| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mitra Esfandiarei, Honglin Luo, Bobby Yanagawa, Agripina Suarez, Darya Dabiri, Jianchang Zhang, Bruce M McManu. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. Journal of virology. vol 78. issue 8. 2004-05-06. PMID:15047842. |
dominant negative akt1 and ly294002 also increase apoptosis in infected cells, which can be reversed by addition of the general caspase inhibitor benzyloxycarbonyl-val-ala-asp-fluoromethylketone (zvad.fmk). |
2004-05-06 |
2023-08-12 |
Not clear |
| Mitra Esfandiarei, Honglin Luo, Bobby Yanagawa, Agripina Suarez, Darya Dabiri, Jianchang Zhang, Bruce M McManu. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. Journal of virology. vol 78. issue 8. 2004-05-06. PMID:15047842. |
interestingly, blocking of apoptosis by zvad.fmk does not reverse the viral rna translation blockade, indicating that the inhibitory effect of dominant negative akt1 on viral protein expression is not caspase dependent. |
2004-05-06 |
2023-08-12 |
Not clear |
| Han C Dan, Mei Sun, Satoshi Kaneko, Richard I Feldman, Santo V Nicosia, Hong-Gang Wang, Benjamin K Tsang, Jin Q Chen. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. vol 279. issue 7. 2004-03-30. PMID:14645242. |
here, we demonstrate that akt, including akt1 and akt2, interacts with and phosphorylates x-linked inhibitor of apoptosis protein (xiap) at residue serine-87 in vitro and in vivo. |
2004-03-30 |
2023-08-12 |
Not clear |
| Mary L Hixon, Kim Boekelheid. Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium. Journal of andrology. vol 24. issue 6. 2004-01-15. PMID:14581516. |
akt1 is a survival factor that is believed to play a role in the transcriptional modulation of a subset of genes associated with cell growth, proliferation, and apoptosis. |
2004-01-15 |
2023-08-12 |
rat |
| Jing-Qiong Kang, Zhao Zhong Chong, Kenneth Maies. Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity. Journal of neuroscience research. vol 74. issue 1. 2003-11-10. PMID:13130504. |
given that early cellular membrane phosphatidylserine exposure is a critical component of apoptosis, we investigated the role of akt1 during neuronal apoptotic injury. |
2003-11-10 |
2023-08-12 |
Not clear |
| Nicolas Di-Poï, Liliane Michalik, Nguan Soon Tan, Béatrice Desvergne, Walter Wahl. The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing. The Journal of steroid biochemistry and molecular biology. vol 85. issue 2-5. 2003-10-29. PMID:12943711. |
we show here that pparbeta protects keratinocytes from growth factor deprivation, anoikis and tnf-alpha-induced apoptosis, by modulating both early and late apoptotic events via the akt1 signaling pathway and dna fragmentation, respectively. |
2003-10-29 |
2023-08-12 |
mouse |
| Marta Salinas, Raquel Diaz, Nader G Abraham, Carlos M Ruiz de Galarreta, Antonio Cuadrad. Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12578834. |
by contrast, cells transfected with a membrane-targeted active version of akt1 exhibited increased ho-1 expression, even in the absence of ngf, and displayed a greatly attenuated production of ros and apoptosis in response to 6-ohda. |
2003-05-22 |
2023-08-12 |
human |
| H-L Lin, W-Y Lui, T-Y Liu, C-W Ch. Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway. British journal of cancer. vol 88. issue 6. 2003-05-05. PMID:12644839. |
pi3 kinase inhibitor, wortmannin, or a dominant-negative akt1 expression vector treatment partially enhanced taxol-induced apoptosis indicating that pi3 kinase-akt pathway was involved in taxol-resistance pathway. |
2003-05-05 |
2023-08-12 |
mouse |
| R Bortul, P L Tazzari, A Cappellini, G Tabellini, A M Billi, R Bareggi, L Manzoli, L Cocco, A M Martell. Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation. Leukemia. vol 17. issue 2. 2003-04-11. PMID:12592338. |
constitutively active akt1 protects hl60 leukemia cells from trail-induced apoptosis through a mechanism involving nf-kappab activation and cflip(l) up-regulation. |
2003-04-11 |
2023-08-12 |
human |
| R Bortul, P L Tazzari, A Cappellini, G Tabellini, A M Billi, R Bareggi, L Manzoli, L Cocco, A M Martell. Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation. Leukemia. vol 17. issue 2. 2003-04-11. PMID:12592338. |
akt1 promotes cell survival and blocks apoptosis. |
2003-04-11 |
2023-08-12 |
human |
| M Schmidt, S Hövelmann, T L Becker. A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis. British journal of cancer. vol 87. issue 8. 2002-11-14. PMID:12373610. |
a novel form of constitutively active farnesylated akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis. |
2002-11-14 |
2023-08-12 |
human |
| Albert H Kim, Hiroko Yano, Han Cho, Debra Meyer, Bob Monks, Ben Margolis, Morris J Birnbaum, Moses V Cha. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. vol 35. issue 4. 2002-09-20. PMID:12194869. |
akt1 regulates a jnk scaffold during excitotoxic apoptosis. |
2002-09-20 |
2023-08-12 |
mouse |
| Albert H Kim, Hiroko Yano, Han Cho, Debra Meyer, Bob Monks, Ben Margolis, Morris J Birnbaum, Moses V Cha. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. vol 35. issue 4. 2002-09-20. PMID:12194869. |
overexpression of akt1 mutants that bind jip1 reduced excitotoxic apoptosis. |
2002-09-20 |
2023-08-12 |
mouse |
| X Liu, Y Shi, E K Han, Z Chen, S H Rosenberg, V L Giranda, Y Luo, S C N. Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells. Neoplasia (New York, N.Y.). vol 3. issue 4. 2001-12-04. PMID:11571628. |
downregulation of akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells. |
2001-12-04 |
2023-08-12 |
human |
| D Martín, M Salinas, R López-Valdaliso, E Serrano, M Recuero, A Cuadrad. Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells. Journal of neurochemistry. vol 78. issue 5. 2001-10-25. PMID:11553674. |
we tested the hypothesis that akt1 might modify the vulnerability of neural cells to apoptosis induced by abeta(25-35). |
2001-10-25 |
2023-08-12 |
mouse |
| W S Chen, P Z Xu, K Gottlob, M L Chen, K Sokol, T Shiyanova, I Roninson, W Weng, R Suzuki, K Tobe, T Kadowaki, N Ha. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & development. vol 15. issue 17. 2001-10-11. PMID:11544177. |
growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene. |
2001-10-11 |
2023-08-12 |
mouse |
| W S Chen, P Z Xu, K Gottlob, M L Chen, K Sokol, T Shiyanova, I Roninson, W Weng, R Suzuki, K Tobe, T Kadowaki, N Ha. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & development. vol 15. issue 17. 2001-10-11. PMID:11544177. |
increased spontaneous apoptosis in testes, and attenuation of spermatogenesis is observed in akt1(-/-) male mice. |
2001-10-11 |
2023-08-12 |
mouse |
| W S Chen, P Z Xu, K Gottlob, M L Chen, K Sokol, T Shiyanova, I Roninson, W Weng, R Suzuki, K Tobe, T Kadowaki, N Ha. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & development. vol 15. issue 17. 2001-10-11. PMID:11544177. |
increased spontaneous apoptosis is also observed in the thymi of akt1(-/-) mice, and akt1(-/-) thymocytes are more sensitive to apoptosis induced by gamma-irradiation and dexamethasone. |
2001-10-11 |
2023-08-12 |
mouse |
| W S Chen, P Z Xu, K Gottlob, M L Chen, K Sokol, T Shiyanova, I Roninson, W Weng, R Suzuki, K Tobe, T Kadowaki, N Ha. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & development. vol 15. issue 17. 2001-10-11. PMID:11544177. |
finally, akt1(-/-) mouse embryo fibroblasts (mefs) are more susceptible to apoptosis induced by tnf, anti-fas, uv irradiation, and serum withdrawal. |
2001-10-11 |
2023-08-12 |
mouse |
| b' S Janelidze, B R Hu, P Siesj\\xc3\\xb6, B K Siesj\\xc3\\xb. Alterations of Akt1 (PKBalpha) and p70(S6K) in transient focal ischemia. Neurobiology of disease. vol 8. issue 1. 2001-05-24. PMID:11162248.' |
the serine-threonine kinase akt1 promotes cell survival through inhibition of apoptosis. |
2001-05-24 |
2023-08-12 |
rat |