| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gunjan Thakur, Vikas Kumar, Keun Woo Lee, Chungkil Wo. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes. vol 13. issue 8. 2022-08-26. PMID:36011337. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. |
2022-08-26 |
2023-08-14 |
Not clear |
| Abel Worku Tessema, Hansol Lee, Yelim Gong, Hwapyeong Cho, Hamdia Murad Adem, Ilwoo Lyu, Jae-Hyeok Lee, Hyung Joon Ch. Automated Volumetric Determination of High R NMR in biomedicine. 2022-07-01. PMID:35775868. |
automated volumetric determination of high r the establishment of an unbiased protocol for the automated volumetric measurement of iron-rich regions in the substantia nigra (sn) is clinically important for diagnosing neurodegenerative diseases exhibiting midbrain atrophy, such as progressive supranuclear palsy (psp). |
2022-07-01 |
2023-08-14 |
Not clear |
| Jinchuan Zhao, Xin Gao, Liangyou Zhao, Yiqing Wang, Jingbo Zhang, Shumin Li. Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-04-01. PMID:35360659. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical pd motor symptoms. |
2022-04-01 |
2023-08-13 |
mouse |
| Dewei He, Guiqiu Hu, Ang Zhou, Yanting Liu, Bingxu Huang, Yingchun Su, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Shoupeng Fu, Dianfeng Li. Echinocystic Acid Inhibits Inflammation and Exerts Neuroprotective Effects in MPTP-Induced Parkinson's Disease Model Mice. Frontiers in pharmacology. vol 12. 2022-02-07. PMID:35126128. |
parkinson's disease (pd), the second primary neurodegenerative disease affecting human health, is mainly characterized by dopaminergic neuron damage in the midbrain and the clinical manifestation of movement disorders. |
2022-02-07 |
2023-08-13 |
mouse |
| Chitrakshi Pant, Moumita Chakrabarti, Jolly Janette Mendonza, Bogonda Ganganna, Srihari Pabbaraja, Manika Pal Bhadr. ACS chemical neuroscience. vol 12. issue 23. 2021-12-01. PMID:34763419. |
parkinson's disease is a chronic and progressive neurodegenerative disease, induced by slow and progressive death of the dopaminergic (da) neurons from the midbrain region called substantia nigra (snc) leading to difficulty in locomotion. |
2021-12-01 |
2023-08-13 |
Not clear |
| Bo Ning, Gongbo Guo, Chunming Gu, Jiadi Xu, Adnan Bibic, Xiaofei He, Hongshuai Liu, Lin Chen, Zhiliang Wei, Wenzhen Duan, Peiying Liu, Hanzhang Lu, Peter C M van Zijl, Christopher A Ross, Wanli Smith, Jun Hu. Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study. Neuro-degenerative diseases. vol 20. issue 2-3. 2021-10-14. PMID:33152738. |
parkinson's disease (pd) is the second most common neurodegenerative disease and the most common movement disorder characterized by motor impairments resulting from midbrain dopamine neuron loss. |
2021-10-14 |
2023-08-13 |
mouse |
| Jayanth Anantha, Susan R Goulding, Eszter Tuboly, Adam G O'Mahony, Gerard M Moloney, Gareth Lomansey, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease. Molecular neurobiology. 2021-10-08. PMID:34623600. |
parkinson's disease (pd) is a neurodegenerative disease characterised by the progressive degeneration of midbrain dopaminergic neurons, coupled with the intracellular accumulation of α-synuclein. |
2021-10-08 |
2023-08-13 |
human |
| Rajasree Odumpatta, Mohanapriya Arumuga. Integrative Analysis of Gene Expression and Regulatory Network Interaction Data Reveals the Protein Kinase C Family of Serine/Threonine Receptors as a Significant Druggable Target for Parkinson's Disease. Journal of molecular neuroscience : MN. vol 71. issue 3. 2021-10-04. PMID:32728898. |
parkinson's disease (pd) is a progressive neurodegenerative disease affecting the ventral midbrain dopaminergic neurons, resulting in motor defects mainly tremor, rigidity, and bradykinesia along with a wide array of non-motor symptoms. |
2021-10-04 |
2023-08-13 |
Not clear |
| Rong Yin, Jie Xue, Yanfeng Tan, Chuantao Fang, Chunchun Hu, Qian Yang, Xinyu Mei, Dashi Q. The Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2021. 2021-09-29. PMID:34567415. |
parkinson's disease (pd) is a complex neurodegenerative disease, manifested by the progressive functional impairment of the midbrain nigral dopaminergic neurons. |
2021-09-29 |
2023-08-13 |
Not clear |
| Henrik Renner, Hans R Schöler, Jan M Brude. Combining Automated Organoid Workflows With Artificial Intelligence-Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High-Throughput Screens for Parkinson's Disease and Beyond. Movement disorders : official journal of the Movement Disorder Society. 2021-09-20. PMID:34498298. |
parkinson's disease (pd) is the second most common neurodegenerative disease and primarily characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2021-09-20 |
2023-08-13 |
human |
| Luca Magistrelli, Elena Contaldi, Cristoforo Com. The Impact of Life (Basel, Switzerland). vol 11. issue 8. 2021-08-31. PMID:34440548. |
the impact of parkinson's disease (pd) is a common and progressive neurodegenerative disease, caused by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain, which is clinically characterized by a constellation of motor and non-motor manifestations. |
2021-08-31 |
2023-08-13 |
Not clear |
| Marianne Amalric, Tommy Pattij, Ioannis Sotiropoulos, Joana M Silva, Nuno Sousa, Samira Ztaou, Cristiano Chiamulera, Lars U Wahlberg, Dwaine F Emerich, Giovanna Paolon. Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders. Frontiers in behavioral neuroscience. vol 15. 2021-08-10. PMID:34366802. |
historically, many investigations into neurodegenerative diseases have focused on alterations in specific neuronal populations such as, for example, the loss of midbrain dopaminergic neurons in parkinson's disease (pd) and loss of cholinergic transmission in alzheimer's disease (ad). |
2021-08-10 |
2023-08-13 |
human |
| Derya Cansız, Unsal Veli Ustundag, Ismail Unal, A Ata Alturfan, Ebru Emekli-Alturfa. Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity. Drug and chemical toxicology. 2021-08-03. PMID:34340603. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases due to the loss of dopaminergic neurons in the midbrain in the substantia nigra. |
2021-08-03 |
2023-08-13 |
zebrafish |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (sn) in the midbrain due to loss of dopaminergic neurons. |
2021-07-26 |
2023-08-13 |
rat |
| Qiankun Lv, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Wei Huan. MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33448372. |
parkinson disease (pd) is a neurodegenerative disease characterized by selective loss of dopaminergic (da) neurons in the midbrain. |
2021-06-21 |
2023-08-13 |
mouse |
| Mahalaxmi Iyer, Mohana Devi Subramaniam, Dhivya Venkatesan, Ssang-Goo Cho, Matias Ryding, Morten Meyer, Balachandar Vellingir. Role of RhoA-ROCK signaling in Parkinson's disease. European journal of pharmacology. vol 894. 2021-05-28. PMID:33345850. |
parkinson's disease (pd) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (da) neurons. |
2021-05-28 |
2023-08-13 |
Not clear |
| Luca Magistrelli, Marco Ferrari, Alessia Furgiuele, Anna Vera Milner, Elena Contaldi, Cristoforo Comi, Marco Cosentino, Franca Marin. Polymorphisms of Dopamine Receptor Genes and Parkinson's Disease: Clinical Relevance and Future Perspectives. International journal of molecular sciences. vol 22. issue 7. 2021-05-12. PMID:33917417. |
parkinson's disease (pd) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. |
2021-05-12 |
2023-08-13 |
Not clear |
| Yumin Zheng, Li Dong, Na Liu, Xiaoguang Luo, Zhiyi H. Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. BioMed research international. vol 2020. 2021-04-15. PMID:33204711. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons in the substantia nigra. |
2021-04-15 |
2023-08-13 |
Not clear |
| Akio Mori, Yuzuru Imai, Nobutaka Hattor. Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease. International journal of molecular sciences. vol 21. issue 9. 2021-02-10. PMID:32392751. |
parkinson's disease (pd) is the second most common neurodegenerative disease; it is characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of neuronal inclusions, mainly consisting of α-synuclein (α-syn) fibrils in the affected regions. |
2021-02-10 |
2023-08-13 |
Not clear |
| Fabin Han, Baoyang H. Stem Cell Therapy for Parkinson's Disease. Advances in experimental medicine and biology. vol 1266. 2021-01-08. PMID:33105493. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases caused by specific degeneration and loss of dopamine neurons in substantia nigra of the midbrain. |
2021-01-08 |
2023-08-13 |
human |