| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Goswami, J Kilkus, S A Dawson, G Dawso. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. Journal of neuroscience research. vol 57. issue 6. 1999-10-19. PMID:10467260. |
to elucidate the mechanism of apoptosis we generated f-11 clones which overexpressed either the p110 subunit of pi3k, a constitutively active form of protein kinase b/akt (myristoylated akt), or a dominant-negative form (c-akt). |
1999-10-19 |
2023-08-12 |
Not clear |
| R Goswami, J Kilkus, S A Dawson, G Dawso. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. Journal of neuroscience research. vol 57. issue 6. 1999-10-19. PMID:10467260. |
overexpression of pi3k (p110) and akt protected cells against ceramide-induced apoptosis, suggesting that ceramide action is upstream of akt in these cells and suggesting that akt might be a target for inhibition by ceramide. |
1999-10-19 |
2023-08-12 |
Not clear |
| F François, M L Grime. Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501228. |
phosphorylation-dependent akt cleavage in neural cell in vitro reconstitution of apoptosis. |
1999-10-14 |
2023-08-12 |
human |
| A D Ebert, C Wechselberger, S Frank, B Wallace-Jones, M Seno, I Martinez-Lacaci, C Bianco, M De Santis, H K Weitzel, D S Salomo. Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. Cancer research. vol 59. issue 18. 1999-10-08. PMID:10493495. |
phosphorylation of akt and gsk-3beta by cr-1 can be blocked by ly294002, a specific inhibitor of pi3k, thus leading to apoptosis. |
1999-10-08 |
2023-08-12 |
human |
| M Tamura, J Gu, E H Danen, T Takino, S Miyamoto, K M Yamad. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400703. |
moreover, overexpression of fak in pten-transfected cells reversed the decreased fak phosphorylation and pi 3-k activity, and it partially rescued pip3 levels, akt phosphorylation, and pten-induced apoptosis. |
1999-08-19 |
2023-08-12 |
Not clear |
| S G Kennedy, E S Kandel, T K Cross, N Ha. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Molecular and cellular biology. vol 19. issue 8. 1999-08-19. PMID:10409766. |
here we show that akt inhibits apoptosis and the processing of procaspases to their active forms by delaying mitochondrial changes in a caspase-independent manner. |
1999-08-19 |
2023-08-12 |
Not clear |
| S G Kennedy, E S Kandel, T K Cross, N Ha. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Molecular and cellular biology. vol 19. issue 8. 1999-08-19. PMID:10409766. |
however, akt cannot inhibit apoptosis induced by microinjection of cytochrome c. we also demonstrated that akt inhibits apoptosis and cytochrome c release induced by several proapoptotic bcl-2 family members. |
1999-08-19 |
2023-08-12 |
Not clear |
| S G Kennedy, E S Kandel, T K Cross, N Ha. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Molecular and cellular biology. vol 19. issue 8. 1999-08-19. PMID:10409766. |
taken together, our results show that akt promotes cell survival by intervening in the apoptosis cascade before cytochrome c release and caspase activation via a mechanism that is distinct from bad phosphorylation. |
1999-08-19 |
2023-08-12 |
Not clear |
| P Carmeliet, M G Lampugnani, L Moons, F Breviario, V Compernolle, F Bono, G Balconi, R Spagnuolo, B Oosthuyse, M Dewerchin, A Zanetti, A Angellilo, V Mattot, D Nuyens, E Lutgens, F Clotman, M C de Ruiter, A Gittenberger-de Groot, R Poelmann, F Lupu, J M Herbert, D Collen, E Dejan. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. vol 98. issue 2. 1999-08-13. PMID:10428027. |
deficiency or truncation of ve-cadherin induced endothelial apoptosis and abolished transmission of the endothelial survival signal by vegf-a to akt kinase and bcl2 via reduced complex formation with vegf receptor-2, beta-catenin, and phosphoinositide 3 (pi3)-kinase. |
1999-08-13 |
2023-08-12 |
mouse |
| A Gautreau, P Poullet, D Louvard, M Arpi. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 13. 1999-07-19. PMID:10377409. |
cells producing y353f ezrin are defective in activation of the protein kinase akt, a downstream target of pi 3-kinase that protects cells against apoptosis. |
1999-07-19 |
2023-08-12 |
Not clear |
| S Gibson, S Tu, R Oyer, S M Anderson, G L Johnso. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation. The Journal of biological chemistry. vol 274. issue 25. 1999-07-15. PMID:10364198. |
egf stimulation of akt kinase activity blocked fas-induced apoptosis. |
1999-07-15 |
2023-08-12 |
Not clear |
| S Gibson, S Tu, R Oyer, S M Anderson, G L Johnso. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation. The Journal of biological chemistry. vol 274. issue 25. 1999-07-15. PMID:10364198. |
expression of activated akt in mcf-7 breast adenocarcinoma cells was sufficient to block fas-mediated apoptosis. |
1999-07-15 |
2023-08-12 |
Not clear |
| S Gibson, S Tu, R Oyer, S M Anderson, G L Johnso. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation. The Journal of biological chemistry. vol 274. issue 25. 1999-07-15. PMID:10364198. |
the findings indicate that egf receptor stimulation of epithelial cells has a significant survival function against death receptor-induced apoptosis mediated by akt. |
1999-07-15 |
2023-08-12 |
Not clear |
| K Nakatani, H Sakaue, D A Thompson, R J Weigel, R A Rot. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Biochemical and biophysical research communications. vol 257. issue 3. 1999-06-01. PMID:10208883. |
the family of protein kinases called akt, protein kinase b (pkb), or related to a and c kinase (rac) have been implicated in numerous biological processes including adipocyte and muscle differentiation, glycogen synthesis, glucose uptake, apoptosis and cellular proliferation. |
1999-06-01 |
2023-08-12 |
human |
| S J Watton, J Downwar. Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Current biology : CB. vol 9. issue 8. 1999-06-01. PMID:10226029. |
protein kinase b (pkb or akt) is a mitogen-regulated protein kinase involved in the protection of cells from apoptosis, the promotion of cell proliferation and diverse metabolic responses [1]. |
1999-06-01 |
2023-08-12 |
Not clear |
| Y Sonoda, S Watanabe, Y Matsumoto, E Aizu-Yokota, T Kasahar. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. The Journal of biological chemistry. vol 274. issue 15. 1999-05-03. PMID:10187851. |
when t98g cells were incubated with wortmannin, a pi 3-kinase inhibitor, both pi 3-kinase activity and phosphorylation of akt were inhibited, whereas apoptosis by oxidative stress was accelerated. |
1999-05-03 |
2023-08-12 |
human |
| A Brunet, A Bonni, M J Zigmond, M Z Lin, P Juo, L S Hu, M J Anderson, K C Arden, J Blenis, M E Greenber. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. vol 96. issue 6. 1999-04-27. PMID:10102273. |
survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase akt, which then phosphorylates and inactivates components of the apoptotic machinery, including bad and caspase 9. |
1999-04-27 |
2023-08-12 |
Not clear |
| T Kinashi, T Asaoka, R Setoguchi, K Takats. Affinity modulation of very late antigen-5 through phosphatidylinositol 3-kinase in mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 5. 1999-04-14. PMID:10072533. |
failure of a constitutively active akt to stimulate adhesion suggested that the affinity modulation mechanisms mediated by pi 3-kinase are distinct from the mechanisms to control growth and apoptosis by pi 3-kinase. |
1999-04-14 |
2023-08-12 |
Not clear |
| K Shimoke, S Yamagishi, M Yamada, T Ikeuchi, H Hatanak. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain research. Developmental brain research. vol 112. issue 2. 1999-04-13. PMID:9878764. |
to investigate the intracellular signaling mechanism of ly294002-induced apoptosis, the activities of akt and c-jun n-terminal kinase (jnk) were measured in cells in hk (26 mm potassium) medium or lk+ (5 mm potassium) medium containing bdnf, with or without 10 microm ly294002. |
1999-04-13 |
2023-08-12 |
Not clear |
| K Shimoke, S Yamagishi, M Yamada, T Ikeuchi, H Hatanak. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain research. Developmental brain research. vol 112. issue 2. 1999-04-13. PMID:9878764. |
these findings demonstrated that apoptosis induced by inhibition of pi3-k activity involves suppression of the akt activity and elevation of the jnk activity in cerebellar granule neurons. |
1999-04-13 |
2023-08-12 |
Not clear |