| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hang Cao, Anja T Umbach, Rosi Bissinger, Meinrad Gawaz, Florian Lan. Inhibition of Collagen Related Peptide Induced Platelet Activation and Apoptosis by Ceritinib. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 4. 2018-05-22. PMID:29490295. |
the anaplastic lymphoma (tyrosine) kinase (alk) inhibitor ceritinib triggers apoptosis of tumor cells and eryptosis of erythrocytes. |
2018-05-22 |
2023-08-13 |
Not clear |
| Mengting Han, Jiwei Shen, Lijing Wang, Yu Wang, Xin Zhai, Yao Li, Meiqiao Liu, Zengqiang Li, Daiying Zuo, Yingliang W. 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells. Chemico-biological interactions. vol 284. 2018-03-27. PMID:29458018. |
5-chloro-n4-(2-(isopropylsulfonyl)phenyl)-n2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1h-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (wy-135), a novel alk inhibitor, induces cell cycle arrest and apoptosis through inhibiting alk and its downstream pathways in karpas299 and h2228 cells. |
2018-03-27 |
2023-08-13 |
Not clear |
| Mengting Han, Jiwei Shen, Lijing Wang, Yu Wang, Xin Zhai, Yao Li, Meiqiao Liu, Zengqiang Li, Daiying Zuo, Yingliang W. 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells. Chemico-biological interactions. vol 284. 2018-03-27. PMID:29458018. |
taken together, wy-135 exhibits significant anti-cancer activity through inhibiting alk and its downstream protein expression, arresting cell cycle and eventually inducing cell apoptosis in karpas299 and h2228 cells. |
2018-03-27 |
2023-08-13 |
Not clear |
| Safiullah Najem, Doerte Langemann, Birgit Appl, Magdalena Trochimiuk, Patrick Hundsdoerfer, Konrad Reinshagen, Georg Eschenbur. Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L. Oncotarget. vol 7. issue 45. 2018-03-16. PMID:27655666. |
treatment of nb cell lines with sm lcl161 and vinca alkaloids revealed a strong synergistic inhibition of proliferation and significant induction of apoptosis in virtually all established and de novo nb cell lines (n=8).in contrast, combination of anthracyclines or topoisomerase inhibitors with lcl161 showed a synergism for single drugs and/or cell lines only.furthermore, we could show that insensibility to lcl161-mediated sensitization for chemotherapeutics is associated with aberrant activation of anaplastic lymphoma kinase (alk) by common mutation f1174l. |
2018-03-16 |
2023-08-13 |
Not clear |
| Lindi Chen, Angharad Humphreys, Lisa Turnbull, Angela Bellini, Gudrun Schleiermacher, Helen Salwen, Susan L Cohn, Nick Bown, Deborah A Tweddl. Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27888620. |
analysis of the sensitivity of nblw and nblw-r cells to a panel of alk inhibitors (tae-684, crizotinib, alectinib and lorlatinib) revealed differences between the paired cell lines, and overall nblw-r cells with the f1174l mutation were more resistant to alk inhibitor induced apoptosis compared with nblw cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Patrizia Gasparini, Michela Casanova, Raffaella Villa, Paola Collini, Rita Alaggio, Angelica Zin, Paolo Bonvini, Cristina R Antonescu, Renata Boldrini, Roberto Caserini, Massimo Moro, Giovanni Centonze, Cristina Meazza, Maura Massimino, Luca Bergamaschi, Roberto Luksch, Stefano Chiaravalli, Gianni Bisogno, Nadia Zaffaroni, Maria Grazia Daidone, Gabriella Sozzi, Andrea Ferrar. Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma. Oncotarget. vol 7. issue 37. 2018-01-29. PMID:27385213. |
moreover, to get insight into its possible therapeutic relevance, effects of alk silencing on cell proliferation, invasion and apoptosis were studied in rms cells. |
2018-01-29 |
2023-08-13 |
Not clear |
| Yongfei Chen, Jiaxin Wu, Aoli Wang, Ziping Qi, Taoshan Jiang, Cheng Chen, Fengming Zou, Chen Hu, Wei Wang, Hong Wu, Zhenquan Hu, Wenchao Wang, Beilei Wang, Li Wang, Tao Ren, Shanchun Zhang, Qingsong Liu, Jing Li. Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC. European journal of medicinal chemistry. vol 139. 2017-10-16. PMID:28850922. |
in the cellular context it strongly affected egfr and alk mediated signaling pathways, induced apoptosis and arrested cell cycle at g0/g1 phase. |
2017-10-16 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Fumihito Ueda, Kenji Tago, Yosuke Nakazawa, Tomoyuki Ohe, Tadahiko Mashino, Shigenobu Yokota, Tadashi Kasahara, Hiroomi Tamura, Megumi Funakoshi-Tag. Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK. PloS one. vol 12. issue 8. 2017-10-09. PMID:28806414. |
the alk inhibitor, crizotinib specifically induced apoptosis in ba/f3 cells expressing npm-alk by inhibiting the activation of npm-alk and its downstream molecule, signal transducer and activator of transcription factor 3 (stat3). |
2017-10-09 |
2023-08-13 |
Not clear |
| Fei Xu, Hongling Li, Yong Su. Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma. Biochemical and biophysical research communications. vol 454. issue 4. 2017-09-26. PMID:25450694. |
furthermore, a small-molecule inhibitor of axl significantly enhanced alk-targeted therapy, as an increased frequency of apoptosis was observed in nb cells co-expressing alk and axl. |
2017-09-26 |
2023-08-13 |
human |
| Monica Ceccon, Maria Elena Boggio Merlo, Luca Mologni, Teresa Poggio, Lydia M Varesio, Matteo Menotti, Silvia Bombelli, Roberta Rigolio, Andrea D Manazza, Filomena Di Giacomo, Chiara Ambrogio, Giovanni Giudici, Cesare Casati, Cristina Mastini, Mara Compagno, Suzanne D Turner, Carlo Gambacorti-Passerini, Roberto Chiarle, Claudia Voen. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene. vol 35. issue 29. 2017-09-11. PMID:26657151. |
remarkably, human npm-alk-amplified cell lines resistant to alk tyrosine kinase inhibitors (tkis) underwent apoptosis upon drug withdrawal as a consequence of erk1/2 hyperactivation. |
2017-09-11 |
2023-08-13 |
human |
| Jiaxiong Lu, Shan Guan, Yanling Zhao, Yang Yu, Sarah E Woodfield, Huiyuan Zhang, Kristine L Yang, Shayahati Bieerkehazhi, Lin Qi, Xiaonan Li, Jerry Gu, Xin Xu, Jingling Jin, Jodi A Muscal, Tianshu Yang, Guo-Tong Xu, Jianhua Yan. The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model. Cancer letters. vol 400. 2017-08-25. PMID:28455243. |
the second-generation alk inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a th-mycn transgenic neuroblastoma mouse model. |
2017-08-25 |
2023-08-13 |
mouse |
| Jiaxiong Lu, Shan Guan, Yanling Zhao, Yang Yu, Sarah E Woodfield, Huiyuan Zhang, Kristine L Yang, Shayahati Bieerkehazhi, Lin Qi, Xiaonan Li, Jerry Gu, Xin Xu, Jingling Jin, Jodi A Muscal, Tianshu Yang, Guo-Tong Xu, Jianhua Yan. The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model. Cancer letters. vol 400. 2017-08-25. PMID:28455243. |
in this study, we show that the novel alk inhibitor alectinib effectively suppressed cell proliferation and induces apoptosis in nb cell lines with either wild-type alk or mutated alk (f1174l and d1091n) by blocking alk-mediated pi3k/akt/mtor signaling. |
2017-08-25 |
2023-08-13 |
mouse |
| Jiangyong Miao, Lina Wang, Xiangjian Zhang, Chunhua Zhu, Lili Cui, Hui Ji, Ying Liu, Xiaolu Wan. Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression. Neurochemical research. vol 41. issue 9. 2017-04-17. PMID:27180190. |
furthermore, the protection of alk was also related to decreased levels of apoptosis in mice by enhanced activation of phosphatidylinositol 3-kinase (pi3k)/akt pathway, increased level of bcl-2 and reduced bax expression (p < 0.05). |
2017-04-17 |
2023-08-13 |
mouse |
| Yongfeng Wang, Long Wang, Shan Guan, Wenming Cao, Hao Wang, Zhenghu Chen, Yanling Zhao, Yang Yu, Huiyuan Zhang, Jonathan C Pang, Sophia L Huang, Yo Akiyama, Yifan Yang, Wenjing Sun, Xin Xu, Yan Shi, Hong Zhang, Eugene S Kim, Jodi A Muscal, Fengmin Lu, Jianhua Yan. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Scientific reports. vol 6. 2016-12-26. PMID:26786851. |
novel alk inhibitor azd3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. |
2016-12-26 |
2023-08-13 |
mouse |
| Yongfeng Wang, Long Wang, Shan Guan, Wenming Cao, Hao Wang, Zhenghu Chen, Yanling Zhao, Yang Yu, Huiyuan Zhang, Jonathan C Pang, Sophia L Huang, Yo Akiyama, Yifan Yang, Wenjing Sun, Xin Xu, Yan Shi, Hong Zhang, Eugene S Kim, Jodi A Muscal, Fengmin Lu, Jianhua Yan. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Scientific reports. vol 6. 2016-12-26. PMID:26786851. |
here we show that a new alk inhibitor azd3463 effectively suppressed the proliferation of nb cell lines with wild type alk (wt) as well as alk activating mutations (f1174l and d1091n) by blocking the alk-mediated pi3k/akt/mtor pathway and ultimately induced apoptosis and autophagy. |
2016-12-26 |
2023-08-13 |
mouse |
| Chung Hyo Kang, Eun-Young Kim, Hyoung Rae Kim, Chong Ock Lee, Heung Kyoung Lee, Hye Gwang Jeong, Sang Un Choi, Chang-Soo Yun, Jong Yeon Hwang, Joo-Youn Lee, You Hwa Son, Sunjoo Ahn, Byung Hoi Lee, Heejung Jung, Chi Hoon Par. Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer. Cancer letters. vol 374. issue 2. 2016-08-29. PMID:26923554. |
the cell cycle analysis indicates that alk inhibitors induce g1/s arrest, resulting in apoptosis. |
2016-08-29 |
2023-08-13 |
Not clear |
| S Carnesecchi, A-L Rougemont, J H Doroshow, M Nagy, S Mouche, F Gumy-Pause, I Szant. The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines. Free radical biology & medicine. vol 84. 2016-03-04. PMID:25797883. |
apoptosis suppression is the hallmark feature of a rare type of lymphoma, termed anaplastic lymphoma kinase-positive (alk(+)) anaplastic large-cell lymphoma (alcl), and a major factor in the therapy resistance and relapse of alk(+) alcl tumors. |
2016-03-04 |
2023-08-13 |
Not clear |
| S Carnesecchi, A-L Rougemont, J H Doroshow, M Nagy, S Mouche, F Gumy-Pause, I Szant. The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines. Free radical biology & medicine. vol 84. 2016-03-04. PMID:25797883. |
these results indicate that nox5-derived ros contribute to apoptosis blockage in alk(+) alcl cell lines and suggest nox5 as a potential pharmaceutical target to enhance apoptosis and thus to suppress tumor progression and prevent relapse in pediatric alk(+) alcl patients that resist classical therapeutic approaches. |
2016-03-04 |
2023-08-13 |
Not clear |
| A Aubry, S Galiacy, L Ceccato, C Marchand, C Tricoire, F Lopez, R Bremner, C Racaud-Sultan, B Monsarrat, F Malecaze, M Allouch. Peptides derived from the dependence receptor ALK are proapoptotic for ALK-positive tumors. Cell death & disease. vol 6. 2016-02-23. PMID:25950466. |
aiming to develop new tools for alk targeting, we took advantage of our previous demonstration identifying alk as a dependence receptor, implying that in the absence of ligand the kinase-inactive alk triggers or enhances apoptosis. |
2016-02-23 |
2023-08-13 |
human |
| Hong Hua Yan, Kyung Hee Jung, Mi Kwon Son, Zhenghuan Fang, Soo Jung Kim, Ye-Lim Ryu, Juyoung Kim, Mi-Hyun Kim, Soon-Sun Hon. Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer. Oncotarget. vol 5. issue 19. 2015-08-03. PMID:25193856. |
taken together, our investigation shows that crizotinib inhibits the alk signaling pathway in pancreatic cancer, resulting in cell growth/angiogenesis inhibition and apoptosis induction. |
2015-08-03 |
2023-08-13 |
mouse |