| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Y. Tau Toxicity in Neurodegeneration. Molecular neurobiology. 2022-04-01. PMID:35359226. |
after a long period of research on neurodegenerative diseases, the function and dysfunction of the microtubule-associated protein tau in neurodegenerative diseases and tau neurotoxicity have attracted increasing attention. |
2022-04-01 |
2023-08-13 |
Not clear |
| Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Y. Tau Toxicity in Neurodegeneration. Molecular neurobiology. 2022-04-01. PMID:35359226. |
tauopathies are a series of progressive neurodegenerative diseases caused by pathological changes in tau, such as abnormal phosphorylation. |
2022-04-01 |
2023-08-13 |
Not clear |
| Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Y. Tau Toxicity in Neurodegeneration. Molecular neurobiology. 2022-04-01. PMID:35359226. |
this article first describes the normal physiological function and dysfunction of tau proteins and then discusses the enzymes and proteins involved in tau phosphorylation and dephosphorylation, the role of tau in cell dysfunction, and the relationships between tau and several neurodegenerative diseases. |
2022-04-01 |
2023-08-13 |
Not clear |
| Laetitia Miguel, Anne Rovelet-Lecrux, Pascal Chambon, Géraldine Joly-Helas, Stéphane Rousseau, David Wallon, Stéphane Epelbaum, Thierry Frébourg, Dominique Campion, Gaël Nicolas, Magalie Lecourtoi. Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies. Stem cell research. vol 61. 2022-03-31. PMID:35358831. |
tau accumulates in patients' brain in several neurodegenerative diseases, including fronto-temporal dementia and alzheimer's disease. |
2022-03-31 |
2023-08-13 |
Not clear |
| Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amílcar Falcão, M Teresa Cruz, Ana Fortun. Targeting Brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: past, present and future. Ageing research reviews. 2022-03-29. PMID:35346852. |
alzheimer's disease (ad) is a well-known neurodegenerative disease characterized by the presence of two main hallmarks - tau hyperphosphorylation and aβ deposits. |
2022-03-29 |
2023-08-13 |
Not clear |
| Claudia Honisch, Federica Torni, Rohanah Hussain, Paolo Ruzza, Giuliano Siligard. Effect of Trehalose and Ceftriaxone on the Stability of Aggregating-Prone Tau Peptide Containing PHF6* Sequence: An SRCD Study. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328353. |
the tau protein, a soluble protein associated with microtubules, which is involved in the assembly and stabilization of cytoskeletal elements, was found to form neurofibrillary tangles in different neurodegenerative diseases. |
2022-03-25 |
2023-08-13 |
Not clear |
| Haiqiong Ye, Yue Han, Ping Li, Zhengding Su, Yongqi Huan. The Role of Post-Translational Modifications on the Structure and Function of Tau Protein. Journal of molecular neuroscience : MN. 2022-03-24. PMID:35325356. |
accumulated evidence shows that these ptms play a critical role in regulating tau-microtubule interaction, tau localization, tau degradation and aggregation, and reinforces the correlation between tau ptms and pathogenesis of neurodegenerative disease. |
2022-03-24 |
2023-08-13 |
human |
| Nora Lemke, Ahmed H El-Khatib, Teodor Tchipilov, Norbert Jakubowski, Michael G Weller, Jochen Vog. Procedure providing SI-traceable results for the calibration of protein standards by sulfur determination and its application on tau. Analytical and bioanalytical chemistry. 2022-03-22. PMID:35316347. |
finally, the developed procedure was applied to the tau protein, which is a biomarker for a group of neurodegenerative diseases denoted "tauopathies" including, e.g., alzheimer's disease and frontotemporal dementia. |
2022-03-22 |
2023-08-13 |
mouse |
| Shuai Zhang, Hui Wang, Jing Wang, Wenqi Jin, Xiuci Yan, Xuenan Chen, Dandan Wang, Daqing Zhao, Yufeng Wang, Deyu Cong, Liwei Su. Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy. European journal of pharmacology. 2022-03-20. PMID:35306001. |
under pathological conditions, human tau (htau) hyperphosphorylation promotes formation of proteotoxic intracellular amyloid aggregates that may underlie neurodegenerative diseases known as tauopathies, prompting researchers to develop treatments that inhibit htau aggregation as a promising therapeutic strategy. |
2022-03-20 |
2023-08-13 |
human |
| Janine Hochmair, Christian Exner, Maximilian Franck, Alvaro Dominguez-Baquero, Lisa Diez, Hévila Brognaro, Matthew L Kraushar, Thorsten Mielke, Helena Radbruch, Senthil Kaniyappan, Sven Falke, Eckhard Mandelkow, Christian Betzel, Susanne Wegman. Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. The EMBO journal. 2022-03-17. PMID:35298090. |
tau condensates have been linked to both functional microtubule binding and pathological aggregation in neurodegenerative diseases. |
2022-03-17 |
2023-08-13 |
Not clear |
| Yukio Imamura, Akiko Hiyama, Haruko Miyazaki, Tomoyuki Yamanaka, Nobuyuki Nukin. Amyloids facilitate DNA transfection in vivo. Neuroscience research. 2022-03-14. PMID:35283247. |
normal proteins such as tau, alpha-synuclein, tdp-43 and others could form specific conformational fibrils called amyloid, which deposited in the brains of neurodegenerative diseases. |
2022-03-14 |
2023-08-13 |
Not clear |
| Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüske. Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276811. |
to determine long-term effects, we additionally examined mtor signaling and tau phosphorylation, which is altered in neurodegenerative diseases, on pnd 180, but did not find any changes among the experimental groups. |
2022-03-12 |
2023-08-13 |
rat |
| Qiong-Qiong Yao, Jitao Wen, Sarah Perrett, Si W. Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis. Nanoscale. 2022-03-09. PMID:35260870. |
the conversion of intrinsically disordered tau to highly ordered amyloid aggregates is associated with a wide range of neurodegenerative diseases termed tauopathies. |
2022-03-09 |
2023-08-13 |
Not clear |
| Heidi G Standke, Allison Krau. Seed amplification and RT-QuIC assays to investigate protein seed structures and strains. Cell and tissue research. 2022-03-08. PMID:35258712. |
first shown for prp prions and prion diseases, it is now recognized that self-propagating misfolded proteins occur broadly in neurodegenerative diseases and include amyloid-β (aβ) and tau in alzheimer's disease (ad), tau in chronic traumatic encephalopathy (cte), pick's disease (pid), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), and α-synuclein (α-syn) in parkinson's disease (pd) and lewy body dementias (lbd). |
2022-03-08 |
2023-08-13 |
Not clear |
| Thibaut Gauvrit, Hamza Benderradji, Luc Buée, David Blum, Didier Viea. Early-Life Environment Influence on Late-Onset Alzheimer's Disease. Frontiers in cell and developmental biology. vol 10. 2022-03-07. PMID:35252195. |
alzheimer disease (ad) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily characterized by cognitive deficits and neuropathological lesions such as amyloid -β (aβ) plaques and neurofibrillary tangles composed of hyper- and/or abnormally phosphorylated tau protein. |
2022-03-07 |
2023-08-13 |
Not clear |
| Andrew Chang, Xinyu Xiang, Jing Wang, Carolyn Lee, Tamta Arakhamia, Marija Simjanoska, Chi Wang, Yari Carlomagno, Guoan Zhang, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman, Lauren M Forgrave, Michael DeTure, Mari L DeMarco, Casey N Cook, Rosa Rademakers, Dennis W Dickson, Leonard Petrucelli, Michael H B Stowell, Ian R A Mackenzie, Anthony W P Fitzpatric. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell. 2022-03-05. PMID:35247328. |
here we show that a previously unsolved amyloid fibril composed of a 135 amino acid c-terminal fragment of tmem106b is a common finding in distinct human neurodegenerative diseases, including cases characterized by abnormal aggregation of tdp-43, tau, or α-synuclein protein. |
2022-03-05 |
2023-08-13 |
human |
| Sofia Lövestam, Fujiet Adrian Koh, Bart van Knippenberg, Abhay Kotecha, Alexey G Murzin, Michel Goedert, Sjors H W Schere. Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy. eLife. vol 11. 2022-03-04. PMID:35244536. |
abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. |
2022-03-04 |
2023-08-13 |
human |
| Majedul Islam, Fengyun Shen, Deepika Regmi, Deguo D. Therapeutic Strategies for Tauopathies and Drug Repurposing as a Potential Approach. Biochemical pharmacology. 2022-02-27. PMID:35219701. |
tauopathies are neurodegenerative diseases characterized by the deposition of abnormal tau in the brain. |
2022-02-27 |
2023-08-13 |
Not clear |
| Paulo J da Costa, Malika Hamdane, Luc Buée, Franck Marti. Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203451. |
tau mrna metabolism in neurodegenerative diseases: a tangle journey. |
2022-02-25 |
2023-08-13 |
Not clear |
| Paulo J da Costa, Malika Hamdane, Luc Buée, Franck Marti. Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203451. |
moreover, tau proteins are turned into aggregates and consequently trigger many neurodegenerative diseases termed tauopathies, of which alzheimer's disease (ad) is the figurehead. |
2022-02-25 |
2023-08-13 |
Not clear |