| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kirsten H Limesand, Kathryn L Schwertfeger, Steven M Anderso. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Molecular and cellular biology. vol 26. issue 23. 2006-12-26. PMID:16982679. |
reduction of mdm2 levels in myr-akt1 primary salivary acinar cells with small interfering rna increases the levels of p53 protein and renders these cells susceptible to etoposide-induced apoptosis in spite of the presence of activated akt1. |
2006-12-26 |
2023-08-12 |
mouse |
| Kirsten H Limesand, Kathryn L Schwertfeger, Steven M Anderso. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Molecular and cellular biology. vol 26. issue 23. 2006-12-26. PMID:16982679. |
these results indicate that mdm2 is a critical substrate of activated akt1 in the suppression of p53-dependent apoptosis in vivo. |
2006-12-26 |
2023-08-12 |
mouse |
| Xuesong Liu, Yan Shi, Morris J Birnbaum, Keqiang Ye, Ron De Jong, Tillman Oltersdorf, Vincent L Giranda, Yan Lu. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. The Journal of biological chemistry. vol 281. issue 42. 2006-12-06. PMID:16923802. |
in the current study, we used an akt3 small interfering rna (akt3 sirna) to analyze apoptosis induction in akt1 and akt2 double knock-out mouse embryonic fibroblast cells (mef-akt1,2-dko). |
2006-12-06 |
2023-08-12 |
mouse |
| Xuesong Liu, Yan Shi, Morris J Birnbaum, Keqiang Ye, Ron De Jong, Tillman Oltersdorf, Vincent L Giranda, Yan Lu. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. The Journal of biological chemistry. vol 281. issue 42. 2006-12-06. PMID:16923802. |
in addition, reintroducing akt1 also inhibited apoptosis induced by akt3 sirna. |
2006-12-06 |
2023-08-12 |
mouse |
| Hua Yang, Lili He, Patricia Kruk, Santo V Nicosia, Jin Q Chen. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. International journal of cancer. vol 119. issue 10. 2006-11-13. PMID:16894566. |
ectopic expression of aurora-a renders cells resistant to cisplatin (cddp), etoposide and paclitaxel-induced apoptosis and stimulates akt1 and akt2 activity in wild-type p53 but not p53-null ovarian cancer cells. |
2006-11-13 |
2023-08-12 |
human |
| Ke Liang, Yang Lu, Xinqun Li, Xiao Zeng, Robert I Glazer, Gordon B Mills, Zhen Fa. Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16782806. |
cells with high levels of phosphorylated pdk1 were more resistant to gemcitabine-induced apoptosis than cells expressing high levels of phosphorylated akt1. |
2006-09-28 |
2023-08-12 |
mouse |
| Ke Liang, Yang Lu, Xinqun Li, Xiao Zeng, Robert I Glazer, Gordon B Mills, Zhen Fa. Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16782806. |
we found that knockdown of pdk1 expression sensitized mcf7 cells to gemcitabine-induced apoptosis more effectively than did knockdown of akt1 expression in the same cells. |
2006-09-28 |
2023-08-12 |
mouse |
| Teresa Rasoulpour, Kathryn DiPalma, Branko Kolvek, Mary Hixo. Akt1 suppresses radiation-induced germ cell apoptosis in vivo. Endocrinology. vol 147. issue 9. 2006-09-21. PMID:16763066. |
akt1 suppresses radiation-induced germ cell apoptosis in vivo. |
2006-09-21 |
2023-08-12 |
mouse |
| Teresa Rasoulpour, Kathryn DiPalma, Branko Kolvek, Mary Hixo. Akt1 suppresses radiation-induced germ cell apoptosis in vivo. Endocrinology. vol 147. issue 9. 2006-09-21. PMID:16763066. |
to evaluate a protective role for akt1 in the testis in vivo, we examined the incidence of apoptosis in akt1-deficient mice after radiation-induced germ cell injury. |
2006-09-21 |
2023-08-12 |
mouse |
| Teresa Rasoulpour, Kathryn DiPalma, Branko Kolvek, Mary Hixo. Akt1 suppresses radiation-induced germ cell apoptosis in vivo. Endocrinology. vol 147. issue 9. 2006-09-21. PMID:16763066. |
we found that akt kinase activity increases in the testes of wild-type mice after ionizing radiation, and that loss of akt1 results in an earlier onset of germ cell apoptosis and enhanced sensitivity of mitotic spermatogonia to ionizing radiation. |
2006-09-21 |
2023-08-12 |
mouse |
| S L Harris, G Gil, W Hu, H Robins, E Bond, K Hirshfield, Z Feng, X Yu, A K Teresky, G Bond, A J Levin. Single-nucleotide polymorphisms in the p53 pathway. Cold Spring Harbor symposia on quantitative biology. vol 70. 2006-09-08. PMID:16869744. |
polymorphisms in the akt1 and perp genes significantly affect the frequency of apoptosis. |
2006-09-08 |
2023-08-12 |
human |
| Chi Tarn, Yuliya V Skorobogatko, Takahiro Taguchi, Burton Eisenberg, Margaret von Mehren, Andrew K Godwi. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707477. |
importantly, expression of constitutively active akt1 or akt2 does not rescue cells from the imatinib-mediated apoptosis although glucose uptake was not blocked, suggesting that the potential therapeutic effect of imatinib is independent of akt activity and glucose deprivation. |
2006-07-18 |
2023-08-12 |
Not clear |
| Alex Toker, Merav Yoeli-Lerne. Akt signaling and cancer: surviving but not moving on. Cancer research. vol 66. issue 8. 2006-06-07. PMID:16618711. |
these studies suggest that akt1 may have a dual role in tumorigenesis, acting not only pro-oncogenically by suppressing apoptosis but also anti-oncogenically by suppressing invasion and metastasis. |
2006-06-07 |
2023-08-12 |
Not clear |
| Sheng-Hua Wu, Chao Lu, Ling Dong, Guo-Ping Zhou, Zha-Guang He, Zi-Qing Che. High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. Prostaglandins, leukotrienes, and essential fatty acids. vol 73. issue 2. 2005-12-05. PMID:15936930. |
rat renal interstitial fibroblasts (nrk-49f cells) were exposed to lxa4 in 5% fcs for 24 h. lxa4 at 0.1 and 1 microm induced 9.83% and 33.82% apoptosis of the cells, respectively, upregulated the expression of calpain 10 and smac, the levels of [ca2+]i and activity of caspase-3, and downregulated the activity of stat3 and threonine phosphorylated akt1. |
2005-12-05 |
2023-08-12 |
rat |
| Liyan Zhuang, Jayoung Kim, Rosalyn M Adam, Keith R Solomon, Michael R Freema. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. The Journal of clinical investigation. vol 115. issue 4. 2005-06-28. PMID:15776112. |
simvastatin, a cholesterol synthesis inhibitor, lowered raft cholesterol content, inhibited akt1 serine-threonine kinase (protein kinase balpha)/protein kinase b (akt/pkb) pathway signaling, and induced apoptosis in caveolin- and pten-negative lncap pca cells. |
2005-06-28 |
2023-08-12 |
mouse |
| Tianyan Gao, Frank Furnari, Alexandra C Newto. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular cell. vol 18. issue 1. 2005-05-12. PMID:15808505. |
here, we identify a protein phosphatase, ph domain leucine-rich repeat protein phosphatase (phlpp), that specifically dephosphorylates the hydrophobic motif of akt (ser473 in akt1), triggering apoptosis and suppressing tumor growth. |
2005-05-12 |
2023-08-12 |
Not clear |
| Nicolas Di-Poï, Chuan Young Ng, Nguan Soon Tan, Zhongzhou Yang, Brian A Hemmings, Béatrice Desvergne, Liliane Michalik, Walter Wahl. Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Molecular and cellular biology. vol 25. issue 5. 2005-03-28. PMID:15713628. |
subsequent pparbeta/delta-mediated temporal activation of the antiapoptotic akt1 pathway in vivo protects keratinocytes from hair pegs against apoptosis, which is required for normal hair follicle development. |
2005-03-28 |
2023-08-12 |
mouse |
| Toshifumi Sugatani, Keith A Hrusk. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15545269. |
surprisingly, deletion of akt1 and/or akt2 protein did not stimulate cleaved caspase-3 activity and failed to promote apoptosis. |
2005-03-22 |
2023-08-12 |
Not clear |
| N S Tan, L Michalik, N Di-Poï, B Desvergne, W Wahl. Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing. Biochemical Society transactions. vol 32. issue Pt 1. 2004-09-24. PMID:14748722. |
the resulting increase in akt1 activity suppresses apoptosis and ensures the presence of a sufficient number of viable keratinocytes at the wound margin for re-epithelialization. |
2004-09-24 |
2023-08-12 |
mouse |
| Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane, William R Seller. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nature medicine. vol 10. issue 6. 2004-07-28. PMID:15156201. |
here, we report that mtor inhibition induced apoptosis of epithelial cells and the complete reversal of a neoplastic phenotype in the prostate of mice expressing human akt1 in the ventral prostate. |
2004-07-28 |
2023-08-12 |
mouse |