| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Danglot, C Teinturier, A Duverger, A Bernhei. Tissue-specific alternative splicing of neurofibromatosis 1 (NF1) mRNA. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 48. issue 8-9. 1995-03-22. PMID:7858173. |
it is also the form expressed in the peripheral nerve, adrenal medulla, benign nf1 neurofibromas and nf1 neurosarcomas. |
1995-03-22 |
2023-08-12 |
human |
| H Suzuki, K Takahashi, K Yasumoto, S Shibahar. Activation of the tyrosinase gene promoter by neurofibromin. Biochemical and biophysical research communications. vol 205. issue 3. 1995-02-02. PMID:7811291. |
neurofibromatosis type 1 (nf1) is a hereditary cancer syndrome, characterized by café-au-lait skin spots and multiple neurofibromas. |
1995-02-02 |
2023-08-12 |
Not clear |
| E A Sartin, S E Doran, M G Riddell, G A Herrera, G S Tennyson, G D'Andrea, R D Whitley, F S Collin. Characterization of naturally occurring cutaneous neurofibromatosis in Holstein cattle. A disorder resembling neurofibromatosis type 1 in humans. The American journal of pathology. vol 145. issue 5. 1994-11-29. PMID:7977647. |
all cutaneous lesions but one were consistent with neurofibromas in noncutaneous sites in cattle and neurofibromas in patients with nf1. |
1994-11-29 |
2023-08-12 |
cattle |
| H Kehrer, W Kron. Spontaneous chromosomal aberrations in cell cultures from patients with neurofibromatosis 1. Mutation research. vol 306. issue 1. 1994-05-06. PMID:7512203. |
neurofibroma-derived cell cultures, skin fibroblast strains from nf1 patients, melanocyte cultures from café-au-lait spots and melanocytes from skin overlying neurofibroma were investigated with regard to the frequencies of spontaneous chromosomal aberrations. |
1994-05-06 |
2023-08-12 |
Not clear |
| H Kehrer, W Kron. Spontaneous chromosomal aberrations in cell cultures from patients with neurofibromatosis 1. Mutation research. vol 306. issue 1. 1994-05-06. PMID:7512203. |
a 3.4-fold increased rate of stable and unstable chromosome aberrations in 34 neurofibroma cultures of 18 nf1 patients was noticed in comparison to 17 skin biopsy-derived cultures of healthy probands. |
1994-05-06 |
2023-08-12 |
Not clear |
| T Nakamura, T Nemoto, M Arai, Y Yamazaki, T Kasuga, D H Gutmann, F S Collins, T Ishikaw. Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell. The American journal of pathology. vol 144. issue 3. 1994-04-11. PMID:8129040. |
immunoblotting also revealed positive expression of the 250-kd nf1 gene product in the brain, the normal peripheral nerves, and 7 of 14 enu-induced neurofibromas. |
1994-04-11 |
2023-08-12 |
Not clear |
| L M Kayes, W Burke, V M Riccardi, R Bennett, P Ehrlich, A Rubenstein, K Stephen. Deletions spanning the neurofibromatosis 1 gene: identification and phenotype of five patients. American journal of human genetics. vol 54. issue 3. 1994-03-25. PMID:8116612. |
all five patients with deletions were remarkable for exhibiting a large number of neurofibromas for their age, suggesting that deletion of an unknown gene in the nf1 region may affect tumor initiation or development. |
1994-03-25 |
2023-08-12 |
Not clear |
| T Hotta, K Asai, N Takeda, H Yoshizumi, A Tatematsu, K Nakanishi, Y Z Eksioglu, I Isobe, T Kat. Growth-promoting action of adenosine-containing dinucleotide on neuroblastoma cells: detection of adenosine-cytidine dinucleotide (ApCp) in neurofibroma (NF1) extracts. Journal of neurochemistry. vol 61. issue 4. 1993-10-21. PMID:8376996. |
growth-promoting action of adenosine-containing dinucleotide on neuroblastoma cells: detection of adenosine-cytidine dinucleotide (apcp) in neurofibroma (nf1) extracts. |
1993-10-21 |
2023-08-12 |
human |
| R A Lothe, G Saeter, H E Danielsen, A E Stenwig, B Høyheim, P O'Connell, A L Børrese. Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1). Pathology, research and practice. vol 189. issue 4. 1993-09-16. PMID:8351250. |
our data indicate that the nf1 gene may function as a tumour suppressor gene, and that, either by effect of dose reduction or complete inactivation, both the nf1 gene and the tp53 gene may be critical for the progression of a neurofibroma to a malignant schwannoma. |
1993-09-16 |
2023-08-12 |
Not clear |
| W J Neary, V E Newton, M Vidler, R T Ramsden, R H Lye, J E Dutton, P L Richardson, R Harris, D G Evans, T Stracha. A clinical, genetic and audiological study of patients and families with bilateral acoustic neurofibromatosis. The Journal of laryngology and otology. vol 107. issue 1. 1993-04-06. PMID:8445320. |
nf1 is characterized by the appearance of café-au-lait spots and neurofibromas in addition to iris hamartomas, or lisch nodules, of the eye, during the first and second decades. |
1993-04-06 |
2023-08-12 |
human |
| T Hotta, K Asai, N Takeda, A Tatematsu, K Nakanishi, Y Z Eksioglu, I Isobe, T Kat. Neuroblastoma growth factors derived from neurofibroma (NF1): participation of uridine in a neuroblastoma growth. Journal of neurochemistry. vol 60. issue 1. 1993-01-25. PMID:8417151. |
neuroblastoma growth factors derived from neurofibroma (nf1): participation of uridine in a neuroblastoma growth. |
1993-01-25 |
2023-08-12 |
human |
| T Hotta, K Asai, N Takeda, A Tatematsu, K Nakanishi, Y Z Eksioglu, I Isobe, T Kat. Neuroblastoma growth factors derived from neurofibroma (NF1): participation of uridine in a neuroblastoma growth. Journal of neurochemistry. vol 60. issue 1. 1993-01-25. PMID:8417151. |
this activity was also detected in the extracts of neurofibroma type 1 (nf1; von recklinghausen neurofibromatosis) comprising aberrant schwann cell growth. |
1993-01-25 |
2023-08-12 |
human |
| T N Basu, D H Gutmann, J A Fletcher, T W Glover, F S Collins, J Downwar. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature. vol 356. issue 6371. 1992-05-28. PMID:1570015. |
defects in the nf1 gene have been implicated in the inherited disorder neurofibromatosis type 1, which is characterized by several developmental abnormalities including an increased frequency of benign and malignant tumours of neural crest origin (neurofibromas and neurofibrosarcomas respectively). |
1992-05-28 |
2023-08-11 |
Not clear |
| K Asai, T Hotta, K Nakanishi, J Ito, R Tanaka, T Otsuka, N Matsui, T Kat. von Recklinghausen neurofibroma produces neuronal and glial growth-modulating factors. Brain research. vol 556. issue 2. 1991-12-17. PMID:1933368. |
two kinds of novel neural trophic factors were currently detected in von recklinghausen neurofibroma (nf1) extracts. |
1991-12-17 |
2023-08-11 |
human |
| G R Skuse, B A Kosciolek, P T Rowle. The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. American journal of human genetics. vol 49. issue 3. 1991-10-03. PMID:1715669. |
the most common symptomatic manifestation of nf1 is the benign neurofibroma. |
1991-10-03 |
2023-08-11 |
Not clear |
| G R Skuse, B A Kosciolek, P T Rowle. The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. American journal of human genetics. vol 49. issue 3. 1991-10-03. PMID:1715669. |
our previous studies of tumors in nf1, studies which detected a loss of heterozygosity for dna markers from the nf1 region of chromosome 17 in malignant tumors, did not detect a loss in neurofibromas. |
1991-10-03 |
2023-08-11 |
Not clear |
| G R Skuse, B A Kosciolek, P T Rowle. The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. American journal of human genetics. vol 49. issue 3. 1991-10-03. PMID:1715669. |
we report here that a more extensive study, including the analysis of neurofibromas from 19 unrelated nf1 patients by using seven probes, failed to detect a single instance of loss of heterozygosity. |
1991-10-03 |
2023-08-11 |
Not clear |
| G R Skuse, B A Kosciolek, P T Rowle. The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. American journal of human genetics. vol 49. issue 3. 1991-10-03. PMID:1715669. |
this finding suggests that neurofibromas are either polyclonal or monoclonal in origin but arise by a mechanism different from that of nf1 malignancies. |
1991-10-03 |
2023-08-11 |
Not clear |
| G R Skuse, B A Kosciolek, P T Rowle. The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. American journal of human genetics. vol 49. issue 3. 1991-10-03. PMID:1715669. |
in order to investigate the first possibility, we analyzed neurofibromas from female nf1 patients by using an x chromosome-specific probe, from the phosphoglycerokinase (pgk) gene, which detects an rflp. |
1991-10-03 |
2023-08-11 |
Not clear |
| G R Skuse, B A Kosciolek, P T Rowle. The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. American journal of human genetics. vol 49. issue 3. 1991-10-03. PMID:1715669. |
we analyzed neurofibromas from 30 unrelated females with nf1. |
1991-10-03 |
2023-08-11 |
Not clear |