| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristian S Bernabe, Izabela F Caliman, Aline R R de Abreu, Andrei I Molosh, William A Truitt, Anantha Shekhar, Philip L Johnso. Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses. Translational psychiatry. vol 14. issue 1. 2024-01-25. PMID:38272876. |
the serotonin (5-ht) system is heavily implicated in the regulation of anxiety and trauma-related disorders such as panic disorder and post-traumatic stress disorder, respectively. |
2024-01-25 |
2024-01-28 |
Not clear |
| Elise J Heesbeen, Elisabeth Y Bijlsma, P Monika Verdouw, Caspar van Lissa, Carlijn Hooijmans, Lucianne Groenin. The effect of SSRIs on fear learning: a systematic review and meta-analysis. Psychopharmacology. 2023-02-27. PMID:36847831. |
selective serotonin reuptake inhibitors (ssris) are considered first-line medication for anxiety-like disorders such as panic disorder, generalized anxiety disorder, and post-traumatic stress disorder. |
2023-02-27 |
2023-08-14 |
Not clear |
| Jennifer Warner-Schmidt, Christopher Pittenger, Martin Stogniew, Blake Mandell, Sarah J Olmstead, Benjamin Kelmend. Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity. Frontiers in psychiatry. vol 13. 2023-01-27. PMID:36704743. |
selective serotonin reuptake inhibitor (ssri) antidepressants represent first-line pharmacological treatment for a variety of neuropsychiatric illnesses, including major depressive disorder (mdd), anxiety, and post-traumatic stress disorder (ptsd), which show high rates of comorbidity. |
2023-01-27 |
2023-08-14 |
Not clear |
| Yu Ohmur. [Potential PTSD therapeutics targeting 5-HT Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 158. issue 1. 2023-01-03. PMID:36596489. |
[potential ptsd therapeutics targeting 5-ht post-traumatic stress disorder (ptsd) is often treated by (1) selective serotonin reuptake inhibitors (ssris), (2) exposure therapy, or a combination of the two. |
2023-01-03 |
2023-08-14 |
Not clear |
| Sandra T Süß, Linda M Olbricht, Stefan Herlitze, Katharina Spoid. Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway. Translational psychiatry. vol 12. issue 1. 2022-11-19. PMID:36402746. |
serotonin 2c receptors (5-ht2crs) are widely distributed throughout the brain and are strongly implicated in the pathophysiology of anxiety disorders such as post-traumatic stress disorder (ptsd). |
2022-11-19 |
2023-08-14 |
mouse |
| Niklas Reich, Christian Hölsche. Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone. Neuroscience and biobehavioral reviews. 2022-11-11. PMID:36368526. |
as such, in this review, we i) evaluate what specific stages and forms of memory, as well as which respective brain areas are affected by acylated ghrelin, ii) illustrate the plasticity-associated signaling pathways of ag in the hippocampus, also involving memory resolution-enhancing neurogenesis, iii) elucidate how the peptide modulates neurotransmitter systems (glutamate, γ-aminobutyric acid, dopamine, serotonin), iv) clarify the role of ag in conditioned taste aversion, novelty learning and the formation of spatial, recognition, auditory fear, contextual fear and passive avoidance memories in the hippocampus and amygdala as well as v) solve the mystery behind ag, its impact on the 5-ht system, the recently established link to post-traumatic stress disorder and the either fear-suppressing or fear-potentiating effects under neutral and acutely stressed conditions or chronic stress, respectively. |
2022-11-11 |
2023-08-14 |
Not clear |
| Felix P Mayer, Marco Niello, Daniela Cintulova, Spyridon Sideromenos, Julian Maier, Yang Li, Simon Bulling, Oliver Kudlacek, Klaus Schicker, Hideki Iwamoto, Fei Deng, Jinxia Wan, Marion Holy, Rania Katamish, Walter Sandtner, Yulong Li, Daniela D Pollak, Randy D Blakely, Marko D Mihovilovic, Michael H Baumann, Harald H Sitt. Serotonin-releasing agents with reduced off-target effects. Molecular psychiatry. 2022-11-09. PMID:36352123. |
increasing extracellular levels of serotonin (5-ht) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g., social phobias and post-traumatic stress disorder. |
2022-11-09 |
2023-08-14 |
Not clear |
| Dimy Fluyau, Paroma Mitra, Ankit Jain, Vasanth Kattalai Kailasam, Christopher G Pierr. Selective serotonin reuptake inhibitors in the treatment of depression, anxiety, and post-traumatic stress disorder in substance use disorders: a Bayesian meta-analysis. European journal of clinical pharmacology. 2022-03-05. PMID:35246699. |
selective serotonin reuptake inhibitors in the treatment of depression, anxiety, and post-traumatic stress disorder in substance use disorders: a bayesian meta-analysis. |
2022-03-05 |
2023-08-13 |
Not clear |
| Domenico De Berardis, Michele Fornaro, Antonio Ventriglio, Alessandro Valchera, Federica Vellante, Mauro Pettorruso, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantoni. Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 19. issue 4. 2021-12-01. PMID:34690132. |
trazodone add-on in covid-19-related selective serotonin reuptake inhibitor-resistant post-traumatic stress disorder in healthcare workers: two case reports. |
2021-12-01 |
2023-08-13 |
Not clear |
| David Ullrich, David William Mac Gillavr. Mini-review: A possible role for galanin in post-traumatic stress disorder. Neuroscience letters. vol 756. 2021-06-22. PMID:34023414. |
several neuroendocrine systems have been implicated in post-traumatic stress disorder, including the mesocortical and mesolimbic dopamine, the norepinephrine, the β-endorphin, the serotonin, and the oxytocin systems. |
2021-06-22 |
2023-08-13 |
Not clear |
| Christoph U Correll, Samuele Cortese, Giovanni Croatto, Francesco Monaco, Damir Krinitski, Gonzalo Arrondo, Edoardo G Ostinelli, Caroline Zangani, Michele Fornaro, Andrés Estradé, Paolo Fusar-Poli, Andre F Carvalho, Marco Solm. Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 2. 2021-05-27. PMID:34002501. |
based on the meta-analytic evidence, the most convincing efficacy profile emerged for amphetamines, methylphenidate and, to a smaller extent, behavioral therapy in attention-deficit/hyperactivity disorder; aripiprazole, risperidone and several psychosocial interventions in autism; risperidone and behavioral interventions in disruptive behavior disorders; several antipsychotics in schizophrenia spectrum disorders; fluoxetine, the combination of fluoxetine and cognitive behavioral therapy (cbt), and interpersonal therapy in depression; aripiprazole in mania; fluoxetine and group cbt in anxiety disorders; fluoxetine/selective serotonin reuptake inhibitors, cbt, and behavioral therapy with exposure and response prevention in obsessive-compulsive disorder; cbt in post-traumatic stress disorder; imipramine and alarm behavioral intervention in enuresis; behavioral therapy in encopresis; and family therapy in anorexia nervosa. |
2021-05-27 |
2023-08-13 |
Not clear |
| Tajana Ljubin-Golub, Suzana Uzun, Ninoslav Mimica, Oliver Kozumplik, Dubravka Kalinic, Zrnka Kovacic Petrovic, Petra Folnegovic Grosic, Nela Piva. Platelet serotonin concentration and trait aggression in veterans with post-traumatic stress disorder: a preliminary study. Stress (Amsterdam, Netherlands). 2021-05-19. PMID:34006175. |
platelet serotonin concentration and trait aggression in veterans with post-traumatic stress disorder: a preliminary study. |
2021-05-19 |
2023-08-13 |
human |
| Tajana Ljubin-Golub, Suzana Uzun, Ninoslav Mimica, Oliver Kozumplik, Dubravka Kalinic, Zrnka Kovacic Petrovic, Petra Folnegovic Grosic, Nela Piva. Platelet serotonin concentration and trait aggression in veterans with post-traumatic stress disorder: a preliminary study. Stress (Amsterdam, Netherlands). 2021-05-19. PMID:34006175. |
serotonergic (5-ht) dysfunction is associated with post-traumatic stress disorder (ptsd), but also with increased aggression and impulsivity, hallmarks of ptsd. |
2021-05-19 |
2023-08-13 |
human |
| Zackary T Montoya, Amy L Uhernik, Jeffrey P Smit. Comparison of cannabidiol to citalopram in targeting fear memory in female mice. Journal of cannabis research. vol 2. issue 1. 2021-02-06. PMID:33526146. |
cannabidiol (cbd) and selective serotonin reuptake inhibitors (ssris) are currently used to treat post-traumatic stress disorder (ptsd). |
2021-02-06 |
2023-08-13 |
mouse |
| Kenji Sanada, Jesus Montero-Marin, Alberto Barceló-Soler, Daisuke Ikuse, Marie Ota, Akihito Hirata, Akira Yoshizawa, Rieko Hatanaka, Montserrat Salas Valero, Marcelo Demarzo, Javier García Campayo, Akira Iwanam. Effects of Mindfulness-Based Interventions on Biomarkers and Low-Grade Inflammation in Patients with Psychiatric Disorders: A Meta-Analytic Review. International journal of molecular sciences. vol 21. issue 7. 2021-01-13. PMID:32260096. |
mbis showed significant improvements in the event-related potential amplitudes in attention-deficit hyperactivity disorder, the methylation of serotonin transporter genes in post-traumatic stress disorder, the salivary levels of interleukin 6 (il-6) and tumour necrosis factor alpha (tnf-α) in depression, and the blood levels of adrenocorticotropic hormone (acth), il-6, and tnf-α in generalised anxiety disorder. |
2021-01-13 |
2023-08-13 |
human |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
5-hydroxytryptamine receptors 2a and 1a (5-ht2a and 5-ht1a receptors) are most closely related to anxiety-like behavior in post-traumatic stress disorder. |
2020-10-01 |
2023-08-13 |
mouse |
| Bowma. Nonepileptic Seizures. Current treatment options in neurology. vol 2. issue 6. 2020-09-29. PMID:11096780. |
selective serotonin reuptake inhibitor antidepressant medications (first-line drugs) or tricyclic antidepressants (second-line drugs) may be needed to treat comorbid depression, panic, or post-traumatic stress disorder (ptsd), but medications should nearly always be combined with psychotherapeutic approaches. |
2020-09-29 |
2023-08-12 |
Not clear |
| Zhen-Dong Huang, Yi-Fan Zhao, Shuang Li, Hui-Yun Gu, Lu-Lu Lin, Zhi-Yan Yang, Yu-Ming Niu, Chao Zhang, Jie Lu. Comparative Efficacy and Acceptability of Pharmaceutical Management for Adults With Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32457605. |
the current clinical guidelines on post-traumatic stress disorder (ptsd) recommend selective serotonin reuptake inhibitors (ssris) and serotonin and norepinephrine reuptake inhibitors (snris) of drugs. |
2020-09-28 |
2023-08-13 |
Not clear |
| E G Nachtigall, C R G Furini, J A K Behling, C P Farias, I Izquierdo, J de C Myski. Facilitation of fear extinction by novelty is modulated by β-adrenergic and 5-HT Neurobiology of learning and memory. vol 166. 2020-07-28. PMID:31629785. |
facilitation of fear extinction by novelty is modulated by β-adrenergic and 5-ht extinction is the learned inhibition of retrieval of a previously acquired memory and is a major component of exposure therapy, which has attracted much attention because of the use in the treatment of drug addiction, phobias and particularly fear disorders such as post-traumatic stress disorder (ptsd). |
2020-07-28 |
2023-08-13 |
Not clear |
| Fernando Navarro-Mateu, Teresa Escámez, M Paz Quesada, M José Alcaráz, Gemma Vilagut, Diego Salmerón, José M Huerta, M Dolores Chirlaque, Carmen Navarro, Ronald C Kessler, Jordi Alonso, Salvador Martíne. Modification of the risk of post-traumatic stress disorder (PTSD) by the 5-HTTLPR polymorphisms after Lorca's earthquakes (Murcia, Spain). Psychiatry research. vol 282. 2020-04-28. PMID:31727442. |
information of the modulation effect of the serotonin transporter gene-linked polymorphic region (5-httlpr) on post-traumatic stress disorder (ptsd) after earthquakes is scarce and contradictory. |
2020-04-28 |
2023-08-13 |
Not clear |