| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sofia Lövestam, Fujiet Adrian Koh, Bart van Knippenberg, Abhay Kotecha, Alexey G Murzin, Michel Goedert, Sjors H W Schere. Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy. eLife. vol 11. 2022-03-04. PMID:35244536. |
abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. |
2022-03-04 |
2023-08-13 |
human |
| Majedul Islam, Fengyun Shen, Deepika Regmi, Deguo D. Therapeutic Strategies for Tauopathies and Drug Repurposing as a Potential Approach. Biochemical pharmacology. 2022-02-27. PMID:35219701. |
tauopathies are neurodegenerative diseases characterized by the deposition of abnormal tau in the brain. |
2022-02-27 |
2023-08-13 |
Not clear |
| Paulo J da Costa, Malika Hamdane, Luc Buée, Franck Marti. Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203451. |
tau mrna metabolism in neurodegenerative diseases: a tangle journey. |
2022-02-25 |
2023-08-13 |
Not clear |
| Paulo J da Costa, Malika Hamdane, Luc Buée, Franck Marti. Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203451. |
moreover, tau proteins are turned into aggregates and consequently trigger many neurodegenerative diseases termed tauopathies, of which alzheimer's disease (ad) is the figurehead. |
2022-02-25 |
2023-08-13 |
Not clear |
| Paulo J da Costa, Malika Hamdane, Luc Buée, Franck Marti. Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203451. |
thus, we intend to portray how mrna metabolism of, or mediated by, tau is associated with neurodegenerative diseases. |
2022-02-25 |
2023-08-13 |
Not clear |
| Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L Villemagne, Nobuyuki Okamur. Imaging of Reactive Astrogliosis by Positron Emission Tomography. Frontiers in neuroscience. vol 16. 2022-02-25. PMID:35210989. |
many neurodegenerative diseases are neuropathologically characterized by neuronal loss, gliosis, and the deposition of misfolded proteins such as β-amyloid (aβ) plaques and tau tangles in alzheimer's disease (ad). |
2022-02-25 |
2023-08-13 |
Not clear |
| Kazuhisa Ishida, Kaoru Yamada, Risa Nishiyama, Tadafumi Hashimoto, Itaru Nishida, Yoichiro Abe, Masato Yasui, Takeshi Iwatsub. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. The Journal of experimental medicine. vol 219. issue 3. 2022-02-25. PMID:35212707. |
accumulation of tau has been implicated in various neurodegenerative diseases termed tauopathies. |
2022-02-25 |
2023-08-13 |
mouse |
| Solomiia Boyko, Witold K Surewic. Tau liquid-liquid phase separation in neurodegenerative diseases. Trends in cell biology. 2022-02-19. PMID:35181198. |
tau liquid-liquid phase separation in neurodegenerative diseases. |
2022-02-19 |
2023-08-13 |
Not clear |
| Solomiia Boyko, Witold K Surewic. Tau liquid-liquid phase separation in neurodegenerative diseases. Trends in cell biology. 2022-02-19. PMID:35181198. |
an exciting recent development is the finding that, akin to some other proteins associated with neurodegenerative disease, tau has a high propensity to condensate via the mechanism of liquid-liquid phase separation (llps). |
2022-02-19 |
2023-08-13 |
Not clear |
| Baofeng Gong, Wenbo Ji, Xiaohan Chen, Peng Li, Wenbin Cheng, Yuchen Zhao, Bin He, Jianhua Zhuang, Jie Gao, You Yi. Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease. Mini reviews in medicinal chemistry. 2022-02-14. PMID:35156576. |
alzheimer's disease (ad) is a intricate neurodegenerative disease with chronic and progressive development whose typical neuropathological features encompasses senile plaques and neurofibrillary tangles respectively formed by the extracellular deposition of amyloid-beta (aβ) and the intracellular accumulation of hyperphosphorylated tau protein in the brain, particularly in limbic and cortical regions. |
2022-02-14 |
2023-08-13 |
Not clear |
| Alisa Cario, Adriana Savastano, Neil B Wood, Zhu Liu, Michael J Previs, Adam G Hendricks, Markus Zweckstetter, Christopher L Berge. The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 7. 2022-02-09. PMID:35135879. |
tau misregulation and point mutations are linked to neurodegenerative diseases, including progressive supranuclear palsy (psp), pick's disease, and alzheimer's disease. |
2022-02-09 |
2023-08-13 |
Not clear |
| Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. |
tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. |
2022-02-09 |
2023-08-13 |
mouse |
| Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. |
although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as alzheimer's disease has been associated with its ability to phosphorylate tau in neurons. |
2022-02-09 |
2023-08-13 |
mouse |
| b' L\\xc3\\xa1szl\\xc3\\xb3 Petri, P\\xc3\\xa9ter \\xc3\\x81br\\xc3\\xa1nyi-Balogh, Darius Vagrys, T\\xc3\\xadmea Imre, Nikolett Varr\\xc3\\xb3, Istv\\xc3\\xa1n M\\xc3\\xa1ndity, Anita R\\xc3\\xa1cz, Lucia Wittner, Kinga T\\xc3\\xb3th, Estilla Zs\\xc3\\xb3fia T\\xc3\\xb3th, T\\xc3\\xbcnde Juh\\xc3\\xa1sz, Ben Davis, Gy\\xc3\\xb6rgy Mikl\\xc3\\xb3s Keser\\xc5\\xb. A covalent strategy to target intrinsically disordered proteins: Discovery of novel tau aggregation inhibitors. European journal of medicinal chemistry. vol 231. 2022-02-08. PMID:35131537.' |
as a model system we chose tau, an endogenous idp of the central nervous system that is associated with severe neurodegenerative diseases via its aggregation. |
2022-02-08 |
2023-08-13 |
Not clear |
| Rebecca L Kow, Aristide H Black, Aleen D Saxton, Nicole F Liachko, Brian C Kraeme. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. GeroScience. 2022-02-05. PMID:35122183. |
neurodegenerative diseases with tau pathology, or tauopathies, include alzheimer's disease and related dementia disorders. |
2022-02-05 |
2023-08-13 |
mouse |
| Ivan Fernandez Bessone, Ana Damianich, Olivia Pedroncini, Mariana Holubiec, Trinidad Saez, Antonia Marin Burgin, Maria-Elena Avale, Tomas Falzon. Tau conditional reduction in human-derived neurons exposes novel tau-associated functions in electrical activity and axonal transport. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108893. |
abnormal tau accumulation is the hallmark of neurodegenerative diseases, and gain-of-toxic tau function has been pointed as triggering neuronal death. |
2022-02-03 |
2023-08-13 |
human |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
furthermore, tau co-pathology is thought to influence features and progression of other neurodegenerative diseases including lewy body disease (lbd); yet reliable measurements of tau seeds in such diseases remains an unmet need. |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
here, we use tau real-time quaking-induced conversion (rt-quic) assays to directly measure bioactive tau seeds in brain samples across a spectrum of neurodegenerative diseases to determine tau seeding activities at different stages of ad related changes. |
2022-02-03 |
2023-08-13 |
Not clear |
| Aleksandra P Pitera, Iain J Hartnell, Lucy Scullard, Kirsten L Williamson, Delphine Boche, Vincent O'Connor, Katrin Deinhard. Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies. Journal of Alzheimer's disease reports. vol 5. issue 1. 2022-01-28. PMID:35088035. |
tauopathies are a group of neurodegenerative diseases associated with the accumulation of misfolded tau protein. |
2022-01-28 |
2023-08-13 |
human |
| Aleksandra P Pitera, Iain J Hartnell, Lucy Scullard, Kirsten L Williamson, Delphine Boche, Vincent O'Connor, Katrin Deinhard. Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies. Journal of Alzheimer's disease reports. vol 5. issue 1. 2022-01-28. PMID:35088035. |
a protein quality control pathway within the endoplasmic reticulum, the unfolded protein response (upr), has been suggested as a possible pathway modulating cellular responses in a range of neurodegenerative diseases, including those associated with misfolded cytosolic tau. |
2022-01-28 |
2023-08-13 |
human |