| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J Telch, Christopher G Beevers, David Rosenfield, Han-Joo Lee, Albert Reijntjes, Robert E Ferrell, Ahmad R Harir. 5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 14. issue 2. 2015-06-05. PMID:26043338. |
we investigated the role of the serotonin transporter linked polymorphic region (5-httlpr) genotype in predicting the emergence of post-traumatic stress disorder (ptsd), depressive and anxiety symptoms as a function of war zone stressors. |
2015-06-05 |
2023-08-13 |
Not clear |
| Ling Shan, Pieter Schipper, Lourens J P Nonkes, Judith R Homber. Impaired fear extinction as displayed by serotonin transporter knockout rats housed in open cages is disrupted by IVC cage housing. PloS one. vol 9. issue 3. 2015-01-16. PMID:24658187. |
a well-known example for gene x environment interactions in psychiatry is the low activity (s) allelic variant of the serotonin transporter (5-htt) promoter polymorphism (5-httlpr) that in the context of stress increases risk for depression and post-traumatic stress disorder (ptsd). |
2015-01-16 |
2023-08-12 |
rat |
| Hendrikus Hendriksen, Berend Olivier, Ronald S Oostin. From non-pharmacological treatments for post-traumatic stress disorder to novel therapeutic targets. European journal of pharmacology. vol 732. 2014-12-09. PMID:24698651. |
most of the currently described drugs for post-traumatic stress disorder (ptsd) are based on the inhibition of serotonin reuptake. |
2014-12-09 |
2023-08-13 |
human |
| David Nut. Anxiety and depression: individual entities or two sides of the same coin? International journal of psychiatry in clinical practice. vol 8 Suppl 1. 2014-10-15. PMID:24930685. |
selective serotonin reuptake inhibitors (ssris) have shown efficacy in a number of neuroses: depression; obsessive-compulsive disorder (ocd) and anxiety disorders (panic disorder [pd], social anxiety disorder [sad], generalised anxiety disorder and post-traumatic stress disorder). |
2014-10-15 |
2023-08-13 |
Not clear |
| C Brad Wilson, Leslie D McLaughlin, Philip J Ebenezer, Anand R Nair, Rahul Dange, Joseph G Harre, Thomas L Shaak, David M Diamond, Joseph Franci. Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder. Frontiers in behavioral neuroscience. vol 8. 2014-08-15. PMID:25126063. |
serotonin (5-ht), norepinephrine (ne), and other neurotransmitters are modulated in post-traumatic stress disorder (ptsd). |
2014-08-15 |
2023-08-13 |
rat |
| Charlotte Sonne, Jessica Carlsson, Ask Elklit, Erik Lykke Mortensen, Morten Ekstrø. Treatment of traumatized refugees with sertraline versus venlafaxine in combination with psychotherapy - study protocol for a randomized clinical trial. Trials. vol 14. 2013-10-17. PMID:23663588. |
the pharmacological treatments of choice today for post-traumatic stress disorder are antidepressants from the subgroup selective serotonin reuptake inhibitors, especially sertraline. |
2013-10-17 |
2023-08-12 |
Not clear |
| Charlotte Sonne, Jessica Carlsson, Ask Elklit, Erik Lykke Mortensen, Morten Ekstrø. Treatment of traumatized refugees with sertraline versus venlafaxine in combination with psychotherapy - study protocol for a randomized clinical trial. Trials. vol 14. 2013-10-17. PMID:23663588. |
the evidence for the use of selective serotonin reuptake inhibitors in the treatment of complex post-traumatic stress disorder in traumatized refugees is very limited. |
2013-10-17 |
2023-08-12 |
Not clear |
| Russell J Lewis, Mike K Angier, Kelly S Williamson, Robert D Johnso. Analysis of sertraline in postmortem fluids and tissues in 11 aviation accident victims. Journal of analytical toxicology. vol 37. issue 4. 2013-09-25. PMID:23511306. |
sertraline (zoloft) is a selective serotonin reuptake inhibitor that is a commonly prescribed drug for the treatment of depression, obsessive-compulsive disorder, panic disorder, social anxiety disorder, premenstrual dysphoric disorder and post-traumatic stress disorder. |
2013-09-25 |
2023-08-12 |
human |
| George A Kenna, Nick Roder-Hanna, Lorenzo Leggio, William H Zywiak, James Clifford, Steven Edwards, John A Kenna, Jessica Shoaff, Robert M Swif. Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. Pharmacogenomics and personalized medicine. vol 5. 2013-04-01. PMID:23226060. |
for some disorders, such as post-traumatic stress disorder and major depressive disorder, the research suggests that treatment response may vary by allele (such as an enhanced response to serotonin specific reuptake inhibitors in patients with major depressive disorder and post-traumatic stress disorder with l alleles), and for alcohol dependence, the association and treatment for s or l alleles may vary with alcoholic subtype. |
2013-04-01 |
2023-08-12 |
Not clear |
| Mushtaq A Margoob, Dhuha Mushta. Serotonin transporter gene polymorphism and psychiatric disorders: is there a link? Indian journal of psychiatry. vol 53. issue 4. 2012-05-21. PMID:22303036. |
in this article, we review the status of evidence for association between the serotonin gene polymorphism and some common mental disorders like affective disorders, post-traumatic stress disorder, obsessive-compulsive disorder, suicide, autism, and other anxiety and personality disorders. |
2012-05-21 |
2023-08-12 |
Not clear |
| b' I D Neumann, G Wegener, J R Homberg, H Cohen, D A Slattery, J Zohar, J D A Olivier, A A Math\\xc3\\xa. Animal models of depression and anxiety: What do they tell us about human condition? Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 6. 2011-11-29. PMID:21129431.' |
in this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the flinders sensitive rat line (fsl); the genetically "anxious" high anxiety-like behavior (hab) line; the serotonin transporter knockout 5-htt(-/-) rat and mouse lines; and the post-traumatic stress disorder (ptsd) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety. |
2011-11-29 |
2023-08-12 |
mouse |
| Rachel H Sharpe, John C Vori. Nefazodone in the treatment of patients with post-traumatic stress disorder. Expert review of neurotherapeutics. vol 2. issue 5. 2010-06-28. PMID:19810976. |
despite recent reports of hepatotoxicity, when used appropriately, nefazodone is generally as well-tolerated as the medications currently fda-indicated for post-traumatic stress disorder, the selective serotonin reuptake inhibitors. |
2010-06-28 |
2023-08-12 |
Not clear |
| Rachel H Sharpe, John C Vori. Nefazodone in the treatment of patients with post-traumatic stress disorder. Expert review of neurotherapeutics. vol 2. issue 5. 2010-06-28. PMID:19810976. |
through its mechanism inhibiting neuronal uptake of serotonin and norepinephrine and as a potent postsynaptic serotonergic antagonist, nefazodone has proven to be effective in treating post-traumatic stress disorder in several open-label trials. |
2010-06-28 |
2023-08-12 |
Not clear |
| David Baldwin, Christel Buis, Andrew Mayer. Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder. Expert review of neurotherapeutics. vol 2. issue 5. 2010-06-28. PMID:19810988. |
selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder and social anxiety disorder. |
2010-06-28 |
2023-08-12 |
Not clear |
| E Walderhaug, S Kasserman, D Aikins, D Vojvoda, C Nishimura, A Neumeiste. Effects of duloxetine in treatment-refractory men with posttraumatic stress disorder. Pharmacopsychiatry. vol 43. issue 2. 2010-06-11. PMID:20108200. |
although there is evidence that selective serotonin reuptake inhibitors provide some benefit in the treatment of post-traumatic stress disorder (ptsd), most meta-analytical reviews have concluded that effect sizes are small and, moreover, that there may be relatively little benefit for some populations (e. g., combat veterans with co-morbid major depression, mdd). |
2010-06-11 |
2023-08-12 |
Not clear |
| Hana Kuzelova, Radek Ptacek, Milan Mace. The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature. Neuro endocrinology letters. vol 31. issue 1. 2010-05-13. PMID:20150867. |
this repeat length variant in the promoter region of this gene has been shown to affect the rate of serotonin uptake and may play a role in post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. |
2010-05-13 |
2023-08-12 |
Not clear |
| Sanja Radeljak, Tija Zarković-Palijan, Drazen Kovacević, Marina Kova. Chromotherapy in the regulation of neurohormonal balance in human brain--complementary application in modern psychiatric treatment. Collegium antropologicum. vol 32 Suppl 2. 2009-02-11. PMID:19138024. |
studies on sleep disorders, depression, seasonal affective disorder (sad) and post-traumatic stress disorder (ptsd) suggested that symptoms, signs, and biologic markers associated to these psychiatric disorders are due to marked alterations in melatonin and serotonin levels. |
2009-02-11 |
2023-08-12 |
human |
| William Berger, Carla Marques Portella, Leonardo F Fontenelle, Gustavo Kinrys, Mauro Vitor Mendlowic. [Antipsychotics, anticonvulsants, antiadrenergics and other drugs: what to do when posttraumatic stress disorder does not respond to selective serotonin reuptake inhibitors?]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 29 Suppl 2. 2008-04-24. PMID:18157435. |
in this narrative review, we aimed to describe different pharmacological strategies for the treatment of patients with post-traumatic stress disorder who display different levels of intolerance, resistance, refractoriness, or who are unable to take to antidepressants, especially serotonin reuptake inhibitors. |
2008-04-24 |
2023-08-12 |
Not clear |
| Chi-Un Pae, Hyun-Kook Lim, Neena Ajwani, Chul Lee, Ashwin A Patka. Extended-release formulation of venlafaxine in the treatment of post-traumatic stress disorder. Expert review of neurotherapeutics. vol 7. issue 6. 2007-07-03. PMID:17563244. |
there is abundant evidence for abnormalities of both norepinephrine and serotonin neurotransmitter systems in post-traumatic stress disorder (ptsd). |
2007-07-03 |
2023-08-12 |
Not clear |
| Prasad R Padala, James Madison, Melanie Monnahan, William Marcil, Paul Price, Sriram Ramaswamy, Amad U Din, Daniel R Wilson, Frederick Pett. Risperidone monotherapy for post-traumatic stress disorder related to sexual assault and domestic abuse in women. International clinical psychopharmacology. vol 21. issue 5. 2007-01-10. PMID:16877898. |
selective serotonin reuptake inhibitors are the usual first-line treatment for post-traumatic stress disorder, but many patients fail to respond adequately. |
2007-01-10 |
2023-08-12 |
human |