| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srinivas Bharath, Michael Hsu, Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Glutathione, iron and Parkinson's disease. Biochemical pharmacology. vol 64. issue 5-6. 2002-10-17. PMID:12213603. |
parkinson's disease (pd) is a progressive neurodegenerative disease involving neurodegeneration of dopaminergic neurons of the substantia nigra (sn), a part of the midbrain. |
2002-10-17 |
2023-08-12 |
Not clear |
| R H Baloh, M G Tansey, E M Johnson, J Milbrand. Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists. The Journal of biological chemistry. vol 275. issue 5. 2000-03-02. PMID:10652334. |
the glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) (gdnf, neurturin, artemin, and persephin) are critical regulators of neurodevelopment and support the survival of midbrain dopaminergic and spinal motor neurons in vitro and in animal disease models making them attractive therapeutic candidates for treatment of neurodegenerative diseases. |
2000-03-02 |
2023-08-12 |
Not clear |
| D S Albeck, B J Hoffer, D Quissell, L A Sanders, G Zerbe, A C Granhol. A non-invasive transport system for GDNF across the blood-brain barrier. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243628. |
this suggests that the ox-26-gdnf conjugate could be utilized for non-invasive treatment of neurodegenerative diseases of the spinal cord or midbrain dopaminergic neurons. |
1997-10-07 |
2023-08-12 |
Not clear |
| N E Saadé, S F Atweh, N B Bahuth, S J Jabbu. Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons. Brain research. vol 751. issue 1. 1997-06-09. PMID:9098562. |
neurodegenerative diseases affecting the midbrain dopaminergic system have been reported to produce spontaneous pains like in parkinson's disease. |
1997-06-09 |
2023-08-12 |
rat |
| J Villares, B Faucheux, O Strada, E C Hirsch, Y Agid, F Javoy-Agi. Autoradiographic study of [125I]epidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:8313172. |
an autoradiographic study of the distribution of egf-binding sites was performed in the mesencephalon of controls and patients with parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. |
1994-03-23 |
2023-08-12 |
Not clear |