| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria do Socorro do Nascimento Amorim, Álefe Roger Silva França, Ralph Santos-Oliveira, Jonas Rodrigues Sanches, Thamys Marinho Melo, Bruno Araújo Serra Pinto, Leandro R S Barbosa, Luciana Magalhães Rebelo Alenca. Atomic Force Microscopy Applied to the Study of Tauopathies. ACS chemical neuroscience. 2024-02-02. PMID:38305187. |
tauopathies are neurodegenerative diseases featured by aggregation of phosphorylated tau protein inside neurons, leading to functional loss and progressive neurotoxicity. |
2024-02-02 |
2024-02-04 |
Not clear |
| Kathrin Wenger, Arthur Viode, Mukesh Kumar, Hanno Steen, Judith A Stee. Quantitative profiling of posttranslational modifications of pathological tau via sarkosyl fractionation and mass spectrometry. Nature protocols. 2024-01-30. PMID:38291250. |
it also enables the detailed molecular comparison of tau across multiple experiments, including a comparison between neurodegenerative diseases, stages of the disease, human patient heterogeneity and characterization of animal models. |
2024-01-30 |
2024-02-02 |
human |
| Courtney Lane-Donovan, Adam L Boxe. Disentangling tau: One protein, many therapeutic approaches. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-01-26. PMID:38278659. |
the tauopathies encompass over 20 adult neurodegenerative diseases and are characterized by the dysfunction and accumulation of insoluble tau protein. |
2024-01-26 |
2024-01-29 |
Not clear |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (mapt). |
2024-01-23 |
2024-01-25 |
Not clear |
| Kacper Nijakowski, Wojciech Owecki, Jakub Jankowski, Anna Surdack. Salivary Biomarkers for Alzheimer's Disease: A Systematic Review with Meta-Analysis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256241. |
in conclusion, potential markers such as beta-amyloid42, tau and lactoferrin can be detected in the saliva of ad patients, which could reliably support the early diagnosis of this neurodegenerative disease. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ling Wu, Stephanie Arvai, Shih-Hsiu J Wang, Andy J Liu, Bin X. Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF. Frontiers in molecular neuroscience. vol 16. 2024-01-23. PMID:38260807. |
misfolded phosphorylated tau aggregates (p-tau) are present in multiple neurodegenerative diseases known as "tauopathies", with the most common being ad. |
2024-01-23 |
2024-01-25 |
human |
| Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Thomas Arzberger, Sigrun Roeber, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivanna M Van Deerlin, Charles L White, Huw Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, Dennis W Dickson, Günter U Höglinger, Gerard D Schellenberg, Daniel H Geschwind, Wan-Ping Le. Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy. medRxiv : the preprint server for health sciences. 2024-01-18. PMID:38234807. |
progressive supranuclear palsy (psp) is a neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. |
2024-01-18 |
2024-01-20 |
human |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by mapt. |
2024-01-17 |
2024-01-20 |
human |
| François Ruch, Johannes Gnörich, Karin Wind, Mara Köhler, Artem Zatcepin, Thomas Wiedemann, Franz-Joseph Gildehaus, Simon Lindner, Guido Boening, Barbara von Ungern-Sternberg, Leonie Beyer, Jochen Herms, Peter Bartenstein, Matthias Brendel, Florian Eckenwebe. Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy. NeuroImage. 2024-01-08. PMID:38191101. |
the goal of the current work was to analyze and validate metabolic regional network alterations in three different mouse models of neurodegenerative diseases (β-amyloid and tau) by use of 2-deoxy-2-[ |
2024-01-08 |
2024-01-10 |
mouse |
| H Peter L. A Missing Origin of the Tau Protein Aggregation Pathway Triggered by Thermal and Biological Forces. Journal of integrative neuroscience. vol 22. issue 6. 2024-01-04. PMID:38176940. |
this previously hidden phenomenon of proteins rupturing collectively while subsequently and spontaneously refolding into a complex entangled conformation, distinct from the tau protein's folded or unfolded states, could potentially explain the early-event initiation of the aggregation of the tau protein seen in various neurodegenerative diseases. |
2024-01-04 |
2024-01-07 |
Not clear |
| H Peter L. A Missing Origin of the Tau Protein Aggregation Pathway Triggered by Thermal and Biological Forces. Journal of integrative neuroscience. vol 22. issue 6. 2024-01-04. PMID:38176940. |
this article introduces our recent discovery of the missing tau protein property that is of significant relevance to the tau protein and neurodegenerative disease research and medical treatment, aiming to stimulate the collective observation and a new perspective on the tau aggregation mechanism and disease mechanism studies. |
2024-01-04 |
2024-01-07 |
Not clear |
| Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durran. p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica. vol 147. issue 1. 2024-01-04. PMID:38175261. |
tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. |
2024-01-04 |
2024-01-06 |
mouse |
| Sofia Bali, Ruhar Singh, Pawel M Wydorski, Aleksandra Wosztyl, Valerie A Perez, Dailu Chen, Josep Rizo, Lukasz A Joachimia. Ensemble-based design of tau to inhibit aggregation while preserving biological activity. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168322. |
the microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. |
2024-01-03 |
2024-01-06 |
Not clear |
| Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggart. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168389. |
tauopathies are a class of neurodegenerative diseases characterized by the progressive misfolding and accumulation of pathological tau protein in focal regions of the brain, leading to insidious neurodegeneration. |
2024-01-03 |
2024-01-06 |
Not clear |
| Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyma. Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau Biochemistry. 2023-12-28. PMID:38154792. |
reconstitution of the alzheimer's disease tau core structure from recombinant tau the protein tau misfolds into disease-specific fibrillar structures in more than 20 neurodegenerative diseases collectively referred to as tauopathies. |
2023-12-28 |
2023-12-31 |
Not clear |
| Indalo Domene-Serrano, Raquel Cuadros, Felix Hernandez, Jesus Avila, Ismael Santa-Mari. Tridimensional Structural Analysis of Tau Isoforms Generated by Intronic Retention. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-12-25. PMID:38143771. |
tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. |
2023-12-25 |
2023-12-27 |
human |
| Yamei Wang, Jianhao Wang, Hongyu Chen, Xiang Li, Ruifeng Xu, Feng Gao, Hang Yu, Fang Li, Dongdong Qin, Jiabei Wang, Yuke Shi, Yiyi Li, Songyan Liu, Xi Zhang, Shuai Ding, Yiqian Hu, Liqin Huang, Xin-Ya Gao, Zuneng Lu, Jin Luo, Zhi-Hao Wan. A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function. Frontiers in aging neuroscience. vol 15. 2023-12-22. PMID:38131009. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease characterized by extracellular senile plaques including amyloid-β peptides and intracellular neurofibrillary tangles consisting of abnormal tau. |
2023-12-22 |
2023-12-24 |
mouse |
| Joachim Strobel, Hans-Peter Müller, Albert C Ludolph, Ambros J Beer, Nico Sollmann, Jan Kassube. New Perspectives in Radiological and Radiopharmaceutical Hybrid Imaging in Progressive Supranuclear Palsy: A Systematic Review. Cells. vol 12. issue 24. 2023-12-22. PMID:38132096. |
progressive supranuclear palsy (psp) is a neurodegenerative disease characterized by four-repeat tau deposition in various cell types and anatomical regions, and can manifest as several clinical phenotypes, including the most common phenotype, richardson's syndrome. |
2023-12-22 |
2023-12-24 |
Not clear |
| Joachim Strobel, Hans-Peter Müller, Albert C Ludolph, Ambros J Beer, Nico Sollmann, Jan Kassube. New Perspectives in Radiological and Radiopharmaceutical Hybrid Imaging in Progressive Supranuclear Palsy: A Systematic Review. Cells. vol 12. issue 24. 2023-12-22. PMID:38132096. |
specifically, combined pet and mri studies in psp highlight the potential of [18f]av-1451 to detect tau, but also the challenge in differentiating psp from other neurodegenerative diseases. |
2023-12-22 |
2023-12-24 |
Not clear |
| Patrick W Cullinane, Sarah Wrigley, Jacy Bezerra Parmera, Fernanda Valerio, Thomas O Millner, Karen Shaw, Eduardo De Pablo-Fernandez, Thomas T Warner, Zane Jaunmuktan. Pathology of neurodegenerative disease for the general neurologist. Practical neurology. 2023-12-21. PMID:38124186. |
this review aims to elucidate the hallmark pathological features of neurodegenerative diseases commonly seen in general neurology clinics, such as alzheimer's disease and parkinson's disease; rare but well-known diseases, including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy and more recently described entities such as chronic traumatic encephalopathy and age-related tau astrogliopathy. |
2023-12-21 |
2023-12-23 |
Not clear |