| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing He, Zheng Xiang, Xiaoqing Zhu, Zongyong Ai, Jingsong Shen, Tianzhuang Huang, Liegang Liu, Weizhi Ji, Tianqing L. Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP Scientific reports. vol 6. 2018-06-12. PMID:27731318. |
neuroprotective effects of 7, 8-dihydroxyflavone on midbrain dopaminergic neurons in mpp parkinson's disease (pd) is one common neurodegenerative disease caused by a significant loss of midbrain dopaminergic neurons. |
2018-06-12 |
2023-08-13 |
mouse |
| Zhan-Ying Hu, Bo Chen, Jing-Pu Zhang, Yuan-Yuan M. Up-regulation of autophagy-related gene 5 ( The Journal of biological chemistry. vol 292. issue 44. 2017-11-21. PMID:28928221. |
up-regulation of autophagy-related gene 5 ( parkinson's disease (pd) is one of the most epidemic neurodegenerative diseases and is characterized by movement disorders arising from loss of midbrain dopaminergic (da) neurons. |
2017-11-21 |
2023-08-13 |
Not clear |
| Xue-Yuan Niu, Hou-Ju Huang, Jin-Bao Zhang, Chan Zhang, Wei-Guang Chen, Chen-You Sun, Yu-Qiang Ding, Min Lia. Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP. Neuroscience. vol 339. 2017-10-30. PMID:27693472. |
parkinson's disease (pd) is a neurodegenerative disease caused by a gradual loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta (snpc) during aging. |
2017-10-30 |
2023-08-13 |
mouse |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
pre-b-cell leukemia homeobox (pbx) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mdan) as well as their role in neurodegenerative diseases are unknown. |
2017-06-28 |
2023-08-13 |
human |
| Wei Zhu, Jie Li, Yigang Liu, Kun Xie, Le Wang, Jianmin Fan. Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways. Immunopharmacology and immunotoxicology. vol 38. issue 3. 2017-03-21. PMID:27075782. |
mesencephalic astrocyte-derived neurotrophic factor (manf), a new evolutionary conserved neurotrophic factor (ntf), has been reported to protect midbrain dopaminergic neurons of neurodegenerative diseases such as parkinson's disease (pd) model. |
2017-03-21 |
2023-08-13 |
Not clear |
| Noriko Nakano, Satoru Matsuda, Mayuko Ichimura, Akari Minami, Mako Ogino, Toshiyuki Murai, Yasuko Kitagish. PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review). International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28000847. |
parkinson's disease (pd) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| Anu Planken, Lille Kurvits, Ene Reimann, Liis Kadastik-Eerme, Külli Kingo, Sulev Kõks, Pille Tab. Looking beyond the brain to improve the pathogenic understanding of Parkinson's disease: implications of whole transcriptome profiling of Patients' skin. BMC neurology. vol 17. issue 1. 2017-02-27. PMID:28068941. |
parkinson's disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss of dopaminergic neurons in the midbrain, however non-neuronal symptoms are also common. |
2017-02-27 |
2023-08-13 |
Not clear |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
parkinson's disease (pd) is a neurodegenerative disease characterised by histopathological and biochemical manifestations such as loss of midbrain dopaminergic (da) neurons and decrease in dopamine levels accompanied by a concomitant neuroinflammatory response in the affected brain regions. |
2016-10-19 |
2023-08-13 |
mouse |
| Sua In, Chang-Won Hong, Boyoung Choi, Bong-Geum Jang, Min-Ju Ki. Inhibition of Mitochondrial Clearance and Cu/Zn-SOD Activity Enhance 6-Hydroxydopamine-Induced Neuronal Apoptosis. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25631711. |
parkinson's disease (pd) is a common movement disorder among neurodegenerative diseases, involving neuronal cell death in the substantia nigra of the midbrain. |
2016-10-07 |
2023-08-13 |
Not clear |
| Yujeong Lee, Hye Jeong Chun, Kyung Moon Lee, Young-Suk Jung, Jaewon Le. Silibinin suppresses astroglial activation in a mouse model of acute Parkinson's disease by modulating the ERK and JNK signaling pathways. Brain research. vol 1627. 2016-08-17. PMID:26434409. |
parkinson's disease (pd) is the second-most common neurodegenerative disease after alzheimer's disease, and is characterized by dopaminergic neuronal loss in midbrain. |
2016-08-17 |
2023-08-13 |
mouse |
| Gianina Toller, Babu Adhimoolam, Katherine P Rankin, Hans-Jürgen Huppertz, Martin Kurthen, Hennric Jokei. Right fronto-limbic atrophy is associated with reduced empathy in refractory unilateral mesial temporal lobe epilepsy. Neuropsychologia. vol 78. 2016-08-04. PMID:26363299. |
in line with previous evidence from patients with neurodegenerative disease and stroke, the present study suggests that empathy depends upon the integrity of right fronto-limbic and brainstem regions and highlights the importance of the right mesial temporal lobe and midbrain structures for human empathy. |
2016-08-04 |
2023-08-13 |
human |
| Saori Tsujii, Mitsue Ishisaka, Hideaki Har. Modulation of endoplasmic reticulum stress in Parkinson's disease. European journal of pharmacology. vol 765. 2016-08-01. PMID:26297973. |
parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. |
2016-08-01 |
2023-08-13 |
Not clear |
| Zhiguo Che. Cell Therapy for Parkinson's Disease: New Hope from Reprogramming Technologies. Aging and disease. vol 6. issue 6. 2015-11-30. PMID:26618051. |
parkinson's disease (pd) is a neurodegenerative disease with the major pathology being the progressive loss of dopaminergic (da) midbrain neurons in the substantia nigra. |
2015-11-30 |
2023-08-13 |
Not clear |
| Kenneth K B Tan, Jason Y Tann, Sharvari R Sathe, Seok Hong Goh, Dongliang Ma, Eyleen L K Goh, Evelyn K F Yi. Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns. Biomaterials. vol 43. 2015-09-21. PMID:25591959. |
parkinson's disease (pd) is a neurodegenerative disease attributed to the loss of midbrain dopaminergic (da) neurons. |
2015-09-21 |
2023-08-13 |
Not clear |
| Margherita Grasso, Paola Piscopo, Annamaria Confaloni, Michela A Dent. Circulating miRNAs as biomarkers for neurodegenerative disorders. Molecules (Basel, Switzerland). vol 19. issue 5. 2015-06-01. PMID:24858274. |
all neurodegenerative diseases are characterized by neuronal loss and death in specific areas of the brain, for example, hippocampus and cortex for ad, midbrain for pd, frontal and temporal lobes for ftd. |
2015-06-01 |
2023-08-13 |
Not clear |
| Saeed Esmaeili-Mahani, Somayeh Vazifekhah, Hamzeh Pasban-Aliabadi, Mehdi Abbasnejad, Vahid Sheiban. Protective effect of orexin-A on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24135219. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by progressive and selective death of midbrain dopaminergic neurons. |
2014-07-22 |
2023-08-12 |
human |
| Sabrina M Heman-Ackah, Martina Hallegger, Mahendra S Rao, Matthew J A Woo. RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Frontiers in molecular neuroscience. vol 6. 2014-06-24. PMID:24312000. |
parkinson's disease (pd) is a debilitating neurodegenerative disease characterized primarily by the selective death of dopaminergic (da) neurons in the substantia nigra pars compacta of the midbrain. |
2014-06-24 |
2023-08-12 |
Not clear |
| Genaro Gabriel Ortiz, Fermín P Pacheco-Moisés, Víctor M Gómez-Rodríguez, Erika D González-Renovato, Erandhis D Torres-Sánchez, Ana C Ramírez-Anguian. Fish oil, melatonin and vitamin E attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine. Metabolic brain disease. vol 28. issue 4. 2014-06-20. PMID:23703110. |
parkinson's disease is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. |
2014-06-20 |
2023-08-12 |
mouse |
| Hengjun J Kim, Sang Joon Kim, Ho Sung Kim, Choong Gon Choi, Namkug Kim, Seungbong Han, Eun Hye Jang, Sun J Chung, Chong Sik Le. Alterations of mean diffusivity in brain white matter and deep gray matter in Parkinson's disease. Neuroscience letters. vol 550. 2014-04-11. PMID:23831353. |
although parkinson's disease is a neurodegenerative disease primarily involving basal ganglia and midbrain, the deficit of white matter is also involved during the disease progression. |
2014-04-11 |
2023-08-12 |
Not clear |
| Frederick Daidone, Riccardo Montioli, Alessandro Paiardini, Barbara Cellini, Antonio Macchiarulo, Giorgio Giardina, Francesco Bossa, Carla Borri Voltattorn. Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384042. |
pd is a neurodegenerative disease mainly due to a progressive loss of dopamine-producing cells in the midbrain. |
2012-08-27 |
2023-08-12 |
human |