| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rani E George, Takaomi Sanda, Megan Hanna, Stefan Fröhling, William Luther, Jianming Zhang, Yebin Ahn, Wenjun Zhou, Wendy B London, Patrick McGrady, Liquan Xue, Sergey Zozulya, Vlad E Gregor, Thomas R Webb, Nathanael S Gray, D Gary Gilliland, Lisa Diller, Heidi Greulich, Stephan W Morris, Matthew Meyerson, A Thomas Loo. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. vol 455. issue 7215. 2008-11-18. PMID:18923525. |
short hairpin rna (shrna)-mediated knockdown of alk expression in neuroblastoma cell lines with the f1174l mutation also resulted in apoptosis and impaired cell proliferation. |
2008-11-18 |
2023-08-12 |
human |
| Annamaria Galietta, Rosalind H Gunby, Sara Redaelli, Paola Stano, Cristiana Carniti, Angela Bachi, Philip W Tucker, Carmen J Tartari, Ching-Jung Huang, Emanuela Colombo, Karen Pulford, Miriam Puttini, Rocco G Piazza, Holger Ruchatz, Antonello Villa, Arianna Donella-Deana, Oriano Marin, Danilo Perrotti, Carlo Gambacorti-Passerin. NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma. Blood. vol 110. issue 7. 2007-11-06. PMID:17537995. |
the expression of alk fusion proteins induced delocalization of psf from the nucleus to the cytoplasm and forced overexpression of psf-inhibited proliferation and induced apoptosis in cells expressing npm/alk. |
2007-11-06 |
2023-08-12 |
Not clear |
| Michèle Allouch. ALK is a novel dependence receptor: potential implications in development and cancer. Cell cycle (Georgetown, Tex.). vol 6. issue 13. 2007-09-04. PMID:17611412. |
as such, in the absence of ligand, the alk receptor is kinase inactive and its expression results in enhanced apoptosis, whereas kinase activation, due to a ligand or constitutive as in npm-alk, decreases apoptosis. |
2007-09-04 |
2023-08-12 |
human |
| Michèle Allouch. ALK is a novel dependence receptor: potential implications in development and cancer. Cell cycle (Georgetown, Tex.). vol 6. issue 13. 2007-09-04. PMID:17611412. |
unligated/kinase unactivated alk receptor facilitates apoptosis via its own cleavage by caspases, a phenomenon allowing the exposure of a proapoptotic juxta-membrane intra-cellular domain. |
2007-09-04 |
2023-08-12 |
human |
| Michèle Allouch. ALK is a novel dependence receptor: potential implications in development and cancer. Cell cycle (Georgetown, Tex.). vol 6. issue 13. 2007-09-04. PMID:17611412. |
in this part of the nervous system, alk in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, alk expression can lead to developmental neuronal apoptosis. |
2007-09-04 |
2023-08-12 |
human |
| Xinzhe Shi, Bevin Franko, Christine Frantz, Hesham M Amin, Raymond La. JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. British journal of haematology. vol 135. issue 1. 2006-11-06. PMID:16939498. |
jsi-124 (cucurbitacin i) inhibits janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (alk), and induces apoptosis in alk-positive anaplastic large cell lymphoma cells. |
2006-11-06 |
2023-08-12 |
Not clear |
| Jaouhar Mourali, Alan Bénard, Filipe Calheiros Lourenço, Céline Monnet, Catherine Greenland, Christel Moog-Lutz, Claire Racaud-Sultan, Daniel Gonzalez-Dunia, Marc Vigny, Patrick Mehlen, Georges Delsol, Michèle Allouch. Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Molecular and cellular biology. vol 26. issue 16. 2006-09-13. PMID:16880530. |
in contrast, we now show that jurkat cells overexpressing the wild-type alk receptor are more sensitive to doxorubicin-induced apoptosis than parental cells. |
2006-09-13 |
2023-08-12 |
rat |
| Jaouhar Mourali, Alan Bénard, Filipe Calheiros Lourenço, Céline Monnet, Catherine Greenland, Christel Moog-Lutz, Claire Racaud-Sultan, Daniel Gonzalez-Dunia, Marc Vigny, Patrick Mehlen, Georges Delsol, Michèle Allouch. Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Molecular and cellular biology. vol 26. issue 16. 2006-09-13. PMID:16880530. |
moreover, the alk protein is cleaved during apoptosis in a caspase-dependent manner. |
2006-09-13 |
2023-08-12 |
rat |
| Jaouhar Mourali, Alan Bénard, Filipe Calheiros Lourenço, Céline Monnet, Catherine Greenland, Christel Moog-Lutz, Claire Racaud-Sultan, Daniel Gonzalez-Dunia, Marc Vigny, Patrick Mehlen, Georges Delsol, Michèle Allouch. Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Molecular and cellular biology. vol 26. issue 16. 2006-09-13. PMID:16880530. |
alk ligation by specific activating antibodies decreased alk-facilitated apoptosis in both lymphoid and neuronal cell lines. |
2006-09-13 |
2023-08-12 |
rat |
| Michal Marzec, Monika Kasprzycka, Andrzej Ptasznik, Pawel Wlodarski, Qian Zhang, Niels Odum, Mariusz A Wasi. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 12. 2006-02-16. PMID:16170336. |
inhibition of alk enzymatic activity in t-cell lymphoma cells induces apoptosis and suppresses proliferation and stat3 phosphorylation independently of jak3. |
2006-02-16 |
2023-08-12 |
Not clear |
| Roberto Piva, Roberto Chiarle, Andrea D Manazza, Riccardo Taulli, William Simmons, Chiara Ambrogio, Valentina D'Escamard, Elisa Pellegrino, Carola Ponzetto, Giorgio Palestro, Giorgio Inghiram. Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood. vol 107. issue 2. 2006-02-07. PMID:16189272. |
in human alcl cells lentiviral-mediated alk knock-down leads to g(1) cell-cycle arrest and apoptosis in vitro and tumor growth inhibition and regression in vivo. |
2006-02-07 |
2023-08-12 |
mouse |
| Raymond Lai, George Z Rassidakis, Quan Lin, Coralyn Atwell, L Jeffrey Medeiros, Hesham M Ami. Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Human pathology. vol 36. issue 9. 2005-10-13. PMID:16153455. |
in previous studies of anaplastic large cell lymphoma (alcl), we showed that inhibition of jak3 down-regulates activated/phosphorylated stat3 (pstat3), decreases anaplastic lymphoma kinase (alk) enzymatic activity, and induces cell-cycle arrest and apoptosis in alk-positive alcl. |
2005-10-13 |
2023-08-12 |
Not clear |
| Yuko Osajima-Hakomori, Izumi Miyake, Miki Ohira, Akira Nakagawara, Atsuko Nakagawa, Ryuichi Saka. Biological role of anaplastic lymphoma kinase in neuroblastoma. The American journal of pathology. vol 167. issue 1. 2005-08-25. PMID:15972965. |
the suppression of activated alk in neuroblastoma cells by rna interference significantly reduced the phosphorylation of shcc, mitogen-activated protein kinases, and akt, inducing rapid apoptosis in the cells. |
2005-08-25 |
2023-08-12 |
human |
| Hye-Sook Chang, Osamu Yamato, Masahiro Yamasaki, Miyan Ko, Yoshimitsu Maed. Growth inhibitory effect of alk(en)yl thiosulfates derived from onion and garlic in human immortalized and tumor cell lines. Cancer letters. vol 223. issue 1. 2005-07-12. PMID:15890236. |
these results suggest that the alk(en)yl thiosulfates have an antitumor effect through the induction of apoptosis initiated by oxidative stress. |
2005-07-12 |
2023-08-12 |
human |
| Byung-Chul Kim, Howard van Gelder, Tae Aug Kim, Ho-Jae Lee, Kim G Baik, Hyun Hye Chun, David A Lee, Kyeong Sook Choi, Seong-Jin Ki. Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells. The Journal of biological chemistry. vol 279. issue 27. 2004-08-11. PMID:15107418. |
to see whether alk7 can induce apoptosis as can some of the other alk proteins, we infected the fao rat hepatoma cell line with adenovirus expressing a constitutively active form of the alk7. |
2004-08-11 |
2023-08-12 |
human |
| Ciaran Powers, Achim Aigner, Gerald E Stoica, Kevin McDonnell, Anton Wellstei. Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11809760. |
furthermore, this depletion of alk reduced tumor growth of xenografts in athymic nude mice and prolonged survival of the animals because of increased apoptosis in the tumors. |
2002-06-07 |
2023-08-12 |
mouse |