| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Marino, Daniela N Petrusca, Ryan T Bishop, Judith L Anderson, Hayley M Sabol, Cody Ashby, Justin H Layer, Annamaria Cesarano, Utpal P Davé, Fabiana Perna, Jesus Delgado-Calle, John M Chirgwin, G David Roodma. Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma. Haematologica. vol 109. issue 5. 2024-05-02. PMID:37981834. |
here, we demonstrate that xrk3f2, a selective ligand for the zz-domain, dramatically improved two major responses to the proteasome inhibitor bortezomib (btz) by increasing: i) killing of human mm cells by stimulating both btz-mediated apoptosis and necroptosis, a process regulated by p62; and ii) preservation of bone mass by stimulating osteoblast differentiation and inhibiting osteoclastic bone destruction. |
2024-05-02 |
2024-05-04 |
mouse |
| Rafaela G A Costa, Maiara de S Oliveira, Ana Carolina B da C Rodrigues, Suellen L R Silva, Ingrid R S B Dias, Milena B P Soares, Ludmila de Faro Valverde, Clarissa Araujo Gurgel Rocha, Rosane Borges Dias, Daniel P Bezerr. Bortezomib suppresses acute myelogenous leukaemia stem-like KG-1a cells via NF-κB inhibition and the induction of oxidative stress. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-04-23. PMID:38652192. |
furthermore, btz-induced cell death was partially prevented by pretreatment with the pancaspase inhibitor z-vad-(ome)-fmk, indicating that btz induces caspase-mediated apoptosis. |
2024-04-23 |
2024-04-26 |
mouse |
| Rafaela G A Costa, Maiara de S Oliveira, Ana Carolina B da C Rodrigues, Suellen L R Silva, Ingrid R S B Dias, Milena B P Soares, Ludmila de Faro Valverde, Clarissa Araujo Gurgel Rocha, Rosane Borges Dias, Daniel P Bezerr. Bortezomib suppresses acute myelogenous leukaemia stem-like KG-1a cells via NF-κB inhibition and the induction of oxidative stress. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-04-23. PMID:38652192. |
btz also increased mitochondrial superoxide levels in kg-1a cells, and btz-induced apoptosis was partially prevented by pretreatment with the antioxidant n-acetylcysteine, indicating that btz induces oxidative stress-mediated apoptosis in kg-1a cells. |
2024-04-23 |
2024-04-26 |
mouse |
| Chunchun Xue, Jia Tian, Zepeng Cui, Yang Liu, Dawei Sun, Mengting Xiong, Nanxing Yi, Kaiqiang Wang, Xiaofeng Li, Yongjun Wang, Hao Xu, Weian Zhang, Qianqian Lian. Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession. Bioactive materials. vol 33. 2024-01-01. PMID:38162513. |
accordingly, btz@ptk suppressed ros generation and proinflammatory cytokines while promoting m1 macrophage apoptosis in lipopolysaccharide (lps)-activated raw264.7 macrophages or lps/ifn-γ-treated primary macrophages, which leads to a better effect than btz. |
2024-01-01 |
2024-01-05 |
mouse |
| Chunchun Xue, Jia Tian, Zepeng Cui, Yang Liu, Dawei Sun, Mengting Xiong, Nanxing Yi, Kaiqiang Wang, Xiaofeng Li, Yongjun Wang, Hao Xu, Weian Zhang, Qianqian Lian. Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession. Bioactive materials. vol 33. 2024-01-01. PMID:38162513. |
importantly, btz@ptk treatment successfully ameliorates synovitis with the reduction of synovial hyperplasia and synovitis scores by suppressing m1 macrophage polarization and promoting m1 macrophage apoptosis in the synovium, thereby delaying cartilage damage. |
2024-01-01 |
2024-01-05 |
mouse |
| Chunchun Xue, Jia Tian, Zepeng Cui, Yang Liu, Dawei Sun, Mengting Xiong, Nanxing Yi, Kaiqiang Wang, Xiaofeng Li, Yongjun Wang, Hao Xu, Weian Zhang, Qianqian Lian. Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession. Bioactive materials. vol 33. 2024-01-01. PMID:38162513. |
collectively, btz@ptk can effectively modulate inflammatory microenvironment for oa recession by activating m1 macrophage apoptosis and inhibiting m1macrophage-mediated inflammatory response. |
2024-01-01 |
2024-01-05 |
mouse |
| Debasmita Dutta, Jiye Liu, Kenneth Wen, Keiji Kurata, Mariateresa Fulciniti, Annamaria Gulla, Teru Hideshima, Kenneth C Anderso. BCMA-targeted bortezomib nanotherapy improves therapeutic efficacy, overcomes resistance, and modulates the immune microenvironment in multiple myeloma. Blood cancer journal. vol 13. issue 1. 2023-12-10. PMID:38072962. |
furthermore, bcma-btz-nps induced cell death more efficiently than non-targeted nanoparticles or free btz, triggering potent mitochondrial depolarization followed by apoptosis. |
2023-12-10 |
2023-12-17 |
Not clear |
| Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazaw. Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression. PloS one. vol 18. issue 12. 2023-12-01. PMID:38039297. |
we previously reported that macrolide antibiotics, such as clarithromycin (cam), blocked autophagy flux, and simultaneous proteasome and autophagy inhibition by bortezomib (btz) plus cam resulted in enhanced apoptosis induction in multiple myeloma (mm) cells via increased endoplasmic reticulum (er) stress loading. |
2023-12-01 |
2023-12-10 |
Not clear |
| Trini A Ochoa, Amy Rossi, E Steve Woodle, David Hildeman, David Allma. The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells. Journal of immunology (Baltimore, Md. : 1950). 2023-11-15. PMID:37966267. |
furthermore, btz treatment elevated intracellular p53 levels, and p53 deletion constrained apoptosis, as recently stimulated cells first transitioned from the g1 to s phase of the cell cycle. |
2023-11-15 |
2023-11-20 |
mouse |
| Shilpa Kuttikrishnan, Fareed Ahmad, Jericha M Mateo, Kirti S Prabhu, Tamam El-Elimat, Nicholas H Oberlies, Cedric J Pearce, Ammira S Alshabeeb Akil, Ajaz A Bhat, Feras Q Alali, Shahab Uddi. Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway. Cell biology international. 2023-10-27. PMID:37885161. |
overall, our findings demonstrated that nsp-b induces caspase-dependent apoptosis, increases cell damage, and suppresses mm cell proliferation while improving the cytotoxic impact of btz. |
2023-10-27 |
2023-11-08 |
Not clear |
| Yirong Chen, Yuchen Tao, Kexin Hu, Jiahui L. GRP78 inhibitor HA15 increases the effect of Bortezomib on eradicating multiple myeloma cells through triggering endoplasmic reticulum stress. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809599. |
bortezomib (btz), a selective proteasome inhibitor, exhibits a significant efficacy in the therapy of multiple myeloma (mm) partly through triggering endoplasmic reticulum (er) stress-dependent apoptosis. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yirong Chen, Yuchen Tao, Kexin Hu, Jiahui L. GRP78 inhibitor HA15 increases the effect of Bortezomib on eradicating multiple myeloma cells through triggering endoplasmic reticulum stress. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809599. |
the major aim of this study was to investigate whether grp78 inhibitor, ha15, increased the therapeutic effect of btz on mm to through further increasing er stress and shifting the balance towards cell apoptosis. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yirong Chen, Yuchen Tao, Kexin Hu, Jiahui L. GRP78 inhibitor HA15 increases the effect of Bortezomib on eradicating multiple myeloma cells through triggering endoplasmic reticulum stress. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809599. |
btz combined with ha15 also repressed colony formation ability of mm cell and accelerated mm cell apoptosis compared with btz monotherapy. |
2023-10-09 |
2023-10-15 |
Not clear |
| Anna Staskiewicz, Erica Wong, Michael Tucker, Riya Farhin, Jonathan Park, Rana Saade, Tina Alkhazali, Tu Dang, Xinyu Wan. Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628771. |
bortezomib (btz), a common treatment for mm, is a proteasome inhibitor that induces apoptosis in mm cells. |
2023-08-26 |
2023-09-07 |
human |
| Anna Staskiewicz, Erica Wong, Michael Tucker, Riya Farhin, Jonathan Park, Rana Saade, Tina Alkhazali, Tu Dang, Xinyu Wan. Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628771. |
we sought to identify a synergistic combination of btz with a res derivative and analyze the effects on reducing viability and inducing apoptosis in human mm cells. |
2023-08-26 |
2023-09-07 |
human |
| Anna Staskiewicz, Erica Wong, Michael Tucker, Riya Farhin, Jonathan Park, Rana Saade, Tina Alkhazali, Tu Dang, Xinyu Wan. Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628771. |
our results suggest that this combination of btz and pin decreases mm cell viability synergistically by inducing apoptosis and oxidative stress in mm cells. |
2023-08-26 |
2023-09-07 |
human |
| Yun Leng, Xiaoyan Hu, Lin Li, Jewel Nkwocha, Toshihisa Satta, Kanika Sharma, Maciej Kmeiciak, Huixing Zhou, Zhiyao Zhang, Liang Zhou, Wenming Chen, Steven Gran. Mechanisms underlying synergism between circularized tumor necrosis factor-related apoptosis inducing ligand and bortezomib in bortezomib-sensitive or -resistant myeloma cells. Hematological oncology. vol 40. issue 5. 2022-12-15. PMID:35789025. |
mechanisms underlying interactions between a novel, clinically relevant circularized tumor necrosis factor-related apoptosis inducing ligand (trail) agonist, circularly permuted trail (cpt) have been examined in multiple myeloma (mm) cells sensitive or resistant to bortezomib (btz). |
2022-12-15 |
2023-11-29 |
Not clear |
| Sudjit Luanpitpong, Montira Janan, Juthamas Yosudjai, Jirarat Poohadsuan, Pithi Chanvorachote, Surapol Issaragrisi. Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430955. |
overexpression of antiapoptotic bcl-xl and depletion of proapoptotic bax cooperatively protected mcl cells against btz-induced apoptosis, causing acquired btz resistance, likely by tilting the balance of bcl-2 family proteins toward antiapoptotic signaling. |
2022-11-26 |
2023-08-14 |
human |
| Cuicui W. β-catenin inhibitors ICG-001 and pyrvinium sensitize bortezomib-resistant multiple myeloma cells to bortezomib. Oncology letters. vol 24. issue 1. 2022-06-20. PMID:35720475. |
furthermore, the β-catenin inhibitors, icg-001 and pp, plus btz combination treatment revealed a notable decrease in cell viability and a marked increase in cell apoptosis rate, compared with that in cells treated with icg-001, pp or btz alone in the rpmi-8226br and kms-11br cell lines. |
2022-06-20 |
2023-08-14 |
Not clear |
| Cuicui W. β-catenin inhibitors ICG-001 and pyrvinium sensitize bortezomib-resistant multiple myeloma cells to bortezomib. Oncology letters. vol 24. issue 1. 2022-06-20. PMID:35720475. |
in conclusion, the β-catenin inhibitors, icg-001 and pp not only increased apoptosis, but also sensitized btz-resistant mm cells to btz, indicating their potential therapeutic application in mm. |
2022-06-20 |
2023-08-14 |
Not clear |