| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claude A Piantadosi, Martha Sue Carraway, Abdelwahid Babiker, Hagir B Sulima. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circulation research. vol 103. issue 11. 2008-12-31. PMID:18845810. |
in cardiac cells, akt silencing exacerbates doxorubicin-induced apoptosis, and in vivo co rescues wild-type but not akt1(-/-) mice from doxorubicin cardiomyopathy. |
2008-12-31 |
2023-08-12 |
mouse |
| Kuen-Feng Chen, Pei-Yen Yeh, Kun-Huei Yeh, Yen-Shen Lu, Shang-Yi Huang, Ann-Lii Chen. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer research. vol 68. issue 16. 2008-10-02. PMID:18701494. |
down-regulation of akt1 by small interference rna overcame the apoptotic resistance to bortezomib in plc5 cells, but a constitutively activated akt1 protected huh-7 cells from bortezomib-induced apoptosis. |
2008-10-02 |
2023-08-12 |
Not clear |
| Ioanna G Maroulakou, William Oemler, Stephen P Naber, Ina Klebba, Charlotte Kuperwasser, Philip N Tsichli. Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18561256. |
the ablation of akt1 promotes apoptosis and accelerates involution, whereas the ablation of akt2 inhibits apoptosis and delays involution. |
2008-09-12 |
2023-08-12 |
mouse |
| Eun-Sil Kang, Dohyun Han, Jungeun Park, Tae Kyoung Kwak, Min-A Oh, Sin-Ae Lee, Suyong Choi, Zee Yong Park, Youngsoo Kim, Jung Weon Le. O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Experimental cell research. vol 314. issue 11-12. 2008-07-22. PMID:18570920. |
o-glcnac modulation at akt1 ser473 correlates with apoptosis of murine pancreatic beta cells. |
2008-07-22 |
2023-08-12 |
Not clear |
| Eun-Sil Kang, Dohyun Han, Jungeun Park, Tae Kyoung Kwak, Min-A Oh, Sin-Ae Lee, Suyong Choi, Zee Yong Park, Youngsoo Kim, Jung Weon Le. O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Experimental cell research. vol 314. issue 11-12. 2008-07-22. PMID:18570920. |
the relationship of o-glcnac modification and phosphorylation at akt1 ser473 was examined with respect to apoptosis of murine beta-pancreatic cells. |
2008-07-22 |
2023-08-12 |
Not clear |
| Eun-Sil Kang, Dohyun Han, Jungeun Park, Tae Kyoung Kwak, Min-A Oh, Sin-Ae Lee, Suyong Choi, Zee Yong Park, Youngsoo Kim, Jung Weon Le. O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Experimental cell research. vol 314. issue 11-12. 2008-07-22. PMID:18570920. |
glucosamine treatment induced apoptosis, which correlated with enhanced o-glcnac modification of akt1 and concomitant reduction in ser473 phosphorylation. |
2008-07-22 |
2023-08-12 |
Not clear |
| Naohiro Kawamura, Fumitaka Kugimiya, Yasushi Oshima, Shinsuke Ohba, Toshiyuki Ikeda, Taku Saito, Yusuke Shinoda, Yosuke Kawasaki, Naoshi Ogata, Kazuto Hoshi, Toru Akiyama, William S Chen, Nissim Hay, Kazuyuki Tobe, Takashi Kadowaki, Yoshiaki Azuma, Sakae Tanaka, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguch. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PloS one. vol 2. issue 10. 2008-07-15. PMID:17957242. |
notably, our findings revealed a novel role of akt1/forkhead box class o (foxo) 3a/bim axis in the apoptosis of osteoblasts: akt1 phosphorylates the transcription factor foxo3a to prevent its nuclear localization, leading to impaired transactivation of its target gene bim which was also shown to be a potent proapoptotic molecule in osteoblasts. |
2008-07-15 |
2023-08-12 |
mouse |
| Dhananjay Jere, Cheng-Xiong Xu, Rohidas Arote, Cheol-Heui Yun, Myung-Haing Cho, Chong-Su Ch. Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells. Biomaterials. vol 29. issue 16. 2008-06-05. PMID:18316120. |
superior shakt delivery and low cytotoxicity of pae carrier promoted akt1 knock-down specific apoptosis, while low delivery efficiency and high cytotoxicity of pei25k carrier mainly exhibited undesirable necrosis. |
2008-06-05 |
2023-08-12 |
Not clear |
| Yuko Ibuki, Marie Akaike, Tatsushi Toyooka, Rensuke Got. Akt1-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation. Photochemistry and photobiology. vol 84. issue 1. 2008-03-27. PMID:18173715. |
in this study, the role of akt1 in the uvb-induced inhibition of apoptosis was examined by akt1 knockdown using small interfering rna (sirna). |
2008-03-27 |
2023-08-12 |
Not clear |
| Yuko Ibuki, Marie Akaike, Tatsushi Toyooka, Rensuke Got. Akt1-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation. Photochemistry and photobiology. vol 84. issue 1. 2008-03-27. PMID:18173715. |
these findings suggest that appropriate intracellular oxidation after uvb irradiation prevented apoptosis, a process which might be partially regulated by the production of reactive oxygen species mediated by akt1. |
2008-03-27 |
2023-08-12 |
Not clear |
| Jessica K Altman, Patrick Yoon, Efstratios Katsoulidis, Barbara Kroczynska, Antonella Sassano, Amanda J Redig, Heather Glaser, Alison Jordan, Martin S Tallman, Nissim Hay, Leonidas C Platania. Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. The Journal of biological chemistry. vol 283. issue 4. 2008-03-26. PMID:18048359. |
using cells with targeted disruption of both the akt1 and akt2 genes, we found that induction of arsenic trioxide-dependent apoptosis is strongly enhanced in the absence of these kinases, suggesting that akt1/akt2 are activated in a negative feedback regulatory manner, to control generation of as(2)o(3) responses. |
2008-03-26 |
2023-08-12 |
Not clear |
| Sandra Koseoglu, Zhuomei Lu, Chandra Kumar, Paul Kirschmeier, Jun Zo. AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer biology & therapy. vol 6. issue 5. 2008-02-28. PMID:17426444. |
akt1, akt2 and akt3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. |
2008-02-28 |
2023-08-12 |
human |
| Xiao-Tian Wang, Dong-Sheng Pei, Jing Xu, Qiu-Hua Guan, Ya-Feng Sun, Xiao-Mei Liu, Guang-Yi Zhan. Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury. Cellular signalling. vol 19. issue 9. 2007-10-04. PMID:17555943. |
in addition, activated akt1 inhibited the activation of bad(s128) through downregulating jnk1/2 activation, thus inhibiting jnk-mediated bad apoptosis pathway. |
2007-10-04 |
2023-08-12 |
rat |
| Long He, Bo Yeon Kim, Kyoung A Kim, Osong Kwon, Sun Ok Kim, Eun Young Bae, Myung Sun Lee, Min Soo Kim, Mira Jung, A Moon, Kihwan Bae, Jong Seog Ah. NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin. Cellular signalling. vol 19. issue 8. 2007-09-12. PMID:17462862. |
nf-kappab inhibition enhances caspase-3 degradation of akt1 and apoptosis in response to camptothecin. |
2007-09-12 |
2023-08-12 |
Not clear |
| Long He, Bo Yeon Kim, Kyoung A Kim, Osong Kwon, Sun Ok Kim, Eun Young Bae, Myung Sun Lee, Min Soo Kim, Mira Jung, A Moon, Kihwan Bae, Jong Seog Ah. NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin. Cellular signalling. vol 19. issue 8. 2007-09-12. PMID:17462862. |
in the present study, we discovered that akt1 is degraded when cells deficient in ataxia telangiectasia mutated (atm) were treated to cpt for apoptosis induction. |
2007-09-12 |
2023-08-12 |
Not clear |
| Long He, Bo Yeon Kim, Kyoung A Kim, Osong Kwon, Sun Ok Kim, Eun Young Bae, Myung Sun Lee, Min Soo Kim, Mira Jung, A Moon, Kihwan Bae, Jong Seog Ah. NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin. Cellular signalling. vol 19. issue 8. 2007-09-12. PMID:17462862. |
given the accumulating evidences demonstrating akt as a promising anticancer therapeutic target, all these results suggest that dna damage induced apoptosis could be regulated by atm-mediated nf-kappab activation, and that akt1 degradation be necessarily required for this apoptotic process. |
2007-09-12 |
2023-08-12 |
Not clear |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cellular signalling. vol 19. issue 6. 2007-07-24. PMID:17289346. |
through akt1 dependent pathways, wnt1 phosphorylates gsk-3beta and maintains beta-catenin integrity to insure its translocation from the cytoplasm to the nucleus to block apoptosis. |
2007-07-24 |
2023-08-12 |
Not clear |
| Robert B Boxer, Douglas B Stairs, Katherine D Dugan, Kathleen L Notarfrancesco, Carla P Portocarrero, Blaine A Keister, George K Belka, Han Cho, Jeffrey C Rathmell, Craig B Thompson, Morris J Birnbaum, Lewis A Chodos. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell metabolism. vol 4. issue 6. 2007-02-02. PMID:17141631. |
whereas cellular proliferation, differentiation, and apoptosis are unaffected, loss of akt1 disrupts the coordinate regulation of metabolic pathways that normally occurs at the onset of lactation. |
2007-02-02 |
2023-08-12 |
mouse |
| Kirsten H Limesand, Kathryn L Schwertfeger, Steven M Anderso. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Molecular and cellular biology. vol 26. issue 23. 2006-12-26. PMID:16982679. |
mdm2 is required for suppression of apoptosis by activated akt1 in salivary acinar cells. |
2006-12-26 |
2023-08-12 |
mouse |
| Kirsten H Limesand, Kathryn L Schwertfeger, Steven M Anderso. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Molecular and cellular biology. vol 26. issue 23. 2006-12-26. PMID:16982679. |
we report that etoposide and gamma irradiation induce apoptosis of salivary acinar cells from fvb control mice in vitro and in vivo; however, apoptosis is reduced in transgenic mice expressing a constitutively activated mutant of akt1 (myr-akt1). |
2006-12-26 |
2023-08-12 |
mouse |