| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sirkku Peltonen, Arnaud Jannic, Pierre Wolkenstei. Treatment of cutaneous neurofibromas with carbon dioxide laser: Technique and patient experience. European journal of medical genetics. vol 65. issue 1. 2021-12-10. PMID:34768015. |
cutaneous neurofibromas (cnf) are one of the hallmarks of neurofibromatosis 1 (nf1). |
2021-12-10 |
2023-08-13 |
Not clear |
| Francisco Javier García-Martínez, Fernando Alfageme, Anna Duat-Rodríguez, Eva María Andrés Esteban, Angela Hernández-Martí. Clinical and Sonographic Classification of Neurofibromas in Children with Neurofibromatosis Type 1 - A Cluster Analysis. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2021-11-25. PMID:34820795. |
high-frequency ultrasound allows the accurate identification of neurofibromas in neurofibromatosis type 1 (nf1). |
2021-11-25 |
2023-08-13 |
Not clear |
| Francisco Javier García-Martínez, Fernando Alfageme, Anna Duat-Rodríguez, Eva María Andrés Esteban, Angela Hernández-Martí. Clinical and Sonographic Classification of Neurofibromas in Children with Neurofibromatosis Type 1 - A Cluster Analysis. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2021-11-25. PMID:34820795. |
this study aimed to analyze the ultrasound features of neurofibromas in children with nf1, to establish a classification based on the clinical and sonographic patterns of the different types of neurofibromas, and to evaluate the interobserver correlation coefficient (κ) of this classification. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jean-Philippe Brosseau, Adwait A Sathe, Yong Wang, Toan Nguyen, Donald A Glass, Chao Xing, Lu Q L. Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33413690. |
neurofibromatosis type i (nf1) is a neurocutaneous genetic syndrome characterized by a wide spectrum of clinical presentations, including benign peripheral nerve sheath tumor called neurofibroma. |
2021-11-15 |
2023-08-13 |
human |
| Hongyu Lu, Ping Liu, Quantang Pan. MiR-27a-3p/miR-27b-3p Promotes Neurofibromatosis Type 1 via Targeting of NF1. Journal of molecular neuroscience : MN. vol 71. issue 11. 2021-11-12. PMID:33570696. |
mir-27b-3p and mir-27a-3p were upregulated in dermal and plexiform human schwann cells (hsc) from nf1 neurofibromas as well as cell lines of malignant peripheral nerve sheath tumors (mpnsts). |
2021-11-12 |
2023-08-13 |
human |
| Wasim Nasir, Tara Howard, Eduardo Weis. Melanoma Arising From a Pre-existing Neurofibroma in a Patient With No Prior Diagnosis of Systemic Neurofibromatosis 1 or 2: A Case Report. The American Journal of dermatopathology. vol 43. issue 4. 2021-11-09. PMID:33464751. |
a review of the literature suggests there may be a link between the pathogenesis of neurofibroma and malignant melanoma, because nf1 mutations are observed in both neurofibromatosis and malignant melanoma. |
2021-11-09 |
2023-08-13 |
Not clear |
| Hildegard Kehrer-Sawatzki, David N Coope. Classification of NF1 microdeletions and its importance for establishing genotype/phenotype correlations in patients with NF1 microdeletions. Human genetics. vol 140. issue 12. 2021-11-08. PMID:34535841. |
further, patients with type-1 nf1 deletions frequently exhibit high numbers of neurofibromas and have an increased risk of malignant peripheral nerve sheath tumours. |
2021-11-08 |
2023-08-13 |
Not clear |
| Weijie Li, Chenhao Hu, Xingnan Zhang, Binbin Wang, Zhen Li, Miao Ling, Shengqiao Sun, Chao Guo, Dezhi Li, Song Li. SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas. Frontiers in oncology. vol 11. 2021-10-26. PMID:34692515. |
in conclusion, our findings suggested that suz12 loss potentiates the effects of nf1 mutations by amplifying ras signaling through the adcy1/camp/rap1/erk pathway and that suz12 may serve as a therapeutic and prognostic biomarker in nf1-associated neurofibromas. |
2021-10-26 |
2023-08-13 |
Not clear |
| Mitsuaki Ishida, Hidetoshi Okab. Cutaneous squamous cell carcinoma in a patient with neurofibromatosis type 1: A case report. Oncology letters. vol 6. issue 4. 2021-10-21. PMID:24137429. |
the present study describes the second documented case of a cutaneous scc adjacent to a neurofibroma of the forehead with histopathological analyses in a patient with nf1. |
2021-10-21 |
2023-08-12 |
Not clear |
| Liwen Guo, Kuifeng He, Xin Xu, Guangliang Li, Zhongqi Li, Yaxian Xia, Xiaodong Teng, Lisong Ten. Giant appendiceal neurofibroma in von Recklinghausen's disease: A case report and literature review. Oncology letters. vol 8. issue 5. 2021-10-21. PMID:25295078. |
neurofibroma of the appendix is extremely rare, even in patients with nf1. |
2021-10-21 |
2023-08-13 |
Not clear |
| Ashley Bui, Chunhui Jiang, Renee M McKay, Laura J Klesse, Lu Q L. Insights into the Pathogenesis of NF1-Associated Neoplasms. JID innovations. vol 1. issue 3. 2021-10-06. PMID:34604833. |
neurofibromatosis type 1 (nf1) is one of the most common neurocutaneous genetic disorders, presenting with different cutaneous features such as café-au-lait macules, intertriginous skin freckling, and neurofibromas. |
2021-10-06 |
2023-08-13 |
Not clear |
| Xi-Yu Wang, Jian-Peng Cai, Le-Le Song, Chen-Song Huang, Wei Chen, Xi-Tai Huang, Shi-Fu Chen, Xin-Yi Liu, Xiao-Yu Yi. Identification of Genomic Alterations in Sporadic Pancreatic Neurogenic Tumors. Pancreas. vol 49. issue 10. 2021-09-28. PMID:33122531. |
in conclusion, variants in nf1 and nf2 genes, amplification of key driver genes, and somatic and mitochondrial inv variants may play important roles in the development of pancreatic schwannoma and neurofibroma. |
2021-09-28 |
2023-08-13 |
Not clear |
| Lennart Well, Kimberly Döbel, Lan Kluwe, Peter Bannas, Said Farschtschi, Gerhard Adam, Victor-Felix Mautner, Johannes Salamo. Genotype-phenotype correlation in neurofibromatosis type-1: NF1 whole gene deletions lead to high tumor-burden and increased tumor-growth. PLoS genetics. vol 17. issue 5. 2021-09-22. PMID:33951044. |
neurofibromatosis type-1 (nf1) patients suffer from cutaneous and subcutaneous neurofibromas (cnf) and large plexiform neurofibromas (pnf). |
2021-09-22 |
2023-08-13 |
Not clear |
| Juan Mo, Corina Anastasaki, Zhiguo Chen, Tracey Shipman, Jason Papke, Kevin Yin, David H Gutmann, Lu Q L. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. The Journal of clinical investigation. vol 131. issue 1. 2021-09-07. PMID:33108355. |
neurofibromatosis type 1 (nf1) is a common tumor predisposition syndrome caused by nf1 gene mutation, in which affected patients develop schwann cell lineage peripheral nerve sheath tumors (neurofibromas). |
2021-09-07 |
2023-08-13 |
mouse |
| Juan Mo, Corina Anastasaki, Zhiguo Chen, Tracey Shipman, Jason Papke, Kevin Yin, David H Gutmann, Lu Q L. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. The Journal of clinical investigation. vol 131. issue 1. 2021-09-07. PMID:33108355. |
moreover, we discovered that nf1 loss impaired schwann cell differentiation by inducing a persistent stem-like state to expand the pool of progenitors required to initiate tumor formation, indicating that, in addition to regulating mapk-mediated cell growth, nf1 loss also altered schwann cell differentiation to promote neurofibroma development. |
2021-09-07 |
2023-08-13 |
mouse |
| Raquel D Thalheimer, Vanessa L Merker, K Ina Ly, Amanda Champlain, Jennifer Sawaya, Naomi L Askenazi, Hamilton P Herr, Jennifer L W Da, Justin T Jordan, Alona Muzikansky, Elizabeth Morehouse Pearce, Fernanda H Sakamoto, Jaishri O Blakeley, R Rox Anderson, Scott R Plotki. Validating Techniques for Measurement of Cutaneous Neurofibromas: Recommendations for Clinical Trials. Neurology. vol 97. issue 7 Suppl 1. 2021-09-01. PMID:34230197. |
to assess the reliability and variability of digital calipers, 3d photography, and high-frequency ultrasound (hfus) for measurement of cutaneous neurofibromas (cnf) in patients with neurofibromatosis type 1 (nf1). |
2021-09-01 |
2023-08-13 |
Not clear |
| Ashley Cannon, Dominique C Pichard, Pamela L Wolters, Sarah Adsit, Gregg Erickson, Andrés J Lessing, Peng Li, Whitney Narmore, Claas Röhl, Tena Rosser, Brigitte C Widemann, Jaishri O Blakeley, Scott R Plotki. Perspective of Adults With Neurofibromatosis 1 and Cutaneous Neurofibromas: Implications for Clinical Trials. Neurology. vol 97. issue 7 Suppl 1. 2021-09-01. PMID:34230202. |
to assess the perspectives of adults with neurofibromatosis 1 (nf1) regarding cutaneous neurofibroma (cnf) morbidity, treatment options, and acceptable risk-benefit ratio to facilitate the design of patient-centered clinical trials. |
2021-09-01 |
2023-08-13 |
Not clear |
| Ozioma P Nnomadim, Blandine Bustamante Helfric. Complications of Neurofibromatosis 1 (NF1) in an Adult With Multiple Comorbidities. Cureus. vol 13. issue 7. 2021-08-26. PMID:34430126. |
nf1 patients develop multiple tumors (neurofibromas); approximately 8%-15% percent of them present with malignant peripheral nerve sheath tumors (mpnst) within the patient's lifetime. |
2021-08-26 |
2023-08-13 |
Not clear |
| Fahad Aljindan, Lamiaa Aljehani, Bayan Alsharif, Hatan Mortad. Management of Neurofibromatosis of the Nipple-Areolar Complex. Case reports in surgery. vol 2021. 2021-08-24. PMID:34422429. |
on rare occasions, nf1 can affect the breast and manifests as nipple-areolar complex extranipple (pseudopolythelia) like neurofibromas which can be disfiguring and sometimes cause pain and therefore need to be addressed surgically. |
2021-08-24 |
2023-08-13 |
Not clear |
| Fahad Aljindan, Lamiaa Aljehani, Bayan Alsharif, Hatan Mortad. Management of Neurofibromatosis of the Nipple-Areolar Complex. Case reports in surgery. vol 2021. 2021-08-24. PMID:34422429. |
nf1 primarily involves the peripheral nervous system and usually presents with a large number of neurofibromas. |
2021-08-24 |
2023-08-13 |
Not clear |