| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Sawada, S Florell, S M Purandare, M Ota, K Stephens, D Viskochi. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nature genetics. vol 14. issue 1. 1996-10-24. PMID:8782831. |
even though accumulating evidence demonstrates that nf1 acts as a tumour suppressor in some cells, mutations have not been identified in both nf1 alleles in dermal neurofibromas. |
1996-10-24 |
2023-08-12 |
Not clear |
| S Sawada, S Florell, S M Purandare, M Ota, K Stephens, D Viskochi. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nature genetics. vol 14. issue 1. 1996-10-24. PMID:8782831. |
demonstrated nf1 loh of dermal neurofibromas derived from 2 of 5 nf1 patients, yet the constitutional nf1 mutations in these patients were not identified, and the extent of the somatic deletions beyond the nf1 locus were not established. |
1996-10-24 |
2023-08-12 |
Not clear |
| S Sawada, S Florell, S M Purandare, M Ota, K Stephens, D Viskochi. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nature genetics. vol 14. issue 1. 1996-10-24. PMID:8782831. |
in this study, we show that a dermal neurofibroma from an nf1 individual who has a constitutional deletion of the entire nf1 locus harbours a 4-bp deletion of nf1 exon 4b in the other allele. |
1996-10-24 |
2023-08-12 |
Not clear |
| S Sawada, S Florell, S M Purandare, M Ota, K Stephens, D Viskochi. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nature genetics. vol 14. issue 1. 1996-10-24. PMID:8782831. |
this is the first definitive identification of a somatic mutation which is limited to the nf1 locus in a benign neurofibroma from an nf1 individual in whom the constitutional nf1 mutation is known. |
1996-10-24 |
2023-08-12 |
Not clear |
| L Wrabetz, M L Feltri, H Kim, M Daston, J Kamholz, S S Scherer, N Ratne. Regulation of neurofibromin expression in rat sciatic nerve and cultured Schwann cells. Glia. vol 15. issue 1. 1996-10-23. PMID:8847098. |
loss of function mutations at the nf1 locus may act intrinsically in schwann cells to cause the formation of benign schwann cell tumors (neurofibromas) in patients with type 1 neurofibromatosis. |
1996-10-23 |
2023-08-12 |
rat |
| S Van Es, K N North, K McHugh, M De Silv. MRI findings in children with neurofibromatosis type 1: a prospective study. Pediatric radiology. vol 26. issue 7. 1996-08-21. PMID:8662066. |
findings previously unreported in nf1 included an aqueductal web resulting in hydrocephalus, intraocular neurofibroma resulting in retinal detachment, and asymptomatic enlargement of the septum pellucidum. |
1996-08-21 |
2023-08-12 |
Not clear |
| A Guha, N Lau, I Huvar, D Gutmann, J Provias, T Pawson, G Bos. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene. vol 12. issue 3. 1996-07-05. PMID:8637706. |
ras-gtp levels were increased in nf1 neurogenic sarcomas (15 times) and benign nf1 neurofibromas (four times), compared to non nf1 schwannomas. |
1996-07-05 |
2023-08-12 |
human |
| L Feigenbaum, K Fujita, F S Collins, G Ja. Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice. Journal of virology. vol 70. issue 5. 1996-06-21. PMID:8627811. |
repression of the nf1 gene by tax may expain the development of neurofibromas in human t-lymphotropic virus type 1 transgenic mice. |
1996-06-21 |
2023-08-12 |
mouse |
| L Feigenbaum, K Fujita, F S Collins, G Ja. Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice. Journal of virology. vol 70. issue 5. 1996-06-21. PMID:8627811. |
in familial neurofibromatosis type 1 (nf1), individuals with a germ line-transmitted nf1 mutation develop multiple neurofibromas. |
1996-06-21 |
2023-08-12 |
mouse |
| L Feigenbaum, K Fujita, F S Collins, G Ja. Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice. Journal of virology. vol 70. issue 5. 1996-06-21. PMID:8627811. |
to explain the observation that transgenic mice expressing the human t-lymphotropic virus type 1 (htlv-1) tax gene under the control of the viral regulatory element also develop multiple neurofibromas, we demonstrate that the tax trans-regulator can functionally repress nf1 gene expression through a cis-acting element located immediately upstream of its transcriptional start site, thereby allowing the development of benign neurofibromas without the need for direct mutations in nf1. |
1996-06-21 |
2023-08-12 |
mouse |
| M M Feldkamp, N Lau, J P Provias, D H Gutmann, A Guh. Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1: a pathological and molecular explanation. Case report. Journal of neurosurgery. vol 84. issue 5. 1996-06-19. PMID:8622163. |
the molecular basis of neurofibroma development in nf1 is loss of expression of the nf1 gene and its gene product, neurofibromin, resulting in elevated levels of ras-guanosine triphosphate. |
1996-06-19 |
2023-08-12 |
Not clear |
| K A Leppig, D Viskochil, S Neil, A Rubenstein, V P Johnson, X L Zhu, A R Brothman, K Stephen. The detection of contiguous gene deletions at the neurofibromatosis 1 locus with fluorescence in situ hybridization. Cytogenetics and cell genetics. vol 72. issue 1. 1996-03-04. PMID:8565646. |
neurofibromatosis type 1 (nf1) is a common genetic disorder characterized primarily by the development of multiple neurofibromas and pigmentary changes. |
1996-03-04 |
2023-08-12 |
Not clear |
| K A Leppig, D Viskochil, S Neil, A Rubenstein, V P Johnson, X L Zhu, A R Brothman, K Stephen. The detection of contiguous gene deletions at the neurofibromatosis 1 locus with fluorescence in situ hybridization. Cytogenetics and cell genetics. vol 72. issue 1. 1996-03-04. PMID:8565646. |
fish studies performed with p1-9, p1-12, and a set of overlapping 1f10 cosmid clones mapping telomeric to the nf1 locus identified large deletions in two new neurofibromatosis type 1 patients who, like previously characterized deletion patients, had mildly dysmorphic facial features and large numbers of cutaneous neurofibromas. |
1996-03-04 |
2023-08-12 |
Not clear |
| M Stark, G Assum, W Kron. Single-cell PCR performed with neurofibroma Schwann cells reveals the presence of both alleles of the neurofibromatosis type 1 (NF1) gene. Human genetics. vol 96. issue 5. 1996-01-31. PMID:8530015. |
single-cell pcr performed with neurofibroma schwann cells reveals the presence of both alleles of the neurofibromatosis type 1 (nf1) gene. |
1996-01-31 |
2023-08-12 |
Not clear |
| L Ottini, D L Esposito, A Richetta, M Carlesimo, R Palmirotta, M C Verí, P Battista, L Frati, F G Caramia, S Calvier. Alterations of microsatellites in neurofibromas of von Recklinghausen's disease. Cancer research. vol 55. issue 23. 1995-12-14. PMID:7585653. |
we analyzed 5 dinucleotide repeat loci in dnas from neurofibromas and matched normal skin from 16 nf1 patients. |
1995-12-14 |
2023-08-12 |
Not clear |
| L Ottini, D L Esposito, A Richetta, M Carlesimo, R Palmirotta, M C Verí, P Battista, L Frati, F G Caramia, S Calvier. Alterations of microsatellites in neurofibromas of von Recklinghausen's disease. Cancer research. vol 55. issue 23. 1995-12-14. PMID:7585653. |
the surprisingly high frequency of microsatellite alterations suggests that the nf1 gene or another gene(s) contributing to the pathogenesis of neurofibromas might be directly or indirectly implicated in the control of genomic integrity. |
1995-12-14 |
2023-08-12 |
Not clear |
| S D Colman, C A Williams, M R Wallac. Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene. Nature genetics. vol 11. issue 1. 1995-11-20. PMID:7550323. |
benign neurofibromas in type 1 neurofibromatosis (nf1) show somatic deletions of the nf1 gene. |
1995-11-20 |
2023-08-12 |
human |
| S D Colman, C A Williams, M R Wallac. Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene. Nature genetics. vol 11. issue 1. 1995-11-20. PMID:7550323. |
using both nf1 intragenic polymorphisms as well as markers from flanking and more distal regions of chromosome 17, we have investigated loss of heterozygosity (loh) in 22 neurofibromas from five unrelated nf1 patients. |
1995-11-20 |
2023-08-12 |
human |
| S D Colman, C A Williams, M R Wallac. Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene. Nature genetics. vol 11. issue 1. 1995-11-20. PMID:7550323. |
eight of these tumours revealed somatic deletions involving nf1, indicating that inactivation of nf1 is associated with at least some neurofibromas. |
1995-11-20 |
2023-08-12 |
human |
| M T Seppälä, M J Haltia, R J Sankila, J E Jääskeläinen, O Heiskane. Long-term outcome after removal of spinal neurofibroma. Journal of neurosurgery. vol 82. issue 4. 1995-04-21. PMID:7897516. |
patients with nf1 were prone to develop new spinal neurofibromas. |
1995-04-21 |
2023-08-12 |
Not clear |