| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Álvaro Sebastián-Serrano, Jesús Merchán-Rubira, Caterina Di-Lauro, Carolina Bianchi, Lucía Soria-Tobar, Sonoko Narisawa, José L Millán, Jesús Ávila, Félix Hernández, Miguel Díaz-Hernánde. TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy. Neurobiology of disease. 2022-01-22. PMID:35065251. |
tauopathies are a family of neurodegenerative diseases characterized by the presence of abnormally hyperphosphorylated tau protein. |
2022-01-22 |
2023-08-13 |
mouse |
| Bin Tang, Wu Zeng, Lin Lin Song, Hui Miao Wang, Li Qun Qu, Hang Hong Lo, Lu Yu, An Guo Wu, Vincent Kam Wai Wong, Betty Yuen Kwan La. Extracellular Vesicle Delivery of Neferine for the Attenuation of Neurodegenerative Disease Proteins and Motor Deficit in an Alzheimer's Disease Mouse Model. Pharmaceuticals (Basel, Switzerland). vol 15. issue 1. 2022-01-21. PMID:35056140. |
in vitro cellular models confirmed that three of the selected exosome-encapsulated natural compounds-baicalin, hederagenin and neferine-could reduce the level of neurodegenerative disease mutant proteins-including huntingtin 74 (htt74), p301l tau and a53t α-synuclein (a53t α-syn)-more effectively than the compounds alone. |
2022-01-21 |
2023-08-13 |
mouse |
| Martin J Dahl, Mara Mather, Markus Werkle-Bergner, Briana L Kennedy, Samuel Guzman, Kyle Hurth, Carol A Miller, Yuchuan Qiao, Yonggang Shi, Helena C Chui, John M Ringma. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiology of aging. vol 112. 2022-01-19. PMID:35045380. |
our findings link lc degeneration to tau burden and memory in alzheimer's, and highlight a role of the noradrenergic system in this neurodegenerative disease. |
2022-01-19 |
2023-08-13 |
human |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by excessive deposition of β amyloid (aβ), hyperphosphorylation of tau protein, and neuronal cell death. |
2022-01-17 |
2023-08-13 |
mouse |
| Alberto Fernando Oliveira Justo, Claudia Kimie Suemot. The modulation of neuroinflammation by inducible nitric oxide synthase. Journal of cell communication and signaling. 2022-01-15. PMID:35031946. |
the accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of β-amyloid and hyperphosphorylated tau proteins in alzheimer's disease. |
2022-01-15 |
2023-08-13 |
mouse |
| Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao M. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017447. |
however, the exact role of cr1 in tau protein-associated neurodegenerative diseases is unknown. |
2022-01-12 |
2023-08-13 |
mouse |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006431. |
alzheimer's disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of tau protein that forms neurofibrillary tangles (nfts) in neuronal cells. |
2022-01-10 |
2023-08-13 |
Not clear |
| Ada Luigi, Laura Colombo, Luca Russo, Caterina Ricci, Antonio Bastone, Sara Cimini, Fabrizio Tagliavini, Giacomina Rossi, Laura Cantù, Elena Del Favero, Mario Salmon. Biochemical and biophysical features of disease-associated tau mutants V363A and V363I. Biochimica et biophysica acta. Proteins and proteomics. 2022-01-09. PMID:34999006. |
the comprehension of pathogenetic mechanisms in tauopathy-associated neurodegenerative diseases can be improved by the knowledge of the biochemical and biophysical features of mutated tau proteins. |
2022-01-09 |
2023-08-13 |
Not clear |
| Isaline Mees, Shanshan Li, Leah C Beauchamp, Kevin J Barnham, Mathias Dutschmann, Anthony J Hannan, Thibault Renoi. Loss-of-function and gain-of-function studies refute the hypothesis that tau protein is causally involved in the pathogenesis of Huntington's disease. Human molecular genetics. 2022-01-09. PMID:34999772. |
tau is a microtubule-associated protein, whose abnormal phosphorylation and deposition in the brain characterizes a range of neurodegenerative diseases called tauopathies. |
2022-01-09 |
2023-08-13 |
mouse |
| Shaohui Wang, Yao Jiang, Yabo Liu, Qianhui Liu, Hongwei Sun, Mengjie Mei, Xiaomei Lia. Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition. Molecular neurobiology. 2022-01-08. PMID:34997541. |
iron dyshomeostasis and peroxidation damage of neurons in some particular brain regions are closely related to a wide range of neurodegenerative diseases known as "tauopathies," in which intracellular aggregation of microtubule-associated protein tau is the common neuropathological feature. |
2022-01-08 |
2023-08-13 |
mouse |
| Ni-Ni Chiang, Te-Hsien Lin, Yu-Shan Teng, Ying-Chieh Sun, Kuo-Hsuan Chang, Chung-Yin Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Guey-Jen Lee-Che. Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity Frontiers in aging neuroscience. vol 13. 2022-01-03. PMID:34975454. |
flavones 7,8-dhf, quercetin, and apigenin against tau toxicity alzheimer's disease (ad) is a progressive neurodegenerative disease with memory loss and cognitive decline. |
2022-01-03 |
2023-08-13 |
Not clear |
| Ni-Ni Chiang, Te-Hsien Lin, Yu-Shan Teng, Ying-Chieh Sun, Kuo-Hsuan Chang, Chung-Yin Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Guey-Jen Lee-Che. Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity Frontiers in aging neuroscience. vol 13. 2022-01-03. PMID:34975454. |
neurofibrillary tangles (nfts) formed by hyperphosphorylated tau protein are one of the pathological hallmarks of several neurodegenerative diseases including ad. |
2022-01-03 |
2023-08-13 |
Not clear |
| Brianne B Rogers, Shelby N Lauzon, M Natalie Davis, Lindsay F Rizzardi, Sara J Cooper, Richard M Myers, J Nicholas Cochra. Identification of cis-regulatory elements associated with MAPT expression in human induced pluripotent stem cell derived neural cells. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971147. |
tau is encoded by mapt and abnormal aggregates of tau are a hallmark of many neurodegenerative diseases. |
2021-12-31 |
2023-08-13 |
human |
| Sarah Bachmann, Michael Bell, Mhd Aghyad Al Kabbani, Jennifer Klimek, Hans Zempe. Investigating isoform-specific functions of Tau under healthy and pathological conditions using Tau-deficient hiPSC-derived cortical neurons. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971193. |
one hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad), is the formation of neurofibrillary tangles by hyperphosphorylated tau in the brain, resulting in neuronal death and cognitive decline. |
2021-12-31 |
2023-08-13 |
human |
| Hasan Turkez, Mehmet Enes Arslan, Joice Nascimento Barboza, Cigdem Yuce Kahraman, Damiao Pergentino de Sousa, Adil Mardinoğl. Therapeutic Potential of Ferulic Acid in Alzheimer's Disease. Current drug delivery. 2021-12-29. PMID:34963433. |
ad is a constantly progressing neurodegenerative disease as a result of the production of β-amyloid (aβ) protein and the accumulation of hyper-phosphorylated tau protein; it causes breakages in the synaptic bonds and neuronal deaths to a large extent. |
2021-12-29 |
2023-08-13 |
Not clear |
| Sansi Xing, Jane Wang, Ruilin Wu, Marco M Hefti, John F Crary, Yu L. Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry. RNA biology. 2021-12-29. PMID:34965173. |
aberrant alternative splicing in tau exon 10 leads to distortion of the balanced 3 r- and 4 r-tau expression levels, which is a causal factor to trigger toxic tau aggregation, neuron dysfunction and patient death in a group of neurodegenerative diseases known as tauopathies. |
2021-12-29 |
2023-08-13 |
human |
| Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Ri. (-)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944489. |
alzheimer's disease (ad) is a complex neurodegenerative disease characterized by functional disruption, death of cholinergic neurons (chns) because of intracellular and extracellular aβ aggregates, and hyperphosphorylation of protein tau (p-tau). |
2021-12-24 |
2023-08-13 |
Not clear |
| M Dylan Tisdall, Daniel T Ohm, Rebecca Lobrovich, Sandhitsu R Das, Gabor Mizsei, Karthik Prabhakaran, Ranjit Ittyerah, Sydney Lim, Corey T McMillan, David A Wolk, James Gee, John Q Trojanowski, Edward B Lee, John A Detre, Paul Yushkevich, Murray Grossman, David J Irwi. Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. NeuroImage. Clinical. vol 33. 2021-12-24. PMID:34952351. |
frontotemporal lobar degeneration (ftld) is a heterogeneous spectrum of age-associated neurodegenerative diseases that include two main pathologic categories of tau (ftld-tau) and tdp-43 (ftld-tdp) proteinopathies. |
2021-12-24 |
2023-08-13 |
Not clear |
| Giambattista Marotta, Filippo Basagni, Michela Rosini, Anna Minarin. Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways. Current medicinal chemistry. 2021-12-23. PMID:34939537. |
based on these premises, fyn emerges as an attractive target in cancer and neurodegenerative disease therapy, particularly alzheimer disease (ad), based on its activation by aβ via cellular prion protein and its interaction with tau protein. |
2021-12-23 |
2023-08-13 |
Not clear |
| Daniela Ushizima, Yuheng Chen, Maryana Alegro, Dulce Ovando, Rana Eser, WingHung Lee, Kinson Poon, Anubhav Shankar, Namrata Kantamneni, Shruti Satrawada, Edson Amaro Junior, Helmut Heinsen, Duygu Tosun, Lea T Grinber. Deep Learning for Alzheimer's Disease: Mapping Large-scale Histological Tau Protein for Neuroimaging Biomarker Validation. NeuroImage. 2021-12-21. PMID:34933123. |
several tau pet tracers are available for neurodegenerative disease research, opening avenues for molecular diagnosis in vivo. |
2021-12-21 |
2023-08-13 |
human |