| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Perla Pucci, Liam C Lee, Miaojun Han, Jamie D Matthews, Leila Jahangiri, Michaela Schlederer, Eleanor Manners, Annabel Sorby-Adams, Joshua Kaggie, Ricky M Trigg, Christopher Steel, Lucy Hare, Emily R James, Nina Prokoph, Stephen P Ducray, Olaf Merkel, Firkret Rifatbegovic, Ji Luo, Sabine Taschner-Mandl, Lukas Kenner, G A Amos Burke, Suzanne D Turne. Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma. Nature communications. vol 15. issue 1. 2024-04-23. PMID:38653965. |
it follows that the farnesyltransferase inhibitor (fti) lonafarnib in addition to alk tkis act synergistically in neuroblastoma, inducing apoptosis in vitro. |
2024-04-23 |
2024-04-26 |
Not clear |
| Chihiro Ando, Eiki Ichihara, Tatsuya Nishi, Ayako Morita, Naofumi Hara, Kenji Takada, Takamasa Nakasuka, Hiromi Watanabe, Hirohisa Kano, Kazuya Nishii, Go Makimoto, Takumi Kondo, Kiichiro Ninomiya, Masanori Fujii, Toshio Kubo, Kadoaki Ohashi, Ken-Ichi Matsuoka, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiur. Efficacy of gilteritinib in comparison with alectinib for the treatment of ALK-rearranged non-small cell lung cancer. Cancer science. 2023-09-15. PMID:37715310. |
to this end, we assessed the effects of gilteritinib on cell proliferation, apoptosis, and acquired resistance responses in several alk-rearranged nsclc cell lines and mouse xenograft tumor models and compared its efficacy to alectinib, a standard alk inhibitor. |
2023-09-15 |
2023-10-07 |
mouse |
| Ying Gao, Tong Liu, Jingang Liu, Yuying Yang, Keyan Sun, Zengqiang Li, Xin Zhai, Daiying Zu. ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells. Chemico-biological interactions. 2023-04-28. PMID:37116853. |
zyy-b-2, a novel alk inhibitor, overcomes resistance to ceritinib by inhibiting p-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant h2228 cells. |
2023-04-28 |
2023-08-14 |
Not clear |
| Correction to: 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells. The Journal of pharmacy and pharmacology. 2023-03-24. PMID:36961312. |
correction to: 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (zx-42), a novel alk inhibitor, induces apoptosis and protective autophagy in h2228 cells. |
2023-03-24 |
2023-08-14 |
Not clear |
| Yangyang Fan, Wei Li, Wenyan Nie, Han Yao, Yuanyuan Ren, Mengxuan Wang, Haoran Nie, Chenxi Gu, Jiadai Liu, Baijiao A. Novel Dual-Target Kinase Inhibitors of EGFR and ALK Were Designed, Synthesized, and Induced Cell Apoptosis in Non-Small Cell Lung Cancer. Molecules (Basel, Switzerland). vol 28. issue 5. 2023-03-11. PMID:36903251. |
novel dual-target kinase inhibitors of egfr and alk were designed, synthesized, and induced cell apoptosis in non-small cell lung cancer. |
2023-03-11 |
2023-08-14 |
Not clear |
| Yuki Katayama, Tadaaki Yamada, Keiko Tanimura, Shinsaku Tokuda, Kenji Morimoto, Soichi Hirai, Yohei Matsui, Ryota Nakamura, Masaki Ishida, Hayato Kawachi, Kazue Yoneda, Kazutaka Hosoya, Takahiro Tsuji, Hiroaki Ozasa, Akihiro Yoshimura, Masahiro Iwasaku, Young Hak Kim, Mano Horinaka, Toshiyuki Sakai, Takahiro Utsumi, Shinsuke Shiotsu, Takayuki Takeda, Ryohei Katayama, Koichi Takayam. Adaptive resistance to lorlatinib via EGFR signaling in ALK-rearranged lung cancer. NPJ precision oncology. vol 7. issue 1. 2023-01-26. PMID:36702855. |
egfr inhibition halted alk-rearranged lung cancer cell proliferation by enhancing alk inhibition-induced apoptosis via suppression of bcl-xl. |
2023-01-26 |
2023-08-14 |
Not clear |
| Wei Li, Han Yao, Chenxi Gu, Yuanyuan Ren, Jiadai Liu, Baijiao An, Wenhao Hu, Xingshu Li, Albert S C Cha. Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold. Bioorganic chemistry. vol 129. 2022-10-11. PMID:36220003. |
the study of anti-tumor mechanism indicated that 8a could effectively block the phosphorylation of egfr and alk proteins, so as to effectively inhibiting the proliferation and inducing apoptosis of h1975 tumor cells, blocking the cell cycle and reducing the mitochondrial membrane potential inhibited the migration of h1975 cells. |
2022-10-11 |
2023-08-14 |
mouse |
| Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H Palme. Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival. Disease models & mechanisms. vol 15. issue 8. 2022-08-16. PMID:35972154. |
we showed that hyperplasia in alk mutants was not caused by significantly increased rates of proliferation, but rather by decreased levels of apoptosis in the larval brain. |
2022-08-16 |
2023-08-14 |
human |
| Xing Chang, Junfang Wang, Jiang Bian, Zi Liu, Ming Guo, Zengqiang Li, Ying Liang Wu, Xin Zhai, Daiying Zu. 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells. Toxicology and applied pharmacology. 2022-07-08. PMID:35803438. |
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (zx-42) inhibits cell proliferation and induces apoptosis via inhibiting alk and its downstream pathways in karpas299 cells. |
2022-07-08 |
2023-08-14 |
Not clear |
| Mengting Han, Jiwei Shen, Lijing Wang, Yu Wang, Xin Zhai, Yao Li, Meiqiao Liu, Meiqi Gao, Zengqiang Li, Daiying Zuo, Yingliang W. Corrigendum to "5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells" [Chem. Biol. Interact. 284 (2018) 24-31]. Chemico-biological interactions. vol 356. 2022-03-03. PMID:35240371. |
corrigendum to "5-chloro-n4-(2-(isopropylsulfonyl)phenyl)-n2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1h-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (wy-135), a novel alk inhibitor, induces cell cycle arrest and apoptosis through inhibiting alk and its downstream pathways in karpas299 and h2228 cells" [chem. |
2022-03-03 |
2023-08-13 |
Not clear |
| Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Sachiko Arai, Azusa Tanimoto, Akihiro Nishiyama, Naohisa Ogo, Hiroyuki Takahashi, Akira Asai, Satoshi Watanabe, Toshiaki Kikuchi, Seiji Yan. STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis. NPJ precision oncology. vol 6. issue 1. 2022-03-01. PMID:35228642. |
stat3 inhibition effectively suppressed the adaptive survival of alk-rearranged lung cancer cells by enhancing alk inhibition-induced apoptosis. |
2022-03-01 |
2023-08-13 |
Not clear |
| Mingyuan Li, Yuan Li, Shiqin Li, Lin Jia, Chunyang Du, Meng Li, Shuangshuang Li, Hervé Galons, Na Guo, Peng Y. Co-delivery of F7 and crizotinib by thermosensitive liposome for breast cancer treatment. Journal of liposome research. 2021-12-14. PMID:34904521. |
cri is an inhibitor for cell proliferation and a promoter of apoptosis, by inhibiting the phosphorylation of intracellular alk and c-met, but its drug resistance limits its application. |
2021-12-14 |
2023-08-13 |
mouse |
| Hong-Quan Duong, Van Thai Than, Huyen-Trang Nguyen, Phuong-Thoa Nguyen, Huyen Trang Ha Thi, Thi Ngoc Ha Bui, Vu Phuong Linh Dang, Thi-Thanh Dinh, Kyu Sic You, The-Hung Dang, Yeon-Sun Seon. Anaplastic lymphoma kinase inhibitor NVP‑TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649854. |
notably, knocking down alk with sirnas also decreased proliferation and promoted g2/m arrest and apoptosis. |
2021-10-28 |
2023-08-13 |
human |
| Hong-Quan Duong, Van Thai Than, Huyen-Trang Nguyen, Phuong-Thoa Nguyen, Huyen Trang Ha Thi, Thi Ngoc Ha Bui, Vu Phuong Linh Dang, Thi-Thanh Dinh, Kyu Sic You, The-Hung Dang, Yeon-Sun Seon. Anaplastic lymphoma kinase inhibitor NVP‑TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649854. |
furthermore, inhibition of alk with nvp‑tae684 or sirna synergistically enhanced gemcitabine‑induced cell death by inducing apoptosis. |
2021-10-28 |
2023-08-13 |
human |
| Hong-Quan Duong, Van Thai Than, Huyen-Trang Nguyen, Phuong-Thoa Nguyen, Huyen Trang Ha Thi, Thi Ngoc Ha Bui, Vu Phuong Linh Dang, Thi-Thanh Dinh, Kyu Sic You, The-Hung Dang, Yeon-Sun Seon. Anaplastic lymphoma kinase inhibitor NVP‑TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649854. |
in conclusion, the findings of the present study indicated that nvp‑tae684 exerted its antitumor effects by inducing g2/m arrest and apoptosis via the inhibition of the alk signaling pathway, and suggests its potential use as an antitumor agent against pancreatic adenocarcinoma. |
2021-10-28 |
2023-08-13 |
human |
| Aijiao Gao, Huixin Tang, Qian Zhang, Ruiqing Liu, Lin Wang, Yashan Liu, Zhi Qi, Yanna She. Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection. Journal of microbiology (Seoul, Korea). vol 59. issue 7. 2021-10-25. PMID:33877580. |
in addition, we also found that the l. monocytogenes-induced apoptosis of j774a.1 cells was reduced by the mst1/2 or alk inhibitor. |
2021-10-25 |
2023-08-13 |
Not clear |
| Yinping Huo, Tangfeng Lv, Mingxiang Ye, Suhua Zhu, Jiaxin Liu, Hongbing Liu, Yong Son. F-circEA1 regulates cell proliferation and apoptosis through ALK downstream signaling pathway in non-small cell lung cancer. Human cell. 2021-10-11. PMID:34633654. |
f-circea1 regulates cell proliferation and apoptosis through alk downstream signaling pathway in non-small cell lung cancer. |
2021-10-11 |
2023-08-13 |
Not clear |
| Yinping Huo, Tangfeng Lv, Mingxiang Ye, Suhua Zhu, Jiaxin Liu, Hongbing Liu, Yong Son. F-circEA1 regulates cell proliferation and apoptosis through ALK downstream signaling pathway in non-small cell lung cancer. Human cell. 2021-10-11. PMID:34633654. |
in conclusion, f-circea1 can be considered as a proto-oncogene that regulates cell proliferation and apoptosis by affecting the expression of the parental gene eml4-alk1 and its alk downstream signaling pathway in non-small cell lung cancer. |
2021-10-11 |
2023-08-13 |
Not clear |
| Jing Li, Yubing Wang, Lisha Li, Penelope M-Y Or, Chi Wai Wong, Tian Liu, Wayne L H Ho, Andrew M Cha. Tumour-derived substrate-adherent cells promote neuroblastoma survival through secreted trophic factors. Molecular oncology. vol 15. issue 8. 2021-08-10. PMID:33932101. |
in coculture experiments, s-type cells protected n-type cells from apoptosis induced by the oncogenic alk inhibitor tae684. |
2021-08-10 |
2023-08-13 |
Not clear |
| Xuejiao Zhou, Xiaoning Zhang, Zhuzhu Wu, Xiaobo Xu, Ming Guo, Xin Zhai, Daiying Zuo, Yingliang W. The novel ALK inhibitor ZX-29 induces apoptosis through inhibiting ALK and inducing ROS-mediated endoplasmic reticulum stress in Karpas299 cells. Journal of biochemical and molecular toxicology. vol 35. issue 3. 2021-07-13. PMID:33140567. |
the novel alk inhibitor zx-29 induces apoptosis through inhibiting alk and inducing ros-mediated endoplasmic reticulum stress in karpas299 cells. |
2021-07-13 |
2023-08-13 |
Not clear |