| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junpeng Zhao, Qunyuan X. Emerging restorative treatments for Parkinson's disease: manipulation and inducement of dopaminergic neurons from adult stem cells. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495964. |
parkinson's disease (pd) is a common neurodegenerative disease, characterized by a selective loss of midbrain dopaminergic (da) neurons. |
2012-01-12 |
2023-08-12 |
human |
| Jeffrey C L Looi, Matthew D Macfarlane, Mark Walterfang, Martin Styner, Dennis Velakoulis, Jimmy Lätt, Danielle van Westen, Christer Nilsso. Morphometric analysis of subcortical structures in progressive supranuclear palsy: In vivo evidence of neostriatal and mesencephalic atrophy. Psychiatry research. vol 194. issue 2. 2011-12-06. PMID:21899988. |
progressive supranuclear palsy (psp) is a neurodegenerative disease characterized by gait and postural disturbance, gaze palsy, apathy, decreased verbal fluency and dysexecutive symptoms, with some of these clinical features potentially having origins in degeneration of frontostriatal circuits and the mesencephalon. |
2011-12-06 |
2023-08-12 |
human |
| Tatsuya Ohnuki, Atsushi Nakamura, Shigeru Okuyama, Shoji Nakamur. Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson's disease. Brain research. vol 1346. 2010-10-19. PMID:20513370. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. |
2010-10-19 |
2023-08-12 |
monkey |
| Aleksandra Glavaski-Joksimovic, Tamas Virag, Qin A Chang, Neva C West, Thomas A Mangatu, Michael P McGrogan, Millicent Dugich-Djordjevic, Martha C Boh. Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitors. Cell transplantation. vol 18. issue 7. 2010-07-08. PMID:19796495. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the selective loss of dopaminergic (da) neurons in the midbrain. |
2010-07-08 |
2023-08-12 |
human |
| Dong-Hyuk Park, David J Eve, Yong-Gu Chung, Paul R Sanber. Regenerative medicine for neurological disorders. TheScientificWorldJournal. vol 10. 2010-06-24. PMID:20305989. |
fetal neural tissues, such as ventral mesencephalon, striatum, and schwann cells, were investigated for neurodegenerative diseases or spinal cord injury. |
2010-06-24 |
2023-08-12 |
human |
| Julia Fuchs, Jakob C Mueller, Peter Lichtner, Claudia Schulte, Marita Munz, Daniela Berg, Ullrich Wüllner, Thomas Illig, Manu Sharma, Thomas Gasse. The transcription factor PITX3 is associated with sporadic Parkinson's disease. Neurobiology of aging. vol 30. issue 5. 2009-06-22. PMID:17905480. |
parkinson's disease (pd) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta. |
2009-06-22 |
2023-08-12 |
Not clear |
| Jaana M Jurvansuu, Adrian Goldma. Recent inventions on receptor tyrosine kinase RET modulation. Recent patents on biotechnology. vol 2. issue 1. 2009-03-16. PMID:19075852. |
therefore, the neuroprotective capacity of ret activation to override the apoptotic program in neurodegenerative diseases, like in dying midbrain dopaminergic neurons in parkinson's disease, is of great interest. |
2009-03-16 |
2023-08-12 |
Not clear |
| Jianyong Wang, Helen M Duhart, Zengjun Xu, Tucker A Patterson, Glenn D Newport, Syed F Al. Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18069091. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. |
2008-07-28 |
2023-08-12 |
Not clear |
| K S Bankiewicz, R Sanchez-Pernaute, Y Oiwa, M Kohutnicka, A Cummins, J Eberlin. Preclinical models of Parkinson's disease. Current protocols in neuroscience. vol Chapter 9. 2008-05-13. PMID:18428552. |
parkinson's disease is a neurodegenerative disease in which pigmented midbrain neurons progressively die producing a dopamine (da) deficit in the striatum which manifests as an akinetic movement disorder. |
2008-05-13 |
2023-08-12 |
Not clear |
| Justin D Boyd, Haeman Jang, Kennie R Shepherd, Ciaran Faherty, Sally Slack, Yun Jiao, Richard J Smeyn. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain research. vol 1175. 2008-01-25. PMID:17884023. |
parkinson's disease (pd) is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. |
2008-01-25 |
2023-08-12 |
mouse |
| Jianyong Wang, Zengjun Xu, Hong Fang, Helen M Duhart, Tucker A Patterson, Syed F Al. Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study. Neurotoxicology. vol 28. issue 5. 2007-12-26. PMID:17475336. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. |
2007-12-26 |
2023-08-12 |
mouse |
| Ikuko Mizuta, Wataru Satake, Yuko Nakabayashi, Chiyomi Ito, Satoko Suzuki, Yoshio Momose, Yoshitaka Nagai, Akira Oka, Hidetoshi Inoko, Jiro Fukae, Yuko Saito, Motoji Sawabe, Shigeo Murayama, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Tatsushi Tod. Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Human molecular genetics. vol 15. issue 7. 2006-09-19. PMID:16500997. |
parkinson's disease (pd), one of the most common human neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2006-09-19 |
2023-08-12 |
human |
| Seung U Kim, In H Park, Tae H Kim, Kwang S Kim, Hyun B Choi, Seok H Hong, Jung H Bang, Myung A Lee, In S Joo, Chong S Lee, Yong S Ki. Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 26. issue 2. 2006-06-23. PMID:16708545. |
parkinson disease is a neurodegenerative disease characterized by loss of midbrain dopaminergic neurons resulting in movement disorder. |
2006-06-23 |
2023-08-12 |
human |
| Hitoshi Fukuda, Jun Takahash. Embryonic stem cells as a cell source for treating Parkinson's disease. Expert opinion on biological therapy. vol 5. issue 10. 2006-05-31. PMID:16197334. |
parkinson's disease (pd) is a neurodegenerative disease characterised by a loss of midbrain dopaminergic (da) neurons. |
2006-05-31 |
2023-08-12 |
Not clear |
| Andisheh Eslambol. Marmoset monkey models of Parkinson's disease: which model, when and why? Brain research bulletin. vol 68. issue 3. 2006-03-30. PMID:16325013. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, with clinical features of tremor, muscular rigidity and akinesia, occurring as a result of midbrain dopamine loss. |
2006-03-30 |
2023-08-12 |
monkey |
| Charleen T Chu, Jian-hui Zhu, Guodong Cao, Armando Signore, Suping Wang, Jun Che. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16156740. |
parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. |
2005-10-27 |
2023-08-12 |
mouse |
| Claudia M Testa, Todd B Sherer, J Timothy Greenamyr. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790535. |
to better investigate the role of mitochondria and complex i inhibition in chronic, progressive neurodegenerative disease, we developed methods for long-term culture of rodent postnatal midbrain organotypic slices. |
2005-06-13 |
2023-08-12 |
rat |
| Dong-Wook Ki. Efficient induction of dopaminergic neurons from embryonic stem cells for application to Parkinson's disease. Yonsei medical journal. vol 45 Suppl. 2004-08-17. PMID:15250046. |
for cell replacement therapy of neurodegenerative diseases such as parkinson's disease (pd), methods for efficiently generating midbrain dopaminergic (da) neurons from embryonic stem (es) cells have been investigated. |
2004-08-17 |
2023-08-12 |
Not clear |
| Yuan-Yang Lai, Jerome M Siege. Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder. Molecular neurobiology. vol 27. issue 2. 2003-08-13. PMID:12777684. |
parkinson's disease (pd) is a progressive neurodegenerative disease that is caused by a loss of neurons in the ventral midbrain. |
2003-08-13 |
2023-08-12 |
human |
| David G Le Couteur, Michael Muller, Maria C Yang, George D Mellick, Allan J McLea. Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on environmental health. vol 17. issue 1. 2002-12-24. PMID:12088093. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by dopaminergic cell death and deposition of lewy bodies within the substantia nigra of the midbrain. |
2002-12-24 |
2023-08-12 |
Not clear |