| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Azusa Tanimoto, Tadaaki Yamada, Shigeki Nanjo, Shinji Takeuchi, Hiromichi Ebi, Kenji Kita, Kunio Matsumoto, Seiji Yan. Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24952482. |
additionally, the heat shock protein 90 (hsp90) inhibitor suppressed protein expression of alk, met, egfr, and akt, and thereby induced apoptosis in eml4-alk nsclc cells, even in the presence of egfr ligands or hgf. |
2015-05-12 |
2023-08-13 |
Not clear |
| Lin Yang, Guangchao Li, Likun Zhao, Fei Pan, Jiankun Qiang, Siqi Ha. Blocking the PI3K pathway enhances the efficacy of ALK-targeted therapy in EML4-ALK-positive nonsmall-cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24972969. |
we found that genetic or pharmacological inhibition of alk markedly abrogated phosphorylated stat3 and erk, but it failed to suppress akt activity or induce apoptosis, in eml4-alk-positive h2228 cells. |
2015-01-05 |
2023-08-13 |
Not clear |
| Rathi N Pillai, Suresh S Ramalinga. Heat shock protein 90 inhibitors in non-small-cell lung cancer. Current opinion in oncology. vol 26. issue 2. 2014-09-29. PMID:24463348. |
many cancers have increased expression of hsp90 to ensure their malignant phenotype of increased proliferation, decreased apoptosis, and metastatic potential by conservation of proteins like epidermal growth factor receptor (egfr), human epidermal growth factor receptor 2, anaplastic lymphoma kinase (alk), v-raf murine sarcoma viral oncogene homologue b1, akt, b-cell lymphoma 2, and cell cycle proteins. |
2014-09-29 |
2023-08-12 |
human |
| Fredika M Robertson, Emanuel F Petricoin Iii, Steven J Van Laere, Francois Bertucci, Khoi Chu, Sandra V Fernandez, Zhaomei Mu, Katherine Alpaugh, Jianming Pei, Rita Circo, Julia Wulfkuhle, Zaiming Ye, Kimberly M Boley, Hui Liu, Ricardo Moraes, Xuejun Zhang, Ruggero Demaria, Sanford H Barsky, Guoxian Sun, Massimo Cristofanill. Presence of anaplastic lymphoma kinase in inflammatory breast cancer. SpringerPlus. vol 2. 2013-10-08. PMID:24102046. |
the small molecule dual tyrosine kinase cmet/alk inhibitor, crizotinib (pf-02341066/xalkori®, pfizer inc), induced both cytotoxicity (ic50 = 0.89 μm) and apoptosis, with abrogation of palk signaling in ibc tumor cells and in fc-ibc01 tumor xenograft model, a new ibc model derived from pleural effusion cells isolated from an alk(+) ibc patient. |
2013-10-08 |
2023-08-12 |
Not clear |
| Rafael de Liz, Heros Horst, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde, Denis Girar. Activation of human neutrophils by Esenbeckia leiocarpa: comparison between the crude hydroalcoholic extract (CHE) and an alkaloid (Alk) fraction. Journal of inflammation (London, England). vol 9. issue 1. 2012-10-02. PMID:22640922. |
in addition, based on catalase treatment, che and alk induced neutrophil apoptosis by a hydrogen peroxide (h2o2)-dependent mechanism. |
2012-10-02 |
2023-08-12 |
human |
| Rafael de Liz, Heros Horst, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde, Denis Girar. Activation of human neutrophils by Esenbeckia leiocarpa: comparison between the crude hydroalcoholic extract (CHE) and an alkaloid (Alk) fraction. Journal of inflammation (London, England). vol 9. issue 1. 2012-10-02. PMID:22640922. |
since the elimination of apoptotic neutrophils by professional phagocytes is important for the resolution of inflammation, the ability of che and alk to induce neutrophil apoptosis has to be considered as one possible mechanism associated with the anti-inflammatory activity of these fractions previously reported in vivo. |
2012-10-02 |
2023-08-12 |
human |
| Azhar Rashikh, Shibli Jameel Ahmad, Krishna Kolappa Pillai, Kanchan Kohli, Abul Kalam Najm. Aliskiren attenuates myocardial apoptosis and oxidative stress in chronic murine model of cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 2. 2012-09-19. PMID:22386366. |
transmission electron microscopic studies showed that dxr caused apoptosis in myocardium, manifested as condensation of chromatin network at the margins and rupture of nuclear membrane which was well protected by alk (100 mg/kg) treatment. |
2012-09-19 |
2023-08-12 |
rat |
| P Bonvini, E Zorzi, L Mussolin, M Pillon, C Romualdi, M Peron, E S G d'Amore, L Lamant, A Rosole. Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30+ NPM-ALK+ anaplastic large-cell lymphomas. Leukemia. vol 26. issue 6. 2012-08-07. PMID:22289917. |
different from other hsps, hsp72 prevents cell injury, bax activation and death by apoptosis in alk(+) cells, acting both upstream and downstream of mitochondria. |
2012-08-07 |
2023-08-12 |
Not clear |
| P Bonvini, E Zorzi, L Mussolin, M Pillon, C Romualdi, M Peron, E S G d'Amore, L Lamant, A Rosole. Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30+ NPM-ALK+ anaplastic large-cell lymphomas. Leukemia. vol 26. issue 6. 2012-08-07. PMID:22289917. |
conversely, hsp72 is underexpressed in alk(-) alcl cells, and it is unable to protect cells from apoptosis under stress. |
2012-08-07 |
2023-08-12 |
Not clear |
| Daniela Di Paolo, Chiara Ambrogio, Fabio Pastorino, Chiara Brignole, Cinzia Martinengo, Roberta Carosio, Monica Loi, Gabriella Pagnan, Laura Emionite, Michele Cilli, Domenico Ribatti, Theresa M Allen, Roberto Chiarle, Mirco Ponzoni, Patrizia Perr. Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma. Molecular therapy : the journal of the American Society of Gene Therapy. vol 19. issue 12. 2012-03-22. PMID:21829174. |
nb cell lines, transduced by lentiviral short hairpin rna (shrna), showed reduced proliferation and increased apoptosis when alk was knocked down. |
2012-03-22 |
2023-08-12 |
mouse |
| Daniela Di Paolo, Chiara Ambrogio, Fabio Pastorino, Chiara Brignole, Cinzia Martinengo, Roberta Carosio, Monica Loi, Gabriella Pagnan, Laura Emionite, Michele Cilli, Domenico Ribatti, Theresa M Allen, Roberto Chiarle, Mirco Ponzoni, Patrizia Perr. Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma. Molecular therapy : the journal of the American Society of Gene Therapy. vol 19. issue 12. 2012-03-22. PMID:21829174. |
in mice, a nanodelivery system for alk-specific small interfering rna (sirna), based on the conjugation of antibodies directed against the nb-selective marker gd(2) to liposomes, showed strong alk knockdown in vivo in nb cells, which resulted in cell growth arrest, apoptosis, and prolonged survival. |
2012-03-22 |
2023-08-12 |
mouse |
| Gustav Boije af Gennäs, Luca Mologni, Shaheen Ahmed, Mohanathas Rajaratnam, Oriano Marin, Niko Lindholm, Michela Viltadi, Carlo Gambacorti-Passerini, Leonardo Scapozza, Jari Yli-Kauhaluom. Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem. vol 6. issue 9. 2012-02-10. PMID:21721129. |
in anaplastic large-cell lymphomas, chromosomal translocations involving the kinase domain of anaplastic lymphoma kinase (alk), generally fused to the 5' part of the nucleophosmin gene, produce highly oncogenic alk fusion proteins that deregulate cell cycle, apoptosis, and differentiation in these cells. |
2012-02-10 |
2023-08-12 |
Not clear |
| Ken Takezawa, Isamu Okamoto, Kazuto Nishio, Pasi A Jänne, Kazuhiko Nakagaw. Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 8. 2011-09-30. PMID:21415216. |
role of erk-bim and stat3-survivin signaling pathways in alk inhibitor-induced apoptosis in eml4-alk-positive lung cancer. |
2011-09-30 |
2023-08-12 |
Not clear |
| Takaaki Sasaki, Katsuhiro Okuda, Wei Zheng, James Butrynski, Marzia Capelletti, Liping Wang, Nathanael S Gray, Keith Wilner, James G Christensen, George Demetri, Geoffrey I Shapiro, Scott J Rodig, Michael J Eck, Pasi A Jänn. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer research. vol 70. issue 24. 2011-01-20. PMID:21030459. |
furthermore, the f1174l mutation inhibits crizotinib-mediated downregulation of alk signaling and blocks apoptosis in ranbp2-alk ba/f3 cells. |
2011-01-20 |
2023-08-12 |
Not clear |
| G Delso. [Molecular abnormalities in lymphomas]. Bulletin du cancer. vol 97. issue 11. 2010-12-22. PMID:21084243. |
alk tyrosine kinase activates downstream pathways (stat3/5b, src kinases, plcγ, pi3 kinase) implicated in lymphomagenesis, proliferation and protection against apoptosis. |
2010-12-22 |
2023-08-12 |
Not clear |
| Hitoyasu Futami, Ryuichi Saka. All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK. Cancer letters. vol 297. issue 2. 2010-10-15. PMID:20576349. |
all-trans retinoic acid downregulates alk in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated alk. |
2010-10-15 |
2023-08-12 |
Not clear |
| Hitoyasu Futami, Ryuichi Saka. All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK. Cancer letters. vol 297. issue 2. 2010-10-15. PMID:20576349. |
we have previously reported that knockdown of alk by rnai induced apoptosis in neuroblastoma cells with gene amplification of alk. |
2010-10-15 |
2023-08-12 |
Not clear |
| Hitoyasu Futami, Ryuichi Saka. All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK. Cancer letters. vol 297. issue 2. 2010-10-15. PMID:20576349. |
downregulation of alk protein by atra was accompanied by apoptosis in neuroblastoma cells with gene amplification or gain-of-function mutation of alk but not in neuroblastoma cells without these genetic alterations. |
2010-10-15 |
2023-08-12 |
Not clear |
| Hitoyasu Futami, Ryuichi Saka. All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK. Cancer letters. vol 297. issue 2. 2010-10-15. PMID:20576349. |
these results suggest that alk downregulation by atra might lead to apoptosis in neuroblastoma cells with activated alk. |
2010-10-15 |
2023-08-12 |
Not clear |
| Ping Shi, Raymond Lai, Quan Lin, Abid S Iqbal, Leah C Young, Larry W Kwak, Richard J Ford, Hesham M Ami. IGF-IR tyrosine kinase interacts with NPM-ALK oncogene to induce survival of T-cell ALK+ anaplastic large-cell lymphoma cells. Blood. vol 114. issue 2. 2009-07-27. PMID:19423729. |
antagonism of igf-ir decreased the viability, induced apoptosis and cell-cycle arrest, and decreased proliferation and colony formation of alk(+) alcl cell lines. |
2009-07-27 |
2023-08-12 |
Not clear |