenio Meza, Dina Petranovi. Systems biology of yeast cell death. FEMS yeast research. vol 12. issue 2. 2014-07-02. PMID:22188402. |
programmed cell death (pcd) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. |
2014-07-02 |
2023-08-12 |
human |
| Mohammad Mijanur Rahman, Siew Hua Gan, Md Ibrahim Khali. Neurological effects of honey: current and future prospects. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-06-24. PMID:24876885. |
therefore, the ultimate biochemical impact of honey on specific neurodegenerative diseases, apoptosis, necrosis, neuroinflammation, synaptic plasticity, and behavior-modulating neural circuitry should be evaluated with appropriate mechanistic approaches using biochemical and molecular tools. |
2014-06-24 |
2023-08-13 |
Not clear |
| Angela Trovato Salinaro, Carolin Cornelius, Guido Koverech, Angela Koverech, Maria Scuto, Francesca Lodato, Vincenzo Fronte, Vera Muccilli, Michele Reibaldi, Antonio Longo, Maurizio G Uva, Vittorio Calabres. Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer's disease. Frontiers in pharmacology. vol 5. 2014-06-17. PMID:24936186. |
further, several heat shock proteins (hsps) members have been implicated both in neurodegenerative diseases and glaucomatous apoptosis. |
2014-06-17 |
2023-08-13 |
human |
| Juan A Marchal, Gabriel J Lopez, Macarena Peran, Ana Comino, Juan R Delgado, Javier A García-García, Veronica Conde, Fernando M Aranda, Carmen Rivas, Mariano Esteban, Maria A Garci. The impact of PKR activation: from neurodegeneration to cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 5. 2014-06-16. PMID:24522206. |
whereas pkr is recognized for its negative effects on neurodegenerative diseases, in part, inducing high level of apoptosis, the role of pkr activation in cancer remains controversial. |
2014-06-16 |
2023-08-12 |
Not clear |
| Francesc Puiggròs, Maria-Josepa Salvadó, Cinta Bladé, Lluís Arol. Differential modulation of apoptotic processes by proanthocyanidins as a dietary strategy for delaying chronic pathologies. Critical reviews in food science and nutrition. vol 54. issue 3. 2014-06-05. PMID:24188302. |
for example, inhibition of apoptotic signaling pathways is linked to the survival of pathological cells, which contributes to cancer, whereas excessive apoptosis is linked to neurodegenerative diseases, partially via oxidative stress. |
2014-06-05 |
2023-08-12 |
Not clear |
| Francesc Puiggròs, Maria-Josepa Salvadó, Cinta Bladé, Lluís Arol. Differential modulation of apoptotic processes by proanthocyanidins as a dietary strategy for delaying chronic pathologies. Critical reviews in food science and nutrition. vol 54. issue 3. 2014-06-05. PMID:24188302. |
proanthocyanidins, a class of flavonoids naturally found in fruits, vegetables, and beverages, have attracted a great deal of attention not only because they are strong antioxidants but also because they appear to exert a different modulation of apoptosis, stimulating apoptosis in damaged cells, thus preventing cancer or reducing apoptosis in healthy cells, and as a result, preserving the integrity of normal cells and protecting against neurodegenerative diseases. |
2014-06-05 |
2023-08-12 |
Not clear |
| Wendan Cheng, Dongying Wu, Qiang Zuo, Zhen Wang, Weimin Fa. Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes. International orthopaedics. vol 37. issue 10. 2014-06-02. PMID:23835558. |
ginsenosides, the most important pharmacological ingredients of ginseng, have been proven to provide effective therapy for neurodegenerative diseases and can inhibit cell apoptosis. |
2014-06-02 |
2023-08-12 |
human |
| Marla Rivera-Oliver, Manuel Díaz-Río. Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review. Life sciences. vol 101. issue 1-2. 2014-06-02. PMID:24530739. |
interestingly, other studies using adenosine receptor agonists have also shown to provide a neuroprotective effect on various models of neurodegenerative diseases through the reduction of excitatory neurotransmitter release, apoptosis and inflammatory responses, among others. |
2014-06-02 |
2023-08-12 |
human |