| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Suzuki, K Takahashi, K Yasumoto, S Amae, M Yoshizawa, N Fuse, S Shibahar. Role of neurofibromin in modulation of expression of the tyrosinase-related protein 2 gene. Journal of biochemistry. vol 124. issue 5. 1999-02-11. PMID:9792924. |
neurofibromin is the protein product of a gene linked to neurofibromatosis type 1 (nf1), which is characterized by multiple neurofibromas and abnormalities in skin pigmentation. |
1999-02-11 |
2023-08-12 |
human |
| P Wolkenstein, P Dec. [Neurofibromatosis]. Neuro-Chirurgie. vol 44. issue 4. 1999-01-26. PMID:9864698. |
nf1 is characterized by its cutaneous manifestations, café au lait spots, lentigines and neurofibromas. |
1999-01-26 |
2023-08-12 |
Not clear |
| V F Mautner, S Schröder, S M Pulst, H Ostertag, L Kluw. [Neurofibromatosis versus schwannomatosis]. Fortschritte der Neurologie-Psychiatrie. vol 66. issue 6. 1998-08-17. PMID:9676422. |
neurofibromas are more common in nf1 and schwannomas are typical for nf2, but pathological histology does not provide sufficient evidence for diagnosis. |
1998-08-17 |
2023-08-12 |
Not clear |
| E Ars, H Kruyer, A Gaona, P Casquero, J Rosell, V Volpini, E Serra, C Lázaro, X Estivil. A clinical variant of neurofibromatosis type 1: familial spinal neurofibromatosis with a frameshift mutation in the NF1 gene. American journal of human genetics. vol 62. issue 4. 1998-06-10. PMID:9529361. |
all the affected members presented multiple spinal neurofibromas and café au lait spots, one member had cutaneous neurofibromas, and some members had other signs of nf1. |
1998-06-10 |
2023-08-12 |
Not clear |
| Y Tang, S Marwaha, J L Rutkowski, G I Tennekoon, P C Phillips, J Fiel. A role for Pak protein kinases in Schwann cell transformation. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560242. |
neurofibromatosis type 1 (nf1), a common autosomal dominant disorder caused by loss of the nf1 gene, is characterized clinically by neurofibromas and more rarely by neurofibrosarcomas. |
1998-06-04 |
2023-08-12 |
rat |
| L Sherman, L B Jacoby, J Lampe, P Pelton, A Aguzzi, P Herrlich, H Pont. CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene. Cancer research. vol 57. issue 21. 1997-11-20. PMID:9354454. |
we examined cd44 expression in normal sciatic nerves, in schwannomas with confirmed nf2 mutations, and in neurofibromas and malignant peripheral nerve sheath tumor tissue and cell lines from nf1 patients. |
1997-11-20 |
2023-08-12 |
Not clear |
| E Serra, S Puig, D Otero, A Gaona, H Kruyer, E Ars, X Estivill, C Lázar. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. American journal of human genetics. vol 61. issue 3. 1997-10-22. PMID:9326316. |
confirmation of a double-hit model for the nf1 gene in benign neurofibromas. |
1997-10-22 |
2023-08-12 |
Not clear |
| E Serra, S Puig, D Otero, A Gaona, H Kruyer, E Ars, X Estivill, C Lázar. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. American journal of human genetics. vol 61. issue 3. 1997-10-22. PMID:9326316. |
recently, somatic loss of heterozygosity (loh) has been described for neurofibromas, and mutations in both copies of the nf1 gene have been reported for a dermal neurofibroma. |
1997-10-22 |
2023-08-12 |
Not clear |
| E Serra, S Puig, D Otero, A Gaona, H Kruyer, E Ars, X Estivill, C Lázar. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. American journal of human genetics. vol 61. issue 3. 1997-10-22. PMID:9326316. |
the aim of our study was the analysis of the nf1 locus in benign neurofibromas in nf1 patients. |
1997-10-22 |
2023-08-12 |
Not clear |
| E Serra, S Puig, D Otero, A Gaona, H Kruyer, E Ars, X Estivill, C Lázar. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. American journal of human genetics. vol 61. issue 3. 1997-10-22. PMID:9326316. |
we have analyzed five intragenic nf1 markers and six extragenic markers, and we have found loh in 25% of the neurofibromas (corresponding to 53% of the patients). |
1997-10-22 |
2023-08-12 |
Not clear |
| E Serra, S Puig, D Otero, A Gaona, H Kruyer, E Ars, X Estivill, C Lázar. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. American journal of human genetics. vol 61. issue 3. 1997-10-22. PMID:9326316. |
in addition, we found that in the neurofibromas of patients from familial cases the deletions occurred in the allele that is not transmitted with the disease, indicating that both copies of the nf1 gene were inactivated in these tumors. |
1997-10-22 |
2023-08-12 |
Not clear |
| E Serra, S Puig, D Otero, A Gaona, H Kruyer, E Ars, X Estivill, C Lázar. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. American journal of human genetics. vol 61. issue 3. 1997-10-22. PMID:9326316. |
therefore, the recent reports mentioned above, together with our findings, strongly support the double inactivation of the nf1 gene in benign neurofibromas. |
1997-10-22 |
2023-08-12 |
Not clear |
| U N Rao, E Sonmez-Alpan, G K Michalopoulo. Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors. Human pathology. vol 28. issue 9. 1997-10-21. PMID:9308731. |
hgf has been recently found to be a mitogen for rat schwann cells and to be present in neurofibromas in nf1 patients. |
1997-10-21 |
2023-08-12 |
rat |
| J M Goujon, B Bataille, E Menet, F Lapierr. [Neurinomas-neurofibromas]. Neuro-Chirurgie. vol 43. issue 1. 1997-08-05. PMID:9205625. |
the behavior of each tumor is quite different and only neurofibromas may present malignant transformation, especially when arising in patients with von recklinghausen disease (nf1 with multiple neurofibromas). |
1997-08-05 |
2023-08-12 |
Not clear |
| K Däschner, G Assum, I Eisenbarth, W Krone, S Hoffmeyer, S Wortmann, B Heymer, H Kehrer-Sawatzk. Clonal origin of tumor cells in a plexiform neurofibroma with LOH in NF1 intron 38 and in dermal neurofibromas without LOH of the NF1 gene. Biochemical and biophysical research communications. vol 234. issue 2. 1997-07-10. PMID:9177273. |
clonal origin of tumor cells in a plexiform neurofibroma with loh in nf1 intron 38 and in dermal neurofibromas without loh of the nf1 gene. |
1997-07-10 |
2023-08-12 |
Not clear |
| K Däschner, G Assum, I Eisenbarth, W Krone, S Hoffmeyer, S Wortmann, B Heymer, H Kehrer-Sawatzk. Clonal origin of tumor cells in a plexiform neurofibroma with LOH in NF1 intron 38 and in dermal neurofibromas without LOH of the NF1 gene. Biochemical and biophysical research communications. vol 234. issue 2. 1997-07-10. PMID:9177273. |
loh at the nf1 locus was investigated in 38 neurofibromas of 26 nf1 patients. |
1997-07-10 |
2023-08-12 |
Not clear |
| M Poyhonen, E L Leisti, S Kytölä, J Leist. Hereditary spinal neurofibromatosis: a rare form of NF1? Journal of medical genetics. vol 34. issue 3. 1997-04-30. PMID:9132486. |
the findings in the present family, together with those in a family previously described, suggest a clinically distinct form of neurofibromatosis with extensive spinal neurofibromas and café au lait macules, which may be allelic to the nf1 gene. |
1997-04-30 |
2023-08-12 |
Not clear |
| H A Kim, B Ling, N Ratne. Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Molecular and cellular biology. vol 17. issue 2. 1997-02-18. PMID:9001241. |
we show that mouse schwann cells heterozygous or null at nf1 display angiogenic and invasive properties, mimicking the behavior of schwann cells from human neurofibromas. |
1997-02-18 |
2023-08-12 |
mouse |
| A J Cappione, B L French, G R Skus. A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. American journal of human genetics. vol 60. issue 2. 1997-02-13. PMID:9012403. |
we observed varying levels of nf1 mrna editing in different tumors, with a higher range of editing levels in more malignant tumors (e.g., neurofibrosarcomas) compared to benign tumors (cutaneous neurofibromas). |
1997-02-13 |
2023-08-12 |
Not clear |
| S Sawada, S Florell, S M Purandare, M Ota, K Stephens, D Viskochi. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nature genetics. vol 14. issue 1. 1996-10-24. PMID:8782831. |
identification of nf1 mutations in both alleles of a dermal neurofibroma. |
1996-10-24 |
2023-08-12 |
Not clear |