| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L V Madrid, C Y Wang, D C Guttridge, A J Schottelius, A S Baldwin, M W May. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Molecular and cellular biology. vol 20. issue 5. 2000-03-16. PMID:10669740. |
oncogenic ras, an upstream activator of akt, requires nf-kappab to initiate transformation, at least partially through the ability of nf-kappab to suppress transformation-associated apoptosis. |
2000-03-16 |
2023-08-12 |
Not clear |
| L V Madrid, C Y Wang, D C Guttridge, A J Schottelius, A S Baldwin, M W May. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Molecular and cellular biology. vol 20. issue 5. 2000-03-16. PMID:10669740. |
inhibition of endogenous akt activity sensitized cells to h-ras(v12)-induced apoptosis, which was associated with a loss of nf-kappab transcriptional activity. |
2000-03-16 |
2023-08-12 |
Not clear |
| C Hermann, B Assmus, C Urbich, A M Zeiher, S Dimmele. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669636. |
the present study demonstrates an important role for insulin-mediated akt activation in the prevention of endothelial cell apoptosis, which may importantly contribute to cell homeostasis and the integrity of the endothelium. |
2000-03-03 |
2023-08-12 |
human |
| R A Roberts, N H James, S C Cosulic. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. Hepatology (Baltimore, Md.). vol 31. issue 2. 2000-02-24. PMID:10655266. |
in contrast, suppression of tgf-beta(1)-induced apoptosis by tnf-alpha does not require pi 3-kinase and protein kinase b (pkb or akt)-mediated pathways, but is dependent on erk and p38 map kinase activity. |
2000-02-24 |
2023-08-12 |
rat |
| K Marushige, Y Marushig. Changes in the mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling associated with the induction of apoptosis. Anticancer research. vol 19. issue 5B. 2000-02-18. PMID:10628325. |
a concomitant inhibition of erk and akt activation induced apoptosis without jnk activation, although with a considerable delay of its onset. |
2000-02-18 |
2023-08-12 |
Not clear |
| Y Arase, T Hiwasa, R Hasegawa, J Nomura, H Ito, N Suzuk. Prevention of v-Ha-Ras-dependent apoptosis by PDGF coordinates in phosphorylation of ERK and Akt. Biochemical and biophysical research communications. vol 267. issue 1. 2000-02-08. PMID:10623570. |
prevention of v-ha-ras-dependent apoptosis by pdgf coordinates in phosphorylation of erk and akt. |
2000-02-08 |
2023-08-12 |
human |
| S Rokudai, N Fujita, Y Hashimoto, T Tsuru. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis. Journal of cellular physiology. vol 182. issue 2. 2000-01-27. PMID:10623893. |
we found that akt protein was down-regulated during apoptosis. |
2000-01-27 |
2023-08-12 |
Not clear |
| S Rokudai, N Fujita, Y Hashimoto, T Tsuru. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis. Journal of cellular physiology. vol 182. issue 2. 2000-01-27. PMID:10623893. |
the down-regulation was blocked by a caspase inhibitor, indicating that akt was cleaved by caspases during apoptosis. |
2000-01-27 |
2023-08-12 |
Not clear |
| K Fujikawa, I de Aos Scherpenseel, S K Jain, E Presman, R A Christensen, L Varticovsk. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells. Experimental cell research. vol 253. issue 2. 2000-01-11. PMID:10585289. |
apoptosis of growth factor-deprived cells grown in monolayer was decreased by angiopoietin-1 and correlated with akt activation. |
2000-01-11 |
2023-08-12 |
Not clear |
| W Li, J Zhang, L Flechner, T Hyun, A Yam, T F Franke, J H Pierc. Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene. vol 18. issue 47. 2000-01-04. PMID:10597260. |
protein kinase c-alpha overexpression stimulates akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. |
2000-01-04 |
2023-08-12 |
Not clear |
| W Li, J Zhang, L Flechner, T Hyun, A Yam, T F Franke, J H Pierc. Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene. vol 18. issue 47. 2000-01-04. PMID:10597260. |
coexpression of wild type akt and pkc-alpha resulted in greater suppression of apoptosis than pkc-alpha expression alone. |
2000-01-04 |
2023-08-12 |
Not clear |
| W Li, J Zhang, L Flechner, T Hyun, A Yam, T F Franke, J H Pierc. Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene. vol 18. issue 47. 2000-01-04. PMID:10597260. |
together, our results demonstrate that suppression of apoptosis by pkc-alpha correlates with its ability of activating endogenous akt. |
2000-01-04 |
2023-08-12 |
Not clear |
| W Li, J Zhang, L Flechner, T Hyun, A Yam, T F Franke, J H Pierc. Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene. vol 18. issue 47. 2000-01-04. PMID:10597260. |
furthermore, activation of overexpressed akt by pkc-alpha is consistent with their synergistic effect on suppressing apoptosis, providing the strong evidence of cross talk between akt and pkc-alpha. |
2000-01-04 |
2023-08-12 |
Not clear |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
in the presence of low concentrations of serum, enforced pten expression results in a marked increase in cellular apoptosis, a finding which is consistent with the capacity of pten to alter the phosphorylation, and presumably function, of the akt, bad, p70s6 kinase and gsk3 alpha apoptosis regulators. |
2000-01-04 |
2023-08-12 |
Not clear |
| T Matsui, L Li, del MonteF, Y Fukui, T F Franke, R J Hajjar, A Rosenzwei. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. vol 100. issue 23. 1999-12-29. PMID:10587343. |
adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. |
1999-12-29 |
2023-08-12 |
Not clear |
| J A Costoya, J Finidori, S Moutoussamy, R Seãris, J Devesa, V M Arc. Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway. Endocrinology. vol 140. issue 12. 1999-12-20. PMID:10579361. |
we also showed that the inhibitory action of gh on apoptosis is probably mediated via stimulation of the serine-threonine kinase akt, as 1) gh treatment induces a prompt phosphorylation of akt; and 2) gh effects on cell survival are abolished by transfection of an akt mutant that exhibits dominant negative function. |
1999-12-20 |
2023-08-12 |
human |
| H Matsuzaki, M Tamatani, N Mitsuda, K Namikawa, H Kiyama, S Miyake, M Tohyam. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537063. |
activation of akt kinase inhibits apoptosis and changes in bcl-2 and bax expression induced by nitric oxide in primary hippocampal neurons. |
1999-11-05 |
2023-08-12 |
Not clear |
| H Matsuzaki, M Tamatani, N Mitsuda, K Namikawa, H Kiyama, S Miyake, M Tohyam. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537063. |
these findings suggest that activation of akt is necessary and sufficient for the effect of igf-1 and is capable of preventing no-induced apoptosis by modulating the no-induced changes in bcl-2 and bax expression. |
1999-11-05 |
2023-08-12 |
Not clear |
| Y B Ouyang, Y Tan, M Comb, C L Liu, M E Martone, B K Siesjö, B R H. Survival- and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 19. issue 10. 1999-10-29. PMID:10532637. |
release of cytochrome c (cyt c) into cytoplasm initiates caspase-mediated apoptosis, whereas activation of akt kinase by phosphorylation at serine-473 prevents apoptosis in several cell systems. |
1999-10-29 |
2023-08-12 |
rat |
| R Goswami, J Kilkus, S A Dawson, G Dawso. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. Journal of neuroscience research. vol 57. issue 6. 1999-10-19. PMID:10467260. |
overexpression of akt (protein kinase b) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. |
1999-10-19 |
2023-08-12 |
Not clear |